LOCUS       NM_018436               1441 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens allantoicase (ALLC), mRNA.
ACCESSION   NM_018436
VERSION     NM_018436.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1441)
  AUTHORS   Park,T.J., Park,J.S., Cheong,H.S., Park,B.L., Kim,L.H., Heo,J.S.,
            Kim,Y.K., Kim,K.U., Uh,S.T., Lee,H.S., Na,J.O., Seo,K.H.,
            Choi,J.S., Kim,Y.H., Kim,M.S., Park,C.S. and Shin,H.D.
  TITLE     Genome-wide association study identifies ALLC polymorphisms
            correlated with FEV change by corticosteroid
  JOURNAL   Clin Chim Acta 436, 20-26 (2014)
   PUBMED   24792382
REFERENCE   2  (bases 1 to 1441)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   3  (bases 1 to 1441)
  AUTHORS   Vigetti,D., Monetti,C., Prati,M., Gornati,R. and Bernardini,G.
  TITLE     Genomic organization and chromosome localization of the murine and
            human allantoicase gene
  JOURNAL   Gene 289 (1-2), 13-17 (2002)
   PUBMED   12036579
REFERENCE   4  (bases 1 to 1441)
  AUTHORS   Vigetti,D., Monetti,C., Acquati,F., Taramelli,R. and Bernardini,G.
  TITLE     Human allantoicase gene: cDNA cloning, genomic organization and
            chromosome localization
  JOURNAL   Gene 256 (1-2), 253-260 (2000)
   PUBMED   11054555
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB054905.1, BC029652.1 and AC010907.10.
            
            On Nov 22, 2018 this sequence version replaced NM_018436.3.
            
            Summary: Allantoicase (EC 3.5.3.4) participates in the uric acid
            degradation pathway. Its enzymatic activity, like that of urate
            oxidase (MIM 191540), was lost during vertebrate
            evolution.[supplied by OMIM, Nov 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.188641.1, AK302299.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000252505.4/ ENSP00000252505.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                DB054905.1         5-24
            21-101              BC029652.1         1-81
            102-102             AC010907.10        85294-85294
            103-485             BC029652.1         83-465
            486-486             AC010907.10        95856-95856
            487-1064            BC029652.1         467-1044
            1065-1067           AC010907.10        115761-115763
            1068-1441           BC029652.1         1045-1418
FEATURES             Location/Qualifiers
     source          1..1441
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p25.3"
     gene            1..1441
                     /gene="ALLC"
                     /gene_synonym="ALC"
                     /note="allantoicase"
                     /db_xref="GeneID:55821"
                     /db_xref="HGNC:HGNC:17377"
                     /db_xref="MIM:612396"
     exon            1..95
                     /gene="ALLC"
                     /gene_synonym="ALC"
                     /inference="alignment:Splign:2.1.0"
     exon            96..190
                     /gene="ALLC"
                     /gene_synonym="ALC"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..1333
                     /gene="ALLC"
                     /gene_synonym="ALC"
                     /EC_number="3.5.3.4"
                     /note="allantoate amidinohydrolase; probable allantoicase"
                     /codon_start=1
                     /product="probable inactive allantoicase"
                     /protein_id="NP_060906.3"
                     /db_xref="CCDS:CCDS46223.1"
                     /db_xref="GeneID:55821"
                     /db_xref="HGNC:HGNC:17377"
                     /db_xref="MIM:612396"
                     /translation="MDMASESVGGKILFATDDFFAPAENLIKSDSPCFKEHEYTEFGK
                     WMDGWETRRKRIPGHDWCVLRLGIQGVIRGFDVDVSYFTGDYAPRVSIQAANLEEDKL
                     PEIPERGTRTGAAATPEEFEAIAELKSDDWSYLVPMTELKPGNPASGHNYFLVNSQQR
                     WTHIRLNIFPDGGIARLRVFGTGQKDWTATDPKEPADLVAIAFGGVCVGFSNAKFGHP
                     NNIIGVGGAKSMADGWETARRLDRPPILENDENGILLVPGCEWAVFRLAHPGVITRIE
                     IDTKYFEGNAPDSCKVDGCILTTQEEEAVIRQKWILPAHKWKPLLPVTKLSPNQSHLF
                     DSLTLELQDVITHARLTIVPDGGVSRLRLRGFPSSICLLRPREKPMLKFSVSFKANP"
     exon            191..241
                     /gene="ALLC"
                     /gene_synonym="ALC"
                     /inference="alignment:Splign:2.1.0"
     exon            242..329
                     /gene="ALLC"
                     /gene_synonym="ALC"
                     /inference="alignment:Splign:2.1.0"
     exon            330..455
                     /gene="ALLC"
                     /gene_synonym="ALC"
                     /inference="alignment:Splign:2.1.0"
     exon            456..535
                     /gene="ALLC"
                     /gene_synonym="ALC"
                     /inference="alignment:Splign:2.1.0"
     exon            536..668
                     /gene="ALLC"
                     /gene_synonym="ALC"
                     /inference="alignment:Splign:2.1.0"
     exon            669..824
                     /gene="ALLC"
                     /gene_synonym="ALC"
                     /inference="alignment:Splign:2.1.0"
     exon            825..898
                     /gene="ALLC"
                     /gene_synonym="ALC"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1007
                     /gene="ALLC"
                     /gene_synonym="ALC"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1132
                     /gene="ALLC"
                     /gene_synonym="ALC"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1441
                     /gene="ALLC"
                     /gene_synonym="ALC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1420..1425
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALLC"
                     /gene_synonym="ALC"
                     /note="hexamer: AATAAA"
     polyA_site      1441
                     /gene="ALLC"
                     /gene_synonym="ALC"
                     /note="major polyA site"
ORIGIN      
        1 attctctctg agctggcact caagcaccgt gggaccttgg ctggcttctg gggagcaaga
       61 gatccattta tgaatacttg atttctgact gctgggaagc acggctgatg ctccgaagga
      121 gggaagactg acccggtttc tggacttcac ccagctgatg gacatggcat ctgaatccgt
      181 aggaggaaaa attttatttg caacagatga cttttttgct cctgcagaaa acctcataaa
      241 gagtgacagc ccgtgcttca aagagcatga atatacggag tttgggaaat ggatggatgg
      301 ctgggagacc aggaggaaaa ggattccagg tcacgactgg tgtgtcctca ggctggggat
      361 ccaaggagtc atccggggct tcgacgtgga cgtttcttac ttcacgggag attacgctcc
      421 tcgagtgtcc attcaagcag caaacttgga agaagataaa ctaccagaaa tcccagaaag
      481 aggaaccagg acaggagctg cagccactcc tgaggagttt gaagccattg ctgagctaaa
      541 atccgacgac tggagttact tggttcccat gactgagctt aagccaggaa accctgcttc
      601 cggccacaac tattttcttg tcaattccca gcagagatgg actcatatca gactcaacat
      661 tttcccagat ggtggaattg cacgacttag agtattcggt actggacaaa aagactggac
      721 tgcaactgac cccaaagaac ctgcagacct agtggccatc gcttttgggg gtgtctgtgt
      781 aggatttagt aatgctaagt ttgggcaccc aaacaatata ataggagttg gcggggcaaa
      841 gtctatggcg gatggttggg aaactgcaag aaggctggac cggccaccaa tattagaaaa
      901 tgatgagaat ggcattctct tggttccggg ttgtgaatgg gcagttttcc gattggcaca
      961 tcctggagta ataactcgaa ttgaaattga cacaaaatat tttgaaggca atgctcctga
     1021 cagctgtaaa gtggatgggt gcatcctgac aactcaggaa gaagaagccg tgatcaggca
     1081 aaagtggatt ctcccggccc acaagtggaa accactgctt ccagtgacca agttgtctcc
     1141 caaccaaagt catctgttcg atagcctgac cctagagctc caagatgtca tcactcacgc
     1201 caggctcacc atcgtccccg acgggggagt gagccgcctt cggctccggg gcttccccag
     1261 ctccatctgc ctcctgaggc cccgggagaa gcccatgttg aagttctcgg tgagcttcaa
     1321 agcaaaccct taacacacac aaagccccgg tgtcggacac acagcagtaa tttcccagtc
     1381 atagtcttct tttcaaatgt tttgaacacc tggtgattta ataaagtggt cgtctcacaa
     1441 a
//
