LOCUS       NM_032306                970 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens alkB homolog 7 (ALKBH7), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_032306
VERSION     NM_032306.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 970)
  AUTHORS   Wang,T., Lin,B., Cai,B., Cao,Z., Liang,C., Wu,S., Xu,E., Li,L.,
            Peng,H. and Liu,H.
  TITLE     Integrative pan-cancer analysis reveals the prognostic and
            immunotherapeutic value of ALKBH7 in HNSC
  JOURNAL   Aging (Albany NY) 16 (19), 12781-12805 (2024)
   PUBMED   39400540
  REMARK    GeneRIF: Integrative pan-cancer analysis reveals the prognostic and
            immunotherapeutic value of ALKBH7 in HNSC.
REFERENCE   2  (bases 1 to 970)
  AUTHORS   Liu,X., Liu,L., Wu,A., Huang,S., Xu,Z., Zhang,X., Li,Z., Li,H. and
            Dong,J.
  TITLE     Transformed astrocytes confer temozolomide resistance on
            glioblastoma via delivering ALKBH7 to enhance APNG expression after
            educating by glioblastoma stem cells-derived exosomes
  JOURNAL   CNS Neurosci Ther 30 (2), e14599 (2024)
   PUBMED   38332576
  REMARK    GeneRIF: Transformed astrocytes confer temozolomide resistance on
            glioblastoma via delivering ALKBH7 to enhance APNG expression after
            educating by glioblastoma stem cells-derived exosomes.
REFERENCE   3  (bases 1 to 970)
  AUTHORS   Lim,S.H., Snider,J., Birimberg-Schwartz,L., Ip,W., Serralha,J.C.,
            Botelho,H.M., Lopes-Pacheco,M., Pinto,M.C., Moutaoufik,M.T.,
            Zilocchi,M., Laselva,O., Esmaeili,M., Kotlyar,M., Lyakisheva,A.,
            Tang,P., Lopez Vazquez,L., Akula,I., Aboualizadeh,F., Wong,V.,
            Grozavu,I., Opacak-Bernardi,T., Yao,Z., Mendoza,M., Babu,M.,
            Jurisica,I., Gonska,T., Bear,C.E., Amaral,M.D. and Stagljar,I.
  TITLE     CFTR interactome mapping using the mammalian membrane two-hybrid
            high-throughput screening system
  JOURNAL   Mol Syst Biol 18 (2), e10629 (2022)
   PUBMED   35156780
REFERENCE   4  (bases 1 to 970)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   5  (bases 1 to 970)
  AUTHORS   Zhang,L.S., Xiong,Q.P., Pena Perez,S., Liu,C., Wei,J., Le,C.,
            Zhang,L., Harada,B.T., Dai,Q., Feng,X., Hao,Z., Wang,Y., Dong,X.,
            Hu,L., Wang,E.D., Pan,T., Klungland,A., Liu,R.J. and He,C.
  TITLE     ALKBH7-mediated demethylation regulates mitochondrial polycistronic
            RNA processing
  JOURNAL   Nat Cell Biol 23 (7), 684-691 (2021)
   PUBMED   34253897
  REMARK    GeneRIF: ALKBH7-mediated demethylation regulates mitochondrial
            polycistronic RNA processing.
REFERENCE   6  (bases 1 to 970)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   7  (bases 1 to 970)
  AUTHORS   Walker,A.R., Silvestrov,P., Muller,T.A., Podolsky,R.H., Dyson,G.,
            Hausinger,R.P. and Cisneros,G.A.
  TITLE     ALKBH7 Variant Related to Prostate Cancer Exhibits Altered
            Substrate Binding
  JOURNAL   PLoS Comput Biol 13 (2), e1005345 (2017)
   PUBMED   28231280
  REMARK    GeneRIF: Our results uncovered a SNP of ALKBH7, rs7540, which is
            associated with prostate cancer disease in a statistically
            significantly manner in two separate cohorts, and maintained in
            African American men.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 970)
  AUTHORS   Wang,G., He,Q., Feng,C., Liu,Y., Deng,Z., Qi,X., Wu,W., Mei,P. and
            Chen,Z.
  TITLE     The atomic resolution structure of human AlkB homolog 7 (ALKBH7), a
            key protein for programmed necrosis and fat metabolism
  JOURNAL   J Biol Chem 289 (40), 27924-27936 (2014)
   PUBMED   25122757
  REMARK    GeneRIF: ALKBH7 possesses the conserved double-stranded beta-helix
            fold that coordinates a catalytically active iron by a conserved
            HX(D/E) em leader Xn em leader H motif.
REFERENCE   9  (bases 1 to 970)
  AUTHORS   Fu,D., Jordan,J.J. and Samson,L.D.
  TITLE     Human ALKBH7 is required for alkylation and oxidation-induced
            programmed necrosis
  JOURNAL   Genes Dev 27 (10), 1089-1100 (2013)
   PUBMED   23666923
  REMARK    GeneRIF: novel role for a AlkB homolog, human ALKBH7, in programmed
            necrosis, presenting a new target for therapeutic intervention in
            cancer cells that are resistant to apoptotic cell death
REFERENCE   10 (bases 1 to 970)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY358858.1 and BM271861.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032306.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.715487.1,
                                           SRR1163655.40748.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000245812.8/ ENSP00000245812.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-749               AY358858.1         362-1110
            750-970             BM271861.1         36-256              c
FEATURES             Location/Qualifiers
     source          1..970
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..970
                     /gene="ALKBH7"
                     /gene_synonym="ABH7; SPATA11; UNQ6002"
                     /note="alkB homolog 7"
                     /db_xref="GeneID:84266"
                     /db_xref="HGNC:HGNC:21306"
                     /db_xref="MIM:613305"
     exon            1..231
                     /gene="ALKBH7"
                     /gene_synonym="ABH7; SPATA11; UNQ6002"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..693
                     /gene="ALKBH7"
                     /gene_synonym="ABH7; SPATA11; UNQ6002"
                     /note="spermatogenesis associated 11; alkylated DNA repair
                     protein alkB homolog 7; alpha-ketoglutarate-dependent
                     dioxygenase alkB homolog 7, mitochondrial; probable
                     alpha-ketoglutarate-dependent dioxygenase ABH7;
                     spermatogenesis cell proliferation related protein;
                     spermatogenesis-associated protein 11; alkB, alkylation
                     repair homolog 7"
                     /codon_start=1
                     /product="alpha-ketoglutarate-dependent dioxygenase alkB
                     homolog 7, mitochondrial precursor"
                     /protein_id="NP_115682.1"
                     /db_xref="CCDS:CCDS12163.1"
                     /db_xref="GeneID:84266"
                     /db_xref="HGNC:HGNC:21306"
                     /db_xref="MIM:613305"
                     /translation="MAGTGLLALRTLPGPSWVRGSGPSVLSRLQDAAVVRPGFLSTAE
                     EETLSRELEPELRRRRYEYDHWDAAIHGFRETEKSRWSEASRAILQRVQAAAFGPGQT
                     LLSSVHVLDLEARGYIKPHVDSIKFCGATIAGLSLLSPSVMRLVHTQEPGEWLELLLE
                     PGSLYILRGSARYDFSHEILRDEESFFGERRIPRGRRISVICRSLPEGMGPGESGQPP
                     PAC"
     exon            232..405
                     /gene="ALKBH7"
                     /gene_synonym="ABH7; SPATA11; UNQ6002"
                     /inference="alignment:Splign:2.1.0"
     exon            406..530
                     /gene="ALKBH7"
                     /gene_synonym="ABH7; SPATA11; UNQ6002"
                     /inference="alignment:Splign:2.1.0"
     exon            531..970
                     /gene="ALKBH7"
                     /gene_synonym="ABH7; SPATA11; UNQ6002"
                     /inference="alignment:Splign:2.1.0"
     regulatory      725..730
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALKBH7"
                     /gene_synonym="ABH7; SPATA11; UNQ6002"
                     /note="hexamer: AATAAA"
     polyA_site      751
                     /gene="ALKBH7"
                     /gene_synonym="ABH7; SPATA11; UNQ6002"
                     /note="major polyA site"
     regulatory      953..958
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALKBH7"
                     /gene_synonym="ABH7; SPATA11; UNQ6002"
                     /note="hexamer: AATAAA"
     polyA_site      970
                     /gene="ALKBH7"
                     /gene_synonym="ABH7; SPATA11; UNQ6002"
ORIGIN      
        1 cctctctcat gaccccgctc cgggattatg gccgggactg ggctgctggc gctgcggacg
       61 ctgccagggc ccagctgggt gcgaggctcg ggcccttccg tgctgagccg cctgcaggac
      121 gcggccgtgg tgcggcctgg cttcctgagc acggcagagg aggagacgct gagccgagaa
      181 ctggagcccg agctgcgccg ccgccgctac gaatacgatc actgggacgc ggccatccac
      241 ggcttccgag agacagagaa gtcgcgctgg tcagaagcca gccgggccat cctgcagcgc
      301 gtgcaggcgg ccgcctttgg ccccggccag accctgctct cctccgtgca cgtgctggac
      361 ctggaagccc gcggctacat caagccccac gtggacagca tcaagttctg cggggccacc
      421 atcgccggcc tgtctctcct gtctcccagc gttatgcggc tggtgcacac ccaggagccg
      481 ggggagtggc tggaactctt gctggagccg ggctccctct acatccttag gggctcagcc
      541 cgttatgact tctcccatga gatccttcgg gatgaagagt ccttctttgg ggaacgccgg
      601 attccccggg gccggcgcat ctccgtgatc tgccgctccc tccctgaggg catggggcca
      661 ggggagtctg gacagccgcc cccagcctgc tgacccccag ctttctacag acaccagatt
      721 tgtgaataaa gttggggaat ggacagccta actgggacat tgcagtggct gcttgctggg
      781 gccgggattt gcaggggaac ccaggatggc actggcccat agggagctcc aggtgtggct
      841 ggctggacac atggtcaaag tcacaaggcc gggagagtgg tgtcctttat tgcactcact
      901 gctggtcgcc ccagcccact cccctcctcg ttgtctctgc atccaggtct ccaataaata
      961 agtcagccga
//
