LOCUS       NM_019109               3900 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens ALG1 chitobiosyldiphosphodolichol
            beta-mannosyltransferase (ALG1), transcript variant 1, mRNA.
ACCESSION   NM_019109
VERSION     NM_019109.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3900)
  AUTHORS   Budhraja,R., Joshi,N., Radenkovic,S., Kozicz,T., Morava,E. and
            Pandey,A.
  TITLE     Dysregulated proteome and N-glycoproteome in ALG1-deficient
            fibroblasts
  JOURNAL   Proteomics 24 (15), e2400012 (2024)
   PUBMED   38470198
  REMARK    GeneRIF: Dysregulated proteome and N-glycoproteome in
            ALG1-deficient fibroblasts.
REFERENCE   2  (bases 1 to 3900)
  AUTHORS   Kobayashi,M., Jitoku,D., Iwayama,Y., Yamamoto,N., Toyota,T.,
            Suzuki,K., Kikuchi,M., Hashimoto,T., Kanahara,N., Kurumaji,A.,
            Yoshikawa,T. and Nishikawa,T.
  TITLE     Association studies of WD repeat domain 3 and
            chitobiosyldiphosphodolichol beta-mannosyltransferase genes with
            schizophrenia in a Japanese population
  JOURNAL   PLoS One 13 (1), e0190991 (2018)
   PUBMED   29309433
  REMARK    GeneRIF: evaluated the genetic association of WDR3 and ALG1 in
            schizophrenia. We examined 21 single nucleotide polymorphisms
            [SNPs; W1 (rs1812607)-W16 (rs6656360), A1 (rs8053916)-A10
            (rs9673733)] from these genes using the Japanese case-control
            sample (1,808 schizophrenics and 2,170 matched controls). No
            significant genetic associations of these SNPs were identified.
            However, we detected a significant association of W4 (rs319471)
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3900)
  AUTHORS   Ng,B.G., Shiryaev,S.A., Rymen,D., Eklund,E.A., Raymond,K.,
            Kircher,M., Abdenur,J.E., Alehan,F., Midro,A.T., Bamshad,M.J.,
            Barone,R., Berry,G.T., Brumbaugh,J.E., Buckingham,K.J.,
            Clarkson,K., Cole,F.S., O'Connor,S., Cooper,G.M., Van Coster,R.,
            Demmer,L.A., Diogo,L., Fay,A.J., Ficicioglu,C., Fiumara,A.,
            Gahl,W.A., Ganetzky,R., Goel,H., Harshman,L.A., He,M., Jaeken,J.,
            James,P.M., Katz,D., Keldermans,L., Kibaek,M., Kornberg,A.J.,
            Lachlan,K., Lam,C., Yaplito-Lee,J., Nickerson,D.A., Peters,H.L.,
            Race,V., Regal,L., Rush,J.S., Rutledge,S.L., Shendure,J.,
            Souche,E., Sparks,S.E., Trapane,P., Sanchez-Valle,A., Vilain,E.,
            Vollo,A., Waechter,C.J., Wang,R.Y., Wolfe,L.A., Wong,D.A., Wood,T.,
            Yang,A.C., Matthijs,G. and Freeze,H.H.
  CONSRTM   University of Washington Center for Mendelian Genomics
  TITLE     ALG1-CDG: Clinical and Molecular Characterization of 39 Unreported
            Patients
  JOURNAL   Hum Mutat 37 (7), 653-660 (2016)
   PUBMED   26931382
  REMARK    GeneRIF: Study presents molecular, clinical and biochemical
            findings in the largest collection of ALG1-CDG cases ever reported
            at a single time with 39 cases, bringing the total number to 57.
            This ranks it the third most common CDG type behind PMM2-CDG and
            ALG6-CDG. In addition, highly lethal genotype were identified and
            confirm the presence of a unique xeno-tetrasaccharide in ALG1-CDG
            patients.
REFERENCE   4  (bases 1 to 3900)
  AUTHORS   Jaeken,J., Lefeber,D. and Matthijs,G.
  TITLE     Clinical utility gene card for: ALG1 defective congenital disorder
            of glycosylation
  JOURNAL   Eur J Hum Genet 23 (10), 1431 (2015)
   PUBMED   25649379
REFERENCE   5  (bases 1 to 3900)
  AUTHORS   Rohlfing,A.K., Rust,S., Reunert,J., Tirre,M., Du Chesne,I.,
            Wemhoff,S., Meinhardt,F., Hartmann,H., Das,A.M. and Marquardt,T.
  TITLE     ALG1-CDG: a new case with early fatal outcome
  JOURNAL   Gene 534 (2), 345-351 (2014)
   PUBMED   24157261
  REMARK    GeneRIF: Was detected in the patient's ALG1-coding sequence.
REFERENCE   6  (bases 1 to 3900)
  AUTHORS   Grubenmann,C.E., Frank,C.G., Hulsmeier,A.J., Schollen,E.,
            Matthijs,G., Mayatepek,E., Berger,E.G., Aebi,M. and Hennet,T.
  TITLE     Deficiency of the first mannosylation step in the N-glycosylation
            pathway causes congenital disorder of glycosylation type Ik
  JOURNAL   Hum Mol Genet 13 (5), 535-542 (2004)
   PUBMED   14709599
REFERENCE   7  (bases 1 to 3900)
  AUTHORS   Schwarz,M., Thiel,C., Lubbehusen,J., Dorland,B., de Koning,T., von
            Figura,K., Lehle,L. and Korner,C.
  TITLE     Deficiency of GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase
            causes congenital disorder of glycosylation type Ik
  JOURNAL   Am J Hum Genet 74 (3), 472-481 (2004)
   PUBMED   14973778
REFERENCE   8  (bases 1 to 3900)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   9  (bases 1 to 3900)
  AUTHORS   Takahashi,T., Honda,R. and Nishikawa,Y.
  TITLE     Cloning of the human cDNA which can complement the defect of the
            yeast mannosyltransferase I-deficient mutant alg 1
  JOURNAL   Glycobiology 10 (3), 321-327 (2000)
   PUBMED   10704531
REFERENCE   10 (bases 1 to 3900)
  AUTHORS   Sparks,S.E. and Krasnewich,D.M.
  TITLE     Congenital Disorders of N-Linked Glycosylation and Multiple Pathway
            Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301507
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC026458.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 15, 2019 this sequence version replaced NM_019109.4.
            
            Summary: The enzyme encoded by this gene catalyzes the first
            mannosylation step in the biosynthesis of lipid-linked
            oligosaccharides. This gene is mutated in congenital disorder of
            glycosylation type Ik. [provided by RefSeq, Dec 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.2451635.1,
                                           SRR1660805.85408.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262374.10/ ENSP00000262374.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-215               AC026458.8         60250-60464
            216-293             AC026458.8         61358-61435
            294-397             AC026458.8         61560-61663
            398-546             AC026458.8         63795-63943
            547-636             AC026458.8         65852-65941
            637-747             AC026458.8         66314-66424
            748-869             AC026458.8         67164-67285
            870-908             AC026458.8         67471-67509
            909-968             AC026458.8         68155-68214
            969-1079            AC026458.8         69353-69463
            1080-1194           AC026458.8         70966-71080
            1195-1270           AC026458.8         72089-72164
            1271-3900           AC026458.8         73157-75786
FEATURES             Location/Qualifiers
     source          1..3900
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..3900
                     /gene="ALG1"
                     /gene_synonym="CDG1K; hMat-1; HMAT1; HMT-1; HMT1; Mat-1;
                     MT-1"
                     /note="ALG1 chitobiosyldiphosphodolichol
                     beta-mannosyltransferase"
                     /db_xref="GeneID:56052"
                     /db_xref="HGNC:HGNC:18294"
                     /db_xref="MIM:605907"
     exon            1..215
                     /gene="ALG1"
                     /gene_synonym="CDG1K; hMat-1; HMAT1; HMT-1; HMT1; Mat-1;
                     MT-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             8..1402
                     /gene="ALG1"
                     /gene_synonym="CDG1K; hMat-1; HMAT1; HMT-1; HMT1; Mat-1;
                     MT-1"
                     /EC_number="2.4.1.142"
                     /note="isoform 1 is encoded by transcript variant 1;
                     asparagine-linked glycosylation 1 homolog (yeast,
                     beta-1,4-mannosyltransferase);
                     chitobiosyldiphosphodolichol beta-mannosyltransferase;
                     GDP-mannose-dolichol diphosphochitobiose
                     mannosyltransferase; GDP-Man:GlcNAc2-PP-dolichol
                     mannosyltransferase; mannosyltransferase-1;
                     asparagine-linked glycosylation protein 1 homolog;
                     asparagine-linked glycosylation 1,
                     beta-1,4-mannosyltransferase homolog; mutant ALG1
                     chitobiosyldiphosphodolichol beta-mannosyltransferase"
                     /codon_start=1
                     /product="chitobiosyldiphosphodolichol
                     beta-mannosyltransferase isoform 1"
                     /protein_id="NP_061982.3"
                     /db_xref="CCDS:CCDS10528.1"
                     /db_xref="GeneID:56052"
                     /db_xref="HGNC:HGNC:18294"
                     /db_xref="MIM:605907"
                     /translation="MAASCLVLLALCLLLPLLLLGGWKRWRRGRAARHVVAVVLGDVG
                     RSPRMQYHALSLAMHGFSVTLLGFCNSKPHDELLQNNRIQIVGLTELQSLAVGPRVFQ
                     YGVKVVLQAMYLLWKLMWREPGAYIFLQNPPGLPSIAVCWFVGCLCGSKLVIDWHNYG
                     YSIMGLVHGPNHPLVLLAKWYEKFFGRLSHLNLCVTNAMREDLADNWHIRAVTVYDKP
                     ASFFKETPLDLQHRLFMKLGSMHSPFRARSEPEDPVTERSAFTERDAGSGLVTRLRER
                     PALLVSSTSWTEDEDFSILLAALEKFEQLTLDGHNLPSLVCVITGKGPLREYYSRLIH
                     QKHFQHIQVCTPWLEAEDYPLLLGSADLGVCLHTSSSGLDLPMKVVDMFGCCLPVCAV
                     NFKCLHELVKHEENGLVFEDSEELAAQLQMLFSNFPDPAGKLNQFRKNLRESQQLRWD
                     ESWVQTVLPLVMDT"
     exon            216..293
                     /gene="ALG1"
                     /gene_synonym="CDG1K; hMat-1; HMAT1; HMT-1; HMT1; Mat-1;
                     MT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            294..397
                     /gene="ALG1"
                     /gene_synonym="CDG1K; hMat-1; HMAT1; HMT-1; HMT1; Mat-1;
                     MT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            398..546
                     /gene="ALG1"
                     /gene_synonym="CDG1K; hMat-1; HMAT1; HMT-1; HMT1; Mat-1;
                     MT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            547..636
                     /gene="ALG1"
                     /gene_synonym="CDG1K; hMat-1; HMAT1; HMT-1; HMT1; Mat-1;
                     MT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            637..747
                     /gene="ALG1"
                     /gene_synonym="CDG1K; hMat-1; HMAT1; HMT-1; HMT1; Mat-1;
                     MT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            748..869
                     /gene="ALG1"
                     /gene_synonym="CDG1K; hMat-1; HMAT1; HMT-1; HMT1; Mat-1;
                     MT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            870..908
                     /gene="ALG1"
                     /gene_synonym="CDG1K; hMat-1; HMAT1; HMT-1; HMT1; Mat-1;
                     MT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            909..968
                     /gene="ALG1"
                     /gene_synonym="CDG1K; hMat-1; HMAT1; HMT-1; HMT1; Mat-1;
                     MT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1079
                     /gene="ALG1"
                     /gene_synonym="CDG1K; hMat-1; HMAT1; HMT-1; HMT1; Mat-1;
                     MT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1194
                     /gene="ALG1"
                     /gene_synonym="CDG1K; hMat-1; HMAT1; HMT-1; HMT1; Mat-1;
                     MT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1270
                     /gene="ALG1"
                     /gene_synonym="CDG1K; hMat-1; HMAT1; HMT-1; HMT1; Mat-1;
                     MT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..3900
                     /gene="ALG1"
                     /gene_synonym="CDG1K; hMat-1; HMAT1; HMT-1; HMT1; Mat-1;
                     MT-1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1566
                     /gene="ALG1"
                     /gene_synonym="CDG1K; hMat-1; HMAT1; HMT-1; HMT1; Mat-1;
                     MT-1"
                     /note="major polyA site"
     regulatory      1889..1894
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALG1"
                     /gene_synonym="CDG1K; hMat-1; HMAT1; HMT-1; HMT1; Mat-1;
                     MT-1"
                     /note="hexamer: AAGAAA"
     polyA_site      1915
                     /gene="ALG1"
                     /gene_synonym="CDG1K; hMat-1; HMAT1; HMT-1; HMT1; Mat-1;
                     MT-1"
     regulatory      2089..2094
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALG1"
                     /gene_synonym="CDG1K; hMat-1; HMAT1; HMT-1; HMT1; Mat-1;
                     MT-1"
                     /note="hexamer: TATAAA"
     polyA_site      2128
                     /gene="ALG1"
                     /gene_synonym="CDG1K; hMat-1; HMAT1; HMT-1; HMT1; Mat-1;
                     MT-1"
     regulatory      3878..3883
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALG1"
                     /gene_synonym="CDG1K; hMat-1; HMAT1; HMT-1; HMT1; Mat-1;
                     MT-1"
                     /note="hexamer: GATAAA"
     polyA_site      3900
                     /gene="ALG1"
                     /gene_synonym="CDG1K; hMat-1; HMAT1; HMT-1; HMT1; Mat-1;
                     MT-1"
ORIGIN      
        1 agccaagatg gcggcctcat gcttggtcct gctggcgctg tgtctgctgc tgccgctgct
       61 gctgctggga ggatggaagc gctggcgccg ggggcgggcg gcccggcatg tagtagcggt
      121 ggtgctgggc gacgtgggcc gcagcccccg tatgcagtac cacgcgctgt cgttggccat
      181 gcacggcttc tcggtgaccc tcctggggtt ctgcaactcc aaaccccatg atgagctctt
      241 gcagaacaac agaattcaga ttgtggggtt gacagaactt cagagtcttg cagttgggcc
      301 ccgagttttc cagtacggag tcaaagttgt acttcaggct atgtacttgc tgtggaagtt
      361 gatgtggagg gagccaggtg cctatatctt tctccagaac cccccaggtc tgcctagcat
      421 tgctgtctgc tggttcgtgg gctgcctttg tggaagcaag ctcgtcattg actggcacaa
      481 ctatggctac tccatcatgg gtctggtgca tggccccaac catcccctcg ttctgctggc
      541 caagtggtac gagaagttct ttgggcgcct gtcccacctg aacctgtgtg ttaccaatgc
      601 tatgcgagaa gacctggcgg ataactggca catcagggct gtgaccgtct acgacaagcc
      661 cgcatctttc tttaaagaga cacctctgga cctgcagcac cggctcttca tgaagctggg
      721 cagcatgcac tctccgttca gggcccgctc agaacctgag gacccagtca cggagcggtc
      781 ggccttcacg gagcgggatg ctgggagcgg gctggtgacg cgtctccgtg agcggccagc
      841 cctgctggtc agcagcacga gctggacaga ggacgaagac ttctccatcc tgctggcagc
      901 tttagaaaag tttgaacaac tgactcttga tggacacaac cttccttctc tcgtctgtgt
      961 gataacaggc aaagggcctc tgagggagta ttatagccgc ctcatccacc agaagcactt
     1021 ccagcacatc caggtctgca ccccctggct ggaggccgag gactaccccc tgcttctagg
     1081 gtcggcggac ctgggtgtct gtctgcacac gtcctccagt ggcctggacc tgcccatgaa
     1141 ggtggtggac atgttcgggt gctgtttgcc tgtgtgtgct gtgaacttca agtgtttaca
     1201 tgagctggtg aaacatgaag aaaatggcct ggtctttgag gactcagagg aactggcagc
     1261 tcagctgcag atgcttttct caaactttcc tgatcctgcg ggcaagctaa accagttccg
     1321 gaagaacctg cgggagtcgc agcagctccg atgggatgag agctgggtgc agactgtgct
     1381 ccctttggtt atggacacat aactcctggg ccagaggcta aaaccccagg acccctgctg
     1441 tccttcccgc agcttcttct tggagtctca gggcaaaccc tttcgagcag cacctcccag
     1501 tggccagaag ctgaaatgac agcagtggta ctgcctggta aaagaattgg ttctgtgacc
     1561 cgggaagctt tggttggcct tgatttcttc tctggaggct tggaaacgct tcctctcttc
     1621 ttctgttctt cacgccccat gcccctgcta gcgtattact gttctgtgac ttccctgtga
     1681 cctctgcaga actcctcatc ctgcgtttgg tctccaggtg tcccctttct gccgtgttcc
     1741 taacattttg attcctgtct tgaaaaaagc acctgctgca ccgtaagccc agggatgtgg
     1801 cagctgcagt gggcttggct ttgtgaggaa ctgagtgtgt ccacgttggg ggaacatcat
     1861 acttgataca cacgttttta tttgcacaaa gaaaatgcta tttttggagc cagaattttc
     1921 atgtctgatt tatggtgatt ttcttaagaa ccagaactgc tggcagaaag ggggcaccca
     1981 cacgcttaga tagccgatgt cttattagag ggcagtttgt ggttcctgat ttggaaatta
     2041 acattctcca aacattccag tccaatgaaa gttttatccg ctttcccata taaaaattct
     2101 tcccatgaga gtgacttgat tctcacaatc ccgttggagt cgtgtgtgag tcctacaggg
     2161 tgagattcag cattgccatc tccaagtgct cttcgtaggg aaacagtttc tgctcatgac
     2221 gaggttccac ttcccatctg atcccggccc ggcctggaaa cagagcacat gtgtttgagg
     2281 atggcggtgt ttggggacag gacatgaggg tattgtgtgg ggctgctagg acaggcctgg
     2341 cggggtaggg gggtgtccaa gtcagtttac ttggttcaca ggttcccagg cccacccagg
     2401 tgcctagaat tggcctccag gatgggacca gaaagctggt tttgcataga aatggctagc
     2461 agcaggcacc gtgccgctgt ccactctctg cctgtgtctg ccccagcact tggcacagcg
     2521 ggacagaagc agagatctga atagtcaacc cactcttcac aaagcttaga aagcggccgg
     2581 gcacagtggc tcatgcctgt aatcccaaca ctttgggagg ccaaggcggg cggatcactt
     2641 gaggtcagga gttcgagacc agcctggcca acatggtgaa atcccatctc tacaaaaata
     2701 cagaaattag ccaggcatga tggcgagtgc ctgtaatccc agctacttgg gaggctgagg
     2761 tgggagaatt gcttgaaccc aggaggtgga ggttgcagtg agctgagatt gtgccactgc
     2821 actccagcct gagtgacagg gtgagactaa gtctcaaaaa aaaaaaaaaa aaaccacacg
     2881 caccacacac acacccacac acacacacag cttagaaggg gctgctgttc tcataagcac
     2941 agatgtctga agagccgtta gccagaatga ttcttttttt ttgttttgag atatgatctt
     3001 gttctgtcac ccaggctgga gtgcagtggc acagtcattg ctcactacag cctcgactcc
     3061 tgggctctag caatcctccc acttcctgag tagctgggat gacaggtgcg tgccaccatg
     3121 ccagtaattt ttttattttg tagagatggg gtcctgaacg catggcctca agtgatgctc
     3181 ctgcctcagc ctcttttatt atttgttttt agacgaagtt ttactctgtt ccccaggctg
     3241 gagtgcagtg gcacaatctc agctcactgc aacgcctccc aggttcaagt gattctcctg
     3301 cctcagtctc ccgagtagct ttgactatag gcgtgcacca ccacgcctgg ctaatttttg
     3361 tgtttttagt agagatgggg tttcaccatg tgggccaggc tggtcttgaa ctcgacctcc
     3421 cgtgatctgc tcacctcagc ctcccaaagc ctcagcctct tacagtgttg ggattacagg
     3481 cgtgagacac tgtgacccgg gacgattttc aatcacagtt ttttgttacg agtggaaaat
     3541 gcgtatttat aagaatgaag tagtacagac atgaatgtgt agaaatctct ataatcctgc
     3601 catccaagga tggcacctgt taatgtgtat atcagggatg tccaatcttt tggcctccct
     3661 gtgccacact ggaagaagaa gaatcgcctt gggccacgca taaaatacac taacactagc
     3721 aatacctgat gagctaaaag aaaaaaaatc acaaaaaaac ctcgtactgt ttgaagaaag
     3781 tttacagatt tgcgttgggc cgcaagttgg acaagactgc tatatgtata ttctaggttt
     3841 tcccctatag gtatacttat gtgaaaatga ttattgtgat aaattttgtt ttgagatgaa
//
