LOCUS       NM_001182               4765 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens aldehyde dehydrogenase 7 family member A1 (ALDH7A1),
            transcript variant 1, mRNA.
ACCESSION   NM_001182 XM_937964
VERSION     NM_001182.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4765)
  AUTHORS   Korasick,D.A., Buckley,D.P., Palpacelli,A., Cursio,I., Cesaroni,E.,
            Cheng,J. and Tanner,J.J.
  TITLE     Biochemical, structural, and computational analyses of two new
            clinically identified missense mutations of ALDH7A1
  JOURNAL   Chem Biol Interact 394, 110993 (2024)
   PUBMED   38604394
  REMARK    GeneRIF: Biochemical, structural, and computational analyses of two
            new clinically identified missense mutations of ALDH7A1.
REFERENCE   2  (bases 1 to 4765)
  AUTHORS   Lu,H.J., Chuang,C.Y., Chen,M.K., Su,C.W., Yang,W.E., Yeh,C.M.,
            Lai,K.M., Tang,C.H., Lin,C.W. and Yang,S.F.
  TITLE     The impact of ALDH7A1 variants in oral cancer development and
            prognosis
  JOURNAL   Aging (Albany NY) 14 (10), 4556-4571 (2022)
   PUBMED   35613852
  REMARK    GeneRIF: The impact of ALDH7A1 variants in oral cancer development
            and prognosis.
REFERENCE   3  (bases 1 to 4765)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   4  (bases 1 to 4765)
  AUTHORS   Tan,M., Meng,J., Sun,X., Fu,X. and Wang,R.
  TITLE     EPS8 supports pancreatic cancer growth by inhibiting BMI1 mediated
            proteasomal degradation of ALDH7A1
  JOURNAL   Exp Cell Res 407 (1), 112782 (2021)
   PUBMED   34391775
  REMARK    GeneRIF: EPS8 supports pancreatic cancer growth by inhibiting BMI1
            mediated proteasomal degradation of ALDH7A1.
REFERENCE   5  (bases 1 to 4765)
  AUTHORS   Brocker,C., Lassen,N., Estey,T., Pappa,A., Cantore,M., Orlova,V.V.,
            Chavakis,T., Kavanagh,K.L., Oppermann,U. and Vasiliou,V.
  TITLE     Aldehyde dehydrogenase 7A1 (ALDH7A1) is a novel enzyme involved in
            cellular defense against hyperosmotic stress
  JOURNAL   J Biol Chem 285 (24), 18452-18463 (2010)
   PUBMED   20207735
  REMARK    GeneRIF: ALDH7A1 is a novel aldehyde dehydrogenase expressed in
            multiple subcellular compartments that protects against
            hyperosmotic stress by generating osmolytes and metabolizing toxic
            aldehydes
REFERENCE   6  (bases 1 to 4765)
  AUTHORS   Wong,J.W., Chan,C.L., Tang,W.K., Cheng,C.H. and Fong,W.P.
  TITLE     Is antiquitin a mitochondrial Enzyme?
  JOURNAL   J Cell Biochem 109 (1), 74-81 (2010)
   PUBMED   19885858
  REMARK    GeneRIF: antiquitin was present not only in the cytosol but also in
            the mitochondria.
REFERENCE   7  (bases 1 to 4765)
  AUTHORS   Cormier-Daire,V., Dagoneau,N., Nabbout,R., Burglen,L., Penet,C.,
            Soufflet,C., Desguerre,I., Munnich,A. and Dulac,O.
  TITLE     A gene for pyridoxine-dependent epilepsy maps to chromosome 5q31
  JOURNAL   Am J Hum Genet 67 (4), 991-993 (2000)
   PUBMED   10978228
REFERENCE   8  (bases 1 to 4765)
  AUTHORS   Skvorak,A.B., Robertson,N.G., Yin,Y., Weremowicz,S., Her,H.,
            Bieber,F.R., Beisel,K.W., Lynch,E.D., Beier,D.R. and Morton,C.C.
  TITLE     An ancient conserved gene expressed in the human inner ear:
            identification, expression analysis, and chromosomal mapping of
            human and mouse antiquitin (ATQ1)
  JOURNAL   Genomics 46 (2), 191-199 (1997)
   PUBMED   9417906
REFERENCE   9  (bases 1 to 4765)
  AUTHORS   Lee,P., Kuhl,W., Gelbart,T., Kamimura,T., West,C. and Beutler,E.
  TITLE     Homology between a human protein and a protein of the green garden
            pea
  JOURNAL   Genomics 21 (2), 371-378 (1994)
   PUBMED   8088832
REFERENCE   10 (bases 1 to 4765)
  AUTHORS   Gospe,S.M. Jr.
  TITLE     Pyridoxine-Dependent Epilepsy - ALDH7A1
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301659
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC099513.3 and AC093535.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_001182.4.
            
            Summary: The protein encoded by this gene is a member of subfamily
            7 in the aldehyde dehydrogenase gene family. These enzymes are
            thought to play a major role in the detoxification of aldehydes
            generated by alcohol metabolism and lipid peroxidation. This
            particular member has homology to a previously described protein
            from the green garden pea, the 26g pea turgor protein. It is also
            involved in lysine catabolism that is known to occur in the
            mitochondrial matrix. Recent reports show that this protein is
            found both in the cytosol and the mitochondria, and the two forms
            likely arise from the use of alternative translation initiation
            sites. An additional variant encoding a different isoform has also
            been found for this gene. Mutations in this gene are associated
            with pyridoxine-dependent epilepsy. Several related pseudogenes
            have also been identified. [provided by RefSeq, Jan 2011].
            
            Transcript Variant: This variant (1) encodes two isoforms resulting
            from the use of alternative in-frame translation initiation codons.
            The longer isoform (1) is derived from an upstream AUG (at nt
            193-195), while the shorter isoform (2) is derived from a
            downstream AUG (at nt 277-279). This RefSeq represents the longer
            isoform, which resides in the mitochondria (PMIDs: 20207735 and
            19885858).
            
            Sequence Note: This Refseq, containing three potential in-frame
            translation initiation codons (all with weak Kozak signals), is
            annotated with a CDS starting from a downstream start codon (at nt
            193-195) based on better conservation, N-terminal consistency with
            homologous proteins, and the presence of a transit peptide, which
            is essential for the localization of this isoform in the
            mitochondria (PMIDs: 20207735 and 19885858), and is consistent with
            the function of this gene in lysine catabolism (which is known to
            occur in the mitochondria). The use of an upstream start codon (at
            nt 112-114) that is present in only a subset of higher mammals,
            would increase the protein length by 27 aa. A shorter, soluble
            isoform resulting from the use of another downstream start codon
            (at nt 277-279) is represented in a separate RefSeq
            (NM_001201377.1). This RefSeq record was created from transcript
            and genomic sequence data to make the sequence consistent with the
            reference genome assembly. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.67118.1,
                                           SRR1660809.42696.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000409134.8/
                                                  ENSP00000387123.3
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-213               AC099513.3         53420-53632
            214-267             AC099513.3         55235-55288
            268-333             AC099513.3         55910-55975
            334-414             AC099513.3         64627-64707
            415-538             AC099513.3         65665-65788
            539-671             AC099513.3         71428-71560
            672-716             AC099513.3         73175-73219
            717-794             AC099513.3         77780-77857
            795-892             AC099513.3         80283-80380
            893-934             AC099513.3         87515-87556
            935-1029            AC099513.3         89305-89399
            1030-1114           AC099513.3         92624-92708
            1115-1221           AC099513.3         94246-94352
            1222-1338           AC099513.3         96502-96618
            1339-1436           AC099513.3         98346-98443
            1437-1510           AC099513.3         98637-98710
            1511-1586           AC099513.3         102240-102315
            1587-4765           AC093535.2         129161-132339       c
FEATURES             Location/Qualifiers
     source          1..4765
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q23.2"
     gene            1..4765
                     /gene="ALDH7A1"
                     /gene_synonym="ATQ1; EPD; EPEO4; PDE"
                     /note="aldehyde dehydrogenase 7 family member A1"
                     /db_xref="GeneID:501"
                     /db_xref="HGNC:HGNC:877"
                     /db_xref="MIM:107323"
     exon            1..213
                     /gene="ALDH7A1"
                     /gene_synonym="ATQ1; EPD; EPEO4; PDE"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1641
                     /gene="ALDH7A1"
                     /gene_synonym="ATQ1; EPD; EPEO4; PDE"
                     /EC_number="1.2.1.3"
                     /EC_number="1.2.1.8"
                     /EC_number="1.2.1.31"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; 26g turgor protein homolog; alpha-aminoadipic
                     semialdehyde dehydrogenase; alpha-AASA dehydrogenase; P6c
                     dehydrogenase; antiquitin-1; betaine aldehyde
                     dehydrogenase; delta1-piperideine-6-carboxylate
                     dehydrogenase; epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="alpha-aminoadipic semialdehyde dehydrogenase
                     isoform 1 precursor"
                     /protein_id="NP_001173.2"
                     /db_xref="CCDS:CCDS4137.2"
                     /db_xref="GeneID:501"
                     /db_xref="HGNC:HGNC:877"
                     /db_xref="MIM:107323"
                     /translation="MWRLPRALCVHAAKTSKLSGPWSRPAAFMSTLLINQPQYAWLKE
                     LGLREENEGVYNGSWGGRGEVITTYCPANNEPIARVRQASVADYEETVKKAREAWKIW
                     ADIPAPKRGEIVRQIGDALREKIQVLGSLVSLEMGKILVEGVGEVQEYVDICDYAVGL
                     SRMIGGPILPSERSGHALIEQWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWK
                     GAPTTSLISVAVTKIIAKVLEDNKLPGAICSLTCGGADIGTAMAKDERVNLLSFTGST
                     QVGKQVGLMVQERFGRSLLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTAR
                     RLFIHESIHDEVVNRLKKAYAQIRVGNPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEG
                     GTVVYGGKVMDRPGNYVEPTIVTGLGHDASIAHTETFAPILYVFKFKNEEEVFAWNNE
                     VKQGLSSSIFTKDLGRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRES
                     GSDAWKQYMRRSTCTINYSKDLPLAQGIKFQ"
     exon            214..267
                     /gene="ALDH7A1"
                     /gene_synonym="ATQ1; EPD; EPEO4; PDE"
                     /inference="alignment:Splign:2.1.0"
     exon            268..333
                     /gene="ALDH7A1"
                     /gene_synonym="ATQ1; EPD; EPEO4; PDE"
                     /inference="alignment:Splign:2.1.0"
     exon            334..414
                     /gene="ALDH7A1"
                     /gene_synonym="ATQ1; EPD; EPEO4; PDE"
                     /inference="alignment:Splign:2.1.0"
     exon            415..538
                     /gene="ALDH7A1"
                     /gene_synonym="ATQ1; EPD; EPEO4; PDE"
                     /inference="alignment:Splign:2.1.0"
     exon            539..671
                     /gene="ALDH7A1"
                     /gene_synonym="ATQ1; EPD; EPEO4; PDE"
                     /inference="alignment:Splign:2.1.0"
     exon            672..716
                     /gene="ALDH7A1"
                     /gene_synonym="ATQ1; EPD; EPEO4; PDE"
                     /inference="alignment:Splign:2.1.0"
     exon            717..794
                     /gene="ALDH7A1"
                     /gene_synonym="ATQ1; EPD; EPEO4; PDE"
                     /inference="alignment:Splign:2.1.0"
     exon            795..892
                     /gene="ALDH7A1"
                     /gene_synonym="ATQ1; EPD; EPEO4; PDE"
                     /inference="alignment:Splign:2.1.0"
     exon            893..934
                     /gene="ALDH7A1"
                     /gene_synonym="ATQ1; EPD; EPEO4; PDE"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1029
                     /gene="ALDH7A1"
                     /gene_synonym="ATQ1; EPD; EPEO4; PDE"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1114
                     /gene="ALDH7A1"
                     /gene_synonym="ATQ1; EPD; EPEO4; PDE"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1221
                     /gene="ALDH7A1"
                     /gene_synonym="ATQ1; EPD; EPEO4; PDE"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1338
                     /gene="ALDH7A1"
                     /gene_synonym="ATQ1; EPD; EPEO4; PDE"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1436
                     /gene="ALDH7A1"
                     /gene_synonym="ATQ1; EPD; EPEO4; PDE"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1510
                     /gene="ALDH7A1"
                     /gene_synonym="ATQ1; EPD; EPEO4; PDE"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1586
                     /gene="ALDH7A1"
                     /gene_synonym="ATQ1; EPD; EPEO4; PDE"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..4765
                     /gene="ALDH7A1"
                     /gene_synonym="ATQ1; EPD; EPEO4; PDE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1818..1823
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALDH7A1"
                     /gene_synonym="ATQ1; EPD; EPEO4; PDE"
                     /note="hexamer: AATAAA"
     polyA_site      1853
                     /gene="ALDH7A1"
                     /gene_synonym="ATQ1; EPD; EPEO4; PDE"
                     /note="major polyA site"
     regulatory      3357..3362
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALDH7A1"
                     /gene_synonym="ATQ1; EPD; EPEO4; PDE"
                     /note="hexamer: ATTAAA"
     polyA_site      3376
                     /gene="ALDH7A1"
                     /gene_synonym="ATQ1; EPD; EPEO4; PDE"
                     /note="major polyA site"
     regulatory      4747..4752
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALDH7A1"
                     /gene_synonym="ATQ1; EPD; EPEO4; PDE"
                     /note="hexamer: AATAAT"
     polyA_site      4765
                     /gene="ALDH7A1"
                     /gene_synonym="ATQ1; EPD; EPEO4; PDE"
ORIGIN      
        1 atcccgagtc ccgggctcag tatgtggcgc cttcctcgcg cgctgtgtgt gcacgctgca
       61 aagaccagca agctctctgg accttggagc aggcctgccg ccttcatgtc cactctcctc
      121 atcaatcagc cccagtatgc gtggctgaaa gagctggggc tccgcgagga aaacgagggc
      181 gtgtataatg gaagctgggg aggccgggga gaggttatta cgacctattg ccctgctaac
      241 aacgagccaa tagcaagagt ccgacaggcc agtgtggcag actatgaaga aactgtaaag
      301 aaagcaagag aagcatggaa aatctgggca gatattcctg ctccaaaacg aggagaaata
      361 gtaagacaga ttggcgatgc cttgcgggag aagatccaag tactaggaag cttggtgtct
      421 ttggagatgg ggaaaatctt agtggaaggt gtgggtgaag ttcaggagta tgtggatatc
      481 tgtgactatg ctgttggttt atcaaggatg attggaggac ctatcttgcc ttctgaaaga
      541 tctggccatg cactgattga gcagtggaat cccgtaggcc tggttggaat catcacggca
      601 ttcaatttcc ctgtggcagt gtatggttgg aacaacgcca tcgccatgat ctgtggaaat
      661 gtctgcctct ggaaaggagc tccaaccact tccctcatta gtgtggctgt cacaaagata
      721 atagccaagg ttctggagga caacaagctg cctggtgcaa tttgttcctt gacttgtggt
      781 ggagcagata ttggcacagc aatggccaaa gatgaacgag tgaacctgct gtccttcact
      841 gggagcactc aggtgggaaa acaggtgggc ctgatggtgc aggagaggtt tgggagaagt
      901 ctgttggaac ttggaggaaa caatgccatt attgcctttg aagatgcaga cctcagctta
      961 gttgttccat cagctctctt cgctgctgtg ggaacagctg gccagaggtg taccactgcg
     1021 aggcgactgt ttatacatga aagcatccat gatgaggttg taaacagact taaaaaggcc
     1081 tatgcacaga tccgagttgg gaacccatgg gaccctaatg ttctctatgg gccactccac
     1141 accaagcagg cagtgagcat gtttcttgga gcagtggaag aagcaaagaa agaaggtggc
     1201 acagtggtct atgggggcaa ggttatggat cgccctggaa attatgtaga accgacaatt
     1261 gtgacaggtc ttggccacga tgcgtccatt gcacacacag agacttttgc tccgattctc
     1321 tatgtcttta aattcaagaa tgaagaagag gtctttgcat ggaataatga agtaaaacag
     1381 ggactttcaa gtagcatctt taccaaagat ctgggcagaa tctttcgctg gcttggacct
     1441 aaaggatcag actgtggcat tgtaaatgtc aacattccaa caagtggggc tgagattgga
     1501 ggtgcctttg gaggagaaaa gcacactggt ggtggcaggg agtctggcag tgatgcctgg
     1561 aaacagtaca tgagaaggtc tacttgtact atcaactaca gtaaagacct tcctctggcc
     1621 caaggaatca agtttcagta aaggtgtttt agatgaacat cccttaattt gaggtgttcc
     1681 agcagctgtt tttggagaag acaaagaaaa ttaaagtttt ccctgaataa atgcattatt
     1741 atgactgtga cagtgactaa tccccctatg accccaaagc cctgattaaa tcaagagatt
     1801 ccttttttaa aaatcaaaat aaaattgtta caacatagcc atagttacta aaagatgagt
     1861 taggtggatt tttattatgt caactagttg tacatggctt tttaaaagtt aatgattatt
     1921 ttgtaattag aaaaaaatag tacgtaccag ggtaggaatt tgggaaaata cagaaccgag
     1981 gagaaaacag aagtctttgc agtagataca gggtgtctcc tgaccaagtg aaggattcag
     2041 gggcgggggg tgaatattgc ttgacattac ccacctatgg catgtgttgg atgtcgtgtg
     2101 attgaaaggg ggatgcattc ccctgtatgc ttggaccaca gttcagtatt catgtggaat
     2161 aacttgcagt gcttaaaatg acaacaggca ttcatcacag ttatggctct tgcttatgaa
     2221 ggctgtgtca acttggaaga gatttctggg gtagacagat tttgttcctg tgctggagtc
     2281 tgccacctgc tggaggactc tgaggccaaa attgcccgtg cagagttgta tagaaaatgc
     2341 gtctggaggc tgggcaaggt ggcttacgcc tataatccca gcactttgag aggccgaggc
     2401 gggtggatca gtagaggcta ggagtttgag accagcctgg ccgatatcgt gaaaccccgt
     2461 ctttaccaaa aaatacaaaa attagcccag tgtggtggca ggcacctgta atcccagcta
     2521 ttagggaggc tgaggcagga gaattgtgtg aacccaggag gcagaggttg cagtgagcct
     2581 agattgtgcc actgcctggg caacagtgag atcctgtcta caaaaaaaaa aaaaaaaaaa
     2641 agtgcatctg gattttttta tacaacctta gaccaccttc tttagcttta ggcgtctgcg
     2701 gttgcccttg gatctgttct caatcctcag tgtgtgtggc agcatgtggt catagagagc
     2761 tgggcaaagt tcactttctc tttgctgaca gtctcacctt ttctcactgg gaagctgcac
     2821 aggagccttt gggctggttc agcccagagg cccctgttct cctgccttcc tggcattctc
     2881 tgctcccctt ctgcatggca cccctctact cctgccaggt tagaatggag cagaggcctt
     2941 tgaacaagat gacatttgta gacaacctga tccatcagga tgtggagaga tctggacaaa
     3001 tggcaaataa tttggggttg aattatggcc cagagaagta agcaaatgaa aaactaaaca
     3061 attataaatg tatctgggaa gcaaaggtat tcataatatg tcccatggcc agctgcgagc
     3121 agtatttaac tagacatgct gttgtcaata ttgaacatga atcaagccaa atactgatat
     3181 agctattgag agaaggttgg caggaagaaa tcatgggtga gggtatgtgg gagtgataat
     3241 cttagctata gattttaggt aaaactgatt ctgaaagctt tctttgaaac aaatttataa
     3301 tttttcttct acatgtttct agcacaagga ctcaattttt tttggttata atgttcatta
     3361 aaacatatgc cttcaatttg ttcctctttg ttcttttttg ctgatttagc agatataaat
     3421 cacttgttag tatttttaac tatccaagtt aaaatgtaca tttgtaagtg ttattactgg
     3481 tcttatattt gaaggtgcaa ggggtcttgt gctgctcatt actggttatc ttgagcattt
     3541 cataactgct gcctcctcct aaatcctgtg ttccaaccgc tactgctggc aatgcccagc
     3601 ctccattgtg gatgcgggga attgtgttca gcatgcttgc ttctgccacg gcactaaagc
     3661 ctaacttgct taggatcttg ctgtacttgg agagagcatc cattcgctga gcctagcagc
     3721 caggctcttg tgactccctg ggaagtgggt gaagacctgg ctcctggctg cagcagtgag
     3781 gaggcaggcc ctccaggtga agacttctca caatggaggg aaggcagttt tctcaaagga
     3841 aattgagtgc tattatgtac tctgcttcct actttctctt tcagggtggg aatctgttaa
     3901 gcctcctctc tctcttgctc tgcaaccaca gaacacttct ttttttttgg tgtctcagtt
     3961 ttgcccacac tggagtgcag tggtgcaata gtggctcact gcagcctcca actcctgggc
     4021 tcaatctatc cttccacctc atgctcccca gtagctggga ctacaggtgc atgccactgt
     4081 gcccagctga ttattatttt tttttgtaaa gattgggtca tactacattg ctcatgctcg
     4141 tcttgaactt gtggcctcaa gcgatcctcc tgcctcagcc tcttgagttg ttgggattac
     4201 aggagtgtgc caccatgccc agctctgtgg aaaattctct gtggcattct gtctcctgaa
     4261 aatgctgaag ggaccaagag ggctctgtgt ccttcctctt ctcttccctg gcactttcag
     4321 accattttct tgttgccttc attctaacaa aggttgcaga ttggaaagct gatttggaat
     4381 gctttttaag tgttttcagt ttcaatattt ttatgaaatt cctatggtct ccaacaaact
     4441 tttttttttt tttttttttc tacacctgga gcttatcctg cagaagcttc ctgccaatga
     4501 ttgttttgga ggaaattaaa agaaaaccaa acgaaacctc tcctatccaa ggggaagaac
     4561 tttatcccca tattgattga atataggatt ctagatttaa aatgttgtag gcagttagag
     4621 tttgctcttt ttttttttct attggaaagg tccacaaatg ttttattgac atttttgtct
     4681 ttaatccatt tggatttggg gtacatgtta cgatttgtct acgttaattt cccttttaaa
     4741 aataaaaata attcctcaac tccaa
//
