LOCUS       NM_024105               5330 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens ALG12 alpha-1,6-mannosyltransferase (ALG12), mRNA.
ACCESSION   NM_024105
VERSION     NM_024105.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5330)
  AUTHORS   Ziburova,J., Nemcovic,M., Sestak,S., Bellova,J., Pakanova,Z.,
            Sivakova,B., Salingova,A., Sebova,C., Ostrozlikova,M., Lekka,D.E.,
            Brucknerova,J., Brucknerova,I., Skoknova,M., Mc Cullough,A.,
            Hrckova,G., Hlavata,A., Bzduch,V., Mucha,J. and Barath,P.
  TITLE     A novel homozygous mutation in the human ALG12 gene results in an
            aberrant profile of oligomannose N-glycans in patient's serum
  JOURNAL   Am J Med Genet A 185 (11), 3494-3501 (2021)
   PUBMED   34467644
  REMARK    GeneRIF: A novel homozygous mutation in the human ALG12 gene
            results in an aberrant profile of oligomannose N-glycans in
            patient's serum.
REFERENCE   2  (bases 1 to 5330)
  AUTHORS   Hiraide,T., Wada,Y., Matsubayashi,T., Kadoya,M., Masunaga,Y.,
            Ohkubo,Y., Nakashima,M., Okamoto,N., Ogata,T. and Saitsu,H.
  TITLE     Novel ALG12 variants and hydronephrosis in siblings with impaired
            N-glycosylation
  JOURNAL   Brain Dev 43 (9), 945-951 (2021)
   PUBMED   34092405
  REMARK    GeneRIF: Novel ALG12 variants and hydronephrosis in siblings with
            impaired N-glycosylation.
REFERENCE   3  (bases 1 to 5330)
  AUTHORS   Sturiale,L., Bianca,S., Garozzo,D., Terracciano,A., Agolini,E.,
            Messina,A., Palmigiano,A., Esposito,F., Barone,C., Novelli,A.,
            Fiumara,A., Jaeken,J. and Barone,R.
  TITLE     ALG12-CDG: novel glycophenotype insights endorse the molecular
            defect
  JOURNAL   Glycoconj J 36 (6), 461-472 (2019)
   PUBMED   31529350
  REMARK    GeneRIF: As a whole, ALG12-CDG behaves as a dual CDG (CDG-I and II
            defects) and it is associated with distinct, abnormal glycosylation
            of total serum and IgG N-glycans
REFERENCE   4  (bases 1 to 5330)
  AUTHORS   Navarini,A.A., Simpson,M.A., Weale,M., Knight,J., Carlavan,I.,
            Reiniche,P., Burden,D.A., Layton,A., Bataille,V., Allen,M.,
            Pleass,R., Pink,A., Creamer,D., English,J., Munn,S., Walton,S.,
            Willis,C., Deret,S., Voegel,J.J., Spector,T., Smith,C.H.,
            Trembath,R.C. and Barker,J.N.
  CONSRTM   Acne Genetic Study Group
  TITLE     Genome-wide association study identifies three novel susceptibility
            loci for severe Acne vulgaris
  JOURNAL   Nat Commun 5, 4020 (2014)
   PUBMED   24927181
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5330)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 5330)
  AUTHORS   Thiel,C., Schwarz,M., Hasilik,M., Grieben,U., Hanefeld,F.,
            Lehle,L., von Figura,K. and Korner,C.
  TITLE     Deficiency of dolichyl-P-Man:Man7GlcNAc2-PP-dolichyl
            mannosyltransferase causes congenital disorder of glycosylation
            type Ig
  JOURNAL   Biochem J 367 (Pt 1), 195-201 (2002)
   PUBMED   12093361
  REMARK    GeneRIF: this enzyme has a role in glycosylation and its deficiency
            causes congenital disorder of glycosylation type Ig
REFERENCE   7  (bases 1 to 5330)
  AUTHORS   Grubenmann,C.E., Frank,C.G., Kjaergaard,S., Berger,E.G., Aebi,M.
            and Hennet,T.
  TITLE     ALG12 mannosyltransferase defect in congenital disorder of
            glycosylation type lg
  JOURNAL   Hum Mol Genet 11 (19), 2331-2339 (2002)
   PUBMED   12217961
REFERENCE   8  (bases 1 to 5330)
  AUTHORS   Chantret,I., Dupre,T., Delenda,C., Bucher,S., Dancourt,J.,
            Barnier,A., Charollais,A., Heron,D., Bader-Meunier,B., Danos,O.,
            Seta,N., Durand,G., Oriol,R., Codogno,P. and Moore,S.E.
  TITLE     Congenital disorders of glycosylation type Ig is defined by a
            deficiency in dolichyl-P-mannose:Man7GlcNAc2-PP-dolichyl
            mannosyltransferase
  JOURNAL   J Biol Chem 277 (28), 25815-25822 (2002)
   PUBMED   11983712
  REMARK    GeneRIF: deficiency results in congenital disorders of
            glycosylation type Ig
REFERENCE   9  (bases 1 to 5330)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
REFERENCE   10 (bases 1 to 5330)
  AUTHORS   Sparks,S.E. and Krasnewich,D.M.
  TITLE     Congenital Disorders of N-Linked Glycosylation and Multiple Pathway
            Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301507
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB858085.1, AF318343.1,
            BM145575.1 and AL671710.13.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_024105.3.
            
            Summary: This gene encodes a member of the glycosyltransferase 22
            family. The encoded protein catalyzes the addition of the eighth
            mannose residue in an alpha-1,6 linkage onto the
            dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2))
            required for protein glycosylation. Mutations in this gene have
            been associated with congenital disorder of glycosylation type Ig
            (CDG-Ig)characterized by abnormal N-glycosylation. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.115912.1,
                                           SRR1803613.2325.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000330817.11/ ENSP00000333813.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                CB858085.1         22-62
            42-1965             AF318343.1         14-1937
            1966-2074           AF318343.1         1939-2047
            2075-2200           AF318343.1         2049-2174
            2201-2355           BM145575.1         13-167              c
            2356-5330           AL671710.13        9544-12518          c
FEATURES             Location/Qualifiers
     source          1..5330
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.33"
     gene            1..5330
                     /gene="ALG12"
                     /gene_synonym="CDG1G; ECM39; hALG12; PP14673"
                     /note="ALG12 alpha-1,6-mannosyltransferase"
                     /db_xref="GeneID:79087"
                     /db_xref="HGNC:HGNC:19358"
                     /db_xref="MIM:607144"
     exon            1..176
                     /gene="ALG12"
                     /gene_synonym="CDG1G; ECM39; hALG12; PP14673"
                     /inference="alignment:Splign:2.1.0"
     exon            177..416
                     /gene="ALG12"
                     /gene_synonym="CDG1G; ECM39; hALG12; PP14673"
                     /inference="alignment:Splign:2.1.0"
     CDS             255..1721
                     /gene="ALG12"
                     /gene_synonym="CDG1G; ECM39; hALG12; PP14673"
                     /EC_number="2.4.1.260"
                     /note="asparagine-linked glycosylation 12 homolog (yeast,
                     alpha-1,6-mannosyltransferase); asparagine-linked
                     glycosylation 12 homolog (S. cerevisiae,
                     alpha-1,6-mannosyltransferase); mannosyltransferase ALG12
                     homolog; membrane protein SB87; asparagine-linked
                     glycosylation 12, alpha-1,6-mannosyltransferase homolog;
                     dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol
                     alpha-1,6-mannosyltransferase; dol-P-Man dependent
                     alpha-1,6-mannosyltransferase;
                     dolichyl-P-mannose:Man-7-GlcNAc-2-PP-dolichyl-alpha-6-
                     mannosyltransferase;
                     dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichyl-alpha-1,
                     6-mannosyltransferase; asparagine-linked glycosylation
                     protein 12 homolog"
                     /codon_start=1
                     /product="dol-P-Man:Man(7)GlcNAc(2)-PP-Dol
                     alpha-1,6-mannosyltransferase"
                     /protein_id="NP_077010.1"
                     /db_xref="CCDS:CCDS14081.1"
                     /db_xref="GeneID:79087"
                     /db_xref="HGNC:HGNC:19358"
                     /db_xref="MIM:607144"
                     /translation="MAGKGSSGRRPLLLGLLVAVATVHLVICPYTKVEESFNLQATHD
                     LLYHWQDLEQYDHLEFPGVVPRTFLGPVVIAVFSSPAVYVLSLLEMSKFYSQLIVRGV
                     LGLGVIFGLWTLQKEVRRHFGAMVATMFCWVTAMQFHLMFYCTRTLPNVLALPVVLLA
                     LAAWLRHEWARFIWLSAFAIIVFRVELCLFLGLLLLLALGNRKVSVVRALRHAVPAGI
                     LCLGLTVAVDSYFWRQLTWPEGKVLWYNTVLNKSSNWGTSPLLWYFYSALPRGLGCSL
                     LFIPLGLVDRRTHAPTVLALGFMALYSLLPHKELRFIIYAFPMLNITAARGCSYLLNN
                     YKKSWLYKAGSLLVIGHLVVNAAYSATALYVSHFNYPGGVAMQRLHQLVPPQTDVLLH
                     IDVAAAQTGVSRFLQVNSAWRYDKREDVQPGTGMLAYTHILMEAAPGLLALYRDTHRV
                     LASVVGTTGVSLNLTQLPPFNVHLQTKLVLLERLPRPS"
     exon            417..549
                     /gene="ALG12"
                     /gene_synonym="CDG1G; ECM39; hALG12; PP14673"
                     /inference="alignment:Splign:2.1.0"
     exon            550..723
                     /gene="ALG12"
                     /gene_synonym="CDG1G; ECM39; hALG12; PP14673"
                     /inference="alignment:Splign:2.1.0"
     exon            724..918
                     /gene="ALG12"
                     /gene_synonym="CDG1G; ECM39; hALG12; PP14673"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1022
                     /gene="ALG12"
                     /gene_synonym="CDG1G; ECM39; hALG12; PP14673"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1246
                     /gene="ALG12"
                     /gene_synonym="CDG1G; ECM39; hALG12; PP14673"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1416
                     /gene="ALG12"
                     /gene_synonym="CDG1G; ECM39; hALG12; PP14673"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1492
                     /gene="ALG12"
                     /gene_synonym="CDG1G; ECM39; hALG12; PP14673"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..5330
                     /gene="ALG12"
                     /gene_synonym="CDG1G; ECM39; hALG12; PP14673"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2318..2323
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALG12"
                     /gene_synonym="CDG1G; ECM39; hALG12; PP14673"
                     /note="hexamer: AATAAA"
     polyA_site      2343
                     /gene="ALG12"
                     /gene_synonym="CDG1G; ECM39; hALG12; PP14673"
                     /note="major polyA site"
     regulatory      2363..2368
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALG12"
                     /gene_synonym="CDG1G; ECM39; hALG12; PP14673"
                     /note="hexamer: AATGAA"
     polyA_site      2378
                     /gene="ALG12"
                     /gene_synonym="CDG1G; ECM39; hALG12; PP14673"
     regulatory      5087..5092
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALG12"
                     /gene_synonym="CDG1G; ECM39; hALG12; PP14673"
                     /note="hexamer: AATACA"
     polyA_site      5107
                     /gene="ALG12"
                     /gene_synonym="CDG1G; ECM39; hALG12; PP14673"
     regulatory      5312..5317
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALG12"
                     /gene_synonym="CDG1G; ECM39; hALG12; PP14673"
                     /note="hexamer: GATAAA"
     polyA_site      5330
                     /gene="ALG12"
                     /gene_synonym="CDG1G; ECM39; hALG12; PP14673"
ORIGIN      
        1 atctttactc agggcacaga gggtctctgc ggccgtagcg gccggggctg cggtagccac
       61 tttagatttg ggcaaggact ttagattcgg gctctgttct gtttccgccg tcctgcttcc
      121 tgccgaggct ggcccaggca gccgcgcttc gaaggacgcc gccgggagct gcggagcatg
      181 cgtggagtgg cagtgctaac ggctggtgtc tcgcactgtt ggcctgtgaa ggtacgtgaa
      241 gctgaaagcc tggaatggct ggaaaggggt catcaggcag gcggcccctg ctgctggggc
      301 tgctggtggc cgtagccact gtccacctgg tcatctgtcc ctacaccaaa gtggaggaga
      361 gcttcaacct gcaggccaca catgacctgc tctaccactg gcaagacctg gagcagtacg
      421 accatcttga gttccccgga gtcgtcccca ggacgttcct cgggccagtg gtgatcgcag
      481 tgttctccag ccccgcggtt tacgtgcttt cgctgttaga aatgtccaag ttttactctc
      541 agctaatagt tagaggagtg cttggactcg gcgtgatttt tggactctgg acgttacaaa
      601 aggaagtgag acggcacttc ggggccatgg tggccaccat gttctgctgg gtgacggcca
      661 tgcagttcca cctgatgttc tactgcacgc ggacactgcc caatgtgctg gccctgcctg
      721 tagtcctgct ggccctcgcg gcctggctgc ggcacgagtg ggcccgcttc atctggctgt
      781 cagccttcgc catcatcgtg ttcagggtgg agctgtgcct gttcctgggc ctcctgctgc
      841 tgctggcctt gggcaaccga aaggtttctg tagtcagagc ccttcgccac gccgtcccgg
      901 cagggatcct ctgtttagga ctgacggttg ctgtggactc ttatttttgg cggcagctca
      961 cttggccgga aggaaaggtg ctttggtaca acactgtcct gaacaaaagc tccaactggg
     1021 ggacctcccc gctgctgtgg tacttctact cagccctgcc ccgcggcctg ggctgcagcc
     1081 tgctcttcat ccccctgggc ttggtagaca gaaggacgca cgcgccgacg gtgctggcac
     1141 tgggcttcat ggcactctac tccctcctgc cacacaagga gctacgcttc atcatctatg
     1201 ccttccccat gctcaacatc acggctgcca gaggctgctc ctacctgctg aataactata
     1261 aaaagtcttg gctgtacaaa gcggggtctc tgcttgtgat cggacacctc gtggtgaatg
     1321 ccgcctactc agccacggcc ctgtatgtgt cccatttcaa ctacccaggt ggcgtcgcaa
     1381 tgcagaggct gcaccagctg gtgccccccc agacagacgt ccttctgcac attgacgtgg
     1441 cagccgccca gacaggtgtg tctcggtttc tccaagtcaa cagcgcctgg aggtacgaca
     1501 agagggagga tgtgcagccg gggacaggca tgctggcata cacacacatc ctcatggagg
     1561 cggcccctgg gctcctggcc ctctacaggg acacacaccg ggtcctggcc agcgtcgtgg
     1621 ggaccacagg tgtgagtctg aacctgaccc aactgccccc cttcaacgtc cacctgcaga
     1681 caaagctggt gcttctggag aggctccccc ggccgtcctg agggggacca ggcagccctc
     1741 agcagccaca ggccttccag gagctgttat cactaccagt ttctggcaca attccagcac
     1801 aattatgaca attcagagaa gcaagtcaaa ggactgggca cctgcctctg acagacacca
     1861 gaccaggtcc agggcctcct ccacagcctc agctggggct ctcagcacca aagaacgagg
     1921 ggcccaggtc ttgttggcac cccgggagcc actgcccagg gtgatggtgg ccagctcagg
     1981 gcttcctgcg ggtgactgtc gcccagacca ggtgccattc atgactaatc aggagcagcg
     2041 ggctcaccca ggcacctgtc tgccaggagg ccacgtgtgt cctgcccacc cagggggagc
     2101 tgtattttgg cagcacccca cgcttgctgc ccgagggcct cttggggcac ctaagacagc
     2161 accccctctc aggggagacc atggtggccc cggccgcacc cccccaccct ggtgccacca
     2221 ctgcaacttt tgtattcaca ggcatcccat ctccatcaca gataaaatct taggagataa
     2281 acacattcaa aaaggaatga gataaaaaga ataaggcaat aaatgttgat tggaacctct
     2341 caagattaca gaaaataatg agaatgaaat tttaaaaatg tttcctatgt gatagcttat
     2401 cacaggtgac tattccaggt gttatggtaa agggacagct tggtgctgtc agcctcactg
     2461 accatgcatt tataaagcac caaagtgcgt gtgatgctgc tgggcactgg agatgggacc
     2521 aggtgctgct gcacacgtat gcacacacca tgcatacatg cacacacacc acacacgcat
     2581 gcacacagtg cacacgtgca cacaccatgc atacacacca cacaccgtgc acacgtgcac
     2641 acaccatgca tacacaccac acacagtgca cacgtgcaca ttaccatgca tccacacaca
     2701 gtgcacacgt gcacacacta tgcatacaca gtgcacacgt gcacacacca tgcatacaca
     2761 ccacacaccg tgcacacgtg cacacaccat gcatacacac cacacacagt gcacacgtgc
     2821 acattaccat gcatccacac acagtgcaca cgtgcacaca ctatgcatac acagtgcaca
     2881 cgtgcacaca ccatgcatac acaccacaca gtgcacacgt gcacattacc atgcatacac
     2941 agtgcacacg tgcacacacc atgcatacac accacacaca gtgcacacgt gcacattacc
     3001 atgcatacac acagtgcacg cgtgcacatt accatgcata cacagtgcac atgtgcacac
     3061 accatgcata cacaccacac agtgcacacg tgcacacacc atgcatacac agtgcacacg
     3121 tgcacacacc atgcatacac agtgcacatg tgcacacacc atgcatacac accacacacc
     3181 gtgcacacgt gcacacacca tgcatacaca ccacacacag tgcacacgtg cacattacca
     3241 tgcatccaca cacagtgcac acgtgcacac tatgcataca gtgcacacat gcacacacca
     3301 tgcatacaca gtgcacacgt gcacacacca tgcatacaca ccacacagtg cacatgtgca
     3361 cacaccatgc atacacacca cacacagtgc acacgtgcac acaccatgca tacacaccac
     3421 acacagtgca cacgtgcaca ttaccatgca tacacagtgc acacgtgcac acaccatgca
     3481 tgcacaccac acacagtgca cacgtgtacg ttaccatgca tacacacagt gcacgcgtgc
     3541 acattaccat gcatacacag tgcacacgtg cacacaccat gcatacacac cacacacagt
     3601 gcacacgtgc acattaccgt gcatacacac agtgcatgcg tgcacattac catgcataca
     3661 cacagtgcac acgtgcacac accatgaata cacaccacac acagtgcaca cgtgcacaca
     3721 ccatgcatac acacagtgca cacgtgcaca caccatgcat acataccaca cacagtgcac
     3781 acgtgcacat taccatgcat acaccacgca tgcacaatgc acgtgcacac catgcataca
     3841 caccacacat gcatccacac acaatgcaca gatgcgcaca ccatgcatac acaccataca
     3901 tgcatgatca cacgtgcaca caccatacat acccaccacg catgcacaca cacaatgcac
     3961 aggtgcacac accatgcata cacaccacac aatgcaatcg tgcacacaca atgcacacgt
     4021 gcacacacca tgcatacaca ccacacaatg caatcatgca cacaatgcac acgtgcacac
     4081 accatgcata cataccacac atgcacacac gtgtgcataa agacatgatt tcttcctgtg
     4141 ctctttgaga gcttgtggct gttgcccagg tgccctgggg ctgcctctcc acctgatgcc
     4201 tcctggtttt cccattgcgt ctggcgaaca tctgtgcaga cacttcctga ctcccacaga
     4261 ggccagatgg tgagggctgg agagcaggct tcctggcccc agcatcccac agacatgggc
     4321 tccctccccc atccatccac ctgtgtgtct caggtattca ctggttatcc acgctcgttt
     4381 gttctctttt atcgctggcc acatgtggat tgcctcccga cttcagtggt ctgtgagtca
     4441 ctcctgtctt taattatcct ggtgttcaaa gtgtacgaga tttgctggcg ggaaccctgc
     4501 catgctctgc ctgtgtgccg tgcctctcct tcgagcacct cctcatgacc aggcatggca
     4561 gggcgtcctc ttgggcctct ggcctcggcc attgctctgt gggtcttggc tccctttggt
     4621 ggggaacagc gttagagacc gggatctaga cacgaggtgt gctcgatgcc acggggtgcc
     4681 tgagctttag gccctttctg tggacaggct agggaggaca ggcatgctgc gtgcagttgc
     4741 acacgtacat atgtaatatg tgtgtacaga tctgaaacag cacagaaccg tgcctggatt
     4801 ccgtcccacc ttgcacggtt ctcccccacc ccccatctcc accctgagga ccctggcccc
     4861 cagcaacagc agcatcctca cgcatctgct agggagtcca gtgcacgcct gctcgagagc
     4921 tccagtgcag ctttgccaca ggattgcaaa aacaaaccca ccatgaagag gtcgggattg
     4981 tgtgcagttc actccctgcc cacaactgcg ggtgccgtca agcactgtgc tcatgagttc
     5041 cttgggtcgg cttctccacc gtcagtgtag tggtgccttc gttggaaata cagctgggtt
     5101 catccttccc gtttgctttc agtcttgtgc ctcccaccat accccacacc cccatcctgt
     5161 taggtttgta gagtgtgacc atccttctag atgtcaaaac tgcccctgaa gacagatgca
     5221 gggagccact ccctcctgta cctcctcctc gctttttggt aatgagcata attgtctcct
     5281 ggtttatctc ccatgtgttt aattttgtaa agataaacat tacacatata
//
