LOCUS       NM_001140               2697 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens arachidonate 15-lipoxygenase (ALOX15), mRNA.
ACCESSION   NM_001140 XM_937556
VERSION     NM_001140.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2697)
  AUTHORS   Zhang,W., Huang,F., Ding,X., Qin,J., Wang,W. and Luo,L.
  TITLE     Identifying ALOX15-initiated lipid peroxidation increases
            susceptibility to ferroptosis in asthma epithelial cells
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (5), 167176 (2024)
   PUBMED   38641013
  REMARK    GeneRIF: Identifying ALOX15-initiated lipid peroxidation increases
            susceptibility to ferroptosis in asthma epithelial cells.
REFERENCE   2  (bases 1 to 2697)
  AUTHORS   Hussein,M.M., Fouda,E.M., Shehab,Y., Nabih,E.S., Osman,A.M. and
            Ishak,S.R.
  TITLE     Association between arachidonate lipoxygenase 15,c.-292 C > T gene
            polymorphism and non-cystic fibrosis bronchiectasis in children: a
            pilot study on the effects on airway lipoxin A4 and disease
            phenotype
  JOURNAL   Ital J Pediatr 50 (1), 90 (2024)
   PUBMED   38685084
  REMARK    GeneRIF: Association between arachidonate lipoxygenase 15,c.-292 C
            > T gene polymorphism and non-cystic fibrosis bronchiectasis in
            children: a pilot study on the effects on airway lipoxin A4 and
            disease phenotype.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2697)
  AUTHORS   Alsabri,S.G., Guedi,G.G., Najar,M., Merimi,M., Lavoie,F., Grabs,D.,
            Fernandes,J., Pelletier,J.P., Martel-Pelletier,J., Benderdour,M.
            and Fahmi,H.
  TITLE     Epigenetic regulation of 15-lipoxygenase-1 expression in human
            chondrocytes by promoter methylation
  JOURNAL   Inflamm Res 72 (12), 2145-2153 (2023)
   PUBMED   37874359
  REMARK    GeneRIF: Epigenetic regulation of 15-lipoxygenase-1 expression in
            human chondrocytes by promoter methylation.
REFERENCE   4  (bases 1 to 2697)
  AUTHORS   He,K., Zhou,X., Du,H., Zhao,J., Deng,R. and Wang,J.
  TITLE     A review on the relationship between Arachidonic acid
            15-Lipoxygenase (ALOX15) and diabetes mellitus
  JOURNAL   PeerJ 11, e16239 (2023)
   PUBMED   37849828
  REMARK    GeneRIF: A review on the relationship between Arachidonic acid
            15-Lipoxygenase (ALOX15) and diabetes mellitus.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2697)
  AUTHORS   Kianfar,S., Salimi,V., Jahangirifard,A., Mirtajani,S.B.,
            Vaezi,M.A., Yavarian,J., Mokhtari-Azad,T. and Tavakoli-Yaraki,M.
  TITLE     15-lipoxygenase and cyclooxygenase expression profile and their
            related modulators in COVID-19 infection
  JOURNAL   Prostaglandins Leukot Essent Fatty Acids 197, 102587 (2023)
   PUBMED   37716021
  REMARK    GeneRIF: 15-lipoxygenase and cyclooxygenase expression profile and
            their related modulators in COVID-19 infection.
REFERENCE   6  (bases 1 to 2697)
  AUTHORS   Ackermann,J.A., Hofheinz,K., Zaiss,M.M. and Kronke,G.
  TITLE     The double-edged role of 12/15-lipoxygenase during inflammation and
            immunity
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1862 (4), 371-381 (2017)
   PUBMED   27480217
  REMARK    Review article
REFERENCE   7  (bases 1 to 2697)
  AUTHORS   Funk,C.D., Funk,L.B., FitzGerald,G.A. and Samuelsson,B.
  TITLE     Characterization of human 12-lipoxygenase genes
  JOURNAL   Proc Natl Acad Sci U S A 89 (9), 3962-3966 (1992)
   PUBMED   1570320
REFERENCE   8  (bases 1 to 2697)
  AUTHORS   Sigal,E., Dicharry,S., Highland,E. and Finkbeiner,W.E.
  TITLE     Cloning of human airway 15-lipoxygenase: identity to the
            reticulocyte enzyme and expression in epithelium
  JOURNAL   Am J Physiol 262 (4 Pt 1), L392-L398 (1992)
   PUBMED   1566855
REFERENCE   9  (bases 1 to 2697)
  AUTHORS   Conrad,D.J., Kuhn,H., Mulkins,M., Highland,E. and Sigal,E.
  TITLE     Specific inflammatory cytokines regulate the expression of human
            monocyte 15-lipoxygenase
  JOURNAL   Proc Natl Acad Sci U S A 89 (1), 217-221 (1992)
   PUBMED   1729692
REFERENCE   10 (bases 1 to 2697)
  AUTHORS   Izumi,T., Radmark,O., Jornvall,H. and Samuelsson,B.
  TITLE     Purification of two forms of arachidonate 15-lipoxygenase from
            human leukocytes
  JOURNAL   Eur J Biochem 202 (3), 1231-1238 (1991)
   PUBMED   1662607
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK312557.1, BC029032.1 and
            M23892.1.
            
            On Jul 5, 2019 this sequence version replaced NM_001140.4.
            
            Summary: This gene encodes a member of the lipoxygenase family of
            proteins. The encoded enzyme acts on various polyunsaturated fatty
            acid substrates to generate various bioactive lipid mediators such
            as eicosanoids, hepoxilins, lipoxins, and other molecules. The
            encoded enzyme and its reaction products have been shown to
            regulate inflammation and immunity. Multiple pseudogenes of this
            gene have been identified in the human genome. [provided by RefSeq,
            Aug 2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029032.1, AK290309.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000293761.8/ ENSP00000293761.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AK312557.1         1-13
            14-1407             BC029032.1         1-1394
            1408-2695           M23892.1           1384-2671
            2696-2697           BC029032.1         2683-2684
FEATURES             Location/Qualifiers
     source          1..2697
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.2"
     gene            1..2697
                     /gene="ALOX15"
                     /gene_synonym="12-LOX; 15-LOX; 15-LOX-1; LOG15"
                     /note="arachidonate 15-lipoxygenase"
                     /db_xref="GeneID:246"
                     /db_xref="HGNC:HGNC:433"
                     /db_xref="MIM:152392"
     exon            1..162
                     /gene="ALOX15"
                     /gene_synonym="12-LOX; 15-LOX; 15-LOX-1; LOG15"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..2016
                     /gene="ALOX15"
                     /gene_synonym="12-LOX; 15-LOX; 15-LOX-1; LOG15"
                     /EC_number="1.13.11.31"
                     /EC_number="1.13.11.33"
                     /EC_number="1.13.11.12"
                     /note="15-lipooxygenase-1; arachidonate omega-6
                     lipoxygenase; 12/15-lipoxygenase; arachidonate
                     12-lipoxygenase, leukocyte-type; 15-lipoxygenase type 1;
                     15-LOX type 1; linoleate 13S-lipoxygenase; hepoxilin A3
                     synthase Alox15"
                     /codon_start=1
                     /product="polyunsaturated fatty acid lipoxygenase ALOX15"
                     /protein_id="NP_001131.3"
                     /db_xref="CCDS:CCDS11049.1"
                     /db_xref="GeneID:246"
                     /db_xref="HGNC:HGNC:433"
                     /db_xref="MIM:152392"
                     /translation="MGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARG
                     KETELKVEVPEYLGPLLFVKLRKRHLLKDDAWFCNWISVQGPGAGDEVRFPCYRWVEG
                     NGVLSLPEGTGRTVGEDPQGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLYDL
                     PVDERFLEDKRVDFEVSLAKGLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERV
                     RDSWKEDALFGYQFLNGANPVVLRRSAHLPARLVFPPGMEELQAQLEKELEGGTLFEA
                     DFSLLDGIKANVILCSQQHLAAPLVMLKLQPDGKLLPMVIQLQLPRTGSPPPPLFLPT
                     DPPMAWLLAKCWVRSSDFQLHELQSHLLRGHLMAEVIVVATMRCLPSIHPIFKLIIPH
                     LRYTLEINVRARTGLVSDMGIFDQIMSTGGGGHVQLLKQAGAFLTYSSFCPPDDLADR
                     GLLGVKSSFYAQDALRLWEIIYRYVEGIVSLHYKTDVAVKDDPELQTWCREITEIGLQ
                     GAQDRGFPVSLQARDQVCHFVTMCIFTCTGQHASVHLGQLDWYSWVPNAPCTMRLPPP
                     TTKDATLETVMATLPNFHQASLQMSITWQLGRRQPVMVAVGQHEEEYFSGPEPKAVLK
                     KFREELAALDKEIEIRNAKLDMPYEYLRPSVVENSVAI"
     exon            163..364
                     /gene="ALOX15"
                     /gene_synonym="12-LOX; 15-LOX; 15-LOX-1; LOG15"
                     /inference="alignment:Splign:2.1.0"
     exon            365..446
                     /gene="ALOX15"
                     /gene_synonym="12-LOX; 15-LOX; 15-LOX-1; LOG15"
                     /inference="alignment:Splign:2.1.0"
     exon            447..569
                     /gene="ALOX15"
                     /gene_synonym="12-LOX; 15-LOX; 15-LOX-1; LOG15"
                     /inference="alignment:Splign:2.1.0"
     exon            570..673
                     /gene="ALOX15"
                     /gene_synonym="12-LOX; 15-LOX; 15-LOX-1; LOG15"
                     /inference="alignment:Splign:2.1.0"
     exon            674..834
                     /gene="ALOX15"
                     /gene_synonym="12-LOX; 15-LOX; 15-LOX-1; LOG15"
                     /inference="alignment:Splign:2.1.0"
     exon            835..978
                     /gene="ALOX15"
                     /gene_synonym="12-LOX; 15-LOX; 15-LOX-1; LOG15"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1188
                     /gene="ALOX15"
                     /gene_synonym="12-LOX; 15-LOX; 15-LOX-1; LOG15"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1275
                     /gene="ALOX15"
                     /gene_synonym="12-LOX; 15-LOX; 15-LOX-1; LOG15"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1445
                     /gene="ALOX15"
                     /gene_synonym="12-LOX; 15-LOX; 15-LOX-1; LOG15"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1567
                     /gene="ALOX15"
                     /gene_synonym="12-LOX; 15-LOX; 15-LOX-1; LOG15"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1668
                     /gene="ALOX15"
                     /gene_synonym="12-LOX; 15-LOX; 15-LOX-1; LOG15"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1836
                     /gene="ALOX15"
                     /gene_synonym="12-LOX; 15-LOX; 15-LOX-1; LOG15"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..2697
                     /gene="ALOX15"
                     /gene_synonym="12-LOX; 15-LOX; 15-LOX-1; LOG15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2677..2682
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALOX15"
                     /gene_synonym="12-LOX; 15-LOX; 15-LOX-1; LOG15"
                     /note="hexamer: AATAAA"
     polyA_site      2697
                     /gene="ALOX15"
                     /gene_synonym="12-LOX; 15-LOX; 15-LOX-1; LOG15"
                     /note="major polyA site"
ORIGIN      
        1 agaaggagcg aaacatcttt gagcaagatg ggtctctacc gcatccgcgt gtccactggg
       61 gcctcgctct atgccggttc caacaaccag gtgcagctgt ggctggtcgg ccagcacggg
      121 gaggcggcgc tcgggaagcg actgtggccc gcacggggca aggagacaga actcaaggtg
      181 gaagtaccgg agtatctggg gccgctgctg tttgtgaaac tgcgcaaacg gcacctcctt
      241 aaggacgacg cctggttctg caactggatc tctgtgcagg gccccggagc cggggacgag
      301 gtcaggttcc cttgttaccg ctgggtggag ggcaacggcg tcctgagcct gcctgaaggc
      361 accggccgca ctgtgggcga ggaccctcag ggcctgttcc agaaacaccg ggaagaagag
      421 ctggaagaga gaaggaagtt gtaccggtgg ggaaactgga aggacgggtt aattctgaat
      481 atggctgggg ccaaactata tgacctccct gtggatgagc gatttctgga agacaagaga
      541 gttgactttg aggtttcgct ggccaagggg ctggccgacc tcgctatcaa agactctcta
      601 aatgttctga cttgctggaa ggatctagat gacttcaacc ggattttctg gtgtggtcag
      661 agcaagctgg ctgagcgcgt gcgggactcc tggaaggaag atgccttatt tgggtaccag
      721 tttcttaatg gcgccaaccc cgtggtgctg aggcgctctg ctcaccttcc tgctcgccta
      781 gtgttccctc caggcatgga ggaactgcag gcccagctgg agaaggagct ggagggaggc
      841 acactgttcg aagctgactt ctccctgctg gatgggatca aggccaacgt cattctctgt
      901 agccagcagc acctggctgc ccctctagtc atgctgaaat tgcagcctga tgggaaactc
      961 ttgcccatgg tcatccagct ccagctgccc cgcacaggat ccccaccacc tccccttttc
     1021 ttgcctacgg atcccccaat ggcctggctt ctggccaaat gctgggtgcg cagctctgac
     1081 ttccagctcc atgagctgca gtctcatctt ctgaggggac acttgatggc tgaggtcatt
     1141 gttgtggcca ccatgaggtg cctgccgtcg atacatccta tcttcaagct tataattccc
     1201 cacctgcgat acaccctgga aattaacgtc cgggccagga ctgggctggt ctctgacatg
     1261 ggaattttcg accagataat gagcactggt gggggaggcc acgtgcagct gctcaagcaa
     1321 gctggagcct tcctaaccta cagctccttc tgtccccctg atgacttggc cgaccggggg
     1381 ctcctgggag tgaagtcttc cttctatgcc caagatgcgc tgcggctctg ggaaatcatc
     1441 tatcggtatg tggaaggaat cgtgagtctc cactataaga cagacgtggc tgtgaaagac
     1501 gacccagagc tgcagacctg gtgtcgagag atcactgaaa tcgggctgca aggggcccag
     1561 gaccgagggt ttcctgtctc tttacaggct cgggaccagg tttgccactt tgtcaccatg
     1621 tgtatcttca cctgcaccgg ccaacacgcc tctgtgcacc tgggccagct ggactggtac
     1681 tcttgggtgc ctaatgcacc ctgcacgatg cggctgcccc cgccaaccac caaggatgca
     1741 acgctggaga cagtgatggc gacactgccc aacttccacc aggcttctct ccagatgtcc
     1801 atcacttggc agctgggcag acgccagccc gttatggtgg ctgtgggcca gcatgaggag
     1861 gagtattttt cgggccctga gcctaaggct gtgctgaaga agttcaggga ggagctggct
     1921 gccctggata aggaaattga gatccggaat gcaaagctgg acatgcccta cgagtacctg
     1981 cggcccagcg tggtggaaaa cagtgtggcc atctaagcgt cgccaccctt tggttatttc
     2041 agcccccatc acccaagcca caagctgacc ccttcgtggt tatagccctg ccctcccaag
     2101 tcccaccctc ttcccatgtc ccaccctccc tagaggggca ccttttcatg gtctctgcac
     2161 ccagtgaaca cattttactc tagaggcatc acctgggacc ttactcctct ttccttcctt
     2221 cctcctttcc tatcttcctt cctctctctc ttcctctttc ttcattcaga tctatatggc
     2281 aaatagccac aattatataa atcatttcaa gactagaata gggggatata atacatatta
     2341 ctccacacct tttatgaatc aaatatgatt tttttgttgt tgttaagaca gagtctcact
     2401 ttgacaccca ggctggagtg cagtggtgcc atcaccacgg ctcactgcag cctcagcgtc
     2461 ctgggctcaa atgatcctcc cacctcagcc tcctgagtag ctgggactac aggctcatgc
     2521 catcatgccc agctaatatt tttttatttt cgtggagacg gggcctcact atgttgccta
     2581 ggctggaaat aggattttga acccaaattg agtttaacaa taataaaaag ttgttttacg
     2641 ctaaagatgg aaaagaacta ggactgaact attttaaata aaatattggc aaaagaa
//
