LOCUS       NM_024740               6158 bp    mRNA    linear   PRI 06-OCT-2024
DEFINITION  Homo sapiens ALG9 alpha-1,2-mannosyltransferase (ALG9), transcript
            variant 1, mRNA.
ACCESSION   NM_024740
VERSION     NM_024740.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6158)
  AUTHORS   Boerrigter,M.M., Duijzer,R., Te Morsche,R.H.M. and Drenth,J.P.H.
  TITLE     Heterozygosity of ALG9 in Association with Autosomal Dominant
            Polycystic Liver Disease
  JOURNAL   Genes (Basel) 14 (9), 1755 (2023)
   PUBMED   37761895
  REMARK    GeneRIF: Heterozygosity of ALG9 in Association with Autosomal
            Dominant Polycystic Liver Disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6158)
  AUTHORS   Himmelreich,N., Dimitrov,B., Zielonka,M., Hullen,A., Hoffmann,G.F.,
            Juenger,H., Muller,H., Lorenz,I., Busse,B., Marschall,C.,
            Schluter,G. and Thiel,C.
  TITLE     Missense variant c.1460 T > C (p.L487P) enhances protein
            degradation of ER mannosyltransferase ALG9 in two new ALG9-CDG
            patients presenting with West syndrome and review of the literature
  JOURNAL   Mol Genet Metab 136 (4), 274-281 (2022)
   PUBMED   35839600
  REMARK    GeneRIF: Missense variant c.1460 T > C (p.L487P) enhances protein
            degradation of ER mannosyltransferase ALG9 in two new ALG9-CDG
            patients presenting with West syndrome and review of the
            literature.
            Review article
REFERENCE   3  (bases 1 to 6158)
  AUTHORS   Yu,Y., Kou,D., Liu,B., Huang,Y., Li,S., Qi,Y., Guo,Y., Huang,T.,
            Qi,X. and Jia,L.
  TITLE     LncRNA MEG3 contributes to drug resistance in acute myeloid
            leukemia by positively regulating ALG9 through sponging miR-155
  JOURNAL   Int J Lab Hematol 42 (4), 464-472 (2020)
   PUBMED   32359033
  REMARK    GeneRIF: LncRNA MEG3 contributes to drug resistance in acute
            myeloid leukemia by positively regulating ALG9 through sponging
            miR-155.
REFERENCE   4  (bases 1 to 6158)
  AUTHORS   Besse,W., Chang,A.R., Luo,J.Z., Triffo,W.J., Moore,B.S., Gulati,A.,
            Hartzel,D.N., Mane,S., Torres,V.E., Somlo,S. and Mirshahi,T.
  CONSRTM   Regeneron Genetics Center
  TITLE     ALG9 Mutation Carriers Develop Kidney and Liver Cysts
  JOURNAL   J Am Soc Nephrol 30 (11), 2091-2102 (2019)
   PUBMED   31395617
  REMARK    GeneRIF: ALG9 is a novel disease gene in the genetically
            heterogeneous autosomal dominant polycystic kidney disease (ADPKD)
            spectrum.
REFERENCE   5  (bases 1 to 6158)
  AUTHORS   Baysal,B.E., Willett-Brozick,J.E., Bacanu,S.A., Detera-Wadleigh,S.
            and Nimgaonkar,V.L.
  TITLE     Common variations in ALG9 are not associated with bipolar I
            disorder: a family-based study
  JOURNAL   Behav Brain Funct 2, 25 (2006)
   PUBMED   16859551
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6158)
  AUTHORS   Weinstein,M., Schollen,E., Matthijs,G., Neupert,C., Hennet,T.,
            Grubenmann,C.E., Frank,C.G., Aebi,M., Clarke,J.T., Griffiths,A.,
            Seargeant,L. and Poplawski,N.
  TITLE     CDG-IL: an infant with a novel mutation in the ALG9 gene and
            additional phenotypic features
  JOURNAL   Am J Med Genet A 136 (2), 194-197 (2005)
   PUBMED   15945070
REFERENCE   7  (bases 1 to 6158)
  AUTHORS   Frank,C.G., Grubenmann,C.E., Eyaid,W., Berger,E.G., Aebi,M. and
            Hennet,T.
  TITLE     Identification and functional analysis of a defect in the human
            ALG9 gene: definition of congenital disorder of glycosylation type
            IL
  JOURNAL   Am J Hum Genet 75 (1), 146-150 (2004)
   PUBMED   15148656
REFERENCE   8  (bases 1 to 6158)
  AUTHORS   Baysal,B.E., Willett-Brozick,J.E., Badner,J.A., Corona,W.,
            Ferrell,R.E., Nimgaonkar,V.L. and Detera-Wadleigh,S.D.
  TITLE     A mannosyltransferase gene at 11q23 is disrupted by a translocation
            breakpoint that co-segregates with bipolar affective disorder in a
            small family
  JOURNAL   Neurogenetics 4 (1), 43-53 (2002)
   PUBMED   12030331
REFERENCE   9  (bases 1 to 6158)
  AUTHORS   Sparks,S.E. and Krasnewich,D.M.
  TITLE     Congenital Disorders of N-Linked Glycosylation and Multiple Pathway
            Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301507
REFERENCE   10 (bases 1 to 6158)
  AUTHORS   Harris,P.C. and Torres,V.E.
  TITLE     Polycystic Kidney Disease, Autosomal Dominant
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301424
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK025498.1, BC009255.2 and
            AP001781.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 16, 2006 this sequence version replaced NM_024740.1.
            
            Summary: This gene encodes an alpha-1,2-mannosyltransferase enzyme
            that functions in lipid-linked oligosaccharide assembly. Mutations
            in this gene result in congenital disorder of glycosylation type
            Il. Multiple transcript variants encoding different isoforms have
            been found for this gene. [provided by RefSeq, Dec 2008].
            
            Transcript Variant: This variant (1) encodes isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK025498.1, SRR1803613.9011.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000616540.5/ ENSP00000482437.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-963               AK025498.1         1-963
            964-2069            BC009255.2         913-2018
            2070-6158           AP001781.5         62986-67074         c
FEATURES             Location/Qualifiers
     source          1..6158
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.1"
     gene            1..6158
                     /gene="ALG9"
                     /gene_synonym="CDG1L; DIBD1; GIKANIS; LOH11CR1J"
                     /note="ALG9 alpha-1,2-mannosyltransferase"
                     /db_xref="GeneID:79796"
                     /db_xref="HGNC:HGNC:15672"
                     /db_xref="MIM:606941"
     exon            1..230
                     /gene="ALG9"
                     /gene_synonym="CDG1L; DIBD1; GIKANIS; LOH11CR1J"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1956
                     /gene="ALG9"
                     /gene_synonym="CDG1L; DIBD1; GIKANIS; LOH11CR1J"
                     /EC_number="2.4.1.259"
                     /EC_number="2.4.1.261"
                     /note="isoform a is encoded by transcript variant 1;
                     asparagine-linked glycosylation 9 homolog (yeast, alpha-
                     1,2-mannosyltransferase); disrupted in bipolar affective
                     disorder 1; asparagine-linked glycosylation 9 homolog (S.
                     cerevisiae, alpha- 1,2-mannosyltransferase);
                     alpha-1,2-mannosyltransferase ALG9; loss of
                     heterozygosity, 11, chromosomal region 1 gene J product;
                     disrupted in bipolar disorder protein 1; asparagine-linked
                     glycosylation protein 9 homolog;
                     dol-P-Man:Man(6)GlcNAc(2)-PP-Dol
                     alpha-1,2-mannosyltransferase;
                     dol-P-Man:Man(8)GlcNAc(2)-PP-Dol
                     alpha-1,2-mannosyltransferase; asparagine-linked
                     glycosylation 9, alpha-1,2-mannosyltransferase homolog;
                     dol-P-Man dependent alpha-1,2-mannosyltransferase;
                     dolichyl-P-Man:Man(6)GlcNAc(2)-PP-dolichol
                     alpha-1,2-mannosyltransferase;
                     dolichyl-P-Man:Man(8)GlcNAc(2)-PP-dolichol
                     alpha-1,2-mannosyltransferase; asparagine-linked
                     glycosylation 9 alpha-12-mannosyltransferase-like protein"
                     /codon_start=1
                     /product="alpha-1,2-mannosyltransferase ALG9 isoform a"
                     /protein_id="NP_079016.2"
                     /db_xref="CCDS:CCDS73380.1"
                     /db_xref="GeneID:79796"
                     /db_xref="HGNC:HGNC:15672"
                     /db_xref="MIM:606941"
                     /translation="MASRGARQRLKGSGASSGDTAPAADKLRELLGSREAGGAEHRTE
                     LSGNKAGQVWAPEGSTAFKCLLSARLCAALLSNISDCDETFNYWEPTHYLIYGEGFQT
                     WEYSPAYAIRSYAYLLLHAWPAAFHARILQTNKILVFYFLRCLLAFVSCICELYFYKA
                     VCKKFGLHVSRMMLAFLVLSTGMFCSSSAFLPSSFCMYTTLIAMTGWYMDKTSIAVLG
                     VAAGAILGWPFSAALGLPIAFDLLVMKHRWKSFFHWSLMALILFLVPVVVIDSYYYGK
                     LVIAPLNIVLYNVFTPHGPDLYGTEPWYFYLINGFLNFNVAFALALLVLPLTSLMEYL
                     LQRFHVQNLGHPYWLTLAPMYIWFIIFFIQPHKEERFLFPVYPLICLCGAVALSALQH
                     SFLYFQKCYHFVFQRYRLEHYTVTSNWLALGTVFLFGLLSFSRSVALFRGYHGPLDLY
                     PEFYRIATDPTIHTVPEGRPVNVCVGKEWYRFPSSFLLPDNWQLQFIPSEFRGQLPKP
                     FAEGPLATRIVPTDMNDQNLEEPSRYIDISKCHYLVDLDTMRETPREPKYSSNKEEWI
                     SLAYRPFLDASRSSKLLRAFYVPFLSDQYTVYVNYTILKPRKAKQIRKKSGG"
     exon            231..369
                     /gene="ALG9"
                     /gene_synonym="CDG1L; DIBD1; GIKANIS; LOH11CR1J"
                     /inference="alignment:Splign:2.1.0"
     exon            370..504
                     /gene="ALG9"
                     /gene_synonym="CDG1L; DIBD1; GIKANIS; LOH11CR1J"
                     /inference="alignment:Splign:2.1.0"
     exon            505..575
                     /gene="ALG9"
                     /gene_synonym="CDG1L; DIBD1; GIKANIS; LOH11CR1J"
                     /inference="alignment:Splign:2.1.0"
     exon            576..664
                     /gene="ALG9"
                     /gene_synonym="CDG1L; DIBD1; GIKANIS; LOH11CR1J"
                     /inference="alignment:Splign:2.1.0"
     exon            665..800
                     /gene="ALG9"
                     /gene_synonym="CDG1L; DIBD1; GIKANIS; LOH11CR1J"
                     /inference="alignment:Splign:2.1.0"
     exon            801..888
                     /gene="ALG9"
                     /gene_synonym="CDG1L; DIBD1; GIKANIS; LOH11CR1J"
                     /inference="alignment:Splign:2.1.0"
     exon            889..994
                     /gene="ALG9"
                     /gene_synonym="CDG1L; DIBD1; GIKANIS; LOH11CR1J"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1117
                     /gene="ALG9"
                     /gene_synonym="CDG1L; DIBD1; GIKANIS; LOH11CR1J"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1272
                     /gene="ALG9"
                     /gene_synonym="CDG1L; DIBD1; GIKANIS; LOH11CR1J"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1423
                     /gene="ALG9"
                     /gene_synonym="CDG1L; DIBD1; GIKANIS; LOH11CR1J"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1571
                     /gene="ALG9"
                     /gene_synonym="CDG1L; DIBD1; GIKANIS; LOH11CR1J"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1701
                     /gene="ALG9"
                     /gene_synonym="CDG1L; DIBD1; GIKANIS; LOH11CR1J"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1832
                     /gene="ALG9"
                     /gene_synonym="CDG1L; DIBD1; GIKANIS; LOH11CR1J"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..6158
                     /gene="ALG9"
                     /gene_synonym="CDG1L; DIBD1; GIKANIS; LOH11CR1J"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2048..2053
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALG9"
                     /gene_synonym="CDG1L; DIBD1; GIKANIS; LOH11CR1J"
                     /note="hexamer: AATAAA"
     polyA_site      2069
                     /gene="ALG9"
                     /gene_synonym="CDG1L; DIBD1; GIKANIS; LOH11CR1J"
                     /note="major polyA site"
     regulatory      6139..6144
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALG9"
                     /gene_synonym="CDG1L; DIBD1; GIKANIS; LOH11CR1J"
                     /note="hexamer: AATAAA"
     polyA_site      6158
                     /gene="ALG9"
                     /gene_synonym="CDG1L; DIBD1; GIKANIS; LOH11CR1J"
ORIGIN      
        1 gtcttttgtc cctcggcgga caccgtttgc cagccaaagc tatgtctgcg cgctcaccga
       61 cttcataggg tgccgaattc ttttttcccc aggcttgcca tggctagtcg aggggctcgg
      121 cagcgcctga agggcagcgg ggccagcagt ggggatacgg ccccggctgc ggacaagctg
      181 cgggagctgc tgggcagccg agaggcgggc ggcgcggagc accggaccga gttatctggg
      241 aacaaagcag gacaagtctg ggcacctgaa ggatctactg ctttcaagtg tctgctttca
      301 gcaaggttat gtgctgctct cctgagcaac atctctgact gtgatgaaac attcaactac
      361 tgggagccaa cacactacct catctatggg gaagggtttc agacttggga atattcccca
      421 gcatatgcca ttcgctccta tgcttacctg ttgcttcatg cctggccagc tgcatttcat
      481 gcaagaattc tacaaactaa taagattctt gtgttttact ttttgcgatg tcttctggct
      541 tttgtgagct gtatttgtga actttacttt tacaaggctg tgtgcaagaa gtttgggttg
      601 cacgtgagtc gaatgatgct agccttcttg gttctcagca ctggcatgtt ttgctcatca
      661 tcagcattcc ttcctagtag cttctgtatg tacactacgt tgatagccat gactggatgg
      721 tatatggaca agacttccat tgctgtgctg ggagtagcag ctggggctat cttaggctgg
      781 ccattcagtg cagctcttgg tttacccatt gcctttgatt tgctggtcat gaaacacagg
      841 tggaagagtt tctttcattg gtcgctgatg gccctcatac tatttctggt gcctgtggtg
      901 gtcattgaca gctactatta tgggaagttg gtgattgcac cactcaacat tgttttgtat
      961 aatgtcttta ctcctcatgg acctgatctt tatggtacag aaccctggta tttctattta
     1021 attaatggat ttctgaattt caatgtagcc tttgctttgg ctctcctagt cctaccactg
     1081 acttctctta tggaatacct gctgcagaga tttcatgttc agaatttagg ccacccgtat
     1141 tggcttacct tggctccaat gtatatttgg tttataattt tcttcatcca gcctcacaaa
     1201 gaggagagat ttcttttccc tgtgtatcca cttatatgtc tctgtggcgc tgtggctctc
     1261 tctgcacttc agcacagttt tctgtacttc cagaaatgtt accactttgt gtttcaacga
     1321 tatcgcctgg agcactatac tgtgacatcg aattggctgg cattaggaac tgtcttcctg
     1381 tttgggctct tgtcattttc tcgctctgtg gcactgttca gaggatatca cgggcccctt
     1441 gatttgtatc cagaatttta ccgaattgct acagacccaa ccatccacac tgtcccagaa
     1501 ggcagacctg tgaatgtctg tgtgggaaaa gagtggtatc gatttcccag cagcttcctt
     1561 cttcctgaca attggcagct tcagttcatt ccatcagagt tcagaggtca gttaccaaaa
     1621 ccttttgcag aaggacctct ggccacccgg attgttccta ctgacatgaa tgaccagaat
     1681 ctagaagagc catccagata tattgatatc agtaaatgcc attatttagt ggatttggac
     1741 accatgagag aaacaccccg ggagccaaaa tattcatcca ataaagaaga atggatcagc
     1801 ttggcctata gaccattcct tgatgcttct agatcttcaa agctgctgcg ggcattctat
     1861 gtccccttcc tgtcagatca gtatacagtg tacgtaaact acaccatcct caaaccccgg
     1921 aaagcaaagc aaatcaggaa gaaaagtgga ggttagcaac acacctgtgg ccccaaagga
     1981 caaccatctt gttaactatt gattccagtg acctgactcc ctgcaagtca tcgcctgtaa
     2041 catttgtaat aaaggtcttc tgacatgaat actggaatct gggtgctctg ggctagtcaa
     2101 agtctatttc aaagtctaat caaagtcaca tttgctccct gtgtgtgtct ctgttctgca
     2161 tgtaaacttt ttgcagctag gcagagaaag gccctaaagc acagatagat atattgctcc
     2221 acatctcatt gtttttcctc tgttcaatta tttactagac cggagaagag cagaaccaac
     2281 ttacaggaag aattgaaaat cctggtactg gatggctgtg ataagctgtt ctccacactc
     2341 tggcctggca tctgagaact agcaagcctc tcttaggcca tatgggcttc tccaccaaag
     2401 ctgtttggca gctcctagca gaccttctta ttgaaatcct catgctgaaa atgaacacag
     2461 cctagttgcc aacccacatg tccttttcac ctccagcaag actaagcttc tttaaagcac
     2521 ttcacaggac taggaccctg tcctggagct atctcaggaa aaaggtgacc atttgaggaa
     2581 ctgtgaccta attttattat aatgatgcct ctaattttca tttcctttac aaccaactgt
     2641 aactataagg ttgtattgct tttttgttca gttttagcat gctatttttt gaattctaga
     2701 ctcctccatg tgaagatatc aacagacaaa actacaactg tataggacat atttggagaa
     2761 aattctatca attgatacat ttggatgaca tcacattttt aagtaatgta atctgaggcc
     2821 attgctgagg aaattaagaa ttttcctttt tttttaacca cccccagtga aaaggatcag
     2881 tgtatattta tagcacctat tttttagttc tgtctgttgt gaggcacatc ctgcatgggg
     2941 cacttctagt caaataggca atgataagga cctaattaaa atgtgataag tgtatactat
     3001 tactttaaaa gcctttacag tcagtacttc agtttacaag gcactttcac agcatctcgt
     3061 ttgatcctca cagtcacaac atgtggtaga caaggcaggt gatttttatc cccattttac
     3121 agataaggaa acaggctgcg ggtggggagt gaggggaggt aaagatagtt agttgcctaa
     3181 ggtcacacag ccagtaagta atagagctgg gactggaacc caggtttcct tactctcatc
     3241 tattgctcct ccatattcct cactcaacca tgaaaacatt acttgaaagg actgatgagg
     3301 ttaaccagag acctaactga tattgtaact ttctatttta aggaagaatt gtgtctgtat
     3361 ttgagttctt tggagcctcc agtctgcctg tgtgttagac cagcacagca gtgctgtgtg
     3421 atgcagcctg acctgtggca ggaaagtagt gcttctgttt ggaagtcatg ttcttttgca
     3481 gccacacagg atccaaatat cagtactatt cctgtagtca atctggggtc acattatagg
     3541 tgccttattt ccctaagggt aactgatctg aatatctgca aataggatga atctattttt
     3601 cagaagttcc atctttcatt tttctttttt tttttgagac agagtctcat tctgtcgccc
     3661 atgctggagt gcagtggcgc gatctcggct cgctgcaacc tctgcctccc aggttgaagc
     3721 aattctcatg cctcagccac ccgagtagct gggattacag gcatgcgcca tcatgcccag
     3781 ctaatttatg tatttttagt agagttggag tttcaccatg ttggccaggc tggtcttgga
     3841 ctcctgacct caggtcatcc acccgcctca gcctcccaaa gtgctggtat tacaggcgtg
     3901 agccaccgca cccagcccca tctttcattt tcaaagagaa gggcattcta ataggaactg
     3961 gtgccaagag agaagaaaag aagtgataac agaagaaatg gctagttaca atattaaaaa
     4021 gctcctcttt gagatctcct ctgcaggaat atcagagacg gagttgaagc gctggagagg
     4081 taataggtct agacagtaca gaacaataac tggggagtgt gtgaggatag actgggctcc
     4141 cccttgcttg aaagatctct ggcatttaat tctcaattct tgattactat tttccagtgt
     4201 aaaactagca catatgatct gactacagga cagagaattt taagtgaaac atttgcctta
     4261 cttgcagtaa taatgtgctg ttcttcacag tagctaaggc cctctatgtt tcccagaggt
     4321 aaataagaat ccaggaatgg aggtccatct gtgatgaatg gcttttttct aatcaaagta
     4381 gtataatgct gttttatctg ttttgtcatc ttgttttttt ttttttttaa aaaaacaaaa
     4441 ccttaattat aatatagcgc aaagaaaggc caggactgat gcagggattc cttggaaata
     4501 tcagttccta tcacttttaa aacctgattt tggatctctc tgttctatgt atgtctttag
     4561 tgagagcaca atacatggca gaacgctgtg ccaaatgtta taggtaagga atatagaaat
     4621 gaatgttttt tgttgtgaag gtgttttcat gtgatatttt ataaacacat tttaaaaaat
     4681 ctccatcact ttttagtata ggaaggatag ctttgcctgg gaaaaacagt ttcaacacac
     4741 ctgctcagag tagcagttct ccctcaaaaa agcagtgttc agcctgcact gactgttctg
     4801 cttgccaaaa ggaggaagca tgcaagatac ttatttctcc atagattgtg gagtatagag
     4861 ggatgtggga ctacagatta ttattttttt tccccgagac agagtcttgc tctgtcgccc
     4921 aggttggaac acaatggcac gacctcagct cactgcaacc tctgtctccc gggttcaagc
     4981 aattctcctg cttcagcctc ctgagtagct gggattacag gcacacacca ccaccgcact
     5041 cagctaattt ttgtattttt agtagaggtg gggttttacc atgttggcca ggctggtctt
     5101 aaactcctga ccttgtaatc atcccgcctc ggcctcctaa agtgctagga ttacaggcat
     5161 gagccaccgc acccggccca gataattttt aatagccttt gatcatgggg tgagtgaggg
     5221 agtaggtata cttggcaaat gcatggttct ctgatttcta gctctaaagc agccttatct
     5281 gaatccccaa atcttgtgat gctgagtacc attactgaac cagtctgcac ggtaggcatc
     5341 tgctaccaaa atttacctcc tacctggtag gtgtcatctg ataagaaaga agacaggtta
     5401 ttttaatttt ttgagataat cacagaaaat tgcagcccat actctttatt accgaattca
     5461 agtttggaaa tagacccttt gttttaaatc atgatgggtc tttatcccaa tcatttatct
     5521 gggtcatttt tccaactttg gagttctagg aaagaacctt gaaaacctga tatgattctg
     5581 cagcatgagg tctacggtga ccatttgggc aaagctccag tggcaatcat ttattgtgtt
     5641 ttgcatttcc tgggatttat tgaaataaga attcactgtg attatgtagt cttctggcta
     5701 gtatcaggca gctctgcttt taatttggtt aattttattt tctctgaaga gggagaagag
     5761 gtacaattta atcttggcct ccacaagcat attaaagctc acgtgttaat cagtgcattc
     5821 ttatgctcct acattaaatg ccttgggtaa atggataaat ggacatgtgc ccagctttaa
     5881 ttttttttgc aacagaaaga tcagacttcc gtatggcatc gttggatttc agaggctttc
     5941 tggtgtatct gtaaatctga atgttgcctt ctgccagtct gtataaccag gtgattcatg
     6001 ctgcaaatga aatcaggaag cagtaaagtg ttaaagcaag agtattgtcc aattcacttg
     6061 tcttcctgat ccttgtactt tatttcacgt gtcggtgttt acattacata cttatatttc
     6121 ctgtgaaaga aagagttaaa taaattgtag cagtttga
//
