LOCUS       NM_017758               3159 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens alkB homolog 5, RNA demethylase (ALKBH5), mRNA.
ACCESSION   NM_017758
VERSION     NM_017758.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3159)
  AUTHORS   Qin,C., Wu,J., Wei,X., Liu,X. and Lin,Y.
  TITLE     ALKBH5 modulation of ferroptosis in recurrent miscarriage:
            implications in cytotrophoblast dysfunction
  JOURNAL   PeerJ 12, e18227 (2024)
   PUBMED   39434797
  REMARK    GeneRIF: ALKBH5 modulation of ferroptosis in recurrent miscarriage:
            implications in cytotrophoblast dysfunction.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3159)
  AUTHORS   Liang,Z., Huang,T., Li,W., Ma,Z., Wang,K., Zhai,Z., Fan,Y., Fu,Y.,
            Wang,X., Qin,Y., Wang,B., Zhao,C., Kuang,J. and Pei,D.
  TITLE     ALKBH5 governs human endoderm fate by regulating the
            DKK1/4-mediated Wnt/beta-catenin activation
  JOURNAL   Nucleic Acids Res 52 (18), 10879-10896 (2024)
   PUBMED   39166492
  REMARK    GeneRIF: ALKBH5 governs human endoderm fate by regulating the
            DKK1/4-mediated Wnt/beta-catenin activation.
REFERENCE   3  (bases 1 to 3159)
  AUTHORS   Wang,W., Li,H., Qian,Y., Li,M., Deng,M., Bi,D. and Zou,J.
  TITLE     ALKBH5 Regulates Corneal Neovascularization by Mediating FOXM1 M6A
            Demethylation
  JOURNAL   Invest Ophthalmol Vis Sci 65 (12), 34 (2024)
   PUBMED   39441582
  REMARK    GeneRIF: ALKBH5 Regulates Corneal Neovascularization by Mediating
            FOXM1 M6A Demethylation.
REFERENCE   4  (bases 1 to 3159)
  AUTHORS   Song,Y., Gao,H., Pan,Y., Gu,Y., Sun,W., Wang,Y. and Liu,J.
  TITLE     ALKBH5 Regulates Osteogenic Differentiation via the lncRNA/mRNA
            Complex
  JOURNAL   J Dent Res 103 (11), 1119-1129 (2024)
   PUBMED   39311450
  REMARK    GeneRIF: ALKBH5 Regulates Osteogenic Differentiation via the
            lncRNA/mRNA Complex.
REFERENCE   5  (bases 1 to 3159)
  AUTHORS   Mao,L., Wang,L., Lyu,Y., Zhuang,Q., Li,Z., Zhang,J., Gu,Z., Lu,S.,
            Wang,X., Guan,Y., Xiong,J., Wang,Y., Mao,Y., Yang,H. and Liu,Y.
  TITLE     Branch Chain Amino Acid Metabolism Promotes Brain Metastasis of
            NSCLC through EMT Occurrence by Regulating ALKBH5 activity
  JOURNAL   Int J Biol Sci 20 (9), 3285-3301 (2024)
   PUBMED   38993559
  REMARK    GeneRIF: Branch Chain Amino Acid Metabolism Promotes Brain
            Metastasis of NSCLC through EMT Occurrence by Regulating ALKBH5
            activity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3159)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   7  (bases 1 to 3159)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   8  (bases 1 to 3159)
  AUTHORS   Orvedahl,A., Sumpter,R. Jr., Xiao,G., Ng,A., Zou,Z., Tang,Y.,
            Narimatsu,M., Gilpin,C., Sun,Q., Roth,M., Forst,C.V., Wrana,J.L.,
            Zhang,Y.E., Luby-Phelps,K., Xavier,R.J., Xie,Y. and Levine,B.
  TITLE     Image-based genome-wide siRNA screen identifies selective autophagy
            factors
  JOURNAL   Nature 480 (7375), 113-117 (2011)
   PUBMED   22020285
REFERENCE   9  (bases 1 to 3159)
  AUTHORS   Thalhammer,A., Bencokova,Z., Poole,R., Loenarz,C., Adam,J.,
            O'Flaherty,L., Schodel,J., Mole,D., Giaslakiotis,K.,
            Schofield,C.J., Hammond,E.M., Ratcliffe,P.J. and Pollard,P.J.
  TITLE     Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent
            oxygenase and a direct target of hypoxia-inducible factor 1alpha
            (HIF-1alpha)
  JOURNAL   PLoS One 6 (1), e16210 (2011)
   PUBMED   21264265
  REMARK    GeneRIF: ALKBH5 may have a role in the regulation of cellular
            responses to hypoxia as a class of HIF-transcriptional target gene
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 3159)
  AUTHORS   Bi,W., Yan,J., Stankiewicz,P., Park,S.S., Walz,K., Boerkoel,C.F.,
            Potocki,L., Shaffer,L.G., Devriendt,K., Nowaczyk,M.J., Inoue,K. and
            Lupski,J.R.
  TITLE     Genes in a refined Smith-Magenis syndrome critical deletion
            interval on chromosome 17p11.2 and the syntenic region of the mouse
  JOURNAL   Genome Res 12 (5), 713-728 (2002)
   PUBMED   11997338
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI823385.1, BC062339.1, AK000315.1 and BU740432.1.
            
            On Nov 23, 2018 this sequence version replaced NM_017758.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.895201.1,
                                           SRR3476690.241698.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000399138.5/ ENSP00000382091.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-249               BI823385.1         276-524
            250-1432            BC062339.1         103-1285
            1433-2728           AK000315.1         1059-2354
            2729-3159           BU740432.1         16-446              c
FEATURES             Location/Qualifiers
     source          1..3159
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p11.2"
     gene            1..3159
                     /gene="ALKBH5"
                     /gene_synonym="ABH5; OFOXD; OFOXD1"
                     /note="alkB homolog 5, RNA demethylase"
                     /db_xref="GeneID:54890"
                     /db_xref="HGNC:HGNC:25996"
                     /db_xref="MIM:613303"
     exon            1..1186
                     /gene="ALKBH5"
                     /gene_synonym="ABH5; OFOXD; OFOXD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             417..1601
                     /gene="ALKBH5"
                     /gene_synonym="ABH5; OFOXD; OFOXD1"
                     /EC_number="1.14.11.53"
                     /note="oxoglutarate and iron-dependent oxygenase domain
                     containing; alpha-ketoglutarate-dependent dioxygenase alkB
                     homolog 5; alkB, alkylation repair homolog 5; alkylated
                     DNA repair protein alkB homolog 5; probable
                     alpha-ketoglutarate-dependent dioxygenase ABH5; AlkB
                     family member 5, RNA demethylase"
                     /codon_start=1
                     /product="RNA demethylase ALKBH5"
                     /protein_id="NP_060228.3"
                     /db_xref="CCDS:CCDS42272.1"
                     /db_xref="GeneID:54890"
                     /db_xref="HGNC:HGNC:25996"
                     /db_xref="MIM:613303"
                     /translation="MAAASGYTDLREKLKSMTSRDNYKAGSREAAAAAAAAVAAAAAA
                     AAAAEPYPVSGAKRKYQEDSDPERSDYEEQQLQKEEEARKVKSGIRQMRLFSQDECAK
                     IEARIDEVVSRAEKGLYNEHTVDRAPLRNKYFFGEGYTYGAQLQKRGPGQERLYPPGD
                     VDEIPEWVHQLVIQKLVEHRVIPEGFVNSAVINDYQPGGCIVSHVDPIHIFERPIVSV
                     SFFSDSALCFGCKFQFKPIRVSEPVLSLPVRRGSVTVLSGYAADEITHCIRPQDIKER
                     RAVIILRKTRLDAPRLETKSLSSSVLPPSYASDRLSGNNRDPALKPKRSHRKADPDAA
                     HRPRILEMDKEENRRSVLLPTHRRRGSFSSENYWRKSYESSEDCSEAAGSPARKVKMR
                     RH"
     exon            1187..1267
                     /gene="ALKBH5"
                     /gene_synonym="ABH5; OFOXD; OFOXD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1423
                     /gene="ALKBH5"
                     /gene_synonym="ABH5; OFOXD; OFOXD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..3159
                     /gene="ALKBH5"
                     /gene_synonym="ABH5; OFOXD; OFOXD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3130..3135
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALKBH5"
                     /gene_synonym="ABH5; OFOXD; OFOXD1"
                     /note="hexamer: AATAAA"
     polyA_site      3159
                     /gene="ALKBH5"
                     /gene_synonym="ABH5; OFOXD; OFOXD1"
                     /note="major polyA site"
ORIGIN      
        1 gaggagcccg ctaaggagcg gcgctggcgg acgtcgggct ggctgcccgt gacgtcgtgc
       61 ggagagcttt aaagtgcggg ccgggccggg cgtccgaggg tctggtcggg agtcgggccg
      121 cgtctccgca gcagccctcc gcggcatgag gcgctgccgg cgcccctgcc ccgcgggacg
      181 tggagaaggt ggaggaggaa gaagccccgt tgtcgccacc gttgcatgac ccgccgctcc
      241 tgaggcccta ccccacgccc ggaccctcga cgccccccgc cgggtccccc actcacgcat
      301 gggggttcgg cgctaaggac ccccctccct ccgggggccc cggggcgcgt ccccttagag
      361 ccatgcccgg ctgccccgcc cgccccggag gaccctagag cagcgtcgtg ggggccatgg
      421 cggccgccag cggctacacg gacctgcgtg agaagctcaa gtccatgacg tcccgggaca
      481 actataaggc gggcagccgg gaggccgccg ccgctgccgc agccgccgta gccgccgcag
      541 ccgcagccgc cgctgccgcc gaaccttacc ctgtgtccgg ggccaagcgc aagtatcagg
      601 aggactcgga ccccgagcgc agcgactatg aggagcagca gctgcagaag gaggaggagg
      661 cgcgcaaggt gaagagcggc atccgccaga tgcgcctctt cagccaggac gagtgcgcca
      721 agatcgaggc ccgcattgac gaggtggtgt cccgcgctga gaagggcctg tacaacgagc
      781 acacggtgga ccgggcccca ctgcgcaaca agtacttctt cggcgaaggc tacacttacg
      841 gcgcccagct gcagaagcgc gggcccggcc aggagcgcct ctacccgccg ggcgacgtgg
      901 acgagatccc cgagtgggtg caccagctgg tgatccaaaa gctggtggag caccgcgtca
      961 tccccgaggg cttcgtcaac agcgccgtca tcaacgacta ccagcccggc ggctgcatcg
     1021 tgtctcacgt ggaccccatc cacatcttcg agcgccccat cgtgtccgtg tccttcttta
     1081 gcgactctgc gctgtgcttc ggctgcaagt tccagttcaa gcctattcgg gtgtcggaac
     1141 cagtgctttc cctgccggtg cgcaggggaa gcgtgactgt gctcagtgga tatgctgctg
     1201 atgaaatcac tcactgcata cggcctcagg acatcaagga gcgccgagca gtcatcatcc
     1261 tcaggaagac aagattagat gcaccccggt tggaaacaaa gtccctgagc agctccgtgt
     1321 taccacccag ctatgcttca gatcgcctgt caggaaacaa cagggaccct gctctgaaac
     1381 ccaagcggtc ccaccgcaag gcagaccctg atgctgccca caggccacgg atcctggaga
     1441 tggacaagga agagaaccgg cgctcggtgc tgctgcccac acaccggcgg aggggtagct
     1501 tcagctctga gaactactgg cgcaagtcat acgagtcctc agaggactgc tctgaggcag
     1561 caggcagccc tgcccgaaag gtgaagatgc ggcggcactg agtctacccg ccgccctcct
     1621 gggaactctg gctcatcctt acgtagttgc ccctcctttt gttttgaggg ttttgttttt
     1681 gttcattggg gggtttttgt tttttgtttt ttgttttttt tgattctata tatttttcct
     1741 tggttttgtt gcctgttagg gctgaagaat agaattggcc aggacctagg ttctcatatt
     1801 cttggtattc ctcctggatg gaaaggctgt tggcatcaat aggggacaga ggctgatgct
     1861 ggagtggcca gtagaggtgg tggagcagag cagccatctt ttaagtgggg ctgtatcagg
     1921 ctgggtttat ttaaaagcaa caaaatgttt tggttaagaa aattattttg ctttcagtgt
     1981 aaatcttcgc agtgttctaa acaaagttca gtcttctgct cgcccctttc cctcactgat
     2041 gtctgcactt ggttgaggtc tcctggagcc tcacaggctc tgctgttctc cacttctcac
     2101 ctgccatcca cgccctgcaa gctcatgcaa acaccctttc ttcctcctgc ggcagagttg
     2161 ttcaggttgc ctgggcaggg gcttaaacag tgccagcccc tgccatccca aagctattgt
     2221 taagcccccc aggcgtcctc cacccacgcc cactagcctg ccatgtccac agttccttgg
     2281 gctgctgagg ggctagtgca gtggtcctga cctctcttat caagagcaca cttctttgct
     2341 ggttgctcct tttgagcata tgcgtgtgat tatttggaac agttagactt gccacgttgg
     2401 gtcagtttta gaaattgttt ctagctagag ggactggtgt ccttccaagt ctagcatttg
     2461 gggtatggaa aattgttgtg gtgtgtggta gggtttttgt tttctttttt gagttttttt
     2521 tcccccttta gtctcctggc tttttccttt cccttccctt ctccactggc cagcttgggc
     2581 ctcatcctca tgtcatcctt ctaggaaggc gcctgcccca tcttgtctgc cggcagcatg
     2641 catccaaggc cagagctcag gcctgcagac tgggctggtg cctcctccgc ttcagggtat
     2701 gggagttggt gaaggggctt tcaaaaaata ataaggaaaa aaaggtaaag tctttggtag
     2761 cttctatcca ctcagatcct ggaaggcagc aaggttttgt ggatctagat tcattaggaa
     2821 tgtcttcttg tcagccaggc caggacccgg gcttgccaag agcagaggcc ctcccagcaa
     2881 ccaggatacc accactttgg gggctttgtg tacagaggtc cgggtctgag acctcatagg
     2941 ctgcagaaat ctggggcagc caccatcaag aagcccctct caggggccag aactcctttg
     3001 ccagcgtgga tttctcaagt cgggactgca taattaaagc agttgcagtt ttattttttt
     3061 tacagctttt ttcccaaaaa tgatttgtag ttgtgtgtgc agcacttcgc cctgatatgt
     3121 gtgctctaca ataaaaacca aatctaatat attttgaaa
//
