LOCUS       NM_004304               6240 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens ALK receptor tyrosine kinase (ALK), transcript variant
            1, mRNA.
ACCESSION   NM_004304
VERSION     NM_004304.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6240)
  AUTHORS   Gonzalez-Martinez,D., Roth,L., Mumford,T.R., Guan,J., Le,A.,
            Doebele,R.C., Huang,B., Tulpule,A., Niewiadomska-Bugaj,M.,
            Bivona,T.G. and Bugaj,L.J.
  TITLE     Oncogenic EML4-ALK assemblies suppress growth factor perception and
            modulate drug tolerance
  JOURNAL   Nat Commun 15 (1), 9473 (2024)
   PUBMED   39488530
  REMARK    GeneRIF: Oncogenic EML4-ALK assemblies suppress growth factor
            perception and modulate drug tolerance.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6240)
  AUTHORS   Cho,W.C., Prieto,V.G. and Yang,R.K.
  TITLE     Spitz Melanoma With SLC20A1::ALK Fusion: A Novel Fusion Previously
            Undescribed in Spitz Melanocytic Neoplasm
  JOURNAL   Am J Dermatopathol 46 (10), 700-703 (2024)
   PUBMED   38941542
  REMARK    GeneRIF: Spitz Melanoma With SLC20A1::ALK Fusion: A Novel Fusion
            Previously Undescribed in Spitz Melanocytic Neoplasm.
REFERENCE   3  (bases 1 to 6240)
  AUTHORS   Tu,Y., Lu,W.P. and Wang,J.
  TITLE     [ALK rearranged Spitz melanocytoma: a clinicopathological and
            molecular genetic analysis of two cases]
  JOURNAL   Zhonghua Bing Li Xue Za Zhi 53 (8), 816-821 (2024)
   PUBMED   39103263
  REMARK    GeneRIF: [ALK rearranged Spitz melanocytoma: a clinicopathological
            and molecular genetic analysis of two cases].
REFERENCE   4  (bases 1 to 6240)
  AUTHORS   Yang,L., Ren,Y. and Yin,X.
  TITLE     Mucinous epidermoid carcinoma of the lung with ALK mutation: Case
            report and literature review
  JOURNAL   Medicine (Baltimore) 103 (22), e38301 (2024)
   PUBMED   39259069
  REMARK    GeneRIF: Mucinous epidermoid carcinoma of the lung with ALK
            mutation: Case report and literature review.
            Review article
REFERENCE   5  (bases 1 to 6240)
  AUTHORS   Wiesner,T., Lee,W., Obenauf,A.C., Ran,L., Murali,R., Zhang,Q.F.,
            Wong,E.W., Hu,W., Scott,S.N., Shah,R.H., Landa,I., Button,J.,
            Lailler,N., Sboner,A., Gao,D., Murphy,D.A., Cao,Z., Shukla,S.,
            Hollmann,T.J., Wang,L., Borsu,L., Merghoub,T., Schwartz,G.K.,
            Postow,M.A., Ariyan,C.E., Fagin,J.A., Zheng,D., Ladanyi,M.,
            Busam,K.J., Berger,M.F., Chen,Y. and Chi,P.
  TITLE     Alternative transcription initiation leads to expression of a novel
            ALK isoform in cancer
  JOURNAL   Nature 526 (7573), 453-457 (2015)
   PUBMED   26444240
  REMARK    GeneRIF: findings suggest a novel mechanism of oncogene activation
            in cancer through de novo alternative transcription initiation,
            such as for ALK
REFERENCE   6  (bases 1 to 6240)
  AUTHORS   Morris,S.W., Naeve,C., Mathew,P., James,P.L., Kirstein,M.N., Cui,X.
            and Witte,D.P.
  TITLE     ALK, the chromosome 2 gene locus altered by the t(2;5) in
            non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine
            kinase that is highly related to leukocyte tyrosine kinase (LTK)
  JOURNAL   Oncogene 14 (18), 2175-2188 (1997)
   PUBMED   9174053
  REMARK    Erratum:[Oncogene 1997 Dec 4;15(23):2883]
REFERENCE   7  (bases 1 to 6240)
  AUTHORS   Iwahara,T., Fujimoto,J., Wen,D., Cupples,R., Bucay,N., Arakawa,T.,
            Mori,S., Ratzkin,B. and Yamamoto,T.
  TITLE     Molecular characterization of ALK, a receptor tyrosine kinase
            expressed specifically in the nervous system
  JOURNAL   Oncogene 14 (4), 439-449 (1997)
   PUBMED   9053841
REFERENCE   8  (bases 1 to 6240)
  AUTHORS   Fujimoto,J., Shiota,M., Iwahara,T., Seki,N., Satoh,H., Mori,S. and
            Yamamoto,T.
  TITLE     Characterization of the transforming activity of p80, a
            hyperphosphorylated protein in a Ki-1 lymphoma cell line with
            chromosomal translocation t(2;5)
  JOURNAL   Proc Natl Acad Sci U S A 93 (9), 4181-4186 (1996)
   PUBMED   8633037
REFERENCE   9  (bases 1 to 6240)
  AUTHORS   Morris,S.W., Kirstein,M.N., Valentine,M.B., Dittmer,K.G.,
            Shapiro,D.N., Saltman,D.L. and Look,A.T.
  TITLE     Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in
            non-Hodgkin's lymphoma
  JOURNAL   Science 263 (5151), 1281-1284 (1994)
   PUBMED   8122112
  REMARK    Erratum:[Science. 1995 Jan 20;267(5196):316-7. doi:
            10.1126/science.267.5196.316-b.. PMID: 7824924]
REFERENCE   10 (bases 1 to 6240)
  AUTHORS   Greengard,E.G., Perrino,M.R. and Park,J.R.
  TITLE     ALK-Related Neuroblastic Tumor Susceptibility
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301782
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA455128.1, EU788004.1 and
            U62540.1.
            
            On Nov 23, 2018 this sequence version replaced NM_004304.4.
            
            Summary: This gene encodes a receptor tyrosine kinase, which
            belongs to the insulin receptor superfamily. This protein comprises
            an extracellular domain, an hydrophobic stretch corresponding to a
            single pass transmembrane region, and an intracellular kinase
            domain. It plays an important role in the development of the brain
            and exerts its effects on specific neurons in the nervous system.
            This gene has been found to be rearranged, mutated, or amplified in
            a series of tumours including anaplastic large cell lymphomas,
            neuroblastoma, and non-small cell lung cancer. The chromosomal
            rearrangements are the most common genetic alterations in this
            gene, which result in creation of multiple fusion genes in
            tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2),
            ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG
            (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5),
            ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4
            (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq,
            Jan 2011].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FJ838787.1, FJ838786.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000389048.8/ ENSP00000373700.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                DA455128.1         26-45
            21-4186             EU788004.1         1-4166
            4187-5307           U62540.1           4171-5291
            5308-6240           EU788004.1         5288-6220
FEATURES             Location/Qualifiers
     source          1..6240
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.2-p23.1"
     gene            1..6240
                     /gene="ALK"
                     /gene_synonym="ALK1; CD246; NBLST3"
                     /note="ALK receptor tyrosine kinase"
                     /db_xref="GeneID:238"
                     /db_xref="HGNC:HGNC:427"
                     /db_xref="MIM:105590"
     exon            1..1594
                     /gene="ALK"
                     /gene_synonym="ALK1; CD246; NBLST3"
                     /inference="alignment:Splign:2.1.0"
     CDS             928..5790
                     /gene="ALK"
                     /gene_synonym="ALK1; CD246; NBLST3"
                     /EC_number="2.7.10.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; CD246 antigen; ALK tyrosine kinase receptor;
                     mutant anaplastic lymphoma kinase; anaplastic lymphoma
                     receptor tyrosine kinase"
                     /codon_start=1
                     /product="ALK tyrosine kinase receptor isoform 1
                     precursor"
                     /protein_id="NP_004295.2"
                     /db_xref="CCDS:CCDS33172.1"
                     /db_xref="GeneID:238"
                     /db_xref="HGNC:HGNC:427"
                     /db_xref="MIM:105590"
                     /translation="MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPL
                     SYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLL
                     GPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGE
                     AAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQ
                     IFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEY
                     SPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTIL
                     SPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGR
                     IGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQ
                     LGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKD
                     ARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSL
                     VLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVA
                     FDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVH
                     WLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYG
                     AAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGEN
                     NVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTF
                     HPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWG
                     WETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKV
                     MEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPH
                     LPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTI
                     MTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQ
                     VAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDL
                     KSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGP
                     GRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLW
                     EIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAI
                     ILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEER
                     SPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHG
                     SRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPG
                     ASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILK
                     SKNSMNQPGP"
     exon            1595..1714
                     /gene="ALK"
                     /gene_synonym="ALK1; CD246; NBLST3"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1879
                     /gene="ALK"
                     /gene_synonym="ALK1; CD246; NBLST3"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..2081
                     /gene="ALK"
                     /gene_synonym="ALK1; CD246; NBLST3"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2209
                     /gene="ALK"
                     /gene_synonym="ALK1; CD246; NBLST3"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2341
                     /gene="ALK"
                     /gene_synonym="ALK1; CD246; NBLST3"
                     /inference="alignment:Splign:2.1.0"
     exon            2342..2473
                     /gene="ALK"
                     /gene_synonym="ALK1; CD246; NBLST3"
                     /inference="alignment:Splign:2.1.0"
     exon            2474..2574
                     /gene="ALK"
                     /gene_synonym="ALK1; CD246; NBLST3"
                     /inference="alignment:Splign:2.1.0"
     exon            2575..2744
                     /gene="ALK"
                     /gene_synonym="ALK1; CD246; NBLST3"
                     /inference="alignment:Splign:2.1.0"
     exon            2745..2839
                     /gene="ALK"
                     /gene_synonym="ALK1; CD246; NBLST3"
                     /inference="alignment:Splign:2.1.0"
     exon            2840..2968
                     /gene="ALK"
                     /gene_synonym="ALK1; CD246; NBLST3"
                     /inference="alignment:Splign:2.1.0"
     exon            2969..3131
                     /gene="ALK"
                     /gene_synonym="ALK1; CD246; NBLST3"
                     /inference="alignment:Splign:2.1.0"
     exon            3132..3282
                     /gene="ALK"
                     /gene_synonym="ALK1; CD246; NBLST3"
                     /inference="alignment:Splign:2.1.0"
     exon            3283..3414
                     /gene="ALK"
                     /gene_synonym="ALK1; CD246; NBLST3"
                     /inference="alignment:Splign:2.1.0"
     exon            3415..3559
                     /gene="ALK"
                     /gene_synonym="ALK1; CD246; NBLST3"
                     /inference="alignment:Splign:2.1.0"
     exon            3560..3742
                     /gene="ALK"
                     /gene_synonym="ALK1; CD246; NBLST3"
                     /inference="alignment:Splign:2.1.0"
     exon            3743..3841
                     /gene="ALK"
                     /gene_synonym="ALK1; CD246; NBLST3"
                     /inference="alignment:Splign:2.1.0"
     exon            3842..3994
                     /gene="ALK"
                     /gene_synonym="ALK1; CD246; NBLST3"
                     /inference="alignment:Splign:2.1.0"
     exon            3995..4099
                     /gene="ALK"
                     /gene_synonym="ALK1; CD246; NBLST3"
                     /inference="alignment:Splign:2.1.0"
     exon            4100..4286
                     /gene="ALK"
                     /gene_synonym="ALK1; CD246; NBLST3"
                     /inference="alignment:Splign:2.1.0"
     exon            4287..4377
                     /gene="ALK"
                     /gene_synonym="ALK1; CD246; NBLST3"
                     /inference="alignment:Splign:2.1.0"
     exon            4378..4442
                     /gene="ALK"
                     /gene_synonym="ALK1; CD246; NBLST3"
                     /inference="alignment:Splign:2.1.0"
     exon            4443..4572
                     /gene="ALK"
                     /gene_synonym="ALK1; CD246; NBLST3"
                     /inference="alignment:Splign:2.1.0"
     exon            4573..4670
                     /gene="ALK"
                     /gene_synonym="ALK1; CD246; NBLST3"
                     /inference="alignment:Splign:2.1.0"
     exon            4671..4763
                     /gene="ALK"
                     /gene_synonym="ALK1; CD246; NBLST3"
                     /inference="alignment:Splign:2.1.0"
     exon            4764..4865
                     /gene="ALK"
                     /gene_synonym="ALK1; CD246; NBLST3"
                     /inference="alignment:Splign:2.1.0"
     exon            4866..5000
                     /gene="ALK"
                     /gene_synonym="ALK1; CD246; NBLST3"
                     /inference="alignment:Splign:2.1.0"
     exon            5001..5091
                     /gene="ALK"
                     /gene_synonym="ALK1; CD246; NBLST3"
                     /inference="alignment:Splign:2.1.0"
     exon            5092..6240
                     /gene="ALK"
                     /gene_synonym="ALK1; CD246; NBLST3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6214..6219
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALK"
                     /gene_synonym="ALK1; CD246; NBLST3"
                     /note="hexamer: AATAAA"
     polyA_site      6240
                     /gene="ALK"
                     /gene_synonym="ALK1; CD246; NBLST3"
                     /note="major polyA site"
ORIGIN      
        1 agatgcgatc cagcggctct gggggcggca gcggtggtag cagctggtac ctcccgccgc
       61 ctctgttcgg agggtcgcgg ggcaccgagg tgctttccgg ccgccctctg gtcggccacc
      121 caaagccgcg ggcgctgatg atgggtgagg agggggcggc aagatttcgg gcgcccctgc
      181 cctgaacgcc ctcagctgct gccgccgggg ccgctccagt gcctgcgaac tctgaggagc
      241 cgaggcgccg gtgagagcaa ggacgctgca aacttgcgca gcgcgggggc tgggattcac
      301 gcccagaagt tcagcaggca gacagtccga agccttcccg cagcggagag atagcttgag
      361 ggtgcgcaag acggcagcct ccgccctcgg ttcccgccca gaccgggcag aagagcttgg
      421 aggagccaaa aggaacgcaa aaggcggcca ggacagcgtg cagcagctgg gagccgccgt
      481 tctcagcctt aaaagttgca gagattggag gctgccccga gaggggacag accccagctc
      541 cgactgcggg gggcaggaga ggacggtacc caactgccac ctcccttcaa ccatagtagt
      601 tcctctgtac cgagcgcagc gagctacaga cgggggcgcg gcactcggcg cggagagcgg
      661 gaggctcaag gtcccagcca gtgagcccag tgtgcttgag tgtctctgga ctcgcccctg
      721 agcttccagg tctgtttcat ttagactcct gctcgcctcc gtgcagttgg gggaaagcaa
      781 gagacttgcg cgcacgcaca gtcctctgga gatcaggtgg aaggagccgc tgggtaccaa
      841 ggactgttca gagcctcttc ccatctcggg gagagcgaag ggtgaggctg ggcccggaga
      901 gcagtgtaaa cggcctcctc cggcgggatg ggagccatcg ggctcctgtg gctcctgccg
      961 ctgctgcttt ccacggcagc tgtgggctcc gggatgggga ccggccagcg cgcgggctcc
     1021 ccagctgcgg ggccgccgct gcagccccgg gagccactca gctactcgcg cctgcagagg
     1081 aagagtctgg cagttgactt cgtggtgccc tcgctcttcc gtgtctacgc ccgggaccta
     1141 ctgctgccac catcctcctc ggagctgaag gctggcaggc ccgaggcccg cggctcgcta
     1201 gctctggact gcgccccgct gctcaggttg ctggggccgg cgccgggggt ctcctggacc
     1261 gccggttcac cagccccggc agaggcccgg acgctgtcca gggtgctgaa gggcggctcc
     1321 gtgcgcaagc tccggcgtgc caagcagttg gtgctggagc tgggcgagga ggcgatcttg
     1381 gagggttgcg tcgggccccc cggggaggcg gctgtggggc tgctccagtt caatctcagc
     1441 gagctgttca gttggtggat tcgccaaggc gaagggcgac tgaggatccg cctgatgccc
     1501 gagaagaagg cgtcggaagt gggcagagag ggaaggctgt ccgcggcaat tcgcgcctcc
     1561 cagccccgcc ttctcttcca gatcttcggg actggtcata gctccttgga atcaccaaca
     1621 aacatgcctt ctccttctcc tgattatttt acatggaatc tcacctggat aatgaaagac
     1681 tccttccctt tcctgtctca tcgcagccga tatggtctgg agtgcagctt tgacttcccc
     1741 tgtgagctgg agtattcccc tccactgcat gacctcagga accagagctg gtcctggcgc
     1801 cgcatcccct ccgaggaggc ctcccagatg gacttgctgg atgggcctgg ggcagagcgt
     1861 tctaaggaga tgcccagagg ctcctttctc cttctcaaca cctcagctga ctccaagcac
     1921 accatcctga gtccgtggat gaggagcagc agtgagcact gcacactggc cgtctcggtg
     1981 cacaggcacc tgcagccctc tggaaggtac attgcccagc tgctgcccca caacgaggct
     2041 gcaagagaga tcctcctgat gcccactcca gggaagcatg gttggacagt gctccaggga
     2101 agaatcgggc gtccagacaa cccatttcga gtggccctgg aatacatctc cagtggaaac
     2161 cgcagcttgt ctgcagtgga cttctttgcc ctgaagaact gcagtgaagg aacatcccca
     2221 ggctccaaga tggccctgca gagctccttc acttgttgga atgggacagt cctccagctt
     2281 gggcaggcct gtgacttcca ccaggactgt gcccagggag aagatgagag ccagatgtgc
     2341 cggaaactgc ctgtgggttt ttactgcaac tttgaagatg gcttctgtgg ctggacccaa
     2401 ggcacactgt caccccacac tcctcaatgg caggtcagga ccctaaagga tgcccggttc
     2461 caggaccacc aagaccatgc tctattgctc agtaccactg atgtccccgc ttctgaaagt
     2521 gctacagtga ccagtgctac gtttcctgca ccgatcaaga gctctccatg tgagctccga
     2581 atgtcctggc tcattcgtgg agtcttgagg ggaaacgtgt ccttggtgct agtggagaac
     2641 aaaaccggga aggagcaagg caggatggtc tggcatgtcg ccgcctatga aggcttgagc
     2701 ctgtggcagt ggatggtgtt gcctctcctc gatgtgtctg acaggttctg gctgcagatg
     2761 gtcgcatggt ggggacaagg atccagagcc atcgtggctt ttgacaatat ctccatcagc
     2821 ctggactgct acctcaccat tagcggagag gacaagatcc tgcagaatac agcacccaaa
     2881 tcaagaaacc tgtttgagag aaacccaaac aaggagctga aacccgggga aaattcacca
     2941 agacagaccc ccatctttga ccctacagtt cattggctgt tcaccacatg tggggccagc
     3001 gggccccatg gccccaccca ggcacagtgc aacaacgcct accagaactc caacctgagc
     3061 gtggaggtgg ggagcgaggg ccccctgaaa ggcatccaga tctggaaggt gccagccacc
     3121 gacacctaca gcatctcggg ctacggagct gctggcggga aaggcgggaa gaacaccatg
     3181 atgcggtccc acggcgtgtc tgtgctgggc atcttcaacc tggagaagga tgacatgctg
     3241 tacatcctgg ttgggcagca gggagaggac gcctgcccca gtacaaacca gttaatccag
     3301 aaagtctgca ttggagagaa caatgtgata gaagaagaaa tccgtgtgaa cagaagcgtg
     3361 catgagtggg caggaggcgg aggaggaggg ggtggagcca cctacgtatt taagatgaag
     3421 gatggagtgc cggtgcccct gatcattgca gccggaggtg gtggcagggc ctacggggcc
     3481 aagacagaca cgttccaccc agagagactg gagaataact cctcggttct agggctaaac
     3541 ggcaattccg gagccgcagg tggtggaggt ggctggaatg ataacacttc cttgctctgg
     3601 gccggaaaat ctttgcagga gggtgccacc ggaggacatt cctgccccca ggccatgaag
     3661 aagtgggggt gggagacaag agggggtttc ggagggggtg gaggggggtg ctcctcaggt
     3721 ggaggaggcg gaggatatat aggcggcaat gcagcctcaa acaatgaccc cgaaatggat
     3781 ggggaagatg gggtttcctt catcagtcca ctgggcatcc tgtacacccc agctttaaaa
     3841 gtgatggaag gccacgggga agtgaatatt aagcattatc taaactgcag tcactgtgag
     3901 gtagacgaat gtcacatgga ccctgaaagc cacaaggtca tctgcttctg tgaccacggg
     3961 acggtgctgg ctgaggatgg cgtctcctgc attgtgtcac ccaccccgga gccacacctg
     4021 ccactctcgc tgatcctctc tgtggtgacc tctgccctcg tggccgccct ggtcctggct
     4081 ttctccggca tcatgattgt gtaccgccgg aagcaccagg agctgcaagc catgcagatg
     4141 gagctgcaga gccctgagta caagctgagc aagctccgca cctcgaccat catgaccgac
     4201 tacaacccca actactgctt tgctggcaag acctcctcca tcagtgacct gaaggaggtg
     4261 ccgcggaaaa acatcaccct cattcggggt ctgggccatg gcgcctttgg ggaggtgtat
     4321 gaaggccagg tgtccggaat gcccaacgac ccaagccccc tgcaagtggc tgtgaagacg
     4381 ctgcctgaag tgtgctctga acaggacgaa ctggatttcc tcatggaagc cctgatcatc
     4441 agcaaattca accaccagaa cattgttcgc tgcattgggg tgagcctgca atccctgccc
     4501 cggttcatcc tgctggagct catggcgggg ggagacctca agtccttcct ccgagagacc
     4561 cgccctcgcc cgagccagcc ctcctccctg gccatgctgg accttctgca cgtggctcgg
     4621 gacattgcct gtggctgtca gtatttggag gaaaaccact tcatccaccg agacattgct
     4681 gccagaaact gcctcttgac ctgtccaggc cctggaagag tggccaagat tggagacttc
     4741 gggatggccc gagacatcta cagggcgagc tactatagaa agggaggctg tgccatgctg
     4801 ccagttaagt ggatgccccc agaggccttc atggaaggaa tattcacttc taaaacagac
     4861 acatggtcct ttggagtgct gctatgggaa atcttttctc ttggatatat gccatacccc
     4921 agcaaaagca accaggaagt tctggagttt gtcaccagtg gaggccggat ggacccaccc
     4981 aagaactgcc ctgggcctgt ataccggata atgactcagt gctggcaaca tcagcctgaa
     5041 gacaggccca actttgccat cattttggag aggattgaat actgcaccca ggacccggat
     5101 gtaatcaaca ccgctttgcc gatagaatat ggtccacttg tggaagagga agagaaagtg
     5161 cctgtgaggc ccaaggaccc tgagggggtt cctcctctcc tggtctctca acaggcaaaa
     5221 cgggaggagg agcgcagccc agctgcccca ccacctctgc ctaccacctc ctctggcaag
     5281 gctgcaaaga aacccacagc tgcagagatc tctgttcgag tccctagagg gccggccgtg
     5341 gaagggggac acgtgaatat ggcattctct cagtccaacc ctccttcgga gttgcacaag
     5401 gtccacggat ccagaaacaa gcccaccagc ttgtggaacc caacgtacgg ctcctggttt
     5461 acagagaaac ccaccaaaaa gaataatcct atagcaaaga aggagccaca cgacaggggt
     5521 aacctggggc tggagggaag ctgtactgtc ccacctaacg ttgcaactgg gagacttccg
     5581 ggggcctcac tgctcctaga gccctcttcg ctgactgcca atatgaagga ggtacctctg
     5641 ttcaggctac gtcacttccc ttgtgggaat gtcaattacg gctaccagca acagggcttg
     5701 cccttagaag ccgctactgc ccctggagct ggtcattacg aggataccat tctgaaaagc
     5761 aagaatagca tgaaccagcc tgggccctga gctcggtcgc acactcactt ctcttccttg
     5821 ggatccctaa gaccgtggag gagagagagg caatggctcc ttcacaaacc agagaccaaa
     5881 tgtcacgttt tgttttgtgc caacctattt tgaagtacca ccaaaaaagc tgtattttga
     5941 aaatgcttta gaaaggtttt gagcatgggt tcatcctatt ctttcgaaag aagaaaatat
     6001 cataaaaatg agtgataaat acaaggccca gatgtggttg cataaggttt ttatgcatgt
     6061 ttgttgtata cttccttatg cttctttcaa attgtgtgtg ctctgcttca atgtagtcag
     6121 aattagctgc ttctatgttt catagttggg gtcatagatg tttccttgcc ttgttgatgt
     6181 ggacatgagc catttgaggg gagagggaac ggaaataaag gagttatttg taatgactaa
//
