LOCUS       NM_005165               1608 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens aldolase, fructose-bisphosphate C (ALDOC), mRNA.
ACCESSION   NM_005165
VERSION     NM_005165.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1608)
  AUTHORS   Chen,L., Zeng,Y., Ren,B., Wang,X., Zhao,F., Du,J., Zhang,R. and
            Deng,J.
  TITLE     ALDOC regulated the biological function and immune infiltration of
            gastric cancer cells
  JOURNAL   Int J Biochem Cell Biol 158, 106407 (2023)
   PUBMED   36997056
  REMARK    GeneRIF: ALDOC regulated the biological function and immune
            infiltration of gastric cancer cells.
REFERENCE   2  (bases 1 to 1608)
  AUTHORS   De Vitis,C., Battaglia,A.M., Pallocca,M., Santamaria,G.,
            Mimmi,M.C., Sacco,A., De Nicola,F., Gaspari,M., Salvati,V.,
            Ascenzi,F., Bruschini,S., Esposito,A., Ricci,G., Sperandio,E.,
            Massacci,A., Prestagiacomo,L.E., Vecchione,A., Ricci,A.,
            Sciacchitano,S., Salerno,G., French,D., Aversa,I., Cereda,C.,
            Fanciulli,M., Chiaradonna,F., Solito,E., Cuda,G., Costanzo,F.,
            Ciliberto,G., Mancini,R. and Biamonte,F.
  TITLE     ALDOC- and ENO2- driven glucose metabolism sustains 3D tumor
            spheroids growth regardless of nutrient environmental conditions: a
            multi-omics analysis
  JOURNAL   J Exp Clin Cancer Res 42 (1), 69 (2023)
   PUBMED   36945054
  REMARK    GeneRIF: ALDOC- and ENO2- driven glucose metabolism sustains 3D
            tumor spheroids growth regardless of nutrient environmental
            conditions: a multi-omics analysis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1608)
  AUTHORS   Chevalier,B., Baatallah,N., Najm,M., Castanier,S., Jung,V.,
            Pranke,I., Golec,A., Stoven,V., Marullo,S., Antigny,F.,
            Guerrera,I.C., Sermet-Gaudelus,I., Edelman,A. and Hinzpeter,A.
  TITLE     Differential CFTR-Interactome Proximity Labeling Procedures
            Identify Enrichment in Multiple SLC Transporters
  JOURNAL   Int J Mol Sci 23 (16), 8937 (2022)
   PUBMED   36012204
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1608)
  AUTHORS   Maruyama,R., Nagaoka,Y., Ishikawa,A., Akabane,S., Fujiki,Y.,
            Taniyama,D., Sentani,K. and Oue,N.
  TITLE     Overexpression of aldolase, fructose-bisphosphate C and its
            association with spheroid formation in colorectal cancer
  JOURNAL   Pathol Int 72 (3), 176-186 (2022)
   PUBMED   35147255
  REMARK    GeneRIF: Overexpression of aldolase, fructose-bisphosphate C and
            its association with spheroid formation in colorectal cancer.
REFERENCE   5  (bases 1 to 1608)
  AUTHORS   Lim,S.H., Snider,J., Birimberg-Schwartz,L., Ip,W., Serralha,J.C.,
            Botelho,H.M., Lopes-Pacheco,M., Pinto,M.C., Moutaoufik,M.T.,
            Zilocchi,M., Laselva,O., Esmaeili,M., Kotlyar,M., Lyakisheva,A.,
            Tang,P., Lopez Vazquez,L., Akula,I., Aboualizadeh,F., Wong,V.,
            Grozavu,I., Opacak-Bernardi,T., Yao,Z., Mendoza,M., Babu,M.,
            Jurisica,I., Gonska,T., Bear,C.E., Amaral,M.D. and Stagljar,I.
  TITLE     CFTR interactome mapping using the mammalian membrane two-hybrid
            high-throughput screening system
  JOURNAL   Mol Syst Biol 18 (2), e10629 (2022)
   PUBMED   35156780
REFERENCE   6  (bases 1 to 1608)
  AUTHORS   Buono,P., Mancini,F.P., Izzo,P. and Salvatore,F.
  TITLE     Characterization of the transcription-initiation site and of the
            promoter region within the 5' flanking region of the human aldolase
            C gene
  JOURNAL   Eur J Biochem 192 (3), 805-811 (1990)
   PUBMED   2209624
REFERENCE   7  (bases 1 to 1608)
  AUTHORS   Rocchi,M., Vitale,E., Covone,A., Romeo,G., Santamaria,R., Buono,P.,
            Paolella,G. and Salvatore,F.
  TITLE     Assignment of human aldolase C gene to chromosome 17, region
            cen----q21.1
  JOURNAL   Hum Genet 82 (3), 279-282 (1989)
   PUBMED   2731939
REFERENCE   8  (bases 1 to 1608)
  AUTHORS   Buono,P., Paolella,G., Mancini,F.P., Izzo,P. and Salvatore,F.
  TITLE     The complete nucleotide sequence of the gene coding for the human
            aldolase C
  JOURNAL   Nucleic Acids Res 16 (10), 4733 (1988)
   PUBMED   3267224
REFERENCE   9  (bases 1 to 1608)
  AUTHORS   Tolan,D.R., Niclas,J., Bruce,B.D. and Lebo,R.V.
  TITLE     Evolutionary implications of the human aldolase-A, -B, -C, and
            -pseudogene chromosome locations
  JOURNAL   Am J Hum Genet 41 (5), 907-924 (1987)
   PUBMED   3674018
REFERENCE   10 (bases 1 to 1608)
  AUTHORS   Rottmann,W.H., Deselms,K.R., Niclas,J., Camerato,T., Holman,P.S.,
            Green,C.J. and Tolan,D.R.
  TITLE     The complete amino acid sequence of the human aldolase C isozyme
            derived from genomic clones
  JOURNAL   Biochimie 69 (2), 137-145 (1987)
   PUBMED   3105602
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005726.1, AF054987.1 and
            BF345067.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005165.2.
            
            Summary: This gene encodes a member of the class I
            fructose-biphosphate aldolase gene family. Expressed specifically
            in the hippocampus and Purkinje cells of the brain, the encoded
            protein is a glycolytic enzyme that catalyzes the reversible aldol
            cleavage of fructose-1,6-biphosphate and fructose 1-phosphate to
            dihydroxyacetone phosphate and either glyceraldehyde-3-phosphate or
            glyceraldehyde, respectively. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.124528.1,
                                           SRR3476690.1069107.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586, SAMEA2146236
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000226253.9/ ENSP00000226253.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                AC005726.1         80917-80967
            52-1607             AF054987.1         1-1556
            1608-1608           BF345067.1         153-153
FEATURES             Location/Qualifiers
     source          1..1608
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..1608
                     /gene="ALDOC"
                     /gene_synonym="ALDC"
                     /note="aldolase, fructose-bisphosphate C"
                     /db_xref="GeneID:230"
                     /db_xref="HGNC:HGNC:418"
                     /db_xref="MIM:103870"
     exon            1..95
                     /gene="ALDOC"
                     /gene_synonym="ALDC"
                     /inference="alignment:Splign:2.1.0"
     exon            96..219
                     /gene="ALDOC"
                     /gene_synonym="ALDC"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..1202
                     /gene="ALDOC"
                     /gene_synonym="ALDC"
                     /EC_number="4.1.2.13"
                     /note="fructoaldolase C; aldolase 3; brain-type aldolase;
                     fructose-1,6-biphosphate triosephosphate lyase; aldolase
                     C, fructose-bisphosphate; epididymis secretory sperm
                     binding protein"
                     /codon_start=1
                     /product="fructose-bisphosphate aldolase C"
                     /protein_id="NP_005156.1"
                     /db_xref="CCDS:CCDS11236.1"
                     /db_xref="GeneID:230"
                     /db_xref="HGNC:HGNC:418"
                     /db_xref="MIM:103870"
                     /translation="MPHSYPALSAEQKKELSDIALRIVAPGKGILAADESVGSMAKRL
                     SQIGVENTEENRRLYRQVLFSADDRVKKCIGGVIFFHETLYQKDDNGVPFVRTIQDKG
                     IVVGIKVDKGVVPLAGTDGETTTQGLDGLSERCAQYKKDGADFAKWRCVLKISERTPS
                     ALAILENANVLARYASICQQNGIVPIVEPEILPDGDHDLKRCQYVTEKVLAAVYKALS
                     DHHVYLEGTLLKPNMVTPGHACPIKYTPEEIAMATVTALRRTVPPAVPGVTFLSGGQS
                     EEEASFNLNAINRCPLPRPWALTFSYGRALQASALNAWRGQRDNAGAATEEFIKRAEV
                     NGLAAQGKYEGSGEDGGAAAQSLYIANHAY"
     exon            220..431
                     /gene="ALDOC"
                     /gene_synonym="ALDC"
                     /inference="alignment:Splign:2.1.0"
     exon            432..486
                     /gene="ALDOC"
                     /gene_synonym="ALDC"
                     /inference="alignment:Splign:2.1.0"
     exon            487..647
                     /gene="ALDOC"
                     /gene_synonym="ALDC"
                     /inference="alignment:Splign:2.1.0"
     exon            648..731
                     /gene="ALDOC"
                     /gene_synonym="ALDC"
                     /inference="alignment:Splign:2.1.0"
     exon            732..906
                     /gene="ALDOC"
                     /gene_synonym="ALDC"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1106
                     /gene="ALDOC"
                     /gene_synonym="ALDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1608
                     /gene="ALDOC"
                     /gene_synonym="ALDC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1590..1595
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALDOC"
                     /gene_synonym="ALDC"
                     /note="hexamer: AATAAA"
     polyA_site      1608
                     /gene="ALDOC"
                     /gene_synonym="ALDC"
                     /note="major polyA site"
ORIGIN      
        1 atttaccaga gggagccagg gctgcagcct catctgtttg cggatcagaa cccgagctgt
       61 gcttgtggct gcggctgcta actggctgcg cacagggagc tgtcaccatg cctcactcgt
      121 acccagccct ttctgctgag cagaagaagg agttgtctga cattgccctg cggattgtag
      181 ccccgggcaa aggcattctg gctgcggatg agtctgtagg cagcatggcc aagcggctga
      241 gccaaattgg ggtggaaaac acagaggaga accgccggct gtaccgccag gtcctgttca
      301 gtgctgatga ccgtgtgaaa aagtgcattg gaggcgtcat tttcttccat gagaccctct
      361 accagaaaga tgataatggt gttcccttcg tccgaaccat ccaggataag ggcatcgtcg
      421 tgggcatcaa ggttgacaag ggtgtggtgc ctctagctgg gactgatgga gaaaccacca
      481 ctcaagggct ggatgggctc tcagaacgct gtgcccaata caagaaggat ggtgctgact
      541 ttgccaagtg gcgctgtgtg ctgaaaatca gtgagcgtac accctctgca cttgccattc
      601 tggagaacgc caacgtgctg gcccgttatg ccagtatctg ccagcagaat ggcattgtgc
      661 ctattgtgga acctgaaata ttgcctgatg gagaccacga cctcaaacgt tgtcagtatg
      721 ttacagagaa ggtcttggct gctgtgtaca aggccctgag tgaccatcat gtatacctgg
      781 aggggaccct gctcaagccc aacatggtga ccccgggcca tgcctgtccc atcaagtata
      841 ccccagagga gattgccatg gcaactgtca ctgccctgcg tcgcactgtg cccccagctg
      901 tcccaggagt gaccttcctg tctgggggtc agagcgaaga agaggcatca ttcaacctca
      961 atgccatcaa ccgctgcccc cttccccgac cctgggcgct taccttctcc tatgggcgtg
     1021 ccctgcaagc ctctgcactc aatgcctggc gagggcaacg ggacaatgct ggggctgcca
     1081 ctgaggagtt catcaagcgg gctgaggtga atgggcttgc agcccagggc aagtatgaag
     1141 gcagtggaga agatggtgga gcagcagcac agtcactcta cattgccaac catgcctact
     1201 gagtatccac tccataccac agcccttggc ccagccatct gcacccactt ttgcttgtag
     1261 tcatggccag ggccaaatag ctatgcagag cagagatgcc ttcacctggc accaacttgt
     1321 cttcctttct ctcttccctt cccctctctc attgctgcac ctgggaccat aggatgggag
     1381 gatagggagc ccctcatgac tgagggcaga agaaattgct agaagtcaga acaggatggc
     1441 tgggtctccc cctacctctt ccagctccca caattttccc atgatgaggt agcttctccc
     1501 tgggctctcc ttcttgcctg ccctgtctcc tgggatcaga gggtagtaca gaagccctga
     1561 ctcatgcctt gagtacatac catacagcaa ataaatggta gcaaaaca
//
