LOCUS       NM_000694               2811 bp    mRNA    linear   PRI 08-DEC-2024
DEFINITION  Homo sapiens aldehyde dehydrogenase 3 family member B1 (ALDH3B1),
            transcript variant 1, mRNA.
ACCESSION   NM_000694
VERSION     NM_000694.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2811)
  AUTHORS   Tang,C., Xu,J., Zheng,M., Qian,D., Gao,Z., Li,X. and Zhang,W.
  TITLE     Potential clinical significance of ALDH3B1 in auxiliary diagnosis
            of gastric cancer
  JOURNAL   Biomark Med 18 (1), 15-23 (2024)
   PUBMED   38334412
  REMARK    GeneRIF: Potential clinical significance of ALDH3B1 in auxiliary
            diagnosis of gastric cancer.
REFERENCE   2  (bases 1 to 2811)
  AUTHORS   Li,Q., Qiu,Q., Zhang,L., Zhang,X., Wang,Y., Geng,Z., Ge,S., Zuo,L.,
            Song,X., Li,J. and Hu,J.
  TITLE     [ALDH3B1 expression is correlated with histopathology and long-term
            prognosis of gastric cancer]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 42 (5), 633-640 (2022)
   PUBMED   35673905
  REMARK    GeneRIF: [ALDH3B1 expression is correlated with histopathology and
            long-term prognosis of gastric cancer].
REFERENCE   3  (bases 1 to 2811)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2811)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2811)
  AUTHORS   Sun,H., Zhang,M., Li,L. and Huang,Z.
  TITLE     ALDH3B1 Is an Independent Prognostic Biomarker of Lung
            Adenocarcinoma
  JOURNAL   Technol Cancer Res Treat 19, 1533033820946018 (2020)
   PUBMED   32744175
  REMARK    GeneRIF: ALDH3B1 Is an Independent Prognostic Biomarker of Lung
            Adenocarcinoma.
REFERENCE   6  (bases 1 to 2811)
  AUTHORS   Kitamura,T., Naganuma,T., Abe,K., Nakahara,K., Ohno,Y. and
            Kihara,A.
  TITLE     Substrate specificity, plasma membrane localization, and lipid
            modification of the aldehyde dehydrogenase ALDH3B1
  JOURNAL   Biochim Biophys Acta 1831 (8), 1395-1401 (2013)
   PUBMED   23721920
  REMARK    GeneRIF: the likely physiological function of ALDH3B1 is to oxidize
            lipid-derived aldehydes generated in the plasma membrane and not to
            be involved in the sphingolipid metabolism in the endoplasmic
            reticulum.
REFERENCE   7  (bases 1 to 2811)
  AUTHORS   Jin,P., Fu,G.K., Wilson,A.D., Yang,J., Chien,D., Hawkins,P.R.,
            Au-Young,J. and Stuve,L.L.
  TITLE     PCR isolation and cloning of novel splice variant mRNAs from known
            drug target genes
  JOURNAL   Genomics 83 (4), 566-571 (2004)
   PUBMED   15028279
REFERENCE   8  (bases 1 to 2811)
  AUTHORS   Yoshida,A., Rzhetsky,A., Hsu,L.C. and Chang,C.
  TITLE     Human aldehyde dehydrogenase gene family
  JOURNAL   Eur J Biochem 251 (3), 549-557 (1998)
   PUBMED   9490025
  REMARK    Review article
REFERENCE   9  (bases 1 to 2811)
  AUTHORS   Hsu,L.C., Chang,W.C. and Yoshida,A.
  TITLE     Human aldehyde dehydrogenase genes, ALDH7 and ALDH8: genomic
            organization and gene structure comparison
  JOURNAL   Gene 189 (1), 89-94 (1997)
   PUBMED   9161417
REFERENCE   10 (bases 1 to 2811)
  AUTHORS   Hsu,L.C., Chang,W.C. and Yoshida,A.
  TITLE     Cloning of a cDNA encoding human ALDH7, a new member of the
            aldehyde dehydrogenase family
  JOURNAL   Gene 151 (1-2), 285-289 (1994)
   PUBMED   7828891
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA624671.1 and BC013584.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_000694.3.
            
            Summary: This gene encodes a member of the aldehyde dehydrogenase
            protein family. Aldehyde dehydrogenases are a family of isozymes
            that may play a major role in the detoxification of aldehydes
            generated by alcohol metabolism and lipid peroxidation. The encoded
            protein is able to oxidize long-chain fatty aldehydes in vitro, and
            may play a role in protection from oxidative stress. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Feb 2014].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a). Variants 1 and 3 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013584.2, SRR3476690.601337.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000342456.11/ ENSP00000473990.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                DA624671.1         23-47
            26-2811             BC013584.2         1-2786
FEATURES             Location/Qualifiers
     source          1..2811
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.2"
     gene            1..2811
                     /gene="ALDH3B1"
                     /gene_synonym="ALDH4; ALDH7"
                     /note="aldehyde dehydrogenase 3 family member B1"
                     /db_xref="GeneID:221"
                     /db_xref="HGNC:HGNC:410"
                     /db_xref="MIM:600466"
     exon            1..66
                     /gene="ALDH3B1"
                     /gene_synonym="ALDH4; ALDH7"
                     /inference="alignment:Splign:2.1.0"
     exon            67..229
                     /gene="ALDH3B1"
                     /gene_synonym="ALDH4; ALDH7"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..1474
                     /gene="ALDH3B1"
                     /gene_synonym="ALDH4; ALDH7"
                     /EC_number="1.2.1.5"
                     /EC_number="1.2.1.28"
                     /EC_number="1.2.1.7"
                     /EC_number="1.2.1.48"
                     /note="isoform a is encoded by transcript variant 1;
                     aldehyde dehydrogenase 3B1; aldehyde dehydrogenase 7;
                     long-chain fatty aldehyde dehydrogenase; medium-chain
                     fatty aldehyde dehydrogenase"
                     /codon_start=1
                     /product="aldehyde dehydrogenase family 3 member B1
                     isoform a"
                     /protein_id="NP_000685.1"
                     /db_xref="CCDS:CCDS73335.1"
                     /db_xref="GeneID:221"
                     /db_xref="HGNC:HGNC:410"
                     /db_xref="MIM:600466"
                     /translation="MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLL
                     HDALAQDLHKSAFESEVSEVAISQGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRK
                     EPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQ
                     SCFAVVLGGPQETGQLLEHRFDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCY
                     VDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDP
                     QSSPNLGRIINQKQFQRLRALLGCGRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEE
                     IFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFCGNDGF
                     MHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRACLLRSPGMEKLNALRYPPQSPRR
                     LRMLLVAMEAQGCSCTLL"
     exon            230..340
                     /gene="ALDH3B1"
                     /gene_synonym="ALDH4; ALDH7"
                     /inference="alignment:Splign:2.1.0"
     exon            341..461
                     /gene="ALDH3B1"
                     /gene_synonym="ALDH4; ALDH7"
                     /inference="alignment:Splign:2.1.0"
     exon            462..547
                     /gene="ALDH3B1"
                     /gene_synonym="ALDH4; ALDH7"
                     /inference="alignment:Splign:2.1.0"
     exon            548..629
                     /gene="ALDH3B1"
                     /gene_synonym="ALDH4; ALDH7"
                     /inference="alignment:Splign:2.1.0"
     exon            630..1016
                     /gene="ALDH3B1"
                     /gene_synonym="ALDH4; ALDH7"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1183
                     /gene="ALDH3B1"
                     /gene_synonym="ALDH4; ALDH7"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1283
                     /gene="ALDH3B1"
                     /gene_synonym="ALDH4; ALDH7"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..2811
                     /gene="ALDH3B1"
                     /gene_synonym="ALDH4; ALDH7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2789..2794
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALDH3B1"
                     /gene_synonym="ALDH4; ALDH7"
                     /note="hexamer: AATAAA"
     polyA_site      2811
                     /gene="ALDH3B1"
                     /gene_synonym="ALDH4; ALDH7"
                     /note="major polyA site"
ORIGIN      
        1 cttaacagca gggccaccag gcagagcggg acagccagga ggaagggcag cttggcagag
       61 cctcaggatg gacccccttg gggacacgct gcggcgactg cgggaggcct tccacgcggg
      121 gcgcacgcgg ccagctgagt tccgggctgc gcagctccaa ggcctgggcc gcttcctgca
      181 agaaaacaag cagcttctgc acgacgcact ggcccaggac ctgcacaagt cagccttcga
      241 gtcggaggtg tctgaggttg ccatcagcca gggcgaggtc accctggccc tcaggaacct
      301 ccgggcctgg atgaaggacg agcgtgtgcc caagaacctg gccacgcagc tggactccgc
      361 cttcatccgg aaggagccct ttggcctggt cctcatcatt gcgccctgga actatccgct
      421 gaacctgacg ctggtgcccc tcgtgggagc cctcgctgca gggaactgtg tggtgctgaa
      481 gccatcggag attagcaaga acgtcgagaa gatcctggcc gaggtgctgc cccaatacgt
      541 ggaccagagc tgctttgctg tggtgctggg cgggccccag gagacggggc agctgctaga
      601 gcacaggttc gactacatct tcttcacagg gagccctcgt gtgggcaaga ttgttatgac
      661 tgctgccgcc aagcacctga cacctgtcac cctggagctg gggggcaaga acccttgcta
      721 cgtggacgac aactgcgacc cccagaccgt ggccaaccgc gtggcctggt tccgctactt
      781 caacgccggc cagacctgcg tggcccccga ctacgtccta tgcagccctg agatgcagga
      841 gaggctgctg cctgccctgc agagcaccat cacccgtttc tatggcgacg acccccagag
      901 ctccccaaac ctgggccgca tcatcaacca gaaacagttc cagcggctgc gggcattgct
      961 gggctgcggc cgtgtggcca ttgggggcca gagcgatgag agcgatcgct acatcgcccc
     1021 cacggtgctg gtggatgtgc aggagatgga gcctgtgatg caggaggaga tcttcgggcc
     1081 catcctgccc atcgtgaacg tgcagagctt ggacgaggcc atcgagttca tcaaccggcg
     1141 ggagaagccc ctggccctgt acgccttctc caacagcagc caggtggtca agcgggtgct
     1201 gacccagacc agcagcgggg gcttctgtgg gaacgacggc ttcatgcaca tgaccctggc
     1261 cagcctgcct tttggaggag tgggtgccag tgggatgggc cggtaccatg gcaagttctc
     1321 cttcgacacc ttctcccacc atcgcgcctg cctcctgcgc agcccgggga tggagaagct
     1381 caacgccctc cgctacccgc cgcaatcgcc gcgccgcctg aggatgctgc tggtggccat
     1441 ggaggcccaa ggctgcagct gcacactgct ctgagccctt ccccaggccc aggctgtaga
     1501 ccaccatgac agctgtcgcc tgcggctggt ggagacgggg cctgggctcc cgggcccgag
     1561 gaggaaaagg attgccaagg ctccagggca cccctcaaag cagcgcctgc ctcctccctc
     1621 ctgggtcttc cctctccctg cctcagcctc ctccctcagc cgctcccaac catgagagcc
     1681 gaggtgggag gcatgggaaa cagtgcagtg actcaccccc tgcccccgca ccaaccaccc
     1741 atattcagga gaagaggaca gacacggcac ctctgagtca cccctctcct gtggagcggg
     1801 cgtccgaggg gccctggcat ctgactcagg ccacaccatg gaatcactgc atccaaggcc
     1861 attcctgccc tctctgagtc tcagtttttc catttgttca gtggagagaa ttaaccattg
     1921 atacctcctg gctgggtgag gcggctcaca cctgtaatcc cagcactttg ggaggccgag
     1981 gcaggcggat cacctgaaat caggagttca agatcagcct ggctaacatg gcgaaacccc
     2041 gtctctacta aaaatacaaa aattagcctg gcgtggtggc gcatgcctgt aatcccagct
     2101 actcaggagg ctaaggcagg agaatcgctt gaacccggga ggtggaggtt gccgtgagct
     2161 gagattgcgt cactgaactc cggcctgggt gacagaagga ggctctgcct taaaaaaaaa
     2221 aaaaaaaaaa acctcctggg actgttgcaa ggatgaaatg aaggattgag ggattgaggg
     2281 attgctgagc tggagctcca ggtgtcctat ctttctcagt ggggtggcac ggagcggggc
     2341 cgcctccctc ttctctccag gcaggtgggg ctgtggttat gcgatagggt ctcccttccc
     2401 tccagcccat gccagaggag cttgtaactc tttatcctca tggtgcccac tacgagtcat
     2461 actcttcccc atgctgctca tcctcctggg ccccatccac tcagccaaag cagaatgcag
     2521 ggtttcctgc ctgacaaccc ttctcacctc ccaagtccca cttttgaaca agctgatgat
     2581 tctgaaactg gcccaatttc ctaacaagcc ggatgcttga gaaacctaca tttggacaat
     2641 gagaggctgc tcctgcggcc tgcgggccac ctcctcttcc ttggctcctg ctttcttttt
     2701 agactatatc aacctacaac tttagtcggg aagagggaca ggggtggacc tgagtttcgt
     2761 ctcctgtctc tctggctgat gtcacctgaa taaagccttc ttccctggca a
//
