LOCUS       NM_000035               2420 bp    mRNA    linear   PRI 06-OCT-2024
DEFINITION  Homo sapiens aldolase, fructose-bisphosphate B (ALDOB), mRNA.
ACCESSION   NM_000035
VERSION     NM_000035.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2420)
  AUTHORS   Wu,L., Dong,J., Fei,D., Le,T., Xiao,L., Liu,J. and Yu,Z.
  TITLE     Fructose-1, 6-Bisphosphate Aldolase B Suppresses Glycolysis and
            Tumor Progression of Gastric Cancer
  JOURNAL   Dig Dis Sci 69 (9), 3290-3304 (2024)
   PUBMED   39068380
  REMARK    GeneRIF: Fructose-1, 6-Bisphosphate Aldolase B Suppresses
            Glycolysis and Tumor Progression of Gastric Cancer.
REFERENCE   2  (bases 1 to 2420)
  AUTHORS   Zheng,Y., Huang,Y., Li,W. and Cheng,H.
  TITLE     MRTO4 Enhances Glycolysis to Facilitate HCC Progression by
            Inhibiting ALDOB
  JOURNAL   Med Sci Monit 30, e944685 (2024)
   PUBMED   38778508
  REMARK    GeneRIF: MRTO4 Enhances Glycolysis to Facilitate HCC Progression by
            Inhibiting ALDOB.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2420)
  AUTHORS   Liu,X., Xin,S., Zheng,J., Liu,H., Zeng,Y., Wu,X., Zhang,F.,
            Zeng,X., Zou,Y. and Lai,H.
  TITLE     Associations between ALDOB polymorphisms and intrahepatic
            cholestasis of pregnancy susceptibility in the Chinese Han
            population
  JOURNAL   Ginekol Pol 95 (2), 132-142 (2024)
   PUBMED   37743645
  REMARK    GeneRIF: Associations between ALDOB polymorphisms and intrahepatic
            cholestasis of pregnancy susceptibility in the Chinese Han
            population.
REFERENCE   4  (bases 1 to 2420)
  AUTHORS   Chu,Y.D., Cheng,L.C., Lim,S.N., Lai,M.W., Yeh,C.T. and Lin,W.R.
  TITLE     Aldolase B-driven lactagenesis and CEACAM6 activation promote cell
            renewal and chemoresistance in colorectal cancer through the
            Warburg effect
  JOURNAL   Cell Death Dis 14 (10), 660 (2023)
   PUBMED   37816733
  REMARK    GeneRIF: Aldolase B-driven lactagenesis and CEACAM6 activation
            promote cell renewal and chemoresistance in colorectal cancer
            through the Warburg effect.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2420)
  AUTHORS   Li,Y., Tang,S., Shi,X., Lv,J., Wu,X., Zhang,Y., Wang,H., He,J.,
            Zhu,Y., Ju,Y., Zhang,Y., Guo,S., Yang,W., Yin,H., Chen,L., Gao,D.
            and Jin,G.
  TITLE     Metabolic classification suggests the GLUT1/ALDOB/G6PD axis as a
            therapeutic target in chemotherapy-resistant pancreatic cancer
  JOURNAL   Cell Rep Med 4 (9), 101162 (2023)
   PUBMED   37597521
  REMARK    GeneRIF: Metabolic classification suggests the GLUT1/ALDOB/G6PD
            axis as a therapeutic target in chemotherapy-resistant pancreatic
            cancer.
REFERENCE   6  (bases 1 to 2420)
  AUTHORS   Gaughan,S., Ayres,L. and Baker,P.R. II.
  TITLE     Hereditary Fructose Intolerance
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   26677512
REFERENCE   7  (bases 1 to 2420)
  AUTHORS   Cross,N.C., Stojanov,L.M. and Cox,T.M.
  TITLE     A new aldolase B variant, N334K, is a common cause of hereditary
            fructose intolerance in Yugoslavia
  JOURNAL   Nucleic Acids Res 18 (7), 1925 (1990)
   PUBMED   2336380
REFERENCE   8  (bases 1 to 2420)
  AUTHORS   Cross,N.C., de Franchis,R., Sebastio,G., Dazzo,C., Tolan,D.R.,
            Gregori,C., Odievre,M., Vidailhet,M., Romano,V., Mascali,G. et al.
  TITLE     Molecular analysis of aldolase B genes in hereditary fructose
            intolerance
  JOURNAL   Lancet 335 (8685), 306-309 (1990)
   PUBMED   1967768
REFERENCE   9  (bases 1 to 2420)
  AUTHORS   Sakakibara,M., Takahashi,I., Takasaki,Y., Mukai,T. and Hori,K.
  TITLE     Construction and expression of human aldolase A and B expression
            plasmids in Escherichia coli host
  JOURNAL   Biochim Biophys Acta 1007 (3), 334-342 (1989)
   PUBMED   2649152
REFERENCE   10 (bases 1 to 2420)
  AUTHORS   Sakakibara,M., Mukai,T., Yatsuki,H. and Hori,K.
  TITLE     Human aldolase isozyme gene: the structure of multispecies aldolase
            B mRNAs
  JOURNAL   Nucleic Acids Res 13 (14), 5055-5069 (1985)
   PUBMED   2410860
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from X02747.1, AL353621.19 and
            AW242415.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jul 11, 2018 this sequence version replaced NM_000035.3.
            
            Summary: Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a
            tetrameric glycolytic enzyme that catalyzes the reversible
            conversion of fructose-1,6-bisphosphate to glyceraldehyde
            3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3
            aldolase isozymes which are distinguished by their electrophoretic
            and catalytic properties. Differences indicate that aldolases A, B,
            and C are distinct proteins, the products of a family of related
            'housekeeping' genes exhibiting developmentally regulated
            expression of the different isozymes. The developing embryo
            produces aldolase A, which is produced in even greater amounts in
            adult muscle where it can be as much as 5% of total cellular
            protein. In adult liver, kidney and intestine, aldolase A
            expression is repressed and aldolase B is produced. In brain and
            other nervous tissue, aldolase A and C are expressed about equally.
            There is a high degree of homology between aldolase A and C.
            Defects in ALDOB cause hereditary fructose intolerance. [provided
            by RefSeq, Dec 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290795.1, SRR5189664.143737.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2144835
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000647789.2/ ENSP00000497767.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1239              X02747.1           50-1288
            1240-2402           AL353621.19        44287-45449         c
            2403-2420           AW242415.1         4-21                c
FEATURES             Location/Qualifiers
     source          1..2420
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q31.1"
     gene            1..2420
                     /gene="ALDOB"
                     /gene_synonym="ALDB; ALDO2"
                     /note="aldolase, fructose-bisphosphate B"
                     /db_xref="GeneID:229"
                     /db_xref="HGNC:HGNC:417"
                     /db_xref="MIM:612724"
     exon            1..66
                     /gene="ALDOB"
                     /gene_synonym="ALDB; ALDO2"
                     /inference="alignment:Splign:2.1.0"
     exon            67..188
                     /gene="ALDOB"
                     /gene_synonym="ALDB; ALDO2"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..1171
                     /gene="ALDOB"
                     /gene_synonym="ALDB; ALDO2"
                     /EC_number="4.1.2.13"
                     /note="aldolase 2; aldolase B, fructose-bisphosphatase;
                     liver-type aldolase; aldolase B, fructose-bisphosphate"
                     /codon_start=1
                     /product="fructose-bisphosphate aldolase B"
                     /protein_id="NP_000026.2"
                     /db_xref="CCDS:CCDS6756.1"
                     /db_xref="GeneID:229"
                     /db_xref="HGNC:HGNC:417"
                     /db_xref="MIM:612724"
                     /translation="MAHRFPALTQEQKKELSEIAQSIVANGKGILAADESVGTMGNRL
                     QRIKVENTEENRRQFREILFSVDSSINQSIGGVILFHETLYQKDSQGKLFRNILKEKG
                     IVVGIKLDQGGAPLAGTNKETTIQGLDGLSERCAQYKKDGVDFGKWRAVLRIADQCPS
                     SLAIQENANALARYASICQQNGLVPIVEPEVIPDGDHDLEHCQYVTEKVLAAVYKALN
                     DHHVYLEGTLLKPNMVTAGHACTKKYTPEQVAMATVTALHRTVPAAVPGICFLSGGMS
                     EEDATLNLNAINLCPLPKPWKLSFSYGRALQASALAAWGGKAANKEATQEAFMKRAMA
                     NCQAAKGQYVHTGSSGAASTQSLFTACYTY"
     exon            189..400
                     /gene="ALDOB"
                     /gene_synonym="ALDB; ALDO2"
                     /inference="alignment:Splign:2.1.0"
     exon            401..455
                     /gene="ALDOB"
                     /gene_synonym="ALDB; ALDO2"
                     /inference="alignment:Splign:2.1.0"
     exon            456..616
                     /gene="ALDOB"
                     /gene_synonym="ALDB; ALDO2"
                     /inference="alignment:Splign:2.1.0"
     exon            617..700
                     /gene="ALDOB"
                     /gene_synonym="ALDB; ALDO2"
                     /inference="alignment:Splign:2.1.0"
     exon            701..875
                     /gene="ALDOB"
                     /gene_synonym="ALDB; ALDO2"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1075
                     /gene="ALDOB"
                     /gene_synonym="ALDB; ALDO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..2420
                     /gene="ALDOB"
                     /gene_synonym="ALDB; ALDO2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1579
                     /gene="ALDOB"
                     /gene_synonym="ALDB; ALDO2"
                     /note="major polyA site"
     regulatory      1582..1587
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALDOB"
                     /gene_synonym="ALDB; ALDO2"
                     /note="hexamer: AATAAA"
     polyA_site      1604
                     /gene="ALDOB"
                     /gene_synonym="ALDB; ALDO2"
                     /note="major polyA site"
     regulatory      1911..1916
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALDOB"
                     /gene_synonym="ALDB; ALDO2"
                     /note="hexamer: ATTAAA"
     polyA_site      1933
                     /gene="ALDOB"
                     /gene_synonym="ALDB; ALDO2"
     regulatory      2093..2098
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALDOB"
                     /gene_synonym="ALDB; ALDO2"
                     /note="hexamer: AGTAAA"
     polyA_site      2112
                     /gene="ALDOB"
                     /gene_synonym="ALDB; ALDO2"
     regulatory      2389..2394
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALDOB"
                     /gene_synonym="ALDB; ALDO2"
                     /note="hexamer: ATTAAA"
     polyA_site      2416
                     /gene="ALDOB"
                     /gene_synonym="ALDB; ALDO2"
ORIGIN      
        1 cttatttggc agctgctgcc tcacccacag cttttgatat ctaggaggac tcttctctcc
       61 caaactacct gtcaccatgg cccaccgatt tccagccctc acccaggagc agaagaagga
      121 gctctcagaa attgcccaga gcattgttgc caatggaaag gggatcctgg ctgcagatga
      181 atctgtaggt accatgggga accgcctgca gaggatcaag gtggaaaaca ctgaagagaa
      241 ccgccggcag ttccgagaaa tcctcttctc tgtggacagt tccatcaacc agagcatcgg
      301 gggtgtgatc cttttccacg agaccctcta ccagaaggac agccagggaa agctgttcag
      361 aaacatcctc aaggaaaagg ggatcgtggt gggaatcaag ttagaccaag gaggtgctcc
      421 tcttgcagga acaaacaaag aaaccaccat tcaagggctt gatggcctct cagagcgctg
      481 tgctcagtac aagaaagatg gtgttgactt tgggaagtgg cgtgctgtgc tgaggattgc
      541 cgaccagtgt ccatccagcc tcgctatcca ggaaaacgcc aacgccctgg ctcgctacgc
      601 cagcatctgt cagcagaatg gactggtacc tattgttgaa ccagaggtaa ttcctgatgg
      661 agaccatgac ctggaacact gccagtatgt tactgagaag gtcctggctg ctgtctacaa
      721 ggccctgaat gaccatcatg tttacctgga gggcaccctg ctaaagccca acatggtgac
      781 tgctggacat gcctgcacca agaagtatac tccagaacaa gtagctatgg ccaccgtaac
      841 agctctccac cgtactgttc ctgcagctgt tcctggcatc tgctttttgt ctggtggcat
      901 gagtgaagag gatgccactc tcaacctcaa tgctatcaac ctttgccctc taccaaagcc
      961 ctggaaacta agtttctctt atggacgggc cctgcaggcc agtgcactgg ctgcctgggg
     1021 tggcaaggct gcaaacaagg aggcaaccca ggaggctttt atgaagcggg ccatggctaa
     1081 ctgccaggcg gccaaaggac agtatgttca cacgggttct tctggggctg cttccaccca
     1141 gtcgctcttc acagcctgct atacctacta gggtccaatg cccgccagcc tagctccagt
     1201 gcttctagta ggagggctga aagggagcaa cttttcctcc aatcctggaa attcgacaca
     1261 attagatttg aactgctgga aatacaacac atgttaaatc ttaagtacaa gggggaaaaa
     1321 ataaatcagt tattgaaaca taaaaatgaa taccaaggac ctgatcaaat ttcacacagc
     1381 agtttccttg caacactttc agctccccat gctccagaat acccacccaa gaaaataata
     1441 ggctttaaaa caatatcggc tcctcatcca aagaacaact gctgattgaa acacctcatt
     1501 agctgagtgt agagaagtgc atcttatgaa acagtcttag cagtggtagg ttgggaagga
     1561 gatagctgca accaaaaaag aaataaatat tctataaacc ttcagctgct atcgggtttc
     1621 acttttctgc tcttgctgtc caaagactca gtgtatttca ttacttttga ctctactaga
     1681 catgactggg tttcaacagt aaaggtcttc aactcttgct agtcattgga atcaagccgc
     1741 aaaattttaa aaactgagat gctcaggcca caccccagct caattaaatc agaaacccta
     1801 gacttgggat cctctaacta ttagatttct taaagctccc tcagtaattc caatgtacag
     1861 tcaagtttga gaactaccaa tctaaatttc aagtttgagg gtatttgaaa attaaagcca
     1921 ttcacaatac gaagccagct aaaaatgtag aatgattttg agcaacttgt ggagtataat
     1981 aagagaatta atgtgacttc aatgcttgga gcattcttgt tcaagtggcc caggtttggt
     2041 gaaacaggac taccttgtca tctgcacgtc caggcatatt tcgtagtttt gcagtaaata
     2101 atattcacat aatgatactg tattgacttt caattttcag aattaaccta tagttacagc
     2161 acttaagaca accagagtta taaaagagaa tttaaatatt ataactttgg acaatataaa
     2221 agtgatgatt taactgacag aagctaggaa atataagggg gaggagaagt ggaagaaagc
     2281 aaagagagtc aggaatacta cttaaaactg atgggttaag aaatagtgct ttaattctat
     2341 ttaagtaata aaagaaatgg atgtaaatca taaaaatata tatctaaaat taaaatattg
     2401 atggtagtat gctaaatttc
//
