LOCUS       NM_207413               1140 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens ALK and LTK ligand 1 (ALKAL1), mRNA.
ACCESSION   NM_207413
VERSION     NM_207413.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1140)
  AUTHORS   Wu,N., Li,J., Li,L., Yang,L., Dong,L., Shen,C., Sha,S., Fu,Y.,
            Dong,E., Zheng,F., Tan,Z. and Tao,J.
  TITLE     MerTK+ macrophages promote melanoma progression and immunotherapy
            resistance through AhR-ALKAL1 activation
  JOURNAL   Sci Adv 10 (40), eado8366 (2024)
   PUBMED   39365866
  REMARK    GeneRIF: MerTK[+] macrophages promote melanoma progression and
            immunotherapy resistance through AhR-ALKAL1 activation.
REFERENCE   2  (bases 1 to 1140)
  AUTHORS   Reshetnyak,A.V., Rossi,P., Myasnikov,A.G., Sowaileh,M., Mohanty,J.,
            Nourse,A., Miller,D.J., Lax,I., Schlessinger,J. and Kalodimos,C.G.
  TITLE     Mechanism for the activation of the anaplastic lymphoma kinase
            receptor
  JOURNAL   Nature 600 (7887), 153-157 (2021)
   PUBMED   34819673
REFERENCE   3  (bases 1 to 1140)
  AUTHORS   De Munck,S., Provost,M., Kurikawa,M., Omori,I., Mukohyama,J.,
            Felix,J., Bloch,Y., Abdel-Wahab,O., Bazan,J.F., Yoshimi,A. and
            Savvides,S.N.
  TITLE     Structural basis of cytokine-mediated activation of ALK family
            receptors
  JOURNAL   Nature 600 (7887), 143-147 (2021)
   PUBMED   34646012
REFERENCE   4  (bases 1 to 1140)
  AUTHORS   Fadeev,A., Mendoza-Garcia,P., Irion,U., Guan,J., Pfeifer,K.,
            Wiessner,S., Serluca,F., Singh,A.P., Nusslein-Volhard,C. and
            Palmer,R.H.
  TITLE     ALKALs are in vivo ligands for ALK family receptor tyrosine kinases
            in the neural crest and derived cells
  JOURNAL   Proc Natl Acad Sci U S A 115 (4), E630-E638 (2018)
   PUBMED   29317532
  REMARK    GeneRIF: activation of ALK/LTK family receptors by small ALKAL
            proteins (FAM150, AUG) conserved in vertebrates
REFERENCE   5  (bases 1 to 1140)
  AUTHORS   Reshetnyak,A.V., Murray,P.B., Shi,X., Mo,E.S., Mohanty,J., Tome,F.,
            Bai,H., Gunel,M., Lax,I. and Schlessinger,J.
  TITLE     Augmentor alpha and beta (FAM150) are ligands of the receptor
            tyrosine kinases ALK and LTK: Hierarchy and specificity of
            ligand-receptor interactions
  JOURNAL   Proc Natl Acad Sci U S A 112 (52), 15862-15867 (2015)
   PUBMED   26630010
  REMARK    GeneRIF: Data show that leukocyte tyrosine kinase (LTK) ligand
            FAM150A (augmentor-beta; AUG-beta) is specific for LTK and only
            weakly binds to anaplastic lymphoma kinase (ALK).
REFERENCE   6  (bases 1 to 1140)
  AUTHORS   Guan,J., Umapathy,G., Yamazaki,Y., Wolfstetter,G., Mendoza,P.,
            Pfeifer,K., Mohammed,A., Hugosson,F., Zhang,H., Hsu,A.W.,
            Halenbeck,R., Hallberg,B. and Palmer,R.H.
  TITLE     FAM150A and FAM150B are activating ligands for anaplastic lymphoma
            kinase
  JOURNAL   Elife 4, e09811 (2015)
   PUBMED   26418745
  REMARK    GeneRIF: In conclusion, these data show that ALK is robustly
            activated by the FAM150A/B ligands.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1140)
  AUTHORS   Zhang,H., Pao,L.I., Zhou,A., Brace,A.D., Halenbeck,R., Hsu,A.W.,
            Bray,T.L., Hestir,K., Bosch,E., Lee,E., Wang,G., Liu,H., Wong,B.R.,
            Kavanaugh,W.M. and Williams,L.T.
  TITLE     Deorphanization of the human leukocyte tyrosine kinase (LTK)
            receptor by a signaling screen of the extracellular proteome
  JOURNAL   Proc Natl Acad Sci U S A 111 (44), 15741-15745 (2014)
   PUBMED   25331893
  REMARK    GeneRIF: Only two related secreted factors, FAM150A and FAM150B
            (family with sequence similarity 150 member A and member B),
            stimulated LTK phosphorylation.
REFERENCE   8  (bases 1 to 1140)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP423106.1, AY358213.1, AI858920.1 and AC013650.8.
            
            On Nov 22, 2018 this sequence version replaced NM_207413.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279857.251.1, AY358213.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358543.9/ ENSP00000351345.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-388               BP423106.1         78-465
            389-1039            AY358213.1         423-1073
            1040-1047           AI858920.1         106-113             c
            1048-1048           AC013650.8         56733-56733
            1049-1140           AI858920.1         13-104              c
FEATURES             Location/Qualifiers
     source          1..1140
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q11.23"
     gene            1..1140
                     /gene="ALKAL1"
                     /gene_synonym="AUGA; AUGB; FAM150A; UNQ9433"
                     /note="ALK and LTK ligand 1"
                     /db_xref="GeneID:389658"
                     /db_xref="HGNC:HGNC:33775"
                     /db_xref="MIM:619670"
     exon            1..364
                     /gene="ALKAL1"
                     /gene_synonym="AUGA; AUGB; FAM150A; UNQ9433"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..564
                     /gene="ALKAL1"
                     /gene_synonym="AUGA; AUGB; FAM150A; UNQ9433"
                     /note="RPLK9433; protein FAM150A; AUG-beta; augmentor
                     beta; augmentor-alpha; family with sequence similarity 150
                     member A"
                     /codon_start=1
                     /product="ALK and LTK ligand 1 precursor"
                     /protein_id="NP_997296.1"
                     /db_xref="CCDS:CCDS6150.1"
                     /db_xref="GeneID:389658"
                     /db_xref="HGNC:HGNC:33775"
                     /db_xref="MIM:619670"
                     /translation="MRPLKPGAPLPALFLLALALSPHGAHGRPRGRRGARVTDKEPKP
                     LLFLPAAGAGRTPSGSRSAEIFPRDSNLKDKFIKHFTGPVTFSPECSKHFHRLYYNTR
                     ECSTPAYYKRCARLLTRLAVSPLCSQT"
     exon            365..418
                     /gene="ALKAL1"
                     /gene_synonym="AUGA; AUGB; FAM150A; UNQ9433"
                     /inference="alignment:Splign:2.1.0"
     exon            419..499
                     /gene="ALKAL1"
                     /gene_synonym="AUGA; AUGB; FAM150A; UNQ9433"
                     /inference="alignment:Splign:2.1.0"
     exon            500..576
                     /gene="ALKAL1"
                     /gene_synonym="AUGA; AUGB; FAM150A; UNQ9433"
                     /inference="alignment:Splign:2.1.0"
     exon            577..1140
                     /gene="ALKAL1"
                     /gene_synonym="AUGA; AUGB; FAM150A; UNQ9433"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1080..1085
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALKAL1"
                     /gene_synonym="AUGA; AUGB; FAM150A; UNQ9433"
                     /note="hexamer: ATTAAA"
     polyA_site      1102
                     /gene="ALKAL1"
                     /gene_synonym="AUGA; AUGB; FAM150A; UNQ9433"
                     /note="major polyA site"
     regulatory      1120..1125
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALKAL1"
                     /gene_synonym="AUGA; AUGB; FAM150A; UNQ9433"
                     /note="hexamer: ATTAAA"
     polyA_site      1140
                     /gene="ALKAL1"
                     /gene_synonym="AUGA; AUGB; FAM150A; UNQ9433"
ORIGIN      
        1 agtgcagctc cagccgaccc ccgggacgta gacaagggca ggcgcgcggt gaagactgcg
       61 gccggccgcg tagccgcgct gtggtcccgc tggccttctc ttgggccgcg caccctccgg
      121 acctgcgtcg ggatcctccc ggagtctccc gctctctcct cccggcttgc gaacatgcgg
      181 ccccttaagc ccggcgcccc tttgcccgca ctcttcctgc tggcgctggc tttgtccccg
      241 cacggagccc acgggaggcc ccgggggcgc aggggagcgc gcgtcacgga taaggagccc
      301 aagccgttgc ttttcctccc cgcggccggg gccggccgga ctcccagcgg ctcccggagc
      361 gcagaaatat tcccaagaga ctctaactta aaagacaaat tcataaagca tttcacaggg
      421 ccggtcacat tttcaccaga atgcagcaaa catttccacc gactctatta caataccagg
      481 gagtgctcaa cgccagctta ttacaaaaga tgtgctagat tgttaacaag attagcagtg
      541 agtccactgt gctcccagac ctagcaaaac taccctacat ttcctaagaa tgtacatcta
      601 atttgaagaa aaagtgcctc aaatcatgca aaatgtaaaa aaagatgaaa tttatatttt
      661 tatggatatt aagatgagta aaataagaga cttcccagaa ataactggtt agctgtttcc
      721 tgtcatagaa tggagtcttt cttgctttat ctttttgtgt atacagtaat ttataatttt
      781 gtaaaacaga gtttgaatcg catattgaaa attagatatt aaaaattgtg tgattgtatt
      841 ttatttttac tagatatatt attttcttta tatggttaac attctaatta aacatttaat
      901 tgtgtaaatt atatctgtga gtgccagtga gaaataatga tttttttgta tatgactgtt
      961 agtatatatt tgtcaaatca tcgtgtacca agttaaattt tataattctt atttaatatt
     1021 taaatacatt tatttagaac ttgttgtctt cacttgcatt aatttgaact gtgaatttta
     1081 ttaaagttga aatatgaaaa aatgtgttgt ttcctttgaa ttaaagatgt ttgtaataga
//
