LOCUS       NM_001034173            7428 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens aldehyde dehydrogenase 1 family member L2 (ALDH1L2),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001034173 XM_090294
VERSION     NM_001034173.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7428)
  AUTHORS   Cheng,J., Yang,S., Shou,D., Chen,J., Li,Y., Huang,C., Chen,H. and
            Zhou,Y.
  TITLE     FOXO1 induced fatty acid oxidation in hepatic cells by targeting
            ALDH1L2
  JOURNAL   J Gastroenterol Hepatol 39 (10), 2197-2207 (2024)
   PUBMED   38923573
  REMARK    GeneRIF: FOXO1 induced fatty acid oxidation in hepatic cells by
            targeting ALDH1L2.
REFERENCE   2  (bases 1 to 7428)
  AUTHORS   You,M., Shamseldin,H.E., Fogle,H.M., Rushing,B.R., AlMalki,R.H.,
            Jaafar,A., Hashem,M., Abdulwahab,F., Abdel Rahman,A.M.,
            Krupenko,N.I., Alkuraya,F.S. and Krupenko,S.A.
  TITLE     Further delineation of the phenotypic and metabolomic profile of
            ALDH1L2-related neurodevelopmental disorder
  JOURNAL   Clin Genet 105 (5), 488-498 (2024)
   PUBMED   38193334
  REMARK    GeneRIF: Further delineation of the phenotypic and metabolomic
            profile of ALDH1L2-related neurodevelopmental disorder.
REFERENCE   3  (bases 1 to 7428)
  AUTHORS   Hennequart,M., Pilley,S.E., Labuschagne,C.F., Coomes,J.,
            Mervant,L., Driscoll,P.C., Legrave,N.M., Lee,Y., Kreuzaler,P.,
            Macintyre,B., Panina,Y., Blagih,J., Stevenson,D., Strathdee,D.,
            Schneider-Luftman,D., Gronroos,E., Cheung,E.C., Yuneva,M.,
            Swanton,C. and Vousden,K.H.
  TITLE     ALDH1L2 regulation of formate, formyl-methionine, and ROS controls
            cancer cell migration and metastasis
  JOURNAL   Cell Rep 42 (6), 112562 (2023)
   PUBMED   37245210
  REMARK    GeneRIF: ALDH1L2 regulation of formate, formyl-methionine, and ROS
            controls cancer cell migration and metastasis.
REFERENCE   4  (bases 1 to 7428)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   5  (bases 1 to 7428)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 7428)
  AUTHORS   Strickland,K.C., Krupenko,N.I., Dubard,M.E., Hu,C.J., Tsybovsky,Y.
            and Krupenko,S.A.
  TITLE     Enzymatic properties of ALDH1L2, a mitochondrial
            10-formyltetrahydrofolate dehydrogenase
  JOURNAL   Chem Biol Interact 191 (1-3), 129-136 (2011)
   PUBMED   21238436
  REMARK    GeneRIF: ALDH1L2 has enzymatic properties similar to its cytosolic
            counterpart
REFERENCE   7  (bases 1 to 7428)
  AUTHORS   Yan,D., He,D., He,S., Chen,X., Fan,Z. and Chen,R.
  TITLE     Identification and analysis of intermediate size noncoding RNAs in
            the human fetal brain
  JOURNAL   PLoS One 6 (7), e21652 (2011)
   PUBMED   21789175
REFERENCE   8  (bases 1 to 7428)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 7428)
  AUTHORS   Krupenko,N.I., Dubard,M.E., Strickland,K.C., Moxley,K.M.,
            Oleinik,N.V. and Krupenko,S.A.
  TITLE     ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate
            dehydrogenase
  JOURNAL   J Biol Chem 285 (30), 23056-23063 (2010)
   PUBMED   20498374
  REMARK    GeneRIF: a gene at chromosome locus 12q24.11 of the human genome,
            the product of which has 74% sequence similarity with cytosolic FDH
REFERENCE   10 (bases 1 to 7428)
  AUTHORS   Strickland,K.C., Hoeferlin,L.A., Oleinik,N.V., Krupenko,N.I. and
            Krupenko,S.A.
  TITLE     Acyl carrier protein-specific 4'-phosphopantetheinyl transferase
            activates 10-formyltetrahydrofolate dehydrogenase
  JOURNAL   J Biol Chem 285 (3), 1627-1633 (2010)
   PUBMED   19933275
  REMARK    GeneRIF: Our study identifies human PPT as the FDH-modifying enzyme
            and supports the hypothesis that mammals utilize a single enzyme
            for all phosphopantetheinylation reactions.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK300373.1, BC103935.1,
            AC090051.8 and CA418450.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001034173.3.
            
            Summary: This gene encodes a member of both the aldehyde
            dehydrogenase superfamily and the formyl transferase superfamily.
            This member is the mitochondrial form of 10-formyltetrahydrofolate
            dehydrogenase (FDH), which converts 10-formyltetrahydrofolate to
            tetrahydrofolate and CO2 in an NADP(+)-dependent reaction, and
            plays an essential role in the distribution of one-carbon groups
            between the cytosolic and mitochondrial compartments of the cell.
            Alternatively spliced transcript variants have been found for this
            gene.[provided by RefSeq, Oct 2010].
            
            Transcript Variant: This variant (1) encodes a functional protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK300373.1, SRR1660809.130395.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: PMID: 20379614; reported by
                                                  MitoCarta
            MANE Ensembl match                 :: ENST00000258494.14/
                                                  ENSP00000258494.9
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1141              AK300373.1         1-1141
            1142-2266           BC103935.1         1138-2262
            2267-2782           AK300373.1         2267-2782
            2783-6939           AC090051.8         98901-103057        c
            6940-7428           CA418450.1         23-511              c
FEATURES             Location/Qualifiers
     source          1..7428
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q23.3"
     gene            1..7428
                     /gene="ALDH1L2"
                     /gene_synonym="mtFDH"
                     /note="aldehyde dehydrogenase 1 family member L2"
                     /db_xref="GeneID:160428"
                     /db_xref="HGNC:HGNC:26777"
                     /db_xref="MIM:613584"
     exon            1..70
                     /gene="ALDH1L2"
                     /gene_synonym="mtFDH"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..2794
                     /gene="ALDH1L2"
                     /gene_synonym="mtFDH"
                     /EC_number="1.5.1.6"
                     /note="mitochondrial 10-formyltetrahydrofolate
                     dehydrogenase; 10-formyltetrahydrofolate dehydrogenase
                     ALDH1L2; probable 10-formyltetrahydrofolate dehydrogenase
                     ALDH1L2; aldehyde dehydrogenase family 1 member L2,
                     mitochondrial; mitochondrial 10-FTHFDH"
                     /codon_start=1
                     /product="mitochondrial 10-formyltetrahydrofolate
                     dehydrogenase precursor"
                     /protein_id="NP_001029345.2"
                     /db_xref="CCDS:CCDS31891.1"
                     /db_xref="GeneID:160428"
                     /db_xref="HGNC:HGNC:26777"
                     /db_xref="MIM:613584"
                     /translation="MLRRGSQALRRFSTGRVYFKNKLKLALIGQSLFGQEVYSHLRKE
                     GHRVVGVFTVPDKDGKADPLALAAEKDGTPVFKLPKWRVKGKTIKEVAEAYRSVGAEL
                     NVLPFCTQFIPMDIIDSPKHGSIIYHPSILPRHRGASAINWTLIMGDKKAGFSVFWAD
                     DGLDTGPILLQRSCDVEPNDTVDALYNRFLFPEGIKAMVEAVQLIADGKAPRIPQPEE
                     GATYEGIQKKENAEISWDQSAEVLHNWIRGHDKVPGAWTEINGQMVTFYGSTLLNSSV
                     PPGEPLEIKGAKKPGLVTKNGLVLFGNDGKALTVRNLQFEDGKMIPASQYFSTGETSV
                     VELTAEEVKVAETIKVIWAGILSNVPIIEDSTDFFKSGASSMDVARLVEEIRQKCGGL
                     QLQNEDVYMATKFEGFIQKVVRKLRGEDQEVELVVDYISKEVNEIMVKMPYQCFINGQ
                     FTDADDGKTYDTINPTDGSTICKVSYASLADVDKAVAAAKDAFENGEWGRMNARERGR
                     LMYRLADLLEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDKIQGSTI
                     PINQARPNRNLTFTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTP
                     LTALKFAELSVKAGFPKGVINIIPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIMKS
                     CAVSNLKKVSLELGGKSPLIIFNDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEESI
                     HDEFVTRVVEEIKKMKIGDPLDRSTDHGPQNHKAHLEKLLQYCETGVKEGATLVYGGR
                     QVQRPGFFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQNGDIDGVLQRANSTEYGLA
                     SGVFTRDINKAMYVSEKLEAGTVFINTYNKTDVAAPFGGVKQSGFGKDLGEEALNEYL
                     KTKTVTLEY"
     exon            71..215
                     /gene="ALDH1L2"
                     /gene_synonym="mtFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            216..450
                     /gene="ALDH1L2"
                     /gene_synonym="mtFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            451..616
                     /gene="ALDH1L2"
                     /gene_synonym="mtFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            617..718
                     /gene="ALDH1L2"
                     /gene_synonym="mtFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            719..808
                     /gene="ALDH1L2"
                     /gene_synonym="mtFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            809..943
                     /gene="ALDH1L2"
                     /gene_synonym="mtFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1069
                     /gene="ALDH1L2"
                     /gene_synonym="mtFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1161
                     /gene="ALDH1L2"
                     /gene_synonym="mtFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1309
                     /gene="ALDH1L2"
                     /gene_synonym="mtFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1429
                     /gene="ALDH1L2"
                     /gene_synonym="mtFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1557
                     /gene="ALDH1L2"
                     /gene_synonym="mtFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1708
                     /gene="ALDH1L2"
                     /gene_synonym="mtFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1779
                     /gene="ALDH1L2"
                     /gene_synonym="mtFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1885
                     /gene="ALDH1L2"
                     /gene_synonym="mtFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..1973
                     /gene="ALDH1L2"
                     /gene_synonym="mtFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            1974..2067
                     /gene="ALDH1L2"
                     /gene_synonym="mtFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2167
                     /gene="ALDH1L2"
                     /gene_synonym="mtFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2266
                     /gene="ALDH1L2"
                     /gene_synonym="mtFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            2267..2432
                     /gene="ALDH1L2"
                     /gene_synonym="mtFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            2433..2538
                     /gene="ALDH1L2"
                     /gene_synonym="mtFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            2539..2738
                     /gene="ALDH1L2"
                     /gene_synonym="mtFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            2739..7428
                     /gene="ALDH1L2"
                     /gene_synonym="mtFDH"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgctagcg ctcctctcca gcatgctgcg gcggggcagc caggcgctcc ggcgcttctc
       61 cactggccgg gtttatttca aaaacaagct gaagttggca ctaattggcc agagcctctt
      121 tggacaagaa gtctatagcc acctccgcaa agagggccac cgagtagtag gggtgttcac
      181 agttccagac aaggatggaa aagctgaccc tctggctttg gctgcagaga aagatgggac
      241 ccctgtgttc aagcttccta aatggagggt caagggcaag accatcaaag aagtggcaga
      301 agcctacaga tccgtgggtg cagagctaaa tgtgctccct ttctgcactc agttcattcc
      361 catggatata attgatagtc caaagcacgg ctctatcatt tatcacccat ccatcctgcc
      421 caggcacaga ggagcctctg ctatcaattg gactctaatt atgggagata agaaagctgg
      481 gttttctgtt ttctgggctg atgatggctt ggatacagga cccatccttc ttcagagatc
      541 atgtgatgtt gaacccaatg atacagtgga tgcactttat aatcggtttc tttttcctga
      601 aggaatcaag gccatggtag aagctgtcca actcatagct gatggaaaag ctcctcgtat
      661 accccagcca gaagaagggg caacatatga aggtatccag aaaaaggaaa atgctgagat
      721 ttcttgggac cagtctgccg aagttttaca taactggatt cgaggtcatg ataaagtccc
      781 tggagcttgg acagagataa atggacagat ggtcactttc tatggctcga cattactgaa
      841 tagctctgtg cctcctggag aaccactgga aattaaaggt gccaagaagc ctggtctcgt
      901 taccaaaaat ggacttgttc tttttggtaa cgatggaaaa gcactgacgg tgagaaatct
      961 gcagtttgaa gatggaaaaa tgatccctgc ctctcagtac ttttcaacgg gtgagacgtc
     1021 agtggtagaa ctgacagctg aagaggtgaa agtggcagag accatcaagg tcatctgggc
     1081 tggaatttta agcaatgtcc ccattattga agactcaaca gacttcttta aatctggagc
     1141 aagctcaatg gatgttgcca ggctggttga agagatcaga cagaaatgtg gtgggcttca
     1201 gttgcagaat gaagatgtct atatggccac caagtttgaa ggctttatcc aaaaggtcgt
     1261 gaggaaactg agaggagaag atcaagaggt ggagctggtt gtagattata tttcaaagga
     1321 ggtcaatgaa atcatggtaa aaatgccata ccagtgtttc ataaatggac agttcacaga
     1381 tgcagacgat ggaaagactt acgacactat caacccaaca gatggatcta caatatgcaa
     1441 agtatcctac gcttctttgg cggatgttga taaagcagta gcagcagcaa aagatgcttt
     1501 tgaaaacggt gaatggggaa gaatgaatgc aagagaaaga ggaagattga tgtatagact
     1561 tgcagaccta ctggaagaga accaagaaga gctggcaact attgaagccc ttgattcagg
     1621 ggctgtctat accttggccc tgaagacaca cattggaatg tctgtgcaaa cattcagata
     1681 ttttgctggc tggtgcgaca aaattcaggg ttctactatt ccaatcaacc aggcccgtcc
     1741 aaatcgcaat ctgaccttca ccaagaaaga gccactcggt gtctgtgcca ttattattcc
     1801 ctggaactac ccgctgatga tgctggcatg gaagagtgct gcgtgtttgg cagcaggcaa
     1861 taccttagtg ctcaagccag cacaggtcac gcccttgact gctttgaagt ttgcagaact
     1921 gtctgtgaaa gcaggctttc caaagggggt catcaacatc attccaggct caggtggcat
     1981 agcaggacaa cgtctgtctg aacatcctga catccgcaaa cttggtttca ctggatccac
     2041 tcctattggc aaacagatca tgaagagctg tgctgttagc aacttgaaga aagtttccct
     2101 tgagcttggt ggcaagtctc cacttataat atttaatgac tgtgaacttg acaaggctgt
     2161 gcgaatgggc atgggagcag tatttttcaa caaaggagag aactgtattg ctgctgggcg
     2221 gttgttcgtg gaagaatcca tccacgacga atttgtgaca agagtggtag aagaaattaa
     2281 aaagatgaaa attggtgatc cacttgacag atccactgat catgggcccc aaaatcataa
     2341 ggctcatctg gaaaagctgc tgcaatactg tgaaactgga gtgaaagaag gggccacttt
     2401 ggtgtacggg ggaagacaag tccaaaggcc aggctttttc atggagccga ccgtgttcac
     2461 agatgtggaa gactacatgt acctcgccaa agaggaatcc tttgggccta ttatggtcat
     2521 ttctaaattc caaaatgggg acatcgatgg agtgttgcag cgagcaaata gtacagagta
     2581 tggtttggcc tcaggggttt ttacaagaga cataaacaaa gctatgtatg tgagtgaaaa
     2641 actggaagca ggaactgttt ttattaacac atacaacaag acagatgtgg cggccccatt
     2701 tggcggagtt aaacaatctg gctttggaaa agacttaggt gaggaagctc taaatgaata
     2761 tctcaaaacc aagacggtga cactggaata ttagagcaac accatcatca ggaaagcctt
     2821 gacagacagc cctttacaac tctggacaca cttaagaaga ttgggtgtgt tgaggcagga
     2881 ggtgtcagcc acaaaccaaa aaatacacag atggaccatg aagagggcca ggccatgtta
     2941 aagcatttac acatgtgcct gagtattttc taatacacct tccagtgatt tggagttgtt
     3001 gcattttgac tatgttgtat atcatacgta tttctaaaat accaagctgt ttctccccta
     3061 cctagacaaa tctattcatg gttcccatct tgaagatgtc agtaccatgc agttataata
     3121 cacaaggtgc atttattgga aactttgtat aatatgtaca ggtttttaac ctctgaacta
     3181 tacatagggg gttattaaaa agattttcta taagtcttct aaggaacagt ataacctgta
     3241 aggaatgtga aggtagttct tttttagtat ttggaaataa gatacatctt tgtgcctttg
     3301 atattccatt ttttaaccca ctgtgatggg tgatcaacct agaaacatta tcttgagtac
     3361 ctactaggta ccaggtacta tattatgttc tgaggagtat agagaattta atgatatgat
     3421 ggctggcccc cacatagttt aaattttagt aaatagcttt tgaagcaaat tttacatatg
     3481 atatagtaga aggctgatcc tggtcgtatc ataccatctt cctatctatg taactttggg
     3541 aaactctcgc aactcctctg agcctctgct tccctatgtg taaaacaggg atagtaaatg
     3601 ccttcctcag gacccttaat aggagaattc attgcagtaa tgtaagtaaa gcacctcaca
     3661 ttaatgcttt gctcatggta agtactcaaa tttaactctg atttcctccg tcaccattct
     3721 taaaagatat tgagatagtt taattaacta gatgaattca tttcccacaa cccttttcaa
     3781 tcatcaattc ctagatattt ttctcatcca ttgttctgac acaatgcctg atacagcagc
     3841 actgaaaaat gccacacaat gaaaaatggc aatagtacaa ggaaaagggg tgcttttctt
     3901 tgggcagctc gctcgtcctt catgggacat cttactttcc atttttctac ctattggttc
     3961 tgctgttcac tggctgtgtg atcttgggca agatagtaat ctaatatctc agagcctagg
     4021 ttgagtatct ataaaatgaa aatcaaatct ctatctcagt aggtgttgca aggattcagt
     4081 gagataatat acataatgca cttaacaagg cgtttggacc atagcattga agaaatggaa
     4141 actattaaca gcccatttcc cattggcaga cagaagtagt caggtgagta aattttcacc
     4201 atctatgtgt gactagaagg cggcaaattt ctgaatcaca tgagtctcca aaagatagcc
     4261 agaaagttaa attctattaa tcctccttta aaaataaaat ttcagtaaac attccttttt
     4321 ctttggcttt gaagaagcct tagggaatat ttgtcatttt ggagacttgg cagaataaca
     4381 tgaggggatt gtagggaatc aataaaaact aaacaacaaa atcagagtca gagaacattt
     4441 tcaaaaggaa gaataggagg tttgatccca gcatgataaa cagagcgaat ttggcctgga
     4501 agcacttttg attatactat agctcattta ccatcccaga gtttggcaca gctgaaattt
     4561 taagttggaa tgaatattca ctgggcccaa aatgacagtt catatttgaa taaaagtgac
     4621 aaaagccttt ttataagtaa tcacttttaa gtgaaatgtt ttaactgatt tcatgtgatt
     4681 tagaatatga tttaatcaaa ttattttaat gatagatgga atggcagaca aaaacatgcc
     4741 tgtccttcta gactgatttt actttaccct ctaatattca tctcagtagc agtgttttaa
     4801 atattctctg ggctgcaaaa ctctttggga atctgataaa agctatgaac actccctgtg
     4861 tcccgcttct acccccaaaa ttcatgtgca cacacacaat tctgcaagta tcttcaaagg
     4921 gttcacagac ctcccaaagg ccatgcttgg gccccagatt aagaactcct ttctccatag
     4981 caagttttaa acatttctta ccagcttaca tttttagatc tggctgatca gaatcaaagg
     5041 ctctgtgtaa tacataaagt taccaagtga actggaattg gaacatcacc ctccccagcc
     5101 tgctaggtga tttacttaac acatagagta ataaaatcat cgctgttgct ttagatcacg
     5161 gattattttg ctaataatgc taaggatgaa gctgtgatct tattatcacc tgaatcggga
     5221 ggtgtggaca ctttaagcag ttccactttc cttctaattc cccatcccca tgcctttgct
     5281 aaagctgtcc cttttgctct aacacccttc ctggaccttc ctaccctagc tgggctaagt
     5341 gtttctcctc agcgttccca cttgtttcaa acatagcact taccacttgt actaaaatta
     5401 cttgccttct taattagata tgaacaaccc tccccaactc cagtatgggc cttctgtcaa
     5461 taataatacg atatgacagc taccatttat taagggcctc ctgtatgaaa gaccttaggc
     5521 taagcatgtt ttaaatgtta tttaatcttc acaatctctg aaaaaaatga agaaatcaac
     5581 gtgcttttct tactacctct acccctaagc cattattact tttttttttt tttgagacag
     5641 agttttgctc ttgttgccca ggctgcagtg cagtggtgca atcttggctc actgcaacct
     5701 ctgcctcttg ggttcaagcg attgtcatgc cttagccttc caagtagctg ggattacagg
     5761 tgtgtgccac tacacctggc taagtagaga tggggtttcg ccatgttggc caggctggtc
     5821 ttgaactcct gacctcaagt gatccacctg cctccgcctc ccaaagtgct gggattacag
     5881 gcatgaacca ctgcacctgg cctgttacct ctttcctaca attttgctca agtctcccaa
     5941 ctggtcttct ggattcctct cttctgcggt cctgttcaaa gcttaagtca gacagtgtca
     6001 cttcactcgt ctgtttaaaa cctttcaatg gcccccattt cacgtagacc aaagtccaac
     6061 gtatttacct ggcctactga tcttgctcct agctacctct gacctcatct cctgtcaatt
     6121 tccctctcat tctgttccac catcctgact gccttgactt cctcaacaga acaagcctgc
     6181 tcctgcctca gggcctctgt ccttattctt cctcttccca ggggtgtgct ggtaaaatat
     6241 ttaacaaata gttctccggg acgggggaga aaaccctcat ttgtagcatt tgcaggtatc
     6301 tatgtgtaaa tactctcatc aaggctattt ttgagccact aatttgcctt cactgaatac
     6361 agagtttggg aagagatgca tgccatcaga acaaatgcaa gccagcacca gcacaccact
     6421 gcctcttcct gcaactcttg tccatacaca acctcatggc tggctggctc acttcctgca
     6481 ggtctctcct caaatatcat ctgatgagag acacattccc tgactatgct ttctaaaata
     6541 ggccatatgc ccccacattc ataccccatc tgctgtcatt ctttattctt tttataagtg
     6601 cattattttc atagcactta tcactacctg ttgtatatta atcaatgatc ttttcccatt
     6661 agaatgtaag tttcatgaac aggtacttgt tttaatactg tatctccagt cctaatgtgt
     6721 aacaggagcc caataaatgt ttgctttcaa atggagaggt taagtaacct gctcaaatca
     6781 cacagctatt aagtggcaga acaggttttc aagcaatgca tctggtggtt ttaactaagt
     6841 cgagatagtt tttattccta atgcctaaat cagggcctag gtagtgagct gtgggcacat
     6901 attaagtatt ggttaaacta aaaataataa gcaaaatgga cattatctat aaaagctttt
     6961 gtggaaatgg ctagagctag ggtaaggaaa caaatttggt tccccatacc tgccctccaa
     7021 gaaaataaag ctgtcaagga aaatctgggc taagagtagg atatgaggga tgatggataa
     7081 ggcatgagac atgagaaata agggggatta aattattatt actattatac aaatgatgcc
     7141 tgagtagatt tttaaaatga ttaaataccc aatgatgtaa aaaacattta taaaatagga
     7201 aagtaagact gactcaacca taatttgttg agtcaaccca aaaatctatt tggttatttt
     7261 caaacagaaa tagcctacag atgatatctg agattgttcc aaactttttc tatgaatatg
     7321 tatacttttt ttacataatt aacataatac tgtatattaa tttgttacct gctttttcaa
     7381 ttaacaatat atcataagca tctatgccaa taaacacaat tctgcata
//
