LOCUS       NM_000697               2392 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens arachidonate 12-lipoxygenase, 12S type (ALOX12), mRNA.
ACCESSION   NM_000697
VERSION     NM_000697.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2392)
  AUTHORS   Canyelles-Nino,M., Gonzalez-Lafont,A. and Lluch,J.M.
  TITLE     Hydroperoxidation of Docosahexaenoic Acid by Human ALOX12 and
            pigALOX15-mini-LOX
  JOURNAL   Int J Mol Sci 24 (7), 6064 (2023)
   PUBMED   37047037
  REMARK    GeneRIF: Hydroperoxidation of Docosahexaenoic Acid by Human ALOX12
            and pigALOX15-mini-LOX.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2392)
  AUTHORS   Tran,M., Signorelli,R.L., Yamaguchi,A., Chen,E., Holinstat,M.,
            Iavarone,A.T., Offenbacher,A.R. and Holman,T.
  TITLE     Biochemical and hydrogen-deuterium exchange studies of the single
            nucleotide polymorphism Y649C in human platelet 12-lipoxygenase
            linked to a bleeding disorder
  JOURNAL   Arch Biochem Biophys 733, 109472 (2023)
   PUBMED   36442529
  REMARK    GeneRIF: Biochemical and hydrogen-deuterium exchange studies of the
            single nucleotide polymorphism Y649C in human platelet
            12-lipoxygenase linked to a bleeding disorder.
REFERENCE   3  (bases 1 to 2392)
  AUTHORS   Weng,S., Liu,Z., Xu,H., Ge,X., Ren,Y., Dang,Q., Liu,L., Zhang,J.,
            Luo,P., Ren,J. and Han,X.
  TITLE     ALOX12: A Novel Insight in Bevacizumab Response, Immunotherapy
            Effect, and Prognosis of Colorectal Cancer
  JOURNAL   Front Immunol 13, 910582 (2022)
   PUBMED   35833141
  REMARK    GeneRIF: ALOX12: A Novel Insight in Bevacizumab Response,
            Immunotherapy Effect, and Prognosis of Colorectal Cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2392)
  AUTHORS   Chen,S. and Zou,H.
  TITLE     Key Role of 12-Lipoxygenase and Its Metabolite
            12-Hydroxyeicosatetraenoic Acid (12-HETE) in Diabetic Retinopathy
  JOURNAL   Curr Eye Res 47 (3), 329-335 (2022)
   PUBMED   35129022
  REMARK    GeneRIF: Key Role of 12-Lipoxygenase and Its Metabolite
            12-Hydroxyeicosatetraenoic Acid (12-HETE) in Diabetic Retinopathy.
            Review article
REFERENCE   5  (bases 1 to 2392)
  AUTHORS   Contursi,A., Schiavone,S., Dovizio,M., Hinz,C., Fullone,R.,
            Tacconelli,S., Tyrrell,V.J., Grande,R., Lanuti,P., Marchisio,M.,
            Zucchelli,M., Ballerini,P., Lanas,A., O'Donnell,V.B. and
            Patrignani,P.
  TITLE     Platelets induce free and phospholipid-esterified
            12-hydroxyeicosatetraenoic acid generation in colon cancer cells by
            delivering 12-lipoxygenase
  JOURNAL   J Lipid Res 62, 100109 (2021)
   PUBMED   34428433
  REMARK    GeneRIF: Platelets induce free and phospholipid-esterified
            12-hydroxyeicosatetraenoic acid generation in colon cancer cells by
            delivering 12-lipoxygenase.
REFERENCE   6  (bases 1 to 2392)
  AUTHORS   Yoshimoto,T., Arakawa,T., Hada,T., Yamamoto,S. and Takahashi,E.
  TITLE     Structure and chromosomal localization of human arachidonate
            12-lipoxygenase gene
  JOURNAL   J Biol Chem 267 (34), 24805-24809 (1992)
   PUBMED   1447217
REFERENCE   7  (bases 1 to 2392)
  AUTHORS   Funk,C.D., Funk,L.B., FitzGerald,G.A. and Samuelsson,B.
  TITLE     Characterization of human 12-lipoxygenase genes
  JOURNAL   Proc Natl Acad Sci U S A 89 (9), 3962-3966 (1992)
   PUBMED   1570320
REFERENCE   8  (bases 1 to 2392)
  AUTHORS   Hada,T., Ueda,N., Takahashi,Y. and Yamamoto,S.
  TITLE     Catalytic properties of human platelet 12-lipoxygenase as compared
            with the enzymes of other origins
  JOURNAL   Biochim Biophys Acta 1083 (1), 89-93 (1991)
   PUBMED   1851637
REFERENCE   9  (bases 1 to 2392)
  AUTHORS   Yoshimoto,T., Yamamoto,Y., Arakawa,T., Suzuki,H., Yamamoto,S.,
            Yokoyama,C., Tanabe,T. and Toh,H.
  TITLE     Molecular cloning and expression of human arachidonate
            12-lipoxygenase
  JOURNAL   Biochem Biophys Res Commun 172 (3), 1230-1235 (1990)
   PUBMED   2244907
REFERENCE   10 (bases 1 to 2392)
  AUTHORS   Izumi,T., Hoshiko,S., Radmark,O. and Samuelsson,B.
  TITLE     Cloning of the cDNA for human 12-lipoxygenase
  JOURNAL   Proc Natl Acad Sci U S A 87 (19), 7477-7481 (1990)
   PUBMED   2217179
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC040977.10 and M58704.1.
            
            On Nov 23, 2018 this sequence version replaced NM_000697.2.
            
            Summary: This gene encodes a member of the lipoxygenase family of
            proteins. The encoded enzyme acts on different polyunsaturated
            fatty acid substrates to generate bioactive lipid mediators
            including eicosanoids and lipoxins. The encoded enzyme and its
            reaction products have been shown to regulate platelet function.
            Elevated expression of this gene has been observed in pancreatic
            islets derived from human diabetes patients. Allelic variants in
            this gene may be associated with susceptibility to toxoplasmosis.
            Multiple pseudogenes of this gene have been identified in the human
            genome. [provided by RefSeq, Aug 2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M62982.1, M35418.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893, SAMEA2147975
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000251535.11/ ENSP00000251535.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AC040977.10        120893-120908
            17-36               AC040977.10        120909-120928
            37-191              M58704.1           1-155
            192-192             AC040977.10        121084-121084
            193-833             M58704.1           157-797
            834-851             AC040977.10        124268-124285
            852-1160            M58704.1           816-1124
            1161-1161           AC040977.10        126586-126586
            1162-2371           M58704.1           1126-2335
            2372-2374           AC040977.10        135578-135580
            2375-2392           AC040977.10        135581-135598
FEATURES             Location/Qualifiers
     source          1..2392
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..2392
                     /gene="ALOX12"
                     /gene_synonym="12-LOX; 12S-LOX; LOG12"
                     /note="arachidonate 12-lipoxygenase, 12S type"
                     /db_xref="GeneID:239"
                     /db_xref="HGNC:HGNC:429"
                     /db_xref="MIM:152391"
     exon            1..204
                     /gene="ALOX12"
                     /gene_synonym="12-LOX; 12S-LOX; LOG12"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..2061
                     /gene="ALOX12"
                     /gene_synonym="12-LOX; 12S-LOX; LOG12"
                     /EC_number="1.13.11.31"
                     /EC_number="1.13.11.33"
                     /note="platelet 12-LOX; platelet-type 12-lipoxygenase;
                     12S-lipoxygenase; platelet-type lipoxygenase 12;
                     Arachidonate 12-lipoxygenase, 12S-type; lipoxin synthase
                     12-LO; linoleate 13S-lipoxygenase; arachidonate
                     15-lipoxygenase,15S-type; arachidonate (12S)-lipoxygenase;
                     arachidonate (15S)-lipoxygenase"
                     /codon_start=1
                     /product="polyunsaturated fatty acid lipoxygenase ALOX12"
                     /protein_id="NP_000688.2"
                     /db_xref="CCDS:CCDS11084.1"
                     /db_xref="GeneID:239"
                     /db_xref="HGNC:HGNC:429"
                     /db_xref="MIM:152391"
                     /translation="MGRYRIRVATGAWLFSGSYNRVQLWLVGTRGEAELELQLRPARG
                     EEEEFDHDVAEDLGLLQFVRLRKHHWLVDDAWFCDRITVQGPGACAEVAFPCYRWVQG
                     EDILSLPEGTARLPGDNALDMFQKHREKELKDRQQIYCWATWKEGLPLTIAADRKDDL
                     PPNMRFHEEKRLDFEWTLKAGALEMALKRVYTLLSSWNCLEDFDQIFWGQKSALAEKV
                     RQCWQDDELFSYQFLNGANPMLLRRSTSLPSRLVLPSGMEELQAQLEKELQNGSLFEA
                     DFILLDGIPANVIRGEKQYLAAPLVMLKMEPNGKLQPMVIQIQPPNPSSPTPTLFLPS
                     DPPLAWLLAKSWVRNSDFQLHEIQYHLLNTHLVAEVIAVATMRCLPGLHPIFKFLIPH
                     IRYTMEINTRARTQLISDGGIFDKAVSTGGGGHVQLLRRAAAQLTYCSLCPPDDLADR
                     GLLGLPGALYAHDALRLWEIIARYVEGIVHLFYQRDDIVKGDPELQAWCREITEVGLC
                     QAQDRGFPVSFQSQSQLCHFLTMCVFTCTAQHAAINQGQLDWYAWVPNAPCTMRMPPP
                     TTKEDVTMATVMGSLPDVRQACLQMAISWHLSRRQPDMVPLGHHKEKYFSGPKPKAVL
                     NQFRTDLEKLEKEITARNEQLDWPYEYLKPSCIENSVTI"
     exon            205..406
                     /gene="ALOX12"
                     /gene_synonym="12-LOX; 12S-LOX; LOG12"
                     /inference="alignment:Splign:2.1.0"
     exon            407..488
                     /gene="ALOX12"
                     /gene_synonym="12-LOX; 12S-LOX; LOG12"
                     /inference="alignment:Splign:2.1.0"
     exon            489..611
                     /gene="ALOX12"
                     /gene_synonym="12-LOX; 12S-LOX; LOG12"
                     /inference="alignment:Splign:2.1.0"
     exon            612..715
                     /gene="ALOX12"
                     /gene_synonym="12-LOX; 12S-LOX; LOG12"
                     /inference="alignment:Splign:2.1.0"
     exon            716..876
                     /gene="ALOX12"
                     /gene_synonym="12-LOX; 12S-LOX; LOG12"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1020
                     /gene="ALOX12"
                     /gene_synonym="12-LOX; 12S-LOX; LOG12"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1230
                     /gene="ALOX12"
                     /gene_synonym="12-LOX; 12S-LOX; LOG12"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1317
                     /gene="ALOX12"
                     /gene_synonym="12-LOX; 12S-LOX; LOG12"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1487
                     /gene="ALOX12"
                     /gene_synonym="12-LOX; 12S-LOX; LOG12"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1609
                     /gene="ALOX12"
                     /gene_synonym="12-LOX; 12S-LOX; LOG12"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1710
                     /gene="ALOX12"
                     /gene_synonym="12-LOX; 12S-LOX; LOG12"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1881
                     /gene="ALOX12"
                     /gene_synonym="12-LOX; 12S-LOX; LOG12"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..2392
                     /gene="ALOX12"
                     /gene_synonym="12-LOX; 12S-LOX; LOG12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2353..2358
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALOX12"
                     /gene_synonym="12-LOX; 12S-LOX; LOG12"
                     /note="hexamer: AATAAA"
     polyA_site      2392
                     /gene="ALOX12"
                     /gene_synonym="12-LOX; 12S-LOX; LOG12"
                     /note="major polyA site"
ORIGIN      
        1 ggcagccctg ggcggtcccg ggaatcgcac aggacccggc tcccctcgcc taagctgctg
       61 gggggcgcca tgggccgcta ccgcatccgc gtggccaccg gggcctggct cttctccggg
      121 tcgtacaacc gcgtgcagct ttggctggtc gggacgcgcg gggaggcgga gctggagctg
      181 cagctgcggc ccgcgcgggg cgaggaggag gagtttgatc atgacgttgc agaggacttg
      241 gggctcctgc agttcgtgag gctgcgcaag caccactggc tggtggacga cgcgtggttc
      301 tgcgaccgca tcacggtgca gggccctgga gcctgcgcgg aggtggcctt cccgtgctac
      361 cgctgggtgc agggcgagga catcctgagc ctgcccgagg gcaccgcccg cctgccagga
      421 gacaatgctt tggacatgtt ccagaagcat cgagagaagg aactgaaaga cagacagcag
      481 atctactgct gggccacctg gaaggaaggg ttacccctga ccatcgctgc agaccgtaag
      541 gatgatctac ctccaaatat gagattccat gaggagaaga ggctggactt tgaatggaca
      601 ctgaaggcag gggctctgga gatggccctc aaacgtgttt acaccctcct gagctcctgg
      661 aactgcctag aagactttga tcagatcttc tggggccaga agagtgccct ggctgagaag
      721 gttcgccagt gctggcagga tgatgagttg ttcagctacc agttcctcaa tggtgccaac
      781 cccatgctgt tgagacgctc gacctctctg ccctccaggc tagtgctgcc ctcggggatg
      841 gaagagcttc aggctcaact ggagaaagaa cttcagaatg gttccctgtt tgaagctgac
      901 ttcatccttc tggatggaat tccagccaac gtgatccgag gagagaagca atacctggct
      961 gcccccctcg ttatgctgaa gatggagccc aatgggaagc tgcagcccat ggtcatccag
     1021 attcagcctc ccaaccccag ctctccaacc ccaacactgt tcctgccctc agacccccca
     1081 cttgcctggc tcctggcaaa gtcctgggtc cgaaattcag atttccaact gcacgagatc
     1141 cagtatcact tgctgaacac tcacctggtg gctgaggtca tcgctgtcgc caccatgcgg
     1201 tgcctcccag gactgcaccc catcttcaag ttcctgatcc cccatatccg ctacaccatg
     1261 gaaatcaaca cccgggcccg gacccaactc atctcagatg gaggaatttt tgataaggca
     1321 gtgagcacag gtggaggggg ccatgtacag ttgctccgtc gggcggcagc tcagctgacc
     1381 tactgctccc tctgtcctcc tgacgacctg gctgaccggg gcctgctggg actcccaggt
     1441 gctctctatg cccatgatgc tttacggctc tgggagatca ttgccaggta tgtggagggg
     1501 atcgtccacc tcttctacca aagggatgac atagtgaagg gggaccctga gctgcaggcc
     1561 tggtgtcggg agatcacgga ggtggggctg tgccaggccc aggaccgagg tttccctgtc
     1621 tccttccagt cccagagtca actctgccat ttcctcacca tgtgcgtctt cacgtgcact
     1681 gcccagcatg ccgccatcaa ccagggccag ctggactggt atgcctgggt ccctaatgct
     1741 ccatgcacaa tgcggatgcc cccacccacc accaaggaag atgtgacgat ggccacagtg
     1801 atggggtcac tacctgatgt ccggcaggcc tgtcttcaaa tggccatctc atggcatctg
     1861 agtcgccgcc agccagacat ggtgcctctg gggcaccaca aagaaaaata tttctcaggc
     1921 cccaagccca aagctgtgct aaaccaattc cgaacagatt tggaaaagct ggaaaaggag
     1981 attacagccc ggaatgagca acttgactgg ccctatgaat atctgaagcc cagctgcata
     2041 gagaacagtg tcaccatctg agccctagag tgactctacc tgcaagattt cacatcagct
     2101 ttaggactga catttctatc ttgaatttca tgctttccta aagtctctgc tgctaaggct
     2161 ctatttcctc ccccagttaa accccctaca ttagtatccc actagcccag gggagcagta
     2221 aactttctct gcaaagacta gatccttttt tacgctttgc agaccgcata gtcactgtct
     2281 caactactca gctctcctgc tgcagcatga aggcagccac agacaacatg gaaatgagtg
     2341 tgactatgtt ccaataaaac tttatggaca ctgagatatg aatgttacat ca
//
