LOCUS       NM_153329               3099 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens aldehyde dehydrogenase 16 family member A1 (ALDH16A1),
            transcript variant 1, mRNA.
ACCESSION   NM_153329
VERSION     NM_153329.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3099)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 3099)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3099)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3099)
  AUTHORS   Vasiliou,V., Sandoval,M., Backos,D.S., Jackson,B.C., Chen,Y.,
            Reigan,P., Lanaspa,M.A., Johnson,R.J., Koppaka,V. and Thompson,D.C.
  TITLE     ALDH16A1 is a novel non-catalytic enzyme that may be involved in
            the etiology of gout via protein-protein interactions with HPRT1
  JOURNAL   Chem Biol Interact 202 (1-3), 22-31 (2013)
   PUBMED   23348497
  REMARK    GeneRIF: Both the short and long forms of human ALDH16A1 protein
            would lack catalytic activity.
REFERENCE   5  (bases 1 to 3099)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 3099)
  AUTHORS   Hanna,M.C. and Blackstone,C.
  TITLE     Interaction of the SPG21 protein ACP33/maspardin with the aldehyde
            dehydrogenase ALDH16A1
  JOURNAL   Neurogenetics 10 (3), 217-228 (2009)
   PUBMED   19184135
  REMARK    GeneRIF: Data report that maspardin localizes prominently to
            cytoplasm as well as to membranes, possibly at trans-Golgi
            network/late endosomal compartments, and that maspardin interacts
            with the aldehyde dehydrogenase ALDH16A1.
REFERENCE   7  (bases 1 to 3099)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA629821.1, BC014895.2,
            DC364604.1, AK297101.1, AY007096.1 and AC010619.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_153329.3.
            
            Summary: This gene encodes a member of the aldehyde dehydrogenase
            superfamily. The family members act on aldehyde substrates and use
            nicotinamide adenine dinucleotide phosphate (NADP) as a cofactor.
            This gene is conserved in chimpanzee, dog, cow, mouse, rat, and
            zebrafish. The protein encoded by this gene interacts with
            maspardin, a protein that when truncated is responsible for Mast
            syndrome. Alternatively spliced transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Apr 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.139915.1, BC014895.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000293350.9/ ENSP00000293350.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-556               DA629821.1         10-565
            557-785             BC014895.2         526-754
            786-899             DC364604.1         379-492
            900-1444            BC014895.2         869-1413
            1445-2634           AK297101.1         1284-2473
            2635-3097           AY007096.1         1577-2039
            3098-3099           AC010619.7         58220-58221
FEATURES             Location/Qualifiers
     source          1..3099
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..3099
                     /gene="ALDH16A1"
                     /note="aldehyde dehydrogenase 16 family member A1"
                     /db_xref="GeneID:126133"
                     /db_xref="HGNC:HGNC:28114"
                     /db_xref="MIM:613358"
     exon            1..197
                     /gene="ALDH16A1"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..2516
                     /gene="ALDH16A1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     aldehyde dehydrogenase family 16 member A1"
                     /codon_start=1
                     /product="aldehyde dehydrogenase family 16 member A1
                     isoform 1"
                     /protein_id="NP_699160.2"
                     /db_xref="CCDS:CCDS12766.1"
                     /db_xref="GeneID:126133"
                     /db_xref="HGNC:HGNC:28114"
                     /db_xref="MIM:613358"
                     /translation="MAATRAGPRAREIFTSLEYGPVPESHACALAWLDTQDRCLGHYV
                     NGKWLKPEHRNSVPCQDPITGENLASCLQAQAEDVAAAVEAARMAFKGWSAHPGVVRA
                     QHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHYHAIQASTQEEAL
                     AGWEPMGVIGLILPPTFSFLEMMWRICPALAVGCTVVALVPPASPAPLLLAQLAGELG
                     PFPGILNVLSGPASLVPILASQPGIRKVAFCGAPEEGRALRRSLAGECAELGLALGTE
                     SLLLLTDTADVDSAVEGVVDAAWSDRGPGGLRLLIQESVWDEAMRRLQERMGRLRSGR
                     GLDGAVDMGARGAAACDLVQRFVREAQSQGAQVFQAGDVPSERPFYPPTLVSNLPPAS
                     PCAQVEVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLGQALELGYGLQVGTV
                     WINAHGLRDPSVPTGGCKESGCSWHGGPDGLYEYLRPSGTPARLSCLSKNLNYDTFGL
                     AVPSTLPAGPEIGPSPAPPYGLFVGGRFQAPGARSSRPIRDSSGNLHGYVAEGGAKDI
                     RGAVEAAHQAFPGWAGQSPGARAALLWALAAALERRKSTLASRLERQGAELKAAEAEV
                     ELSARRLRAWGARVQAQGHTLQVAGLRGPVLRLREPLGVLAVVCPDEWPLLAFVSLLA
                     PALAYGNTVVMVPSAACPLLALEVCQDMATVFPAGLANVVTGDRDHLTRCLALHQDVQ
                     AMWYFGSAQGSQFVEWASAGNLKPVWASRGCPRAWDQEAEGAGPELGLRVARTKALWL
                     PMGD"
     exon            198..300
                     /gene="ALDH16A1"
                     /inference="alignment:Splign:2.1.0"
     exon            301..427
                     /gene="ALDH16A1"
                     /inference="alignment:Splign:2.1.0"
     exon            428..606
                     /gene="ALDH16A1"
                     /inference="alignment:Splign:2.1.0"
     exon            607..684
                     /gene="ALDH16A1"
                     /inference="alignment:Splign:2.1.0"
     exon            685..866
                     /gene="ALDH16A1"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1019
                     /gene="ALDH16A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1205
                     /gene="ALDH16A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1301
                     /gene="ALDH16A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1438
                     /gene="ALDH16A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1544
                     /gene="ALDH16A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1675
                     /gene="ALDH16A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1843
                     /gene="ALDH16A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..2045
                     /gene="ALDH16A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2231
                     /gene="ALDH16A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2232..2354
                     /gene="ALDH16A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2355..3099
                     /gene="ALDH16A1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2616..2621
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALDH16A1"
                     /note="hexamer: AATAAA"
     polyA_site      2638
                     /gene="ALDH16A1"
                     /note="major polyA site"
     regulatory      3077..3082
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALDH16A1"
                     /note="hexamer: AATAAA"
     polyA_site      3099
                     /gene="ALDH16A1"
ORIGIN      
        1 agccccgccc ctttgggctg gaaccggagg tgtcgctctt cggacctcaa ggttcccctt
       61 aacacagagc gccccgcagt cttcgcggaa agcgttcggg gtaggcgatg gctgcgacgc
      121 gtgcagggcc ccgcgcccgc gagatcttca cctcgctgga gtacggaccg gtgccggaga
      181 gccacgcatg cgcactggcc tggctggaca cccaggaccg gtgcttgggc cactatgtga
      241 atgggaagtg gttaaagcct gaacacagaa attcagtgcc ttgccaggat cccatcacag
      301 gagagaactt ggccagttgc ctgcaggcac aggccgagga tgtggctgca gccgtggagg
      361 cagccaggat ggcatttaag ggctggagtg cgcaccccgg cgtcgtccgg gcccagcacc
      421 tgaccaggct ggccgaggtg atccagaagc accagcggct gctgtggacc ctggaatccc
      481 tggtgactgg gcgggctgtt cgagaggttc gagacgggga cgtccagctg gcccagcagc
      541 tgctccacta ccatgcaatc caggcatcca cccaggagga ggcactggca ggctgggagc
      601 ccatgggagt aattggcctc atcctgccac ccacattctc cttccttgag atgatgtgga
      661 ggatttgccc tgccctggct gtgggctgca ccgtggtggc cctcgtgccc ccggcctccc
      721 cggcgcccct cctcctggcc cagctggcgg gggagctggg ccccttcccg ggaatcctga
      781 atgtcctcag tggccctgcg tccctggtgc ccatcctggc ctcccagcct ggaatccgga
      841 aggtggcctt ctgcggagcc ccggaggaag ggcgtgccct tcgacggagc ctggcgggag
      901 agtgtgcgga gctgggcctg gcgctgggga cggagtcgct gctgctgctg acggacacgg
      961 cggacgtaga ctcggccgtg gagggtgtcg tggacgccgc ctggtccgac cgcggcccgg
     1021 gtggcctcag gctcctcatc caggagtctg tgtgggatga agccatgaga cggctgcagg
     1081 agcggatggg gcggcttcgg agtggccgag ggctggatgg ggccgtggac atgggggccc
     1141 ggggggctgc cgcatgtgac ctggtccagc gctttgtgcg tgaggcccag agccagggtg
     1201 cacaggtgtt ccaggctggt gatgtgcctt cggaacgccc attctatccc ccaaccttgg
     1261 tctccaacct gcccccagcc tccccatgtg cccaggtgga ggtgccgtgg cctgtggtcg
     1321 tggcctcccc cttccgcaca gccaaggagg cactgttggt ggccaacggg acgccccgcg
     1381 ggggcagcgc cagtgtgtgg agcgagaggc tggggcaggc gctggagctg ggctatgggc
     1441 tccaggtggg cactgtctgg atcaacgccc acggcctcag agacccttcg gtgcccacag
     1501 gcggctgcaa ggagagtggg tgttcctggc acgggggccc agacgggctg tatgagtatc
     1561 tgcggccctc agggacccct gcccggctgt cctgcctctc caagaacctg aactatgaca
     1621 cctttggcct cgctgttccc tcaaccctgc cggctgggcc tgaaataggg cccagcccag
     1681 caccccccta tgggctcttc gttgggggcc gtttccaggc tcctggggcc cgaagctcca
     1741 ggcccatccg ggattcgtct ggcaacctcc atggctacgt ggctgagggt ggagccaagg
     1801 acatccgagg tgctgtggag gccgctcacc aggctttccc tggctgggcg ggccagtccc
     1861 caggagcccg ggcagccctg ctgtgggccc tggcggctgc actggagcgc cggaagtcta
     1921 ccctggcctc gaggctggag aggcagggag cggagctcaa ggctgcggag gcggaggtgg
     1981 agctgagcgc aagacgactt cgggcgtggg gggcccgggt gcaggcccaa ggccacaccc
     2041 tgcaggtagc cgggctgaga ggccctgtgc tgcgcctgcg ggagccgctg ggtgtgctgg
     2101 ctgtggtgtg tccggacgag tggcccctgc ttgccttcgt gtccctgctg gctcccgccc
     2161 tggcctacgg caacactgtg gtcatggtgc ccagtgcggc ctgtcctctg ctggccctgg
     2221 aggtctgcca ggacatggcc accgtgttcc cagcaggcct ggccaacgtg gtgacaggag
     2281 accgggacca tctgacccgc tgcctggcct tgcaccaaga cgtccaggcc atgtggtatt
     2341 tcggatcagc ccagggttcc cagtttgtcg agtgggcctc ggcaggaaac ctcaaaccgg
     2401 tgtgggcgag caggggctgc ccgcgggcct gggaccagga ggccgagggg gcaggcccag
     2461 agctggggct gcgagtggcg cggaccaagg ccctgtggct gcctatgggg gactgatgcc
     2521 tgagcgccac ctactgcatt ttggacacct cacaccaagg ggagatgcac cccacagaca
     2581 cctgggactt tccccttctg gttcctgtgt ctcccaataa actctctgac caaccctagc
     2641 tgtgcttctg cgagaagaaa gggtgtagca acttctggca gatatgaggc ttttttcttt
     2701 tttttttttt tttttgagac aacgtctggc tctgtcaccc aggctggagc gcagtggcac
     2761 aatctcggcc cactgcagcc tcgacctctg gggctcaagg gatcctcatg cctcagcctc
     2821 atatgtagct ggggccacag acatgcacca ccacacctgg ctcgaggcca ttttagttct
     2881 gaggttgagc agctcaggag ccggctccag cacggtgctg tgtttgtgaa acagagaaag
     2941 gggacccccg aggaccccag acagggcctt aggactctca tatcttcttg tcttctccat
     3001 ctggtggctc ttgctctctg gttttctcta ccttttcatg gccccagaat ccatatgcag
     3061 taaaggaact ctctggaata aaattaaagt cctcctata
//
