LOCUS       NM_032834               2913 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens ALG10 alpha-1,2-glucosyltransferase (ALG10), mRNA.
ACCESSION   NM_032834
VERSION     NM_032834.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2913)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2913)
  AUTHORS   Liu,Y.S., Guo,X.Y., Hirata,T., Rong,Y., Motooka,D., Kitajima,T.,
            Murakami,Y., Gao,X.D., Nakamura,S., Kinoshita,T. and Fujita,M.
  TITLE     N-Glycan-dependent protein folding and endoplasmic reticulum
            retention regulate GPI-anchor processing
  JOURNAL   J Cell Biol 217 (2), 585-599 (2018)
   PUBMED   29255114
REFERENCE   3  (bases 1 to 2913)
  AUTHORS   Chapuis,J., Hot,D., Hansmannel,F., Kerdraon,O., Ferreira,S.,
            Hubans,C., Maurage,C.A., Huot,L., Bensemain,F., Laumet,G.,
            Ayral,A.M., Fievet,N., Hauw,J.J., DeKosky,S.T., Lemoine,Y.,
            Iwatsubo,T., Wavrant-Devrieze,F., Dartigues,J.F., Tzourio,C.,
            Buee,L., Pasquier,F., Berr,C., Mann,D., Lendon,C., Alperovitch,A.,
            Kamboh,M.I., Amouyel,P. and Lambert,J.C.
  TITLE     Transcriptomic and genetic studies identify IL-33 as a candidate
            gene for Alzheimer's disease
  JOURNAL   Mol Psychiatry 14 (11), 1004-1016 (2009)
   PUBMED   19204726
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 2913)
  AUTHORS   Seshadri,S., DeStefano,A.L., Au,R., Massaro,J.M., Beiser,A.S.,
            Kelly-Hayes,M., Kase,C.S., D'Agostino,R.B. Sr., Decarli,C.,
            Atwood,L.D. and Wolf,P.A.
  TITLE     Genetic correlates of brain aging on MRI and cognitive test
            measures: a genome-wide association and linkage analysis in the
            Framingham Study
  JOURNAL   BMC Med Genet 8 Suppl 1 (Suppl 1), S15 (2007)
   PUBMED   17903297
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2913)
  AUTHORS   Kupershmidt,S., Yang,I.C., Hayashi,K., Wei,J., Chanthaphaychith,S.,
            Petersen,C.I., Johns,D.C., George,A.L. Jr., Roden,D.M. and
            Balser,J.R.
  TITLE     The IKr drug response is modulated by KCR1 in transfected cardiac
            and noncardiac cell lines
  JOURNAL   FASEB J 17 (15), 2263-2265 (2003)
   PUBMED   14525949
REFERENCE   6  (bases 1 to 2913)
  AUTHORS   Oriol,R., Martinez-Duncker,I., Chantret,I., Mollicone,R. and
            Codogno,P.
  TITLE     Common origin and evolution of glycosyltransferases using
            Dol-P-monosaccharides as donor substrate
  JOURNAL   Mol Biol Evol 19 (9), 1451-1463 (2002)
   PUBMED   12200473
REFERENCE   7  (bases 1 to 2913)
  AUTHORS   Hoshi,N., Takahashi,H., Shahidullah,M., Yokoyama,S. and
            Higashida,H.
  TITLE     KCR1, a membrane protein that facilitates functional expression of
            non-inactivating K+ currents associates with rat EAG
            voltage-dependent K+ channels
  JOURNAL   J Biol Chem 273 (36), 23080-23085 (1998)
   PUBMED   9722534
REFERENCE   8  (bases 1 to 2913)
  AUTHORS   Burda,P. and Aebi,M.
  TITLE     The ALG10 locus of Saccharomyces cerevisiae encodes the alpha-1,2
            glucosyltransferase of the endoplasmic reticulum: the terminal
            glucose of the lipid-linked oligosaccharide is required for
            efficient N-linked glycosylation
  JOURNAL   Glycobiology 8 (5), 455-462 (1998)
   PUBMED   9597543
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AJ312278.1, BC090948.1,
            AC046130.25, AK027657.1 and W05355.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_032834.3.
            
            Summary: This gene encodes a membrane-associated protein that adds
            the third glucose residue to the lipid-linked oligosaccharide
            precursor for N-linked glycosylation. That is, it transfers the
            terminal glucose from dolichyl phosphate glucose (Dol-P-Glc) onto
            the lipid-linked oligosaccharide Glc2Man9GlcNAc(2)-PP-Dol. The rat
            protein homolog was shown to specifically modulate the gating
            function of the rat neuronal ether-a-go-go (EAG) potassium ion
            channel. [provided by RefSeq, Jan 2010].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070347.1, AJ312278.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000266483.7/ ENSP00000266483.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-876               AJ312278.1         216-1091
            877-1770            BC090948.1         859-1752
            1771-2108           AC046130.25        88988-89325
            2109-2910           AK027657.1         1561-2362
            2911-2913           W05355.1           16-18               c
FEATURES             Location/Qualifiers
     source          1..2913
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p11.1"
     gene            1..2913
                     /gene="ALG10"
                     /gene_synonym="ALG10A; DIE2; KCR1"
                     /note="ALG10 alpha-1,2-glucosyltransferase"
                     /db_xref="GeneID:84920"
                     /db_xref="HGNC:HGNC:23162"
                     /db_xref="MIM:618355"
     exon            1..275
                     /gene="ALG10"
                     /gene_synonym="ALG10A; DIE2; KCR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..1526
                     /gene="ALG10"
                     /gene_synonym="ALG10A; DIE2; KCR1"
                     /EC_number="2.4.1.256"
                     /note="asparagine-linked glycosylation 10 homolog (yeast,
                     alpha-1,2-glucosyltransferase); derepression of ITR1
                     expression 2 homolog; alpha-1,2-glucosyltransferase
                     ALG10-A; alpha2-glucosyltransferase; potassium channel
                     regulator 1; alpha-2-glucosyltransferase ALG10-A;
                     asparagine-linked glycosylation protein 10 homolog A;
                     asparagine-linked glycosylation 10,
                     alpha-1,2-glucosyltransferase homolog;
                     dolichyl-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-dolichol
                     alpha-1,2- glucosyltransferase"
                     /codon_start=1
                     /product="dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol
                     alpha-1,2-glucosyltransferase"
                     /protein_id="NP_116223.3"
                     /db_xref="CCDS:CCDS41769.1"
                     /db_xref="GeneID:84920"
                     /db_xref="HGNC:HGNC:23162"
                     /db_xref="MIM:618355"
                     /translation="MAQLEGYYFSAALSCTFLVSCLLFSAFSRALREPYMDEIFHLPQ
                     AQRYCEGHFSLSQWDPMITTLPGLYLVSIGVIKPAIWIFGWSEHVVCSIGMLRFVNLL
                     FSVGNFYLLYLLFCKVQPRNKAASSIQRVLSTLTLAVFPTLYFFNFLYYTEAGSMFFT
                     LFAYLMCLYGNHKTSAFLGFCGFMFRQTNIIWAVFCAGNVIAQKLTEAWKTELQKKED
                     RLPPIKGPFAEFRKILQFLLAYSMSFKNLSMLLLLTWPYILLGFLFCAFVVVNGGIVI
                     GDRSSHEACLHFPQLFYFFSFTLFFSFPHLLSPSKIKTFLSLVWKRRILFFVVTLVSV
                     FLVWKFTYAHKYLLADNRHYTFYVWKRVFQRYETVKYLLVPAYIFAGWSIADSLKSKS
                     IFWNLMFFICLFTVIVPQKLLEFRYFILPYVIYRLNIPLPPTSRLICELSCYAVVNFI
                     TFFIFLNKTFQWPNSQDIQRFMW"
     exon            276..473
                     /gene="ALG10"
                     /gene_synonym="ALG10A; DIE2; KCR1"
                     /inference="alignment:Splign:2.1.0"
     exon            474..2913
                     /gene="ALG10"
                     /gene_synonym="ALG10A; DIE2; KCR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1746..1751
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALG10"
                     /gene_synonym="ALG10A; DIE2; KCR1"
                     /note="hexamer: AATAAA"
     polyA_site      1770
                     /gene="ALG10"
                     /gene_synonym="ALG10A; DIE2; KCR1"
                     /note="major polyA site"
     regulatory      1831..1836
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALG10"
                     /gene_synonym="ALG10A; DIE2; KCR1"
                     /note="hexamer: ATTAAA"
     polyA_site      1851
                     /gene="ALG10"
                     /gene_synonym="ALG10A; DIE2; KCR1"
     regulatory      2885..2890
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALG10"
                     /gene_synonym="ALG10A; DIE2; KCR1"
                     /note="hexamer: AATAAA"
     polyA_site      2913
                     /gene="ALG10"
                     /gene_synonym="ALG10A; DIE2; KCR1"
                     /note="major polyA site"
ORIGIN      
        1 agtcccgcct agcgcgccca tttcgagccc aagtttccag ctcgggtttc caggctcaga
       61 attttccagg agtaggttct tgggcagtgg ctgtgggagc tggaatggcg cagctggaag
      121 gttactattt ctcggccgcc ttgagctgta cctttttagt atcctgcctc ctcttctccg
      181 ccttcagccg ggcgttgcga gagccctaca tggacgagat cttccacctg cctcaggcgc
      241 agcgctactg tgagggccat ttctcccttt cccagtggga tcccatgatt actacattac
      301 ctggcttgta cctggtgtca attggagtga tcaaacctgc catttggatc tttggatggt
      361 ctgaacatgt tgtctgctcc attgggatgc tcagatttgt taatcttctc ttcagtgttg
      421 gcaacttcta tttactatat ttgcttttct gcaaggtaca acccagaaac aaggctgcct
      481 caagtatcca gagagtcttg tcaacattaa cactagcagt atttccaaca ctttattttt
      541 ttaacttcct ttattataca gaagcaggat ctatgttttt tactcttttt gcgtatttga
      601 tgtgtcttta tggaaatcat aaaacttcag ccttccttgg attttgtggc ttcatgtttc
      661 ggcaaacaaa tatcatctgg gctgtcttct gtgcaggaaa tgtcattgca caaaagttaa
      721 cggaggcttg gaaaactgag ctacaaaaga aggaagacag acttccacct attaaaggac
      781 catttgcaga attcagaaaa attcttcagt ttcttttggc ttattccatg tcctttaaaa
      841 acttgagtat gcttttgctt ctgacttggc cctacatcct tctgggattt ctgttttgtg
      901 cttttgtagt agttaatggt ggaattgtta ttggcgatcg gagtagtcat gaagcctgtc
      961 ttcattttcc tcaactattc tacttttttt catttactct ctttttttcc tttcctcatc
     1021 tcctgtctcc tagcaaaatt aagacttttc tttccttagt ttggaaacgt agaattctgt
     1081 tttttgtggt taccttagtc tctgtgtttt tagtttggaa attcacttat gctcataaat
     1141 acttgctagc agacaataga cattatactt tctatgtgtg gaaaagagtt tttcaaagat
     1201 atgaaactgt aaaatatttg ttagttccag cctatatatt tgctggttgg agtatagctg
     1261 actcattgaa atcaaagtca attttttgga atttaatgtt tttcatatgc ttgttcactg
     1321 ttatagttcc tcagaaactg ctggaatttc gttacttcat tttaccttat gtcatttata
     1381 ggcttaacat acctctgcct cccacatcca gactcatttg tgaactgagc tgctatgcag
     1441 ttgttaattt cataactttt ttcatctttc tgaacaagac ttttcagtgg ccaaatagtc
     1501 aggacattca aaggtttatg tggtaatatc agtgatattt cgaactgtga aaatggactt
     1561 aataattaga ccatttctac aaagaacaac tgaataggtg gaaaacatgg aatttctttt
     1621 aggtgcagtg gtggtcttca aattacatta gtttttttta tatatatttt aaacatatgt
     1681 aagaaattaa gtggcaaaga actgagaaag cttaagacct gcttcaaaag cctgaaaaat
     1741 ggaaaaataa aattgttttc agatatctca tatcactctc ataatgttgg ccccttaaaa
     1801 agcttgggaa tgttttgtat gtacaagttt attaaaactg ggtatgcttc atattactgg
     1861 aatgaattta ttctcttcag agagaaatat taggttagtg caaaagtaat tgtggttttt
     1921 gccattgaaa gtaatggcaa aaccacaatt acttttttac caacctaata acaatgtatt
     1981 agcaaatatt tacaaatggt caggtgatat tcttgattga aaagttgctt aacatttcag
     2041 taatataatt ttaattctaa gtcaaaatac aaatgcatag atagtaaatg ataaagtaga
     2101 gactcatata tgcctgtcta gacatcaaat tgttggttat tgtttacaat ctagaaatga
     2161 tgaagctctt tcactaattc ctaatatgaa atgtatgatg gccaaagaca aattgtattg
     2221 attataatcc tttaaaaggg ggatttcctt tctgaaatac atattgtatt agcttcccag
     2281 ggcttccata acaaatgacg acaaacttgg gtgcttacaa caattttcct cacagtctgg
     2341 aggccagaag tctaaaatca aagtgtcagc agagttggtt ccttctggag gctctaagga
     2401 agaatccata aacagacatt ctatgtctgt ttcctaatat cttgtggctg tgtgcaattc
     2461 ttggagttct ttggcttctg gacaaatctt gtccaagtat tgcagacagc aatcttcact
     2521 ccagtctctg cctctgtgtt cacacggcct ttccctctgt cttctcttca ttacctttta
     2581 aggacagtgt ctttgaatgt agggcccacc ctgatctagg gtgattgtgt ctggagaccc
     2641 ttaattatgt ttacaaagac ccatgttcca agtaagtttg tattcacatg atctgagtag
     2701 acattgtctc ttcgtgggat acttttcagt ccatgacagt tactaaagga cattttagga
     2761 tagtcttcat atgattgtta ggagactacc tttttagatt ttttttatta tatatcaaat
     2821 tatagttgta tatacttatg agaaacaaag tggcattatg atttttgaat ataatgtggg
     2881 attaaataaa gctaatctat ccatcacctc aaa
//
