LOCUS       NM_001013620           10050 bp    mRNA    linear   PRI 02-JUN-2024
DEFINITION  Homo sapiens ALG10 alpha-1,2-glucosyltransferase B (ALG10B),
            transcript variant 1, mRNA.
ACCESSION   NM_001013620 XM_047770
VERSION     NM_001013620.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10050)
  AUTHORS   Zhou,W., Ye,D., Tester,D.J., Bains,S., Giudicessi,J.R.,
            Haglund-Turnquist,C.M., Orland,K.M., January,C.T., Eckhardt,L.L.,
            Maginot,K.R. and Ackerman,M.J.
  TITLE     Elucidation of ALG10B as a Novel Long-QT Syndrome-Susceptibility
            Gene
  JOURNAL   Circ Genom Precis Med 16 (2), e003726 (2023)
   PUBMED   37071726
  REMARK    GeneRIF: Elucidation of ALG10B as a Novel Long-QT
            Syndrome-Susceptibility Gene.
REFERENCE   2  (bases 1 to 10050)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 10050)
  AUTHORS   Probst,F.J., Corrigan,R.R., Del Gaudio,D., Salinger,A.P.,
            Lorenzo,I., Gao,S.S., Chiu,I., Xia,A., Oghalai,J.S. and
            Justice,M.J.
  TITLE     A point mutation in the gene for asparagine-linked glycosylation
            10B (Alg10b) causes nonsyndromic hearing impairment in mice (Mus
            musculus)
  JOURNAL   PLoS One 8 (11), e80408 (2013)
   PUBMED   24303013
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10050)
  AUTHORS   Hayashi,K., Fujino,N., Ino,H., Uchiyama,K., Sakata,K., Konno,T.,
            Masuta,E., Funada,A., Sakamoto,Y., Tsubokawa,T., Hodatsu,A.,
            Yasuda,T., Kanaya,H., Kim,M.Y., Kupershmidt,S., Higashida,H. and
            Yamagishi,M.
  TITLE     A KCR1 variant implicated in susceptibility to the long QT syndrome
  JOURNAL   J Mol Cell Cardiol 50 (1), 50-57 (2011)
   PUBMED   20950623
  REMARK    GeneRIF: Findings suggest that KCR1 genetic variations that
            diminish the ability of KCR1 to protect KCNH2 from inhibition by
            commonly used therapeutic agents constitute a risk factor for the
            aLQTS.
REFERENCE   5  (bases 1 to 10050)
  AUTHORS   Daly,A.K., Donaldson,P.T., Bhatnagar,P., Shen,Y., Pe'er,I.,
            Floratos,A., Daly,M.J., Goldstein,D.B., John,S., Nelson,M.R.,
            Graham,J., Park,B.K., Dillon,J.F., Bernal,W., Cordell,H.J.,
            Pirmohamed,M., Aithal,G.P. and Day,C.P.
  CONSRTM   DILIGEN Study; International SAE Consortium
  TITLE     HLA-B*5701 genotype is a major determinant of drug-induced liver
            injury due to flucloxacillin
  JOURNAL   Nat Genet 41 (7), 816-819 (2009)
   PUBMED   19483685
REFERENCE   6  (bases 1 to 10050)
  AUTHORS   Nakajima,T., Hayashi,K., Viswanathan,P.C., Kim,M.Y., Anghelescu,M.,
            Barksdale,K.A., Shuai,W., Balser,J.R. and Kupershmidt,S.
  TITLE     HERG is protected from pharmacological block by
            alpha-1,2-glucosyltransferase function
  JOURNAL   J Biol Chem 282 (8), 5506-5513 (2007)
   PUBMED   17189275
REFERENCE   7  (bases 1 to 10050)
  AUTHORS   Petersen,C.I., McFarland,T.R., Stepanovic,S.Z., Yang,P.,
            Reiner,D.J., Hayashi,K., George,A.L., Roden,D.M., Thomas,J.H. and
            Balser,J.R.
  TITLE     In vivo identification of genes that modify ether-a-go-go-related
            gene activity in Caenorhabditis elegans may also affect human
            cardiac arrhythmia
  JOURNAL   Proc Natl Acad Sci U S A 101 (32), 11773-11778 (2004)
   PUBMED   15280551
REFERENCE   8  (bases 1 to 10050)
  AUTHORS   Kupershmidt,S., Yang,I.C., Hayashi,K., Wei,J., Chanthaphaychith,S.,
            Petersen,C.I., Johns,D.C., George,A.L. Jr., Roden,D.M. and
            Balser,J.R.
  TITLE     The IKr drug response is modulated by KCR1 in transfected cardiac
            and noncardiac cell lines
  JOURNAL   FASEB J 17 (15), 2263-2265 (2003)
   PUBMED   14525949
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117372.2.
            
            On Nov 23, 2018 this sequence version replaced NM_001013620.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.398127.1,
                                           SRR1163657.499250.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000308742.9/ ENSP00000310120.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-291               AC117372.2         134378-134668
            292-489             AC117372.2         135865-136062
            490-10050           AC117372.2         137765-147325
FEATURES             Location/Qualifiers
     source          1..10050
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q12"
     gene            1..10050
                     /gene="ALG10B"
                     /gene_synonym="ALG10; KCR1"
                     /note="ALG10 alpha-1,2-glucosyltransferase B"
                     /db_xref="GeneID:144245"
                     /db_xref="HGNC:HGNC:31088"
                     /db_xref="MIM:603313"
     exon            1..291
                     /gene="ALG10B"
                     /gene_synonym="ALG10; KCR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..1542
                     /gene="ALG10B"
                     /gene_synonym="ALG10; KCR1"
                     /EC_number="2.4.1.256"
                     /note="isoform 1 is encoded by transcript variant 1;
                     modifier of the HERG potassium channel; putative
                     alpha-1,2-glucosyltransferase ALG10-B; asparagine-linked
                     glycosylation 10 homolog B (yeast,
                     alpha-1,2-glucosyltransferase); potassium channel
                     regulator 1; alpha-2-glucosyltransferase ALG10-B;
                     asparagine-linked glycosylation protein 10 homolog B;
                     alpha-1,2-glucosyltransferase ALG10-A; putative
                     Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol
                     alpha-1,2-glucosyltransferase; asparagine-linked
                     glycosylation 10, alpha-1,2-glucosyltransferase homolog B;
                     dolichyl-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-dolichol
                     alpha-1,2- glucosyltransferase; ALG10B,
                     alpha-1,2-glucosyltransferase;
                     dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol
                     alpha-1,2-glucosyltransferase"
                     /codon_start=1
                     /product="dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol
                     alpha-1,2-glucosyltransferase isoform 1"
                     /protein_id="NP_001013642.2"
                     /db_xref="CCDS:CCDS31772.1"
                     /db_xref="GeneID:144245"
                     /db_xref="HGNC:HGNC:31088"
                     /db_xref="MIM:603313"
                     /translation="MAQLEGYCFSAALSCTFLVSCLLFSAFSRALREPYMDEIFHLPQ
                     AQRYCEGHFSLSQWDPMITTLPGLYLVSVGVVKPAIWIFAWSEHVVCSIGMLRFVNLL
                     FSVGNFYLLYLLFHKVQPRNKAASSIQRVLSTLTLAVFPTLYFFNFLYYTEAGSMFFT
                     LFAYLMCLYGNHKTSAFLGFCGFMFRQTNIIWAVFCAGNVIAQKLTEAWKTELQKKED
                     RLPPIKGPFAEFRKILQFLLAYSMSFKNLSMLFCLTWPYILLGFLFCAFVVVNGGIVI
                     GDRSSHEACLHFPQLFYFFSFTLFFSFPHLLSPSKIKTFLSLVWKHGILFLVVTLVSV
                     FLVWKFTYAHKYLLADNRHYTFYVWKRVFQRYAILKYLLVPAYIFAGWSIADSLKSKP
                     IFWNLMFFICLFIVIVPQKLLEFRYFILPYVIYRLNITLPPTSRLVCELSCYAIVNFI
                     TFYIFLNKTFQWPNSQDIQRFMW"
     exon            292..489
                     /gene="ALG10B"
                     /gene_synonym="ALG10; KCR1"
                     /inference="alignment:Splign:2.1.0"
     exon            490..10050
                     /gene="ALG10B"
                     /gene_synonym="ALG10; KCR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5659..5664
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALG10B"
                     /gene_synonym="ALG10; KCR1"
                     /note="hexamer: AATAAA"
     polyA_site      5681
                     /gene="ALG10B"
                     /gene_synonym="ALG10; KCR1"
                     /note="major polyA site"
     regulatory      10029..10034
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALG10B"
                     /gene_synonym="ALG10; KCR1"
                     /note="hexamer: AATAAA"
     polyA_site      10050
                     /gene="ALG10B"
                     /gene_synonym="ALG10; KCR1"
                     /note="major polyA site"
ORIGIN      
        1 gtggccccgt ctggctagtc ctgtctagcg cgcccatttc gagcccaagt ttccagctcg
       61 ggtttccggg ctcagaattt tccaggagtg ggttcttggg cagtggctgt gggagcagga
      121 atggcgcagc tagagggtta ctgtttctcg gccgccttga gctgtacctt tttagtgtcc
      181 tgcctcctct tctccgcctt cagccgggcg ctgcgagagc cctacatgga cgagatcttc
      241 cacctgcctc aggcgcagcg ctactgtgag ggccatttct ccctttccca gtgggatccc
      301 atgattacta cattacctgg cttgtacctg gtgtcagttg gagtggtcaa acctgccatt
      361 tggatctttg catggtctga acatgttgtc tgctccattg ggatgctcag atttgttaat
      421 cttctcttca gtgttggcaa cttctattta ctatatttgc ttttccacaa ggtacaaccc
      481 agaaacaagg ctgcctcaag tatccagaga gtcttgtcaa cattaacact agcagtattt
      541 ccaacacttt atttttttaa cttcctttat tatacagaag caggatctat gttttttact
      601 ctttttgcat atttgatgtg tctttatgga aatcataaaa cttcagcctt ccttggattt
      661 tgtggcttca tgtttcggca aacaaatatc atctgggctg tcttctgtgc agggaatgtc
      721 attgcacaaa agttaactga ggcttggaaa actgagctac aaaagaagga agacagactt
      781 ccacctatta aaggaccatt tgcagaattc agaaaaattc ttcagtttct tttggcttat
      841 tccatgtcct ttaaaaactt gagtatgctt ttctgtttga cttggcccta catccttctg
      901 ggatttctgt tttgtgcttt tgtagtagtt aatggtggaa ttgttattgg cgatcggagt
      961 agtcatgaag cctgtcttca ttttcctcaa ctattctact ttttttcatt tactctcttt
     1021 ttttcttttc ctcatctcct gtctcctagc aaaattaaga cttttctttc cttagtttgg
     1081 aaacatggaa ttctgttttt ggtggttacc ttagtctctg tgtttttagt ttggaaattc
     1141 acttatgctc ataaatactt gctagcagac aatagacatt atactttcta tgtgtggaaa
     1201 agagtttttc aaagatatgc aattctgaaa tatttgttag ttccagccta tatatttgct
     1261 ggttggagta tagctgactc attgaaatca aagccaattt tttggaattt aatgtttttc
     1321 atatgcttgt tcattgttat agttcctcag aaactgctgg aatttcgtta cttcatttta
     1381 ccttatgtca tttataggct taacataact ctgcctccca catccagact tgtttgtgaa
     1441 ctgagttgct atgcaattgt taatttcata actttttaca tctttctgaa caagactttt
     1501 cagtggccaa atagtcagga cattcaaagg tttatgtggt aatatcagtg atattttgaa
     1561 ctgtaaaaat ggacttaata attagaccat ttctacaaag aacaactgaa taggtggaaa
     1621 acatggaatt tcttttaggt gcagtggtgg tcctcaaatt acattagttt ttttaatata
     1681 tattttaaac atatgtaaga aattaagtgg caaagaactg ggaaagctta agacctgctt
     1741 caaaagcctg aataatggga aaataaaatt gttttcagat atctcatatc gctctcgtaa
     1801 tgttggcccc tcacaaagct tgggaatgtt ttgtatgtat aagtttatta aaactgggta
     1861 tgcttcatat tactagaact aatttattct cttcagagag aactattagg ttagtgcaaa
     1921 agtaattgtg gtttttgcca ttgaaagtaa tggcaaaacc acaattactt ttgtaccaac
     1981 ctaataacaa tgtgttagca aatatttaca aatggtcagg tgatattctt gactgaaaag
     2041 ttccttaaca tttcagtaaa tataatttta attctaagtc aaaatagaaa tgcatagata
     2101 gtaaatgata aagtagagac tcatatatgt ctgtctaggc atcaaattgt tggttattgt
     2161 ttacaatcca gaaatgatga agctctttca ctaattccta atatgaaatg tatgatggcc
     2221 aaagacaaat tgtgttgatt ataatccttt aaaaggggga tttcctttat gaaatacata
     2281 ttgtattagc ttcccagggc tgccataaca aatgaccaca aacttgggtg cttacaacaa
     2341 ttttcctcac agtctggagg ccagaagtct aaaatcaaag tgtcagcaga gttggttcct
     2401 tctggaggct ctaaggaaga atccattcta tgtctgtttc ctaatatctt gtggctgtct
     2461 gcaattcttg gagttctttg gcttatgggc atatcttgtc taagtattgc agacagcaat
     2521 cttcactcca gtctctgcct ctgcgttcac acggcctttc cctctgtctt ttcattacct
     2581 tttaaggaca gtgtctttga atgtagggcc caccctgatc tagggtgatt gtgtctggag
     2641 acccttaatt atgtttacaa agacccatgt tccaagtaag tttgtattca catgttctga
     2701 gtagacattg tctcttcatg ggatactttt cagtccatga cagttactaa aggacatttt
     2761 aggataatcc tcatatgatt gttaggagac tacctttaaa aattttttat tatatatcaa
     2821 attatagttg tatatactta tgaggtacga agtggcatta tgatttttga atataatgtg
     2881 ggatgattaa ataaagctaa tctatccatc acctcaaata tttgacatat tttgtgatga
     2941 aaacatttga aatgtactct caacagtatt gaaatgtaca tacagtgctt aattattagc
     3001 tgtattcacc atgttgtgta atagatctaa aaaaagtcaa acatattcct tctatctaat
     3061 tgaggctttg tatcttttga ttgtcatctc cctattccca catccccggc ctctagcaac
     3121 catcattctt ctctctactt ctgtgagttt aattgtttta gattacacaa ataagtgaga
     3181 tcatgtggta tttgtctttc tgtgcttggc ttatttcact taccataatg tcctccacga
     3241 tcatccatat tgttgcaaat gacacaattt cttccttttt aaaggctgaa tagtattttt
     3301 ttgtatatat atgccacatt ttctttatcc attcatccat ggatggacac ttaggttgat
     3361 cgaatcactt ggttattgtg acttgtctgc aatgaacata gagtgcagac ttctctttga
     3421 catacggatt tcaaatcttc tggataaata gccagaagtg ggattgttgg atcaggagat
     3481 aatatcttag ctgatacctt ttaaataact ctcagtatct ttactgagag gttaaaaaat
     3541 aagtgacttc ttaggtaata taaagctaaa ggtgactagt gtttgattcc attatctatt
     3601 aaaaaaagtc agaattgaaa gaaagttgag aaatcctttg gtctgacttt gtagattagg
     3661 gaacaactgc tggggtagga ttattttgtg ttactttttg aattttgtgt ttattatttt
     3721 gagtgtattt tttgggttgt cattccatta caggaaagta ttatttgggc atgttaactt
     3781 tgacatgtaa acttagaatt gtgaatagaa ctcatctttt aacataattt tatgtttcta
     3841 aactttaaaa gtagctataa gtgaacaaat tactttcccc tcaatgtcaa attttgcttc
     3901 tctgagtttt aagtgatgag tctacattta caaatataaa attgtgtgca ggtgaaaatt
     3961 acaagtataa tttgagtaat aaatgcaggc cattttttgg ttgtactcta gtactcagaa
     4021 aatagatcgg cattagttat aacagtgatt gtagaaaaac gtgttttacc cagacttctt
     4081 aaaaattaga tgagagagga cactcaaaga aattatactt ttgtcattaa tttactatag
     4141 tggagaacta aatctgggaa gtcaaaattg aaaaaagaat gtgtaattta gggaaagtaa
     4201 ctttttgtct gataatatta atgcaaggat tttgtattta ggaatacttc tgagaggaga
     4261 agcttccact ctgatctagt ctggcaaaat tgaggaaaat attctaccct gtaattaaag
     4321 aagactgctc tttggaggga tcactgttct atatcttttt ttgtttgttt ttgtctttga
     4381 ggagaagtct cgctcttgtc ccccaggctg gaatgcaatg gcgcgatctt ggctcactga
     4441 aacctccacc tcctgggttc aagcagttct cctgcctcag cctcccgagt agctgagatt
     4501 ataggcgccc accaccaagc ctggctaatt ttttctattt ttagtagagc cggggtttca
     4561 ccgtgttagc caggctggtc tcgaactcct gacctcaggt aatccacctg cctcgcctcc
     4621 caaagtgctg ggattacagg cgtgagccac tgtgcccagc tcttctagtt catttttaag
     4681 tgttgagtcc ctgctgttta agagatgttt tggtgaaaat ctacattcag agagaaacag
     4741 gttaatcttc cacatttttt ataaaataca taaaatatag tacttggcat tttaagaaaa
     4801 gaatgccatg tattaaaagg tgctattttc aactatttat tattttaaaa caggaatgct
     4861 tatcaatact ttcgaattta agataaatgt cttcgttaaa ttttctaggc agttcaaaga
     4921 tggccatttg ctggtgaatt ttccaaaata gataacagat aaaatgatta tgtaagaact
     4981 tggcacaaca gatcattttg cctttagtcg ttcaagaaat gatactaaac tcaaagtcat
     5041 tcacttgaaa caactgagaa gaccattctt aggtgtttag atccttgctt ttagaaacat
     5101 tcttagttat atttgtgttt tcaaaagtta ttgagtagat agatattttt tcatgaattt
     5161 ttaaacatta gacttagctg aattgattaa aattaggtga ttatgaaaaa aatattgccc
     5221 tgctcgaggg catctggagc cctacagtta ccattactaa agtctgtgag tatgtctatt
     5281 ttgaaaagtg tcataaaaat atctagtcca taaatcatta taggttcagt aatacatcat
     5341 tttgaactga ttctatcttc tgtgaaattc tagagatatg ttatctttag gtagcatgag
     5401 taagattcag gtatgctgtg aattttgtta acgtttatgt tttccattaa tggatagtca
     5461 ggaatctttt gaactgcgtc tatgtattta aatgatttgg aaagatagca tctctcagtt
     5521 taaacttagc atctcatttt ggcaagataa attattttag ctgtctggcc ttttctttgt
     5581 cttcttagag ttatttctga aatgtgcata gccagtcata aaataacttg tgtaaatagc
     5641 ctaatgtaat ttatttctaa taaatacgta gcttaatgaa atgtatttct agtttgaact
     5701 taattgccac ttggcttgat attattttcc ttagaattgt tggaagagag gagagaggaa
     5761 gggatctacc atttttattt ataccaccta aatagtggac tgttattttg gactcacttt
     5821 taaataaaat atttattcac atgaagaaat aaattttgtg tttattaggt tagcaagcgt
     5881 ttattatctt tgaagtaatt ggaatttcat taaaaagtga agcaagtaag aattgtgata
     5941 taaatttgaa aatttttaaa tggaaattga aatatgactt aggaactgtg ggcttgtaga
     6001 aaaaaacatt taacatggga gttaagattt ttatatttgg ttgtggctct gggatcaata
     6061 aggcaagtgg tttagtcttt agtcctcatt tcaaatgaga atagtatttg tcctaactct
     6121 agtcagtgtc tgattggtat gtgtataacc ttattttaaa aaggattcat tcctgccata
     6181 tactcataat atttataagt atgtcatatg ataaatattg agtaaatata tactgaatga
     6241 agtttttagt atagagtgaa gtgaatagaa aaaacatcct acataaccgt ggctaatttt
     6301 aggaagtaaa tcatgtttca taataagagt catcctaaac atttttctgt gtaattttct
     6361 gacccagtgt taacaatttt tatttgcctt agtgcaagct tgttcaaccc acaggccaca
     6421 tgcagcccag gatggctttg aatgcggccc caacacaaat tttgtaagct ttcttaaaac
     6481 atgatgagat attttgtgat tttattttat tttattttat ttattatttt attttatttt
     6541 attttatttt ttagctcatc agctatcatt agtgttcgtg tattttatgt gtggcccaag
     6601 atggttcttc cagtgtggcc cagggaagcc aaaagattgg agacccctgc tagcatttaa
     6661 tgcttataca tgtatttact tgtaaacatg ttgtttcttt gataggatat gatttcaaca
     6721 taattactgt ttatttaaaa taagaaaaac aaataacttt caaccattaa aaggttataa
     6781 cactttaaag gaaagtttct tattaaagaa actttatacc ctattaaggg tataatttca
     6841 aaataattgc tttttattta aaataagaaa atattcttat ttctatttaa aataagaaaa
     6901 atcagtaacc ttcaacgaat aacaggttaa agaatttaaa ggtaaaagac atttcaacta
     6961 attacaaata ctttgttttt tttagttggg ctacatttta ccactctagg aatagctgtt
     7021 aattattttt tatatagggc atttttatgt atttaatgtt gacaactgac gtttccaata
     7081 tacaaaaact tgtgtaactg agaaaattat aataaaaata gagattgagg acatattttt
     7141 aacatatatc catgagtcaa cactaatatt taatatttga gatttgaaaa attatttcta
     7201 gggtaagaaa ttctgtcaca atataatatc tctatattgt gcttttttaa gagataaatt
     7261 tttgatgaat ttaatgttaa ttaaatttta tctcagccta tcaccatcag accaaaagac
     7321 aatacagtat ttttctaaca aggaaaagaa aatacatata tatatattta tatatacaaa
     7381 tatatacgta tttatatata caaatttgta tatatgtaat gtatgtgtgt gtgtatacat
     7441 ataatttctc cttttttttt tttgtaagaa ttgagacagg gtgtcactat gttgtgtggg
     7501 ctggtctcaa aacacctgcc tcaagtgatc ctcccacctt ggcctcccaa agtgctagga
     7561 tttacaatga gccactgtgc cagcttccaa caagaaaaat attaaatgta ttggtttttc
     7621 acagtgaaac ttaattcagt ttagttgaac catatatgtg tgtgtatggc atatataaga
     7681 tgaaaaaagg agaaaaagta acaataataa tgatggttgc catcattcat tgaacaccta
     7741 taatgtttta ggcattatac tagctgattt acaaatattg tctcatttga tgctacattt
     7801 atatttctat gaggcagatg ttgatttctc tttgactgct gaagaaactg aaggtcggtc
     7861 aggtcaggtg atttgcccaa agtccacact gtcactaaat gaacatagat tggtatgact
     7921 cccaagcctg tgagtttttg accgtcatat tctgcctcac tatgaaaagt tttttttcaa
     7981 ttttttttaa atcaaaagaa gtagtatatg gagagagagg tgaaaatcca tgtttgctct
     8041 ctgcagtttc caaaccattc atgacgtgtt atttttgtac tggatatagt cattttttaa
     8101 aatgctacaa actgttcaaa agagcatgaa caacatgata actccttata attttgttgt
     8161 aagataaatg actaaaatta tgtgggatat ttaatttgga taagtggaaa ttctatcact
     8221 tgataagctc tcttgaagaa taattatttg aaagattgga cttaattctg tattgcctga
     8281 agtgtaaatc agaggtcaac aattagattg caaatcatga aaagcataac ttctaattgt
     8341 ttagtctttt tagggaaaca agcccagaaa aaaagtaaga ttctcattca ttggagataa
     8401 gatttctatt tatcaaagat actacacaag agttagatag caagtagttc aaatgtcttt
     8461 taaaggtatc tgacatcttt aaagctctgt aatttttaaa ttctaaattt tgttacagct
     8521 aatttttaaa aattaattgc taagtcatgg tcaagtattt ctgatgactt acatgctgtc
     8581 tttggtatat tttaagtttc taaaccaaaa ctactatttg actctattac accctgtttt
     8641 agaaaaacat ttgagttata caacttacta aaatgtattt tagcggtgat gttttggagc
     8701 actggtaata tagtgtttaa cttattttct attttttatc cctctatatt cgtgaaatta
     8761 cttctatttg aaaagttttc cgccagtgat aaaaaaaggc tgagcactat ctgtaaaaat
     8821 ttttaaggtg tccactaggt ggagatattg tgctacattt ccaagtgttg tagttaaact
     8881 tttattagtc tgaattaaac tcttttatag tgttttattg ttttaaacca caaagattta
     8941 taatcattta tatctattta tctaatgtta ttcaaatgtt ttctgcgttg tatgaagcta
     9001 agataaatgt aaaaaaaaca aacaaaaaaa acctcacttt gtgttttgta atcattagac
     9061 gatttaacct aatatatctt cccatatgat atgatctttg catatggcat acttcattca
     9121 tatgacatag ttagaatctt ttcccacaaa caatgagtga tgatatctca tttgaaaact
     9181 cgtgtaacat tgtatcagcc actgttataa agtgatttac ccatgttagt ctcataacaa
     9241 ctctatgaga tcagtaccgt acacatgggg aaacttagta tagagaggtg aagtattttt
     9301 tccaagatta caaaataact gtctgagctg ggattcgtaa ccaggcagcc tgactccaaa
     9361 atcaatattc ttaactctat tgttatgatg gagaaaggca tgaagtctac cttcaaattc
     9421 atggcatttt agaaggaaaa attgtcgcaa gtaatgtgat tatacttcct agttttatag
     9481 gtcagaaaaa tgaggtccac actaattttg cctcttccac agggagatag attctcatct
     9541 accattgtgt cttttgtttc tgtttttgtc atgatacctc aaattgatat atgttgtaat
     9601 tatgaattta aggaagtaaa aaaataactc agggctggag ccttcagcca tattaacata
     9661 cattgacata aagacctttg ttttaatatg aatgattcca gttaacaaat ggagaaatag
     9721 ttgtttgaaa attaatattt agcttctcaa aagagactcc tgtttggaag caaattgttg
     9781 gtttaacagg acatacttta gatatttgaa aaattctctg tggaatcaca atctcttatt
     9841 tttaagaatg taggaatatg tgttctatat gcttttaagt tatgtattac atactattct
     9901 ctaaaataga aatgtttatt tggcttctaa aagtcatttg tgagttgatg ttatttaaaa
     9961 ctgcttttca gtcaacttat tctttataaa aaagtttgtt caaatagcat gtttttattt
    10021 tgtttctaaa taaattcatg tttgataata
//
