LOCUS       NM_000477               2285 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens albumin (ALB), mRNA.
ACCESSION   NM_000477
VERSION     NM_000477.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2285)
  AUTHORS   Zelenovic,N., Ristic,P., Polovic,N., Todorovic,T., Kojadinovic,M.
            and Popovic,M.
  TITLE     A Multi-Spectroscopic and Molecular Docking Analysis of the
            Biophysical Interaction between Food Polyphenols, Urolithins, and
            Human Serum Albumin
  JOURNAL   Molecules 29 (18), 4474 (2024)
   PUBMED   39339470
  REMARK    GeneRIF: A Multi-Spectroscopic and Molecular Docking Analysis of
            the Biophysical Interaction between Food Polyphenols, Urolithins,
            and Human Serum Albumin.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2285)
  AUTHORS   Cole,J., Guivarch,C., Wu,J., Stallcup,P., Pang,W.W., Zhang,C. and
            Sacks,D.B.
  TITLE     Plasma Glycated Albumin in Early Pregnancy and Gestational Diabetes
            Mellitus: A Prospective and Longitudinal Study
  JOURNAL   Diabetes Care 47 (9), 1593-1596 (2024)
   PUBMED   38968411
  REMARK    GeneRIF: Plasma Glycated Albumin in Early Pregnancy and Gestational
            Diabetes Mellitus: A Prospective and Longitudinal Study.
REFERENCE   3  (bases 1 to 2285)
  AUTHORS   Zirafi,O., Hermann,P.C. and Munch,J.
  TITLE     Proteolytic processing of human serum albumin generates EPI-X4, an
            endogenous antagonist of CXCR4
  JOURNAL   J Leukoc Biol 99 (6), 863-868 (2016)
   PUBMED   26965637
  REMARK    Review article
REFERENCE   4  (bases 1 to 2285)
  AUTHORS   Ha,C.E. and Bhagavan,N.V.
  TITLE     Novel insights into the pleiotropic effects of human serum albumin
            in health and disease
  JOURNAL   Biochim Biophys Acta 1830 (12), 5486-5493 (2013)
   PUBMED   23602811
  REMARK    Review article
REFERENCE   5  (bases 1 to 2285)
  AUTHORS   Sugio,S., Kashima,A., Mochizuki,S., Noda,M. and Kobayashi,K.
  TITLE     Crystal structure of human serum albumin at 2.5 A resolution
  JOURNAL   Protein Eng 12 (6), 439-446 (1999)
   PUBMED   10388840
REFERENCE   6  (bases 1 to 2285)
  AUTHORS   Urano,Y., Watanabe,K., Sakai,M. and Tamaoki,T.
  TITLE     The human albumin gene. Characterization of the 5' and 3' flanking
            regions and the polymorphic gene transcripts
  JOURNAL   J Biol Chem 261 (7), 3244-3251 (1986)
   PUBMED   2419329
REFERENCE   7  (bases 1 to 2285)
  AUTHORS   Hawkins,J.W. and Dugaiczyk,A.
  TITLE     The human serum albumin gene: structure of a unique locus
  JOURNAL   Gene 19 (1), 55-58 (1982)
   PUBMED   6292049
REFERENCE   8  (bases 1 to 2285)
  AUTHORS   Dugaiczyk,A., Law,S.W. and Dennison,O.E.
  TITLE     Nucleotide sequence and the encoded amino acids of human serum
            albumin mRNA
  JOURNAL   Proc Natl Acad Sci U S A 79 (1), 71-75 (1982)
   PUBMED   6275391
REFERENCE   9  (bases 1 to 2285)
  AUTHORS   Heaney-Kieras,J. and King,T.P.
  TITLE     Limited pepsin digestion of human plasma albumin
  JOURNAL   J Biol Chem 252 (12), 4326-4329 (1977)
   PUBMED   325004
REFERENCE   10 (bases 1 to 2285)
  AUTHORS   Meloun,B., Moravek,L. and Kostka,V.
  TITLE     Complete amino acid sequence of human serum albumin
  JOURNAL   FEBS Lett 58 (1), 134-137 (1975)
   PUBMED   1225573
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB186399.1, DA642320.1,
            DQ986150.1, N53869.1 and AC108157.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_000477.6.
            
            Summary: This gene encodes the most abundant protein in human
            blood. This protein functions in the regulation of blood plasma
            colloid osmotic pressure and acts as a carrier protein for a wide
            range of endogenous molecules including hormones, fatty acids, and
            metabolites, as well as exogenous drugs. Additionally, this protein
            exhibits an esterase-like activity with broad substrate
            specificity. The encoded preproprotein is proteolytically processed
            to generate the mature protein. A peptide derived from this
            protein, EPI-X4, is an endogenous inhibitor of the CXCR4 chemokine
            receptor. [provided by RefSeq, Jul 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036003.1, SRR5189664.159361.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2142680
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related                :: relevant for COVID-19
                                                  prognosis
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000295897.9/
                                                  ENSP00000295897.4
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                DB186399.1         49-58
            11-30               DA642320.1         43-62
            31-1914             DQ986150.1         1-1884
            1915-2215           N53869.1           18-318              c
            2216-2285           AC108157.3         87261-87330
FEATURES             Location/Qualifiers
     source          1..2285
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q13.3"
     gene            1..2285
                     /gene="ALB"
                     /gene_synonym="FDAHT; HSA; PRO0883; PRO0903; PRO1341"
                     /note="albumin"
                     /db_xref="GeneID:213"
                     /db_xref="HGNC:HGNC:399"
                     /db_xref="MIM:103600"
     exon            1..120
                     /gene="ALB"
                     /gene_synonym="FDAHT; HSA; PRO0883; PRO0903; PRO1341"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..1871
                     /gene="ALB"
                     /gene_synonym="FDAHT; HSA; PRO0883; PRO0903; PRO1341"
                     /note="serum albumin"
                     /codon_start=1
                     /product="albumin preproprotein"
                     /protein_id="NP_000468.1"
                     /db_xref="CCDS:CCDS3555.1"
                     /db_xref="GeneID:213"
                     /db_xref="HGNC:HGNC:399"
                     /db_xref="MIM:103600"
                     /translation="MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFK
                     ALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVA
                     TLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLK
                     KYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSA
                     KQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLE
                     CADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFV
                     ESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHE
                     CYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEV
                     SRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNR
                     RPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKE
                     QLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAALGL"
     exon            121..178
                     /gene="ALB"
                     /gene_synonym="FDAHT; HSA; PRO0883; PRO0903; PRO1341"
                     /inference="alignment:Splign:2.1.0"
     exon            179..311
                     /gene="ALB"
                     /gene_synonym="FDAHT; HSA; PRO0883; PRO0903; PRO1341"
                     /inference="alignment:Splign:2.1.0"
     exon            312..523
                     /gene="ALB"
                     /gene_synonym="FDAHT; HSA; PRO0883; PRO0903; PRO1341"
                     /inference="alignment:Splign:2.1.0"
     exon            524..656
                     /gene="ALB"
                     /gene_synonym="FDAHT; HSA; PRO0883; PRO0903; PRO1341"
                     /inference="alignment:Splign:2.1.0"
     exon            657..754
                     /gene="ALB"
                     /gene_synonym="FDAHT; HSA; PRO0883; PRO0903; PRO1341"
                     /inference="alignment:Splign:2.1.0"
     exon            755..884
                     /gene="ALB"
                     /gene_synonym="FDAHT; HSA; PRO0883; PRO0903; PRO1341"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1099
                     /gene="ALB"
                     /gene_synonym="FDAHT; HSA; PRO0883; PRO0903; PRO1341"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1232
                     /gene="ALB"
                     /gene_synonym="FDAHT; HSA; PRO0883; PRO0903; PRO1341"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1330
                     /gene="ALB"
                     /gene_synonym="FDAHT; HSA; PRO0883; PRO0903; PRO1341"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1469
                     /gene="ALB"
                     /gene_synonym="FDAHT; HSA; PRO0883; PRO0903; PRO1341"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1693
                     /gene="ALB"
                     /gene_synonym="FDAHT; HSA; PRO0883; PRO0903; PRO1341"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1826
                     /gene="ALB"
                     /gene_synonym="FDAHT; HSA; PRO0883; PRO0903; PRO1341"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1894
                     /gene="ALB"
                     /gene_synonym="FDAHT; HSA; PRO0883; PRO0903; PRO1341"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..2285
                     /gene="ALB"
                     /gene_synonym="FDAHT; HSA; PRO0883; PRO0903; PRO1341"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2037..2042
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALB"
                     /gene_synonym="FDAHT; HSA; PRO0883; PRO0903; PRO1341"
                     /note="hexamer: AATAAA"
     polyA_site      2059
                     /gene="ALB"
                     /gene_synonym="FDAHT; HSA; PRO0883; PRO0903; PRO1341"
                     /note="major polyA site"
     regulatory      2192..2197
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALB"
                     /gene_synonym="FDAHT; HSA; PRO0883; PRO0903; PRO1341"
                     /note="hexamer: AATAAA"
     polyA_site      2215
                     /gene="ALB"
                     /gene_synonym="FDAHT; HSA; PRO0883; PRO0903; PRO1341"
     regulatory      2267..2272
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALB"
                     /gene_synonym="FDAHT; HSA; PRO0883; PRO0903; PRO1341"
                     /note="hexamer: AATAAA"
     polyA_site      2285
                     /gene="ALB"
                     /gene_synonym="FDAHT; HSA; PRO0883; PRO0903; PRO1341"
ORIGIN      
        1 ctagcttttc tcttctgtca accccacacg cctttggcac aatgaagtgg gtaaccttta
       61 tttcccttct ttttctcttt agctcggctt attccagggg tgtgtttcgt cgagatgcac
      121 acaagagtga ggttgctcat cggtttaaag atttgggaga agaaaatttc aaagccttgg
      181 tgttgattgc ctttgctcag tatcttcagc agtgtccatt tgaagatcat gtaaaattag
      241 tgaatgaagt aactgaattt gcaaaaacat gtgttgctga tgagtcagct gaaaattgtg
      301 acaaatcact tcataccctt tttggagaca aattatgcac agttgcaact cttcgtgaaa
      361 cctatggtga aatggctgac tgctgtgcaa aacaagaacc tgagagaaat gaatgcttct
      421 tgcaacacaa agatgacaac ccaaacctcc cccgattggt gagaccagag gttgatgtga
      481 tgtgcactgc ttttcatgac aatgaagaga catttttgaa aaaatactta tatgaaattg
      541 ccagaagaca tccttacttt tatgccccgg aactcctttt ctttgctaaa aggtataaag
      601 ctgcttttac agaatgttgc caagctgctg ataaagctgc ctgcctgttg ccaaagctcg
      661 atgaacttcg ggatgaaggg aaggcttcgt ctgccaaaca gagactcaag tgtgccagtc
      721 tccaaaaatt tggagaaaga gctttcaaag catgggcagt agctcgcctg agccagagat
      781 ttcccaaagc tgagtttgca gaagtttcca agttagtgac agatcttacc aaagtccaca
      841 cggaatgctg ccatggagat ctgcttgaat gtgctgatga cagggcggac cttgccaagt
      901 atatctgtga aaatcaagat tcgatctcca gtaaactgaa ggaatgctgt gaaaaacctc
      961 tgttggaaaa atcccactgc attgccgaag tggaaaatga tgagatgcct gctgacttgc
     1021 cttcattagc tgctgatttt gttgaaagta aggatgtttg caaaaactat gctgaggcaa
     1081 aggatgtctt cctgggcatg tttttgtatg aatatgcaag aaggcatcct gattactctg
     1141 tcgtgctgct gctgagactt gccaagacat atgaaaccac tctagagaag tgctgtgccg
     1201 ctgcagatcc tcatgaatgc tatgccaaag tgttcgatga atttaaacct cttgtggaag
     1261 agcctcagaa tttaatcaaa caaaattgtg agctttttga gcagcttgga gagtacaaat
     1321 tccagaatgc gctattagtt cgttacacca agaaagtacc ccaagtgtca actccaactc
     1381 ttgtagaggt ctcaagaaac ctaggaaaag tgggcagcaa atgttgtaaa catcctgaag
     1441 caaaaagaat gccctgtgca gaagactatc tatccgtggt cctgaaccag ttatgtgtgt
     1501 tgcatgagaa aacgccagta agtgacagag tcaccaaatg ctgcacagaa tccttggtga
     1561 acaggcgacc atgcttttca gctctggaag tcgatgaaac atacgttccc aaagagttta
     1621 atgctgaaac attcaccttc catgcagata tatgcacact ttctgagaag gagagacaaa
     1681 tcaagaaaca aactgcactt gttgagctcg tgaaacacaa gcccaaggca acaaaagagc
     1741 aactgaaagc tgttatggat gatttcgcag cttttgtaga gaagtgctgc aaggctgacg
     1801 ataaggagac ctgctttgcc gaggagggta aaaaacttgt tgctgcaagt caagctgcct
     1861 taggcttata acatcacatt taaaagcatc tcagcctacc atgagaataa gagaaagaaa
     1921 atgaagatca aaagcttatt catctgtttt tctttttcgt tggtgtaaag ccaacaccct
     1981 gtctaaaaaa cataaatttc tttaatcatt ttgcctcttt tctctgtgct tcaattaata
     2041 aaaaatggaa agaatctaat agagtggtac agcactgtta tttttcaaag atgtgttgct
     2101 atcctgaaaa ttctgtaggt tctgtggaag ttccagtgtt ctctcttatt ccacttcggt
     2161 agaggatttc tagtttcttg tgggctaatt aaataaatca ttaatactct tctaagttat
     2221 ggattataaa cattcaaaat aatattttga cattatgata attctgaata aaagaacaaa
     2281 aacca
//
