LOCUS       XM_047422945            7541 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens aminolevulinate dehydratase (ALAD),
            transcript variant X2, mRNA.
ACCESSION   XM_047422945
VERSION     XM_047422945.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000009.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7541
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
     gene            1..7541
                     /gene="ALAD"
                     /gene_synonym="ALADH; PBGS"
                     /note="aminolevulinate dehydratase; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 4
                     mRNAs, 49 ESTs, 862 long SRA reads, 4 Proteins, and 90%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 1 sample with support for all
                     annotated introns"
                     /db_xref="GeneID:210"
                     /db_xref="HGNC:HGNC:395"
                     /db_xref="MIM:125270"
     CDS             4435..5553
                     /gene="ALAD"
                     /gene_synonym="ALADH; PBGS"
                     /codon_start=1
                     /product="delta-aminolevulinic acid dehydratase isoform
                     X1"
                     /protein_id="XP_047278901.1"
                     /db_xref="GeneID:210"
                     /db_xref="HGNC:HGNC:395"
                     /db_xref="MIM:125270"
                     /translation="MNQLWTLPCRSSVYWHETEPAANAPGALGSNQLMPLCPLAHAMQ
                     PQSVLHSGYFHPLLRAWQTATTTLNASNLIYPIFVTDVPDDIQPITSLPGVARYGVKR
                     LEEMLRPLVEEGLRCVLIFGVPSRVPKDERGSAADSEESPAIEAIHLLRKTFPNLLVA
                     CDVCLCPYTSHGHCGLLSENGAFRAEESRQRLAEVALAYAKAGCQVVAPSDMMDGRVE
                     AIKEALMAHGLGNRVSVMSYSAKFASCFYGPFRDAAKSSPAFGDRRCYQLPPGARGLA
                     LRAVDRDVREGADMLMVKPGMPYLDIVREVKDKHPDLPLAVYHVSGEFAMLWHGAQAG
                     AFDLKAAVLEAMTAFRRAGADIIITYYTPQLLQWLKEE"
ORIGIN      
        1 acgcggtctg tgggagaccg gagcgggaga cagcggtgac aggagcagcg gccgggagcc
       61 cttagggagg caggtgagcg ggggctggat gcggggagat agcgggcctg gagggcggct
      121 ccagggcgag gcggggactg tggcaccaag agtcctgcgt ccccagattg tgctgtgcgc
      181 ctgaagccct ggcggtgcag ccgtgcacgg agtcccgtgg agcgtttgtt tgggctggat
      241 tatcccgctg cagccgaggt tgggggcccg ggttcggggc tccgcacctc ttctctgggg
      301 ttcaccctct cggataccgc ctgggcagac tccatcgatg cagaacccga ggtgcgggtg
      361 gtggttggtg ggggggtagg gaggtgaaaa caataacagc cgttttgtac taagcgttgc
      421 gtgcattgac cattcattta ttttatttat ttatttattt ttgagacgga gtttcgctct
      481 tgttgcccag gctggagtgc aatggcgcga tctcagctca ctgcaacctc cgcctcccgg
      541 gttcaagcga ttctcctgcc tcagcctgcc aactagctgg gattacaggc gtgtgccacc
      601 acgcctgcta atttttgtat ttttagtaga gatggggttt ctccctgttg gtcaggctag
      661 tctcgaactc ccgagctcag gtgattcgcc cacctcggcc tcccaaagtg ctgggattac
      721 aggcgtgagc caccacgccc ggcctgaccc attcatttct tacaacaacc cattgaggtc
      781 ggttctagtc cccatttact aaacgaagaa actgaggtca cacaactaga aagctacaga
      841 actaggattt gtacccacat ctatcagact ccagagccca catacttaac catcctgcta
      901 ccaacagcag ccaggcccag agtctggctc acccaaagct ctccacaagc ccaacctgct
      961 gggaaacaga tttgatatct atccttaaag tatggaggtg tcatggtggg cactgaggac
     1021 tgggctgctg gagaccttcc cccagatctg ccgctgaccc actgcgtgat cctgggcctg
     1081 tgtctacccc tctctgagcc cagtttcacc cttgtttcag tgatacaatc agcaaacttt
     1141 aagaagactc ttagccaaga tattctagga ttctgggaat ggcagcttct cctacgtcta
     1201 aatggctaac cccagaggcg atcaggctct tcaaagcccc agggcaaggc tggggtctca
     1261 ttcttctctt taatccctgt gtctagcact tcagcaggcc catagtagat attcaagaaa
     1321 tgtgggttgg ctgaataaac acttcatctc ttttcagaac tgcatgacag ctgctctcct
     1381 gggcctttgt ggggctttgg atttctcagt tctggccacc ttctatctag ctggctctcc
     1441 tgactgcctc ctccctggcc agtggcagag cctgccaggg ctggcagcag gtcctaagcc
     1501 tctgtgcgaa gacccacagc ctctggaatc ctcagcatag tacaacttgc aggggtgggg
     1561 ggtggcacat gaagctcata gcccctcctg gtagcagtgc tcagggccca acttcagtta
     1621 ctcccagttt ggggatgttg ccttccatgg gaggagatac tttcatatta aatctgaaac
     1681 acttcttatc cttcactgtc ccctcttcca tgaaaccacc cttgactcag agacacagtc
     1741 cctctgacag cacctggtcc acccctctac tctggcagcc cggtggtgat tattttgttt
     1801 ttcctccacc acataacctg ctggaaggca gggactccac ttcagaaatc ttggaaaacc
     1861 ctgtggccca caagggtttg agctcatatt cccatctggt gaggtgcaga aggcacagag
     1921 ctgtgccagg acatctcgtt ccaacccagc cccactccta atagtaataa aagtagctac
     1981 atgtttactg tgcagctact tggtgccaga cacctacctt atccctatca ataatctcca
     2041 cagccttgca agttagagat atcatgccta ttttgtagat tatgaaatga acactgaaag
     2101 gtcaattact ttgcccaaaa ttacacagca gagcatagac caaacctggg actgtctgac
     2161 cctgaaacat ggatctttct gcaccgccct atactctgcg tcccagcaaa gctaacctgt
     2221 ctgatgtggt tgggcagagg tgctggacct cctggcggct cgctcctgtc ttcagtgtgg
     2281 taatgtcaca ggcatttaaa ttgtggtttg caagctcgct tgatttggga gaagtgccct
     2341 cccagtctgt gaaattctcc caaactctaa gggccttttt gcaaagcaaa acccaccctg
     2401 catttggctc tgccaatatg tgattcaggg ggtgttttcc cactcacaga atggagtggg
     2461 aaactccact tattaagtac ctcttacaat ggaatgactc tatggtgtag gtatcagggc
     2521 actgaaatag aagccaggag ctgcagggtc agtttatagc tctgtatgtc actcactgtg
     2581 atctccaaaa gtcccgttgc ctctttatac cccattttcc acattaaagt gtaagggatt
     2641 aaacaggatt ggcaattttc aagcttttaa tattttcagc actgacagcc gtttctcaaa
     2701 tcaaatctgt ctctgaatct taaaattcaa aaacagatca aagtggactg ctgtagtgag
     2761 actgttccct ttactctaac cctgccccgg tctcaggctc ctaggcagtc ctgccccagg
     2821 gtttctgcta agcaggagcc agttgttccc tcagcctcct aaaagcgatg gggagttgag
     2881 gccagtggaa tgcagctttg gattcagaag ccagaaaaca acagagattg tttgtgggaa
     2941 gtgagtcaga gagattagac ctctcttcaa catctgacta gactctagaa tggcattaag
     3001 caagtcactg aaccgctcag agcctctgtt tccttatcac taaaagttag gacaattctt
     3061 gcaatgaaat gagatactac taccaagtac ttcagtgctg tgcccagcac agaacgaata
     3121 cactcagtat gtttttcttt tgtttcttct gtctctccag cacccaaagc agaaacagta
     3181 tgggcagaga gacgcctact gaatcagttg ttccctcagc ctcctgaaag caatgaggag
     3241 ttgaggccac gggaatgcag ctttggattc cagaagccaa ggacctgtta caaaggtggt
     3301 tttctgggaa gcaaattaga gggattagac ctggcttcga catctgactt gactccaacc
     3361 taccaaagga tctcccagtt cacctgggag ttaacacacc agggttctag tccttttgct
     3421 cgctgtgtgg ctttgggctg aacccactca tcctgcaaaa ccaagttcaa cgccctgtca
     3481 ttttcttttt tttttttttt tttgagatgg agtctcacac tgtcgcccag gctagagtgc
     3541 aatgggtgca ctctcggctc actgcaacct ctgcctccta ggttcaatcg attcttctgc
     3601 ctcagcctcc agaggaactc tgactacagg tgcacaccac cacacccagc taatttttgt
     3661 atttttattt ttatttctat ttatttattt attgtgagat ggagtttctc tcttgttgcc
     3721 catgctggag tgcaatggca cgatctcggc tcattgcaac ctccgcctcc caagttcaaa
     3781 ggattctcct atctcagctt ctgaagtagc tgggattaca ggcatgtgcc accacacccg
     3841 gctaattttt ttttattttt agtagagatg gggtttcacc atgttggtca ggctggtctc
     3901 aaactcctga cctcaagtga tccacccacc tcggcctccc aaagtgctgg gattacaggc
     3961 gtgagccacc gtgcctggcc taatttttgt atttttagta gagacggagt ttcaccacat
     4021 tggccagcct ggtctcaaac tccagacctc aagtgatcca cccgcctcag cctcccaaag
     4081 tgctggggtt acaggtgtga gccactacgc ctggcgcctg tcttcttcta atatgcctct
     4141 tctgacctcc tcactcccat tggagccatg gctcacttct ggtcaggctc catgcactca
     4201 atcagccctg cctgccagga ctgtagtgcc cacttgatga gaaatcacct gtgaaaatgc
     4261 caggcatggt ctggcacaca gtaggtgctc aagaaacaaa tgttaatgcc ccagcttcct
     4321 tctgtcttgt gtccactaat ttggcatttg gagcatattt ttgtacttca cgtaattaaa
     4381 tatttactgt gtgccaaggt cagtgtgtga cagagcactg taggggaggc aaaaatgaac
     4441 caactctgga ccttgccctg cagaagctct gtctactggc atgagacaga gcctgcagcc
     4501 aatgccccag gagccctcgg ttccaaccaa ctgatgcccc tgtgcccact ggcccacgcc
     4561 atgcagcccc agtccgttct gcacagcggc tacttccacc cactacttcg ggcctggcag
     4621 acagccacca ccaccctcaa tgcctccaac ctcatctacc ccatctttgt cacggatgtt
     4681 cctgatgaca tacagcctat caccagcctc ccaggagtgg ccaggtatgg tgtgaagcgg
     4741 ctggaagaga tgctgaggcc cttggtggaa gagggcctac gctgtgtctt gatctttggc
     4801 gtccccagca gagttcccaa ggacgagcgg ggttccgcag ctgactccga ggagtcccca
     4861 gctattgagg caatccatct gttgaggaag accttcccca acctcctggt ggcctgtgat
     4921 gtctgcctgt gtccctacac ctcccatggt cactgcgggc tcctgagtga aaacggagca
     4981 ttccgggctg aggagagccg ccagcggctg gctgaggtgg cattggcgta tgccaaggca
     5041 ggatgtcagg tggtagcccc gtcggacatg atggatggac gcgtggaagc catcaaagag
     5101 gccctgatgg cacatggact tggcaacagg gtatcggtga tgagctacag tgccaaattt
     5161 gcttcctgtt tctatggccc tttccgggat gcagctaagt caagcccagc ttttggggac
     5221 cgccgctgct accagctgcc ccctggagca cgaggcctgg ctctccgagc tgtggaccgg
     5281 gatgtacggg aaggagctga catgctcatg gtgaagccgg gaatgcccta cctggacatc
     5341 gtgcgggagg taaaggacaa gcaccctgac ctccctctcg ccgtgtacca cgtctctgga
     5401 gagtttgcca tgctgtggca tggagcccag gccggggcat ttgatctcaa ggctgccgta
     5461 ctggaggcca tgactgcctt ccgcagagca ggtgctgaca tcatcatcac ctactacaca
     5521 ccgcagctgc tgcagtggct gaaggaggaa tgatggagac agtgccaggc ccaagaacta
     5581 gaactttaaa acgttcccgg ggcctcagac aagtgaaaac caaagtaaat gctgctttta
     5641 gaactgtgcc ctcatgccct cttcctgctc acatgctagc ggggcccagc agccctgggt
     5701 ggttttgcca gcatgctaac tcttgtaact cgcagctgca tcctatgagc tctcccaagc
     5761 ttccccgccc ctcccctggg tcagccgtga ggcccacctt tgccaccctc agctctttcc
     5821 tctggtgtgg cttcagcttg aaagcaacct ggagtcgggg gcacagcctt tggggcctgg
     5881 ctgggagagg gtcttggagc attaggggaa gaagagagca gtgggatctt ggggcctgag
     5941 aagccttgga acgcttctgg cagcagagct gggtgtggga atgaggccta gatcgatatc
     6001 cctgggttag agttgaaatt tgccgcaatt ccactggaag gcatttccca cgaggccaga
     6061 ggttgccagg ctgcctgagg tctcctattc tactctgaac cataaaccca gagaagaatt
     6121 actcattaac cagcataaat actgcctgag gatcaaaact cagaggcaaa gagggagttc
     6181 ctgactgcta gaggtgccac caccacaaac actttttatt caggagatac tttttgagaa
     6241 tctctgctct gttcctaggt tcagtgctgg gtcctgggaa tacagcagga cagacctcag
     6301 cttatctctt catagaaatt atacaaagag aattggggag acagctaaga agaaaacaaa
     6361 gaaataaagc agttacaaat tgtgataagt gctttgaagg aaagaagggg tctgagacaa
     6421 caacagggaa ggggcctctc ttgaaacagt agttgggaag gaggcagaca tgcaccagtg
     6481 atgtggtgac aggtgctctg aaggaggtca ccaggacctg acctctttga aggatcagaa
     6541 aatacttccc tgaaggactg acatttgagc ctagacctga agggtgagcc atcaagctaa
     6601 gacaattggg gaagagcatt ccagggagag ggaggagttg tgcaaaggcc ctggggctcc
     6661 ttctagctgg aggaatgcaa ggctagcttg tctggagcac tgagaggatg gcctgaactg
     6721 agtggagaga gacagaccag gaccaaacca tgcagaggtc aagggccaca ttcacctttt
     6781 cagagtgact caatcaaatt tgtagtttgt aaaagtattt taacagctct gcggcaaagt
     6841 gcaaatgaaa agtcttgatg gcatggactg gagcggggac agtggggatg gagaaagggg
     6901 aatggattgt ggatgtgttt agaaggtaga ttcgatgtga aggatgaatc tggcttgacc
     6961 ttctgggtgg ctgatgggcc atttactgag atggggcagc ctggaagagg aacagaagca
     7021 gggtcggggt ggagggagaa tactaaactt agcttgagac attttgcaat aaggaagcta
     7081 tatctagagt gcttatgtga ctcacctaag gccactcaac aagtttgtgg cagaactgga
     7141 ttagaactgc acagaaaaca gccaagctgg gatttgaacc catgtagtcc aactccaagg
     7201 cctctgcccc taaccactgt gccataccac ctcccaataa tcaacagcaa aattataggt
     7261 ctaacaatgt tttatagaca cccctccatt tatgtgatgg gtttgcatcc tgataaaccc
     7321 atcataagtt gaaaatatga tcataagttg aaaatatgat cataagtcaa aaatgtattt
     7381 aatataccta acctaccaaa catcatagct tagcctagcc tgccttaaac atgctcagaa
     7441 cacttacatt agcctacagt gggcaaaact atccaacaca aaatctatat tgtaataaag
     7501 ttgtaaagaa ttttgaataa aaattcaata tttgaagtac a
//
