LOCUS       NM_032878                951 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens alkB homolog 6 (ALKBH6), transcript variant 2, mRNA.
ACCESSION   NM_032878
VERSION     NM_032878.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 951)
  AUTHORS   Ma,L., Lu,H., Tian,Z., Yang,M., Ma,J., Shang,G., Liu,Y., Xie,M.,
            Wang,G., Wu,W., Zhang,Z., Dai,S. and Chen,Z.
  TITLE     Structural insights into the interactions and epigenetic functions
            of human nucleic acid repair protein ALKBH6
  JOURNAL   J Biol Chem 298 (3), 101671 (2022)
   PUBMED   35120926
  REMARK    GeneRIF: Structural insights into the interactions and epigenetic
            functions of human nucleic acid repair protein ALKBH6.
REFERENCE   2  (bases 1 to 951)
  AUTHORS   Kernstock,S., Davydova,E., Jakobsson,M., Moen,A., Pettersen,S.,
            Maelandsmo,G.M., Egge-Jacobsen,W. and Falnes,P.O.
  TITLE     Lysine methylation of VCP by a member of a novel human protein
            methyltransferase family
  JOURNAL   Nat Commun 3, 1038 (2012)
   PUBMED   22948820
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM713594.1, BC105801.1 and BU963363.1.
            
            On Apr 21, 2021 this sequence version replaced NM_032878.4.
            
            Transcript Variant: Variants 2, 3, and 5 encode the same isoform
            (3).
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB109556.1, CB109260.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149398, SAMEA2155751
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000378875.8/
                                                ENSP00000368152.4
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression,
                                                longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 BM713594.1         27-32
            7-947               BC105801.1         5-945
            948-951             BU963363.1         155-158
FEATURES             Location/Qualifiers
     source          1..951
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     gene            1..951
                     /gene="ALKBH6"
                     /gene_synonym="ABH6"
                     /note="alkB homolog 6"
                     /db_xref="GeneID:84964"
                     /db_xref="HGNC:HGNC:28243"
                     /db_xref="MIM:613304"
     exon            1..39
                     /gene="ALKBH6"
                     /gene_synonym="ABH6"
                     /inference="alignment:Splign:2.1.0"
     exon            40..118
                     /gene="ALKBH6"
                     /gene_synonym="ABH6"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..781
                     /gene="ALKBH6"
                     /gene_synonym="ABH6"
                     /EC_number="3.4.22.17"
                     /note="isoform 3 is encoded by transcript variant 2;
                     alkylated DNA repair protein alkB homolog 6; probable
                     alpha-ketoglutarate-dependent dioxygenase ABH6; alkB,
                     alkylation repair homolog 6; alpha-ketoglutarate-dependent
                     dioxygenase alkB homolog 6"
                     /codon_start=1
                     /product="alpha-ketoglutarate-dependent dioxygenase alkB
                     homolog 6 isoform 3"
                     /protein_id="NP_116267.4"
                     /db_xref="CCDS:CCDS74342.1"
                     /db_xref="GeneID:84964"
                     /db_xref="HGNC:HGNC:28243"
                     /db_xref="MIM:613304"
                     /translation="MEEQDARVPALEPFRVEQAPPVIYYVPDFISKEEEEYLLRQVFN
                     APKPKWTQLSGRKLQNWGGLPHPRGMVPERLPPWLQRYVDKVSNLSLFGGLPANHVLV
                     NQYLPGEGIMPHEDGPLYYPTVSTISLGSHTVLDFYEPRRPEDDDPTEQPRPPPRPTT
                     SLLLEPRSLLVLRGPAYTRLLHGIAAARVDALDAASSPPNAAACPSARPGACLVRGTR
                     VSLTIRRVPRVLRAGLLLGK"
     exon            119..187
                     /gene="ALKBH6"
                     /gene_synonym="ABH6"
                     /inference="alignment:Splign:2.1.0"
     exon            188..248
                     /gene="ALKBH6"
                     /gene_synonym="ABH6"
                     /inference="alignment:Splign:2.1.0"
     exon            249..400
                     /gene="ALKBH6"
                     /gene_synonym="ABH6"
                     /inference="alignment:Splign:2.1.0"
     exon            401..517
                     /gene="ALKBH6"
                     /gene_synonym="ABH6"
                     /inference="alignment:Splign:2.1.0"
     exon            518..951
                     /gene="ALKBH6"
                     /gene_synonym="ABH6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      932..937
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALKBH6"
                     /gene_synonym="ABH6"
                     /note="hexamer: AATAAA"
     polyA_site      951
                     /gene="ALKBH6"
                     /gene_synonym="ABH6"
                     /note="major polyA site"
ORIGIN      
        1 gatgttgaat ttggaaattg gaggggacgc tggtggacgg attgggtgca aggagttggt
       61 gttgatggag gagcaggacg ccagagtccc agccctggaa ccgttcagag tggagcaggc
      121 accacctgta atctactatg tccctgactt catctccaaa gaagaggagg agtatttgct
      181 tcgacaggtt tttaatgccc caaagccaaa gtggacccag ctctctggga gaaagttaca
      241 gaactggggt gggcttcctc atccccgagg gatggttcct gagcggctgc ccccatggct
      301 ccagcgctac gtggacaaag tgtcaaacct cagcctcttt ggaggcctcc cagctaacca
      361 tgtcctcgtg aaccagtatc tgcctgggga gggcatcatg ccccacgagg acggaccact
      421 gtactacccg actgtcagca ccatcagcct gggctcccac accgtgctgg acttctacga
      481 gccgcggcgg ccagaggacg atgaccctac agaacagcct cggcctccgc cccggcccac
      541 cacctcgcta ctgctggaac cgcgcagcct gctggtgctc cgcggccccg cctacacgcg
      601 tcttctccac ggcatcgccg ccgcccgcgt agacgcgctg gacgccgcct cctcgccgcc
      661 caatgcggca gcctgcccgt cggcgcggcc gggagcctgc ctggtgcgcg gcacccgggt
      721 ctcgctgacc atccgccgcg tgccccgcgt gctgcgcgcc ggcctcctgc tgggcaagtg
      781 accgccaggg ccgggacccc tcggattccc aggttcctgc ccctttgggg ctgctgtgac
      841 tccgcgacct aggaaccgtg ggcaaagggg gctcccctgg gttatttatt ttcccaataa
      901 ttttgtgtga gctacagaag accccatacc aaataaacaa aaaaatcttt c
//
