LOCUS       NM_001099922            4113 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens ALG13 UDP-N-acetylglucosaminyltransferase subunit
            (ALG13), transcript variant 1, mRNA.
ACCESSION   NM_001099922
VERSION     NM_001099922.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4113)
  AUTHORS   Wang,C.D., Xu,S., Chen,S., Chen,Z.H., Dean,N., Wang,N. and Gao,X.D.
  TITLE     An in vitro assay for enzymatic studies on human ALG13/14
            heterodimeric UDP-N-acetylglucosamine transferase
  JOURNAL   Front Cell Dev Biol 10, 1008078 (2022)
   PUBMED   36200043
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4113)
  AUTHORS   Alsharhan,H., He,M., Edmondson,A.C., Daniel,E.J.P., Chen,J.,
            Donald,T., Bakhtiari,S., Amor,D.J., Jones,E.A., Vassallo,G.,
            Vincent,M., Cogne,B., Deb,W., Werners,A.H., Jin,S.C., Bilguvar,K.,
            Christodoulou,J., Webster,R.I., Yearwood,K.R., Ng,B.G.,
            Freeze,H.H., Kruer,M.C., Li,D., Raymond,K.M., Bhoj,E.J. and
            Sobering,A.K.
  TITLE     ALG13 X-linked intellectual disability: New variants, glycosylation
            analysis, and expanded phenotypes
  JOURNAL   J Inherit Metab Dis 44 (4), 1001-1012 (2021)
   PUBMED   33734437
  REMARK    GeneRIF: ALG13 X-linked intellectual disability: New variants,
            glycosylation analysis, and expanded phenotypes.
REFERENCE   3  (bases 1 to 4113)
  AUTHORS   Alsharhan,H., Ng,B.G., Daniel,E.J.P., Friedman,J., Pivnick,E.K.,
            Al-Hashem,A., Faqeih,E.A., Liu,P., Engelhardt,N.M., Keller,K.N.,
            Chen,J., Mazzeo,P.A., Rosenfeld,J.A., Bamshad,M.J., Nickerson,D.A.,
            Raymond,K.M., Freeze,H.H., He,M., Edmondson,A.C. and Lam,C.
  CONSRTM   University of Washington Center for Mendelian Genomics (UW-CMG)
  TITLE     Expanding the phenotype, genotype and biochemical knowledge of
            ALG3-CDG
  JOURNAL   J Inherit Metab Dis 44 (4), 987-1000 (2021)
   PUBMED   33583022
  REMARK    GeneRIF: Expanding the phenotype, genotype and biochemical
            knowledge of ALG3-CDG.
REFERENCE   4  (bases 1 to 4113)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 4113)
  AUTHORS   Datta,A.N., Bahi-Buisson,N., Bienvenu,T., Buerki,S.E., Gardiner,F.,
            Cross,J.H., Heron,B., Kaminska,A., Korff,C.M., Lepine,A., Lesca,G.,
            McTague,A., Mefford,H.C., Mignot,C., Milh,M., Piton,A.,
            Pressler,R.M., Ruf,S., Sadleir,L.G., de Saint Martin,A., Van
            Gassen,K., Verbeek,N.E., Ville,D., Villeneuve,N., Zacher,P.,
            Scheffer,I.E. and Lemke,J.R.
  TITLE     The phenotypic spectrum of X-linked, infantile onset ALG13-related
            developmental and epileptic encephalopathy
  JOURNAL   Epilepsia 62 (2), 325-334 (2021)
   PUBMED   33410528
  REMARK    GeneRIF: The phenotypic spectrum of X-linked, infantile onset
            ALG13-related developmental and epileptic encephalopathy.
REFERENCE   6  (bases 1 to 4113)
  AUTHORS   Esposito,T., Lea,R.A., Maher,B.H., Moses,D., Cox,H.C.,
            Magliocca,S., Angius,A., Nyholt,D.R., Titus,T., Kay,T., Gray,N.A.,
            Rastaldi,M.P., Parnham,A., Gianfrancesco,F. and Griffiths,L.R.
  TITLE     Unique X-linked familial FSGS with co-segregating heart block
            disorder is associated with a mutation in the NXF5 gene
  JOURNAL   Hum Mol Genet 22 (18), 3654-3666 (2013)
   PUBMED   23686279
REFERENCE   7  (bases 1 to 4113)
  AUTHORS   Timal,S., Hoischen,A., Lehle,L., Adamowicz,M., Huijben,K.,
            Sykut-Cegielska,J., Paprocka,J., Jamroz,E., van Spronsen,F.J.,
            Korner,C., Gilissen,C., Rodenburg,R.J., Eidhof,I., Van den
            Heuvel,L., Thiel,C., Wevers,R.A., Morava,E., Veltman,J. and
            Lefeber,D.J.
  TITLE     Gene identification in the congenital disorders of glycosylation
            type I by whole-exome sequencing
  JOURNAL   Hum Mol Genet 21 (19), 4151-4161 (2012)
   PUBMED   22492991
REFERENCE   8  (bases 1 to 4113)
  AUTHORS   Averbeck,N., Keppler-Ross,S. and Dean,N.
  TITLE     Membrane topology of the Alg14 endoplasmic reticulum UDP-GlcNAc
            transferase subunit
  JOURNAL   J Biol Chem 282 (40), 29081-29088 (2007)
   PUBMED   17686769
REFERENCE   9  (bases 1 to 4113)
  AUTHORS   Gao,X.D., Tachikawa,H., Sato,T., Jigami,Y. and Dean,N.
  TITLE     Alg14 recruits Alg13 to the cytoplasmic face of the endoplasmic
            reticulum to form a novel bipartite UDP-N-acetylglucosamine
            transferase required for the second step of N-linked glycosylation
  JOURNAL   J Biol Chem 280 (43), 36254-36262 (2005)
   PUBMED   16100110
  REMARK    GeneRIF: ALG13 and ALG14 form a functional endoplasmic reticulum
            UDP-N-acetylglucosamine transferase
REFERENCE   10 (bases 1 to 4113)
  AUTHORS   Sparks,S.E. and Krasnewich,D.M.
  TITLE     Congenital Disorders of N-Linked Glycosylation and Multiple Pathway
            Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301507
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BF699152.1, AK302729.1,
            AK304712.1, DB516751.3 and BQ015240.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_001099922.2.
            
            Summary: The protein encoded by this gene is a subunit of a
            bipartite UDP-N-acetylglucosamine transferase. It heterodimerizes
            with asparagine-linked glycosylation 14 homolog to form a
            functional UDP-GlcNAc glycosyltransferase that catalyzes the second
            sugar addition of the highly conserved oligosaccharide precursor in
            endoplasmic reticulum N-linked glycosylation. Multiple transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Dec 2009].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK302729.1, AK304712.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394780.8/ ENSP00000378260.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 BF699152.1         54-60
            8-2021              AK302729.1         1-2014
            2022-2825           AK304712.1         1964-2767
            2826-3637           AK302729.1         2819-3630
            3638-4109           DB516751.3         236-707
            4110-4113           BQ015240.1         15-18               c
FEATURES             Location/Qualifiers
     source          1..4113
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq23"
     gene            1..4113
                     /gene="ALG13"
                     /gene_synonym="CDG1S; CXorf45; DEE36; EIEE36; GLT28D1;
                     MDS031; TDRD13; YGL047W"
                     /note="ALG13 UDP-N-acetylglucosaminyltransferase subunit"
                     /db_xref="GeneID:79868"
                     /db_xref="HGNC:HGNC:30881"
                     /db_xref="MIM:300776"
     exon            1..130
                     /gene="ALG13"
                     /gene_synonym="CDG1S; CXorf45; DEE36; EIEE36; GLT28D1;
                     MDS031; TDRD13; YGL047W"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..3463
                     /gene="ALG13"
                     /gene_synonym="CDG1S; CXorf45; DEE36; EIEE36; GLT28D1;
                     MDS031; TDRD13; YGL047W"
                     /EC_number="2.4.1.141"
                     /note="isoform 1 is encoded by transcript variant 1;
                     hematopoietic stem/progenitor cells protein MDS031;
                     UDP-N-acetylglucosamine transferase subunit ALG13 homolog;
                     glycosyltransferase 28 domain-containing protein 1; tudor
                     domain containing 13; asparagine-linked glycosylation 13
                     homolog; N-acetylglucosaminyldiphosphodolichol
                     N-acetylglucosaminyltransferase; putative bifunctional
                     UDP-N-acetylglucosamine transferase and deubiquitinase
                     ALG13"
                     /codon_start=1
                     /product="UDP-N-acetylglucosamine transferase subunit
                     ALG13 isoform 1"
                     /protein_id="NP_001093392.1"
                     /db_xref="CCDS:CCDS55477.1"
                     /db_xref="GeneID:79868"
                     /db_xref="HGNC:HGNC:30881"
                     /db_xref="MIM:300776"
                     /translation="MKCVFVTVGTTSFDDLIACVSAPDSLQKIESLGYNRLILQIGRG
                     TVVPEPFSTESFTLDVYRYKDSLKEDIQKADLVISHAGAGSCLETLEKGKPLVVVINE
                     KLMNNHQLELAKQLHKEGHLFYCTCRVLTCPGQAKSIASAPGKCQDSAALTSTAFSGL
                     DFGLLSGYLHKQALVTATHPTCTLLFPSCHAFFPLPLTPTLYKMHKGWKNYCSQKSLN
                     EASMDEYLGSLGLFRKLTAKDASCLFRAISEQLFCSQVHHLEIRKACVSYMRENQQTF
                     ESYVEGSFEKYLERLGDPKESAGQLEIRALSLIYNRDFILYRFPGKPPTYVTDNGYED
                     KILLCYSSSGHYDSVYSKQFQSSAAVCQAVLYEILYKDVFVVDEEELKTAIKLFRSGS
                     KKNRNNAVTGSEDAHTDYKSSNQNRMEEWGACYNAENIPEGYNKGTEETKSPENPSKM
                     PFPYKVLKALDPEIYRNVEFDVWLDSRKELQKSDYMEYAGRQYYLGDKCQVCLESEGR
                     YYNAHIQEVGNENNSVTVFIEELAEKHVVPLANLKPVTQVMSVPAWNAMPSRKGRGYQ
                     KMPGGYVPEIVISEMDIKQQKKMFKKIRGKEVYMTMAYGKGDPLLPPRLQHSMHYGHD
                     PPMHYSQTAGNVMSNEHFHPQHPSPRQGRGYGMPRNSSRFINRHNMPGPKVDFYPGPG
                     KRCCQSYDNFSYRSRSFRRSHRQMSCVNKESQYGFTPGNGQMPRGLEETITFYEVEEG
                     DETAYPTLPNHGGPSTMVPATSGYCVGRRGHSSGKQTLNLEEGNGQSENGRYHEEYLY
                     RAEPDYETSGVYSTTASTANLSLQDRKSCSMSPQDTVTSYNYPQKMMGNIAAVAASCA
                     NNVPAPVLSNGAAANQAISTTSVSSQNAIQPLFVSPPTHGRPVIASPSYPCHSAIPHA
                     GASLPPPPPPPPPPPPPPPPPPPPPPPPPPPALDVGETSNLQPPPPLPPPPYSCDPSG
                     SDLPQDTKVLQYYFNLGLQCYYHSYWHSMVYVPQMQQQLHVENYPVYTEPPLVDQTVP
                     QCYSEVRREDGIQAEASANDTFPNADSSSVPHGAVYYPVMSDPYGQPPLPGFDSCLPV
                     VPDYSCVPPWHPVGTAYGGSSQIHGAINPGPIGCIAPSPPASHYVPQGM"
     exon            131..293
                     /gene="ALG13"
                     /gene_synonym="CDG1S; CXorf45; DEE36; EIEE36; GLT28D1;
                     MDS031; TDRD13; YGL047W"
                     /inference="alignment:Splign:2.1.0"
     exon            294..432
                     /gene="ALG13"
                     /gene_synonym="CDG1S; CXorf45; DEE36; EIEE36; GLT28D1;
                     MDS031; TDRD13; YGL047W"
                     /inference="alignment:Splign:2.1.0"
     exon            433..799
                     /gene="ALG13"
                     /gene_synonym="CDG1S; CXorf45; DEE36; EIEE36; GLT28D1;
                     MDS031; TDRD13; YGL047W"
                     /inference="alignment:Splign:2.1.0"
     exon            800..883
                     /gene="ALG13"
                     /gene_synonym="CDG1S; CXorf45; DEE36; EIEE36; GLT28D1;
                     MDS031; TDRD13; YGL047W"
                     /inference="alignment:Splign:2.1.0"
     exon            884..934
                     /gene="ALG13"
                     /gene_synonym="CDG1S; CXorf45; DEE36; EIEE36; GLT28D1;
                     MDS031; TDRD13; YGL047W"
                     /inference="alignment:Splign:2.1.0"
     exon            935..981
                     /gene="ALG13"
                     /gene_synonym="CDG1S; CXorf45; DEE36; EIEE36; GLT28D1;
                     MDS031; TDRD13; YGL047W"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1054
                     /gene="ALG13"
                     /gene_synonym="CDG1S; CXorf45; DEE36; EIEE36; GLT28D1;
                     MDS031; TDRD13; YGL047W"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1136
                     /gene="ALG13"
                     /gene_synonym="CDG1S; CXorf45; DEE36; EIEE36; GLT28D1;
                     MDS031; TDRD13; YGL047W"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1299
                     /gene="ALG13"
                     /gene_synonym="CDG1S; CXorf45; DEE36; EIEE36; GLT28D1;
                     MDS031; TDRD13; YGL047W"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1375
                     /gene="ALG13"
                     /gene_synonym="CDG1S; CXorf45; DEE36; EIEE36; GLT28D1;
                     MDS031; TDRD13; YGL047W"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1484
                     /gene="ALG13"
                     /gene_synonym="CDG1S; CXorf45; DEE36; EIEE36; GLT28D1;
                     MDS031; TDRD13; YGL047W"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1549
                     /gene="ALG13"
                     /gene_synonym="CDG1S; CXorf45; DEE36; EIEE36; GLT28D1;
                     MDS031; TDRD13; YGL047W"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1650
                     /gene="ALG13"
                     /gene_synonym="CDG1S; CXorf45; DEE36; EIEE36; GLT28D1;
                     MDS031; TDRD13; YGL047W"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1778
                     /gene="ALG13"
                     /gene_synonym="CDG1S; CXorf45; DEE36; EIEE36; GLT28D1;
                     MDS031; TDRD13; YGL047W"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..2025
                     /gene="ALG13"
                     /gene_synonym="CDG1S; CXorf45; DEE36; EIEE36; GLT28D1;
                     MDS031; TDRD13; YGL047W"
                     /inference="alignment:Splign:2.1.0"
     exon            2026..2139
                     /gene="ALG13"
                     /gene_synonym="CDG1S; CXorf45; DEE36; EIEE36; GLT28D1;
                     MDS031; TDRD13; YGL047W"
                     /inference="alignment:Splign:2.1.0"
     exon            2140..2296
                     /gene="ALG13"
                     /gene_synonym="CDG1S; CXorf45; DEE36; EIEE36; GLT28D1;
                     MDS031; TDRD13; YGL047W"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..2417
                     /gene="ALG13"
                     /gene_synonym="CDG1S; CXorf45; DEE36; EIEE36; GLT28D1;
                     MDS031; TDRD13; YGL047W"
                     /inference="alignment:Splign:2.1.0"
     exon            2418..2450
                     /gene="ALG13"
                     /gene_synonym="CDG1S; CXorf45; DEE36; EIEE36; GLT28D1;
                     MDS031; TDRD13; YGL047W"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2506
                     /gene="ALG13"
                     /gene_synonym="CDG1S; CXorf45; DEE36; EIEE36; GLT28D1;
                     MDS031; TDRD13; YGL047W"
                     /inference="alignment:Splign:2.1.0"
     exon            2507..2578
                     /gene="ALG13"
                     /gene_synonym="CDG1S; CXorf45; DEE36; EIEE36; GLT28D1;
                     MDS031; TDRD13; YGL047W"
                     /inference="alignment:Splign:2.1.0"
     exon            2579..2744
                     /gene="ALG13"
                     /gene_synonym="CDG1S; CXorf45; DEE36; EIEE36; GLT28D1;
                     MDS031; TDRD13; YGL047W"
                     /inference="alignment:Splign:2.1.0"
     exon            2745..2981
                     /gene="ALG13"
                     /gene_synonym="CDG1S; CXorf45; DEE36; EIEE36; GLT28D1;
                     MDS031; TDRD13; YGL047W"
                     /inference="alignment:Splign:2.1.0"
     exon            2982..3022
                     /gene="ALG13"
                     /gene_synonym="CDG1S; CXorf45; DEE36; EIEE36; GLT28D1;
                     MDS031; TDRD13; YGL047W"
                     /inference="alignment:Splign:2.1.0"
     exon            3023..3197
                     /gene="ALG13"
                     /gene_synonym="CDG1S; CXorf45; DEE36; EIEE36; GLT28D1;
                     MDS031; TDRD13; YGL047W"
                     /inference="alignment:Splign:2.1.0"
     exon            3198..4113
                     /gene="ALG13"
                     /gene_synonym="CDG1S; CXorf45; DEE36; EIEE36; GLT28D1;
                     MDS031; TDRD13; YGL047W"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4084..4089
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALG13"
                     /gene_synonym="CDG1S; CXorf45; DEE36; EIEE36; GLT28D1;
                     MDS031; TDRD13; YGL047W"
                     /note="hexamer: AATAAA"
     polyA_site      4113
                     /gene="ALG13"
                     /gene_synonym="CDG1S; CXorf45; DEE36; EIEE36; GLT28D1;
                     MDS031; TDRD13; YGL047W"
                     /note="major polyA site"
ORIGIN      
        1 agttgcgtca tatccggccc ttgcgatcag ggcttgagga acccgcgcca tgaagtgcgt
       61 gtttgttacc gtagggacca ccagctttga cgacctcatt gcgtgtgtgt cggcgcccga
      121 cagtctgcaa aaaatcgaga gccttggtta caaccgactt atcctgcaaa ttggtagagg
      181 aacggtggta cctgaaccct tcagtactga gtcgtttact ctggatgttt acaggtacaa
      241 ggattccttg aaagaagaca ttcagaaagc agatcttgtt attagtcacg caggtgcagg
      301 aagctgtttg gagactctgg aaaaaggaaa gccactcgta gtggttataa acgaaaagtt
      361 gatgaacaat catcagctgg aactggcaaa gcagctacac aaagagggtc atctcttcta
      421 ttgtacctgc agggtcctga cttgtcctgg gcaagccaag tccattgctt ctgctcctgg
      481 gaagtgccaa gattctgcag cgctgacttc aactgccttt tcaggcctag actttgggct
      541 gctttccgga tacctgcata agcaagccct tgttactgct acccatccta cctgcaccct
      601 gctttttccc tcttgccacg ctttttttcc tctccctctt acccccaccc tgtacaaaat
      661 gcataaagga tggaaaaact actgcagcca gaagtctttg aatgaggcat caatggatga
      721 atatttaggc agcttagggc tgtttcgaaa gctgactgcc aaggatgcct cttgcctctt
      781 tcgggccatt tcggagcagt tgttttgcag ccaggtccat catttggaaa tcaggaaggc
      841 ttgtgtctca tatatgaggg aaaatcaaca aacttttgag tcttatgtgg agggatcttt
      901 tgagaaatac ctggaacggt tgggagatcc caaggaaagt gctggccagc tggaaataag
      961 agctctttct ctaatttata atcgggattt cattctttat cgctttcctg gaaaacctcc
     1021 aacttatgtc acagataatg gctatgaaga caagattcta ctctgctact caagtagtgg
     1081 tcactatgat tctgtgtact caaaacaatt tcagtcaagt gcagctgttt gtcaggctgt
     1141 attgtacgaa attctctata aagatgtgtt tgttgtggat gaagaagagt tgaagactgc
     1201 gattaaattg tttcgaagtg gttctaagaa gaacagaaat aatgctgtaa ctggaagcga
     1261 ggatgcccat actgattaca agagttcaaa tcagaatagg atggaagagt ggggtgcctg
     1321 ctacaatgct gaaaatatac cagagggcta caataaagga acagaagaaa caaagtctcc
     1381 agaaaatcca tcaaagatgc ccttccccta taaggtgctc aaagccctgg atccagaaat
     1441 ctatcgtaat gtagaatttg atgtttggtt ggacagcaga aaagaacttc aaaaatctga
     1501 ttacatggag tatgctggga gacagtacta tttgggagac aagtgtcagg tttgcttgga
     1561 atcagaagga agatattata atgctcatat ccaggaagtt ggaaatgaga acaattcagt
     1621 aacagtcttc attgaagaat tggcggaaaa gcatgttgtt ccactggcta acttaaaacc
     1681 agttacccaa gtgatgtctg ttcctgcctg gaatgctatg cccagtcgga aaggaagagg
     1741 ttaccagaaa atgcctgggg gttatgtccc ggaaatagtt atatcagaga tggacataaa
     1801 gcaacagaag aagatgttca agaaaattcg agggaaagaa gtttacatga ctatggctta
     1861 cggcaaggga gaccccctcc tcccacccag gctgcagcac agtatgcatt atgggcacga
     1921 tcctccaatg cactactcac agacagctgg caatgttatg tctaatgaac attttcatcc
     1981 tcagcatcca tctccgagac aaggtcgggg atatgggatg cccaggaatt catctcggtt
     2041 tataaacagg cacaacatgc cgggccctaa agttgatttt tacccaggcc caggtaaaag
     2101 gtgctgccag agctatgata acttctctta tagatctcgt tcatttagac gtagtcaccg
     2161 ccagatgagt tgtgtgaata aggagtccca gtatggattt accccaggga atggacagat
     2221 gcccaggggc ttggaagaaa ctattacttt ttatgaagtt gaagaagggg atgagactgc
     2281 ttatccaact ttacctaatc atggaggtcc ctctacaatg gttcctgcta cttcaggata
     2341 ctgtgttgga aggcggggac atagctcagg caaacagact ttgaatttag aggagggcaa
     2401 tggccagagt gaaaatgggc gatatcatga agaatatctt tatcgtgcag agccagacta
     2461 tgaaacttca ggtgtttata gcacaactgc atctacagca aacttgtctc ttcaggacag
     2521 aaagtcatgt tctatgtctc ctcaggacac agttacctca tacaactacc cccagaagat
     2581 gatgggaaat attgcagcag ttgcagcttc ctgtgccaat aatgttccag ctccagtctt
     2641 atctaacggt gcagcggcta atcaagctat tagtaccact tcagtttcct cacagaatgc
     2701 tatacagcct ctctttgtat ctccacctac acacggcagg ccagtgattg cctcaccatc
     2761 ctatccatgc cattctgcta ttcctcatgc tggtgcctct ctaccaccac caccaccacc
     2821 accaccacca ccaccaccac caccacctcc tcctcctcct cctcctcctc ctcctcctcc
     2881 tcctgctctt gatgtgggag agacttcaaa cttacaacca ccaccaccac taccacctcc
     2941 accttattcc tgtgatccaa gcggcagtga tttgcctcaa gatacaaaag ttttgcagta
     3001 ctatttcaat ctaggattgc agtgctatta ccacagctac tggcactcca tggtctatgt
     3061 gccacagatg cagcagcagc ttcatgtaga gaattatcca gtctatactg agccacctct
     3121 ggtagatcaa accgttcctc aatgctacag tgaggtgagg agagaagatg gcatacaggc
     3181 ggaagcatca gcaaatgata cttttccgaa tgctgattct tcatctgtcc ctcatggagc
     3241 agtctattat ccagtaatgt cagatcccta tgggcagcca cctttgccag gttttgactc
     3301 ctgccttccg gttgtgccag attattcctg tgttcccccc tggcatccag ttggtacagc
     3361 atatggtggt tcttctcaaa ttcatggtgc tataaatcct gggccaattg gctgtattgc
     3421 tccatctccc ccagcttctc attatgtacc tcagggtatg taagatccag cagtatgaag
     3481 tattcttgca ctgccatttt cttgctgttt ttgtttttaa aaagtatttt atgttagtgg
     3541 ttaaatgatt taggtgatta gtgtttacta ttgtatttgt ctttaaaatt attttatctt
     3601 ttgatttaaa atagtacttt aaaattaagg ggtattattt tgggctgtga ctaaggaaat
     3661 tgagatggat gtacaactag ccccatattg agcatacttc attgtattca gctgttttcc
     3721 tgtcagccat ttgtcagctt tatattagct gatggtacca attgataaaa tgaatataaa
     3781 gtatttcatt ggttcaaaaa tcacacatca tattaaacca tgcagaattg gagtaacttc
     3841 cacttttttc tagaaagtaa aaccaagagc ctttgcttct ggataactca cttaatatta
     3901 aattaaagag ctcttcacgt ttcttgagaa ttatctgaag ccagttgcat tctgtgatat
     3961 cagttttgaa ggcacatggt tctctgcttt agatttatcc catatgctat tgtttaatac
     4021 tggatgtatg taagtgtttt actgcactgt attgaattgg tgtcttttgc acagttagca
     4081 gtaaataaaa attagcattt aaaattgcca aaa
//
