LOCUS       NM_001627               4701 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens activated leukocyte cell adhesion molecule (ALCAM),
            transcript variant 1, mRNA.
ACCESSION   NM_001627
VERSION     NM_001627.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4701)
  AUTHORS   Morosi,L.G., Piperno,G.M., Lopez,L., Amadio,R., Joshi,S.,
            Rustighi,A., Del Sal,G. and Benvenuti,F.
  TITLE     ALCAM-mediated cDC1 CD8 T cells interactions are suppressed in
            advanced lung tumors
  JOURNAL   Oncoimmunology 13 (1), 2367843 (2024)
   PUBMED   38887373
  REMARK    GeneRIF: ALCAM-mediated cDC1 CD8 T cells interactions are
            suppressed in advanced lung tumors.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4701)
  AUTHORS   Wagner,M., Sobczynski,M., Wisniewski,A., Matusiak,L.,
            Kusnierczyk,P. and Jasek,M.
  TITLE     Polymorphisms in the CD6-ALCAM axis may modulate psoriasis risk and
            outcomes
  JOURNAL   Hum Immunol 85 (3), 110797 (2024)
   PUBMED   38580538
  REMARK    GeneRIF: Polymorphisms in the CD6-ALCAM axis may modulate psoriasis
            risk and outcomes.
REFERENCE   3  (bases 1 to 4701)
  AUTHORS   Moradi,L., Tajik,F., Saeednejad Zanjani,L., Panahi,M.,
            Gheytanchi,E., Biabanaki,Z.S., Kazemi-Sefat,G.E., Hashemi,F.,
            Dehghan Manshadi,M. and Madjd,Z.
  TITLE     Clinical significance of CD166 and HER-2 in different types of
            gastric cancer
  JOURNAL   Clin Transl Oncol 26 (3), 664-681 (2024)
   PUBMED   37537510
  REMARK    GeneRIF: Clinical significance of CD166 and HER-2 in different
            types of gastric cancer.
REFERENCE   4  (bases 1 to 4701)
  AUTHORS   Jamann,H., Desu,H.L., Cui,Q.L., Halaweh,A., Tastet,O., Klement,W.,
            Zandee,S., Pernin,F., Mamane,V.H., Ouedraogo,O., Daigneault,A.,
            Sidibe,H., Millette,F., Peelen,E., Dhaeze,T., Hoornaert,C.,
            Rebillard,R.M., Thai,K., Grasmuck,C., Vande Velde,C., Prat,A.,
            Arbour,N., Stratton,J.A., Antel,J. and Larochelle,C.
  TITLE     ALCAM on human oligodendrocytes mediates CD4 T cell adhesion
  JOURNAL   Brain 147 (1), 147-162 (2024)
   PUBMED   37640028
  REMARK    GeneRIF: ALCAM on human oligodendrocytes mediates CD4 T cell
            adhesion.
REFERENCE   5  (bases 1 to 4701)
  AUTHORS   Fang,Z., Zeng,J.J., Yang,Y., Ruge,F., Lane,J., Hargest,R. and
            Jiang,W.G.
  TITLE     Expression of ALCAM in Clinical Colon Cancer and Relationship With
            Patients' Treatment Responses
  JOURNAL   In Vivo 37 (3), 1117-1128 (2023)
   PUBMED   37103072
  REMARK    GeneRIF: Expression of ALCAM in Clinical Colon Cancer and
            Relationship With Patients' Treatment Responses.
REFERENCE   6  (bases 1 to 4701)
  AUTHORS   Singer,N.G., Mitra,R., Lialios,F., Richardson,B.C., Marks,R.M.,
            Pesando,J.M., Fox,D.A. and Nickoloff,B.J.
  TITLE     CD6 dependent interactions of T cells and keratinocytes: functional
            evidence for a second CD6 ligand on gamma-interferon activated
            keratinocytes
  JOURNAL   Immunol Lett 58 (1), 9-14 (1997)
   PUBMED   9436462
REFERENCE   7  (bases 1 to 4701)
  AUTHORS   Skonier,J.E., Bowen,M.A., Emswiler,J., Aruffo,A. and Bajorath,J.
  TITLE     Recognition of diverse proteins by members of the immunoglobulin
            superfamily: delineation of the receptor binding site in the human
            CD6 ligand ALCAM
  JOURNAL   Biochemistry 35 (38), 12287-12291 (1996)
   PUBMED   8823162
REFERENCE   8  (bases 1 to 4701)
  AUTHORS   Whitney,G.S., Starling,G.C., Bowen,M.A., Modrell,B., Siadak,A.W.
            and Aruffo,A.
  TITLE     The membrane-proximal scavenger receptor cysteine-rich domain of
            CD6 contains the activated leukocyte cell adhesion molecule binding
            site
  JOURNAL   J Biol Chem 270 (31), 18187-18190 (1995)
   PUBMED   7543097
REFERENCE   9  (bases 1 to 4701)
  AUTHORS   Bajorath,J., Bowen,M.A. and Aruffo,A.
  TITLE     Molecular model of the N-terminal receptor-binding domain of the
            human CD6 ligand ALCAM
  JOURNAL   Protein Sci 4 (8), 1644-1647 (1995)
   PUBMED   8520490
REFERENCE   10 (bases 1 to 4701)
  AUTHORS   Bowen,M.A., Patel,D.D., Li,X., Modrell,B., Malacko,A.R., Wang,W.C.,
            Marquardt,H., Neubauer,M., Pesando,J.M., Francke,U. et al.
  TITLE     Cloning, mapping, and characterization of activated leukocyte-cell
            adhesion molecule (ALCAM), a CD6 ligand
  JOURNAL   J Exp Med 181 (6), 2213-2220 (1995)
   PUBMED   7760007
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC078806.18 and AC023602.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001627.3.
            
            Summary: This gene encodes activated leukocyte cell adhesion
            molecule (ALCAM), also known as CD166 (cluster of differentiation
            166), which is a member of a subfamily of immunoglobulin receptors
            with five immunoglobulin-like domains (VVC2C2C2) in the
            extracellular domain. This protein binds to T-cell differentiation
            antigene CD6, and is implicated in the processes of cell adhesion
            and migration. Multiple alternatively spliced transcript variants
            encoding different isoforms have been found. [provided by RefSeq,
            Aug 2011].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.505.1,
                                           SRR1660809.191196.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306107.9/ ENSP00000305988.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-573               AC078806.18        57710-58282         c
            574-674             AC023602.5         65370-65470         c
            675-894             AC023602.5         61029-61248         c
            895-959             AC023602.5         53471-53535         c
            960-1047            AC023602.5         51847-51934         c
            1048-1230           AC023602.5         50692-50874         c
            1231-1358           AC023602.5         45435-45562         c
            1359-1491           AC023602.5         43772-43904         c
            1492-1604           AC023602.5         40202-40314         c
            1605-1740           AC023602.5         38253-38388         c
            1741-1874           AC023602.5         38014-38147         c
            1875-2007           AC023602.5         35278-35410         c
            2008-2046           AC023602.5         33355-33393         c
            2047-2164           AC023602.5         32952-33069         c
            2165-2277           AC023602.5         13573-13685         c
            2278-4701           AC023602.5         8637-11060          c
FEATURES             Location/Qualifiers
     source          1..4701
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.11"
     gene            1..4701
                     /gene="ALCAM"
                     /gene_synonym="CD166; MEMD"
                     /note="activated leukocyte cell adhesion molecule"
                     /db_xref="GeneID:214"
                     /db_xref="HGNC:HGNC:400"
                     /db_xref="MIM:601662"
     exon            1..573
                     /gene="ALCAM"
                     /gene_synonym="CD166; MEMD"
                     /inference="alignment:Splign:2.1.0"
     CDS             501..2252
                     /gene="ALCAM"
                     /gene_synonym="CD166; MEMD"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; CD166 antigen"
                     /codon_start=1
                     /product="CD166 antigen isoform 1 precursor"
                     /protein_id="NP_001618.2"
                     /db_xref="CCDS:CCDS33810.1"
                     /db_xref="GeneID:214"
                     /db_xref="HGNC:HGNC:400"
                     /db_xref="MIM:601662"
                     /translation="MESKGASSCRLLFCLLISATVFRPGLGWYTVNSAYGDTIIIPCR
                     LDVPQNLMFGKWKYEKPDGSPVFIAFRSSTKKSVQYDDVPEYKDRLNLSENYTLSISN
                     ARISDEKRFVCMLVTEDNVFEAPTIVKVFKQPSKPEIVSKALFLETEQLKKLGDCISE
                     DSYPDGNITWYRNGKVLHPLEGAVVIIFKKEMDPVTQLYTMTSTLEYKTTKADIQMPF
                     TCSVTYYGPSGQKTIHSEQAVFDIYYPTEQVTIQVLPPKNAIKEGDNITLKCLGNGNP
                     PPEEFLFYLPGQPEGIRSSNTYTLTDVRRNATGDYKCSLIDKKSMIASTAITVHYLDL
                     SLNPSGEVTRQIGDALPVSCTISASRNATVVWMKDNIRLRSSPSFSSLHYQDAGNYVC
                     ETALQEVEGLKKRESLTLIVEGKPQIKMTKKTDPSGLSKTIICHVEGFPKPAIQWTIT
                     GSGSVINQTEESPYINGRYYSKIIISPEENVTLTCTAENQLERTVNSLNVSAISIPEH
                     DEADEISDENREKVNDQAKLIVGIVVGLLLAALVAGVVYWLYMKKSKTASKHVNKDLG
                     NMEENKKLEENNHKTEA"
     exon            574..674
                     /gene="ALCAM"
                     /gene_synonym="CD166; MEMD"
                     /inference="alignment:Splign:2.1.0"
     exon            675..894
                     /gene="ALCAM"
                     /gene_synonym="CD166; MEMD"
                     /inference="alignment:Splign:2.1.0"
     exon            895..959
                     /gene="ALCAM"
                     /gene_synonym="CD166; MEMD"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1047
                     /gene="ALCAM"
                     /gene_synonym="CD166; MEMD"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1230
                     /gene="ALCAM"
                     /gene_synonym="CD166; MEMD"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1358
                     /gene="ALCAM"
                     /gene_synonym="CD166; MEMD"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1491
                     /gene="ALCAM"
                     /gene_synonym="CD166; MEMD"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1604
                     /gene="ALCAM"
                     /gene_synonym="CD166; MEMD"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1740
                     /gene="ALCAM"
                     /gene_synonym="CD166; MEMD"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1874
                     /gene="ALCAM"
                     /gene_synonym="CD166; MEMD"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..2007
                     /gene="ALCAM"
                     /gene_synonym="CD166; MEMD"
                     /inference="alignment:Splign:2.1.0"
     exon            2008..2046
                     /gene="ALCAM"
                     /gene_synonym="CD166; MEMD"
                     /inference="alignment:Splign:2.1.0"
     exon            2047..2164
                     /gene="ALCAM"
                     /gene_synonym="CD166; MEMD"
                     /inference="alignment:Splign:2.1.0"
     exon            2165..2277
                     /gene="ALCAM"
                     /gene_synonym="CD166; MEMD"
                     /inference="alignment:Splign:2.1.0"
     exon            2278..4701
                     /gene="ALCAM"
                     /gene_synonym="CD166; MEMD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4679..4684
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALCAM"
                     /gene_synonym="CD166; MEMD"
                     /note="hexamer: AATAAA"
     polyA_site      4701
                     /gene="ALCAM"
                     /gene_synonym="CD166; MEMD"
                     /note="major polyA site"
ORIGIN      
        1 agagcagccc ggagaccgct gccgccgctg ccgctgctac caccgctgcc acctgaggag
       61 acccgccgcc cccccgtcgc cgcctcctgc gagtccttct tagcacctgg cgtttcatgc
      121 acattgccac tgccattatt attatcattc caatacaagg aaaataaaag aagataccag
      181 cgaaaagaac cgcttacacc tttccgaatt actcaagtgt ctcctggaaa cagagggtcg
      241 ttgtccccgg aggagcagcc gaagggcccg tgggctggtg ttgaccggga gggaggagga
      301 gttgggggca ttgcgtggtg gaaagttgcg tgcggcagag aaccgaaggt gcagcgccac
      361 agcccagggg acggtgtgtc tgggagaaga cgctgcccct gcgtcgggac ccgccagcgc
      421 gcgggcaccg cggggcccgg gacgacgccc cctcctgcgg cgtggactcc gtcagtggcc
      481 caccaagaag gaggaggaat atggaatcca agggggccag ttcctgccgt ctgctcttct
      541 gcctcttgat ctccgccacc gtcttcaggc caggccttgg atggtatact gtaaattcag
      601 catatggaga taccattatc ataccttgcc gacttgacgt acctcagaat ctcatgtttg
      661 gcaaatggaa atatgaaaag cccgatggct ccccagtatt tattgccttc agatcctcta
      721 caaagaaaag tgtgcagtac gacgatgtac cagaatacaa agacagattg aacctctcag
      781 aaaactacac tttgtctatc agtaatgcaa ggatcagtga tgaaaagaga tttgtgtgca
      841 tgctagtaac tgaggacaac gtgtttgagg cacctacaat agtcaaggtg ttcaagcaac
      901 catctaaacc tgaaattgta agcaaagcac tgtttctcga aacagagcag ctaaaaaagt
      961 tgggtgactg catttcagaa gacagttatc cagatggcaa tatcacatgg tacaggaatg
     1021 gaaaagtgct acatcccctt gaaggagcgg tggtcataat ttttaaaaag gaaatggacc
     1081 cagtgactca gctctatacc atgacttcca ccctggagta caagacaacc aaggctgaca
     1141 tacaaatgcc attcacctgc tcggtgacat attatggacc atctggccag aaaacaattc
     1201 attctgaaca ggcagtattt gatatttact atcctacaga gcaggtgaca atacaagtgc
     1261 tgccaccaaa aaatgccatc aaagaagggg ataacatcac tcttaaatgc ttagggaatg
     1321 gcaaccctcc cccagaggaa tttttgtttt acttaccagg acagcccgaa ggaataagaa
     1381 gctcaaatac ttacacactg acggatgtga ggcgcaatgc aacaggagac tacaagtgtt
     1441 ccctgataga caaaaaaagc atgattgctt caacagctat cacagttcac tatttggatt
     1501 tgtccttaaa cccaagtgga gaagtgacta gacagattgg tgatgcccta cccgtgtcat
     1561 gcacaatatc tgctagcagg aatgcaactg tggtatggat gaaagataac atcaggcttc
     1621 gatctagccc gtcattttct agtcttcatt atcaggatgc tggaaactat gtctgcgaaa
     1681 ctgctctgca ggaggttgaa ggactaaaga aaagagagtc attgactctc attgtagaag
     1741 gcaaacctca aataaaaatg acaaagaaaa ctgatcccag tggactatct aaaacaataa
     1801 tctgccatgt ggaaggtttt ccaaagccag ccattcaatg gacaattact ggcagtggaa
     1861 gcgtcataaa ccaaacagag gaatctcctt atattaatgg caggtattat agtaaaatta
     1921 tcatttcccc tgaagagaat gttacattaa cttgcacagc agaaaaccaa ctggagagaa
     1981 cagtaaactc cttgaatgtc tctgctataa gtattccaga acacgatgag gcagacgaga
     2041 taagtgatga aaacagagaa aaggtgaatg accaggcaaa actaattgtg ggaatcgttg
     2101 ttggtctcct ccttgctgcc cttgttgctg gtgtcgtcta ctggctgtac atgaagaagt
     2161 caaagactgc atcaaaacat gtaaacaagg acctcggtaa tatggaagaa aacaaaaagt
     2221 tagaagaaaa caatcacaaa actgaagcct aagagagaaa ctgtcctagt tgtccagaga
     2281 taaaaatcat atagaccaat tgaagcatga acgtggattg tatttaagac ataaacaaag
     2341 acattgacag caattcatgg ttcaagtatt aagcagttca ttctaccaag ctgtcacagg
     2401 ttttcagaga attatctcaa gtaaaacaaa tgaaatttaa ttacaaacaa taagaacaag
     2461 ttttggcagc catgataata ggtcatatgt tgtgtttggt tcaatttttt ttccgtaaat
     2521 gtctgcactg aggatttctt tttggtttgc cttttatgta aattttttac gtagctattt
     2581 ttatacactg taagctttgt tctgggagtt gctgttaatc tgatgtataa tgtaatgttt
     2641 ttatttcaat tgtttatatg gataatctga gcaggtacat ttctgattct gattgctatc
     2701 agcaatgccc caaactttct cataagcacc taaaacccaa aggtggcagc ttgtgaagat
     2761 tggggacact catattgccc taattaaaaa ctgtgatttt tatcacaagg gaggggaggc
     2821 cgagagtcag actgatagac accataggag ccgactcttt gatatgccac cagcgaactc
     2881 tcagaaataa atcacagatg catatagaca cacatacata atggtactcc caaactgaca
     2941 attttaccta ttctgaaaaa gacataaaac agaatttggt agcacttacc tctacagaca
     3001 cctgctaata aattattttc tgtcaaaaga aaaaacacaa gcatgtgtga gagacagttt
     3061 ggaaaaatca tggtcaacat tcccattttc atagatcaca atgtaaatca ctataattac
     3121 aaattggtgt taaatccttt gggttatcca ctgccttaaa attataccta tttcatgttt
     3181 aaaaagatat caatcagaat tggagttttt aacagtggtc attatcaaag ctgtgttatt
     3241 ttccacagaa tatagaatat atattttttt cgtgtgtgtt tttgttaact accctacaga
     3301 tattgaatgc accttgagat aatttagtgt ttttaactga tacataattt atcaagcagt
     3361 acatgaaagt gtaataataa aatgtctatg tatctttagt tacattcaaa tttgtaactt
     3421 tataaacatg ttttatgctt gaggaaattt ttaaggtggt agtataaatg gaaacttttt
     3481 gaagtagacc agatatgggc tacttgtgac tagactttta aactttgctc tttcaagcag
     3541 aagcctggtt tctgggagaa cactgcacag cgatttcttt cccaggattt acacaacttt
     3601 aaagggaaga taaatgaaca tcagatttct aggtatagaa ctatgttatt gaaaggaaaa
     3661 ggaaaactgg tgtttgtttc ttagactcat gaaataaaaa attatgaagg caatgaaaaa
     3721 taaattgaaa attaaagtca gatgagaata ggaataatac tttgccactt ctgcattatt
     3781 tagaaacata cgttattgta catttgtaaa ccatttactg tctgggcaat agtgactccg
     3841 tttaataaaa gcttccgtag tgcattggta tggattaaat gcataaaata ttcttagact
     3901 cgatgctgta taaaatatta tgggaaaaaa agaaaatacg ttattttgcc tctaaacttt
     3961 tattgaagtt ttatttggca ggaaaaaaaa ttgaatcttg gtcaacattt aaaccaaagt
     4021 aaaaggggaa aaaccaaagt tatttgtttt gcatggctaa gccattctgt tatctctgta
     4081 aatactgtga tttctttttt attttctctt tagaattttg ttaaagaaat tctaaaattt
     4141 ttaaacacct gctctccaca ataaatcaca aacactaaaa taaaattact tccatataaa
     4201 tattattttc tcttttggtg tgggagatca aaggtttaaa gtctaacttc taagatatat
     4261 ttgcagaaag aagcaacatg acaatagaga gagttatgct acaattattt cttggtttcc
     4321 acttgcaatg gttaattaag tccaaaaaca gctgtcagaa cctcgagagc agaacatgag
     4381 aaactcagag ctctggaccg aaagcagaaa gtttgccggg aaaaaaaaag acaacattat
     4441 taccatcgat tcagtgcctg gataaagagg aaagcttact tgtttaatgg cagccacatg
     4501 cacgaagatg ctaagaagaa aaagaattcc aaatcctcaa cttttgaggt ttcggctctc
     4561 caatttaact ctttggcaac aggaaacagg ttttgcaagt tcaaggttca ctccctatat
     4621 gtgattatag gaattgtttg tggaaatgga ttaacatacc cgtctatgcc taaaagataa
     4681 taaaactgaa atatgtcttc a
//
