LOCUS       NM_001352422            6577 bp    mRNA    linear   PRI 11-OCT-2024
DEFINITION  Homo sapiens ALG9 alpha-1,2-mannosyltransferase (ALG9), transcript
            variant 18, mRNA.
ACCESSION   NM_001352422 XM_017018325
VERSION     NM_001352422.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6577)
  AUTHORS   Boerrigter,M.M., Duijzer,R., Te Morsche,R.H.M. and Drenth,J.P.H.
  TITLE     Heterozygosity of ALG9 in Association with Autosomal Dominant
            Polycystic Liver Disease
  JOURNAL   Genes (Basel) 14 (9), 1755 (2023)
   PUBMED   37761895
  REMARK    GeneRIF: Heterozygosity of ALG9 in Association with Autosomal
            Dominant Polycystic Liver Disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6577)
  AUTHORS   Himmelreich,N., Dimitrov,B., Zielonka,M., Hullen,A., Hoffmann,G.F.,
            Juenger,H., Muller,H., Lorenz,I., Busse,B., Marschall,C.,
            Schluter,G. and Thiel,C.
  TITLE     Missense variant c.1460 T > C (p.L487P) enhances protein
            degradation of ER mannosyltransferase ALG9 in two new ALG9-CDG
            patients presenting with West syndrome and review of the literature
  JOURNAL   Mol Genet Metab 136 (4), 274-281 (2022)
   PUBMED   35839600
  REMARK    GeneRIF: Missense variant c.1460 T > C (p.L487P) enhances protein
            degradation of ER mannosyltransferase ALG9 in two new ALG9-CDG
            patients presenting with West syndrome and review of the
            literature.
            Review article
REFERENCE   3  (bases 1 to 6577)
  AUTHORS   Yu,Y., Kou,D., Liu,B., Huang,Y., Li,S., Qi,Y., Guo,Y., Huang,T.,
            Qi,X. and Jia,L.
  TITLE     LncRNA MEG3 contributes to drug resistance in acute myeloid
            leukemia by positively regulating ALG9 through sponging miR-155
  JOURNAL   Int J Lab Hematol 42 (4), 464-472 (2020)
   PUBMED   32359033
  REMARK    GeneRIF: LncRNA MEG3 contributes to drug resistance in acute
            myeloid leukemia by positively regulating ALG9 through sponging
            miR-155.
REFERENCE   4  (bases 1 to 6577)
  AUTHORS   Besse,W., Chang,A.R., Luo,J.Z., Triffo,W.J., Moore,B.S., Gulati,A.,
            Hartzel,D.N., Mane,S., Torres,V.E., Somlo,S. and Mirshahi,T.
  CONSRTM   Regeneron Genetics Center
  TITLE     ALG9 Mutation Carriers Develop Kidney and Liver Cysts
  JOURNAL   J Am Soc Nephrol 30 (11), 2091-2102 (2019)
   PUBMED   31395617
  REMARK    GeneRIF: ALG9 is a novel disease gene in the genetically
            heterogeneous autosomal dominant polycystic kidney disease (ADPKD)
            spectrum.
REFERENCE   5  (bases 1 to 6577)
  AUTHORS   Baysal,B.E., Willett-Brozick,J.E., Bacanu,S.A., Detera-Wadleigh,S.
            and Nimgaonkar,V.L.
  TITLE     Common variations in ALG9 are not associated with bipolar I
            disorder: a family-based study
  JOURNAL   Behav Brain Funct 2, 25 (2006)
   PUBMED   16859551
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6577)
  AUTHORS   Weinstein,M., Schollen,E., Matthijs,G., Neupert,C., Hennet,T.,
            Grubenmann,C.E., Frank,C.G., Aebi,M., Clarke,J.T., Griffiths,A.,
            Seargeant,L. and Poplawski,N.
  TITLE     CDG-IL: an infant with a novel mutation in the ALG9 gene and
            additional phenotypic features
  JOURNAL   Am J Med Genet A 136 (2), 194-197 (2005)
   PUBMED   15945070
REFERENCE   7  (bases 1 to 6577)
  AUTHORS   Frank,C.G., Grubenmann,C.E., Eyaid,W., Berger,E.G., Aebi,M. and
            Hennet,T.
  TITLE     Identification and functional analysis of a defect in the human
            ALG9 gene: definition of congenital disorder of glycosylation type
            IL
  JOURNAL   Am J Hum Genet 75 (1), 146-150 (2004)
   PUBMED   15148656
REFERENCE   8  (bases 1 to 6577)
  AUTHORS   Baysal,B.E., Willett-Brozick,J.E., Badner,J.A., Corona,W.,
            Ferrell,R.E., Nimgaonkar,V.L. and Detera-Wadleigh,S.D.
  TITLE     A mannosyltransferase gene at 11q23 is disrupted by a translocation
            breakpoint that co-segregates with bipolar affective disorder in a
            small family
  JOURNAL   Neurogenetics 4 (1), 43-53 (2002)
   PUBMED   12030331
REFERENCE   9  (bases 1 to 6577)
  AUTHORS   Sparks,S.E. and Krasnewich,D.M.
  TITLE     Congenital Disorders of N-Linked Glycosylation and Multiple Pathway
            Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301507
REFERENCE   10 (bases 1 to 6577)
  AUTHORS   Harris,P.C. and Torres,V.E.
  TITLE     Polycystic Kidney Disease, Autosomal Dominant
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301424
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from FP884232.2 and AP001781.5.
            
            On May 31, 2019 this sequence version replaced NM_001352422.1.
            
            Summary: This gene encodes an alpha-1,2-mannosyltransferase enzyme
            that functions in lipid-linked oligosaccharide assembly. Mutations
            in this gene result in congenital disorder of glycosylation type
            Il. Multiple transcript variants encoding different isoforms have
            been found for this gene. [provided by RefSeq, Dec 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.184073.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               FP884232.2         387-496
            111-527             AP001781.5         151565-151981       c
            528-666             AP001781.5         151022-151160       c
            667-801             AP001781.5         149392-149526       c
            802-872             AP001781.5         145971-146041       c
            873-961             AP001781.5         141337-141425       c
            962-1104            AP001781.5         140953-141095       c
            1105-1240           AP001781.5         138392-138527       c
            1241-1328           AP001781.5         134439-134526       c
            1329-1434           AP001781.5         134170-134275       c
            1435-1557           AP001781.5         125391-125513       c
            1558-1712           AP001781.5         121445-121599       c
            1713-1842           AP001781.5         119039-119168       c
            1843-1990           AP001781.5         118258-118405       c
            1991-2120           AP001781.5         116955-117084       c
            2121-2251           AP001781.5         90434-90564         c
            2252-6577           AP001781.5         62986-67311         c
FEATURES             Location/Qualifiers
     source          1..6577
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.1"
     gene            1..6577
                     /gene="ALG9"
                     /gene_synonym="CDG1L; DIBD1; GIKANIS; LOH11CR1J"
                     /note="ALG9 alpha-1,2-mannosyltransferase"
                     /db_xref="GeneID:79796"
                     /db_xref="HGNC:HGNC:15672"
                     /db_xref="MIM:606941"
     exon            1..527
                     /gene="ALG9"
                     /gene_synonym="CDG1L; DIBD1; GIKANIS; LOH11CR1J"
                     /inference="alignment:Splign:2.1.0"
     exon            528..666
                     /gene="ALG9"
                     /gene_synonym="CDG1L; DIBD1; GIKANIS; LOH11CR1J"
                     /inference="alignment:Splign:2.1.0"
     exon            667..801
                     /gene="ALG9"
                     /gene_synonym="CDG1L; DIBD1; GIKANIS; LOH11CR1J"
                     /inference="alignment:Splign:2.1.0"
     exon            802..872
                     /gene="ALG9"
                     /gene_synonym="CDG1L; DIBD1; GIKANIS; LOH11CR1J"
                     /inference="alignment:Splign:2.1.0"
     exon            873..961
                     /gene="ALG9"
                     /gene_synonym="CDG1L; DIBD1; GIKANIS; LOH11CR1J"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1104
                     /gene="ALG9"
                     /gene_synonym="CDG1L; DIBD1; GIKANIS; LOH11CR1J"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1240
                     /gene="ALG9"
                     /gene_synonym="CDG1L; DIBD1; GIKANIS; LOH11CR1J"
                     /inference="alignment:Splign:2.1.0"
     CDS             1128..2375
                     /gene="ALG9"
                     /gene_synonym="CDG1L; DIBD1; GIKANIS; LOH11CR1J"
                     /EC_number="2.4.1.259"
                     /EC_number="2.4.1.261"
                     /note="isoform k is encoded by transcript variant 18;
                     asparagine-linked glycosylation 9 homolog (yeast, alpha-
                     1,2-mannosyltransferase); disrupted in bipolar affective
                     disorder 1; asparagine-linked glycosylation 9 homolog (S.
                     cerevisiae, alpha- 1,2-mannosyltransferase);
                     alpha-1,2-mannosyltransferase ALG9; loss of
                     heterozygosity, 11, chromosomal region 1 gene J product;
                     disrupted in bipolar disorder protein 1; asparagine-linked
                     glycosylation protein 9 homolog;
                     dol-P-Man:Man(6)GlcNAc(2)-PP-Dol
                     alpha-1,2-mannosyltransferase;
                     dol-P-Man:Man(8)GlcNAc(2)-PP-Dol
                     alpha-1,2-mannosyltransferase; asparagine-linked
                     glycosylation 9, alpha-1,2-mannosyltransferase homolog;
                     dol-P-Man dependent alpha-1,2-mannosyltransferase;
                     dolichyl-P-Man:Man(6)GlcNAc(2)-PP-dolichol
                     alpha-1,2-mannosyltransferase;
                     dolichyl-P-Man:Man(8)GlcNAc(2)-PP-dolichol
                     alpha-1,2-mannosyltransferase; asparagine-linked
                     glycosylation 9 alpha-12-mannosyltransferase-like protein"
                     /codon_start=1
                     /product="alpha-1,2-mannosyltransferase ALG9 isoform k"
                     /protein_id="NP_001339351.1"
                     /db_xref="GeneID:79796"
                     /db_xref="HGNC:HGNC:15672"
                     /db_xref="MIM:606941"
                     /translation="MYTTLIAMTGWYMDKTSIAVLGVAAGAILGWPFSAALGLPIAFD
                     LLVMKHRWKSFFHWSLMALILFLVPVVVIDSYYYGKLVIAPLNIVLYNVFTPHGPDLY
                     GTEPWYFYLINGFLNFNVAFALALLVLPLTSLMEYLLQRFHVQNLGHPYWLTLAPMYI
                     WFIIFFIQPHKEERFLFPVYPLICLCGAVALSALQKCYHFVFQRYRLEHYTVTSNWLA
                     LGTVFLFGLLSFSRSVALFRGYHGPLDLYPEFYRIATDPTIHTVPEGRPVNVCVGKEW
                     YRFPSSFLLPDNWQLQFIPSEFRGQLPKPFAEGPLATRIVPTDMNDQNLEEPSRYIDI
                     SKCHYLVDLDTMRETPREPKYSSNKEEWISLAYRPFLDASRSSKLLRAFYVPFLSDQY
                     TVYVNYTILKPRKAKQIRKKSGG"
     exon            1241..1328
                     /gene="ALG9"
                     /gene_synonym="CDG1L; DIBD1; GIKANIS; LOH11CR1J"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1434
                     /gene="ALG9"
                     /gene_synonym="CDG1L; DIBD1; GIKANIS; LOH11CR1J"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1557
                     /gene="ALG9"
                     /gene_synonym="CDG1L; DIBD1; GIKANIS; LOH11CR1J"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1712
                     /gene="ALG9"
                     /gene_synonym="CDG1L; DIBD1; GIKANIS; LOH11CR1J"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1842
                     /gene="ALG9"
                     /gene_synonym="CDG1L; DIBD1; GIKANIS; LOH11CR1J"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..1990
                     /gene="ALG9"
                     /gene_synonym="CDG1L; DIBD1; GIKANIS; LOH11CR1J"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..2120
                     /gene="ALG9"
                     /gene_synonym="CDG1L; DIBD1; GIKANIS; LOH11CR1J"
                     /inference="alignment:Splign:2.1.0"
     exon            2121..2251
                     /gene="ALG9"
                     /gene_synonym="CDG1L; DIBD1; GIKANIS; LOH11CR1J"
                     /inference="alignment:Splign:2.1.0"
     exon            2252..6577
                     /gene="ALG9"
                     /gene_synonym="CDG1L; DIBD1; GIKANIS; LOH11CR1J"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2467..2472
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALG9"
                     /gene_synonym="CDG1L; DIBD1; GIKANIS; LOH11CR1J"
                     /note="hexamer: AATAAA"
     polyA_site      2488
                     /gene="ALG9"
                     /gene_synonym="CDG1L; DIBD1; GIKANIS; LOH11CR1J"
                     /note="major polyA site"
     regulatory      6558..6563
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALG9"
                     /gene_synonym="CDG1L; DIBD1; GIKANIS; LOH11CR1J"
                     /note="hexamer: AATAAA"
     polyA_site      6577
                     /gene="ALG9"
                     /gene_synonym="CDG1L; DIBD1; GIKANIS; LOH11CR1J"
ORIGIN      
        1 gctgcccccg ggagggtctt agctgtggcg cgcggggctc agtccggcct ggcctcaccg
       61 cgggaggccc gagctccctc ttcagctagg tcctattggt cttcctgggc gggtcagcat
      121 tcagtcttcg cccaccttag atccctccac tgcgctgtaa aactgccttg gagtgcggat
      181 ctgtgatgct cctgggccag gcctagagtg ggcacagcct ctgtgggaga tgtagacagg
      241 atcaaagagt atacctttta cggctgttcc tcacagctcc ttttattctc cctcaagtcc
      301 cgacccttta ctgggcccat ccaacccgcc atcacctctt cccaaaccct ggaggctgca
      361 ggttagaact gcattaaggg agctgtcaac atatggaatt ggagtaggct atgtaccttg
      421 cacctaggct tctatctgaa cataaggggg aatgaataaa gccatcaaaa gcaatgacct
      481 tgttaagaaa agaaagaaaa ggagaatgac agctttgtgg ccttcaagtt atctgggaac
      541 aaagcaggac aagtctgggc acctgaagga tctactgctt tcaagtgtct gctttcagca
      601 aggttatgtg ctgctctcct gagcaacatc tctgactgtg atgaaacatt caactactgg
      661 gagccaacac actacctcat ctatggggaa gggtttcaga cttgggaata ttccccagca
      721 tatgccattc gctcctatgc ttacctgttg cttcatgcct ggccagctgc atttcatgca
      781 agaattctac aaactaataa gattcttgtg ttttactttt tgcgatgtct tctggctttt
      841 gtgagctgta tttgtgaact ttacttttac aaggctgtgt gcaagaagtt tgggttgcac
      901 gtgagtcgaa tgatgctagc cttcttggtt ctcagcactg gcatgttttg ctcatcatca
      961 ggtaaggaca ttgaaacgta gatgaaatga tttactaaaa gtcaaaattc ataaatggta
     1021 gagctggtag tctcaccagg atgttttcta ttccattctt gcatcaacca cccacctcct
     1081 ttcttggcca ttagtggaaa gaaacattcc ttcctagtag cttctgtatg tacactacgt
     1141 tgatagccat gactggatgg tatatggaca agacttccat tgctgtgctg ggagtagcag
     1201 ctggggctat cttaggctgg ccattcagtg cagctcttgg tttacccatt gcctttgatt
     1261 tgctggtcat gaaacacagg tggaagagtt tctttcattg gtcgctgatg gccctcatac
     1321 tatttctggt gcctgtggtg gtcattgaca gctactatta tgggaagttg gtgattgcac
     1381 cactcaacat tgttttgtat aatgtcttta ctcctcatgg acctgatctt tatggtacag
     1441 aaccctggta tttctattta attaatggat ttctgaattt caatgtagcc tttgctttgg
     1501 ctctcctagt cctaccactg acttctctta tggaatacct gctgcagaga tttcatgttc
     1561 agaatttagg ccacccgtat tggcttacct tggctccaat gtatatttgg tttataattt
     1621 tcttcatcca gcctcacaaa gaggagagat ttcttttccc tgtgtatcca cttatatgtc
     1681 tctgtggcgc tgtggctctc tctgcacttc agaaatgtta ccactttgtg tttcaacgat
     1741 atcgcctgga gcactatact gtgacatcga attggctggc attaggaact gtcttcctgt
     1801 ttgggctctt gtcattttct cgctctgtgg cactgttcag aggatatcac gggccccttg
     1861 atttgtatcc agaattttac cgaattgcta cagacccaac catccacact gtcccagaag
     1921 gcagacctgt gaatgtctgt gtgggaaaag agtggtatcg atttcccagc agcttccttc
     1981 ttcctgacaa ttggcagctt cagttcattc catcagagtt cagaggtcag ttaccaaaac
     2041 cttttgcaga aggacctctg gccacccgga ttgttcctac tgacatgaat gaccagaatc
     2101 tagaagagcc atccagatat attgatatca gtaaatgcca ttatttagtg gatttggaca
     2161 ccatgagaga aacaccccgg gagccaaaat attcatccaa taaagaagaa tggatcagct
     2221 tggcctatag accattcctt gatgcttcta gatcttcaaa gctgctgcgg gcattctatg
     2281 tccccttcct gtcagatcag tatacagtgt acgtaaacta caccatcctc aaaccccgga
     2341 aagcaaagca aatcaggaag aaaagtggag gttagcaaca cacctgtggc cccaaaggac
     2401 aaccatcttg ttaactattg attccagtga cctgactccc tgcaagtcat cgcctgtaac
     2461 atttgtaata aaggtcttct gacatgaata ctggaatctg ggtgctctgg gctagtcaaa
     2521 gtctatttca aagtctaatc aaagtcacat ttgctccctg tgtgtgtctc tgttctgcat
     2581 gtaaactttt tgcagctagg cagagaaagg ccctaaagca cagatagata tattgctcca
     2641 catctcattg tttttcctct gttcaattat ttactagacc ggagaagagc agaaccaact
     2701 tacaggaaga attgaaaatc ctggtactgg atggctgtga taagctgttc tccacactct
     2761 ggcctggcat ctgagaacta gcaagcctct cttaggccat atgggcttct ccaccaaagc
     2821 tgtttggcag ctcctagcag accttcttat tgaaatcctc atgctgaaaa tgaacacagc
     2881 ctagttgcca acccacatgt ccttttcacc tccagcaaga ctaagcttct ttaaagcact
     2941 tcacaggact aggaccctgt cctggagcta tctcaggaaa aaggtgacca tttgaggaac
     3001 tgtgacctaa ttttattata atgatgcctc taattttcat ttcctttaca accaactgta
     3061 actataaggt tgtattgctt ttttgttcag ttttagcatg ctattttttg aattctagac
     3121 tcctccatgt gaagatatca acagacaaaa ctacaactgt ataggacata tttggagaaa
     3181 attctatcaa ttgatacatt tggatgacat cacattttta agtaatgtaa tctgaggcca
     3241 ttgctgagga aattaagaat tttccttttt ttttaaccac ccccagtgaa aaggatcagt
     3301 gtatatttat agcacctatt ttttagttct gtctgttgtg aggcacatcc tgcatggggc
     3361 acttctagtc aaataggcaa tgataaggac ctaattaaaa tgtgataagt gtatactatt
     3421 actttaaaag cctttacagt cagtacttca gtttacaagg cactttcaca gcatctcgtt
     3481 tgatcctcac agtcacaaca tgtggtagac aaggcaggtg atttttatcc ccattttaca
     3541 gataaggaaa caggctgcgg gtggggagtg aggggaggta aagatagtta gttgcctaag
     3601 gtcacacagc cagtaagtaa tagagctggg actggaaccc aggtttcctt actctcatct
     3661 attgctcctc catattcctc actcaaccat gaaaacatta cttgaaagga ctgatgaggt
     3721 taaccagaga cctaactgat attgtaactt tctattttaa ggaagaattg tgtctgtatt
     3781 tgagttcttt ggagcctcca gtctgcctgt gtgttagacc agcacagcag tgctgtgtga
     3841 tgcagcctga cctgtggcag gaaagtagtg cttctgtttg gaagtcatgt tcttttgcag
     3901 ccacacagga tccaaatatc agtactattc ctgtagtcaa tctggggtca cattataggt
     3961 gccttatttc cctaagggta actgatctga atatctgcaa ataggatgaa tctatttttc
     4021 agaagttcca tctttcattt ttcttttttt ttttgagaca gagtctcatt ctgtcgccca
     4081 tgctggagtg cagtggcgcg atctcggctc gctgcaacct ctgcctccca ggttgaagca
     4141 attctcatgc ctcagccacc cgagtagctg ggattacagg catgcgccat catgcccagc
     4201 taatttatgt atttttagta gagttggagt ttcaccatgt tggccaggct ggtcttggac
     4261 tcctgacctc aggtcatcca cccgcctcag cctcccaaag tgctggtatt acaggcgtga
     4321 gccaccgcac ccagccccat ctttcatttt caaagagaag ggcattctaa taggaactgg
     4381 tgccaagaga gaagaaaaga agtgataaca gaagaaatgg ctagttacaa tattaaaaag
     4441 ctcctctttg agatctcctc tgcaggaata tcagagacgg agttgaagcg ctggagaggt
     4501 aataggtcta gacagtacag aacaataact ggggagtgtg tgaggataga ctgggctccc
     4561 ccttgcttga aagatctctg gcatttaatt ctcaattctt gattactatt ttccagtgta
     4621 aaactagcac atatgatctg actacaggac agagaatttt aagtgaaaca tttgccttac
     4681 ttgcagtaat aatgtgctgt tcttcacagt agctaaggcc ctctatgttt cccagaggta
     4741 aataagaatc caggaatgga ggtccatctg tgatgaatgg cttttttcta atcaaagtag
     4801 tataatgctg ttttatctgt tttgtcatct tgtttttttt tttttttaaa aaaacaaaac
     4861 cttaattata atatagcgca aagaaaggcc aggactgatg cagggattcc ttggaaatat
     4921 cagttcctat cacttttaaa acctgatttt ggatctctct gttctatgta tgtctttagt
     4981 gagagcacaa tacatggcag aacgctgtgc caaatgttat aggtaaggaa tatagaaatg
     5041 aatgtttttt gttgtgaagg tgttttcatg tgatatttta taaacacatt ttaaaaaatc
     5101 tccatcactt tttagtatag gaaggatagc tttgcctggg aaaaacagtt tcaacacacc
     5161 tgctcagagt agcagttctc cctcaaaaaa gcagtgttca gcctgcactg actgttctgc
     5221 ttgccaaaag gaggaagcat gcaagatact tatttctcca tagattgtgg agtatagagg
     5281 gatgtgggac tacagattat tatttttttt ccccgagaca gagtcttgct ctgtcgccca
     5341 ggttggaaca caatggcacg acctcagctc actgcaacct ctgtctcccg ggttcaagca
     5401 attctcctgc ttcagcctcc tgagtagctg ggattacagg cacacaccac caccgcactc
     5461 agctaatttt tgtattttta gtagaggtgg ggttttacca tgttggccag gctggtctta
     5521 aactcctgac cttgtaatca tcccgcctcg gcctcctaaa gtgctaggat tacaggcatg
     5581 agccaccgca cccggcccag ataattttta atagcctttg atcatggggt gagtgaggga
     5641 gtaggtatac ttggcaaatg catggttctc tgatttctag ctctaaagca gccttatctg
     5701 aatccccaaa tcttgtgatg ctgagtacca ttactgaacc agtctgcacg gtaggcatct
     5761 gctaccaaaa tttacctcct acctggtagg tgtcatctga taagaaagaa gacaggttat
     5821 tttaattttt tgagataatc acagaaaatt gcagcccata ctctttatta ccgaattcaa
     5881 gtttggaaat agaccctttg ttttaaatca tgatgggtct ttatcccaat catttatctg
     5941 ggtcattttt ccaactttgg agttctagga aagaaccttg aaaacctgat atgattctgc
     6001 agcatgaggt ctacggtgac catttgggca aagctccagt ggcaatcatt tattgtgttt
     6061 tgcatttcct gggatttatt gaaataagaa ttcactgtga ttatgtagtc ttctggctag
     6121 tatcaggcag ctctgctttt aatttggtta attttatttt ctctgaagag ggagaagagg
     6181 tacaatttaa tcttggcctc cacaagcata ttaaagctca cgtgttaatc agtgcattct
     6241 tatgctccta cattaaatgc cttgggtaaa tggataaatg gacatgtgcc cagctttaat
     6301 tttttttgca acagaaagat cagacttccg tatggcatcg ttggatttca gaggctttct
     6361 ggtgtatctg taaatctgaa tgttgccttc tgccagtctg tataaccagg tgattcatgc
     6421 tgcaaatgaa atcaggaagc agtaaagtgt taaagcaaga gtattgtcca attcacttgt
     6481 cttcctgatc cttgtacttt atttcacgtg tcggtgttta cattacatac ttatatttcc
     6541 tgtgaaagaa agagttaaat aaattgtagc agtttga
//
