LOCUS       NM_022476               2384 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens AKT interacting protein (AKTIP), transcript variant 2,
            mRNA.
ACCESSION   NM_022476
VERSION     NM_022476.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2384)
  AUTHORS   Snelleksz,M. and Dean,B.
  TITLE     Higher levels of AKT-interacting protein in the frontal pole from
            people with schizophrenia are limited to a sub-group who have a
            marked deficit in cortical muscarinic M1 receptors
  JOURNAL   Psychiatry Res 341, 116156 (2024)
   PUBMED   39236366
  REMARK    GeneRIF: Higher levels of AKT-interacting protein in the frontal
            pole from people with schizophrenia are limited to a sub-group who
            have a marked deficit in cortical muscarinic M1 receptors.
REFERENCE   2  (bases 1 to 2384)
  AUTHORS   Ng,A.S.N., Zhang,S., Mak,V.C.Y., Zhou,Y., Yuen,Y., Sharma,R.,
            Lu,Y., Zhuang,G., Zhao,W., Pang,H.H. and Cheung,L.W.T.
  TITLE     AKTIP loss is enriched in ERalpha-positive breast cancer for
            tumorigenesis and confers endocrine resistance
  JOURNAL   Cell Rep 41 (11), 111821 (2022)
   PUBMED   36516775
  REMARK    GeneRIF: AKTIP loss is enriched in ERalpha-positive breast cancer
            for tumorigenesis and confers endocrine resistance.
REFERENCE   3  (bases 1 to 2384)
  AUTHORS   La Torre,M., Merigliano,C., Maccaroni,K., Chojnowski,A., Goh,W.I.,
            Giubettini,M., Verni,F., Capanni,C., Rhodes,D., Wright,G.,
            Burke,B., Soddu,S., Burla,R. and Saggio,I.
  TITLE     Combined alteration of lamin and nuclear morphology influences the
            localization of the tumor-associated factor AKTIP
  JOURNAL   J Exp Clin Cancer Res 41 (1), 273 (2022)
   PUBMED   36096808
  REMARK    GeneRIF: Combined alteration of lamin and nuclear morphology
            influences the localization of the tumor-associated factor AKTIP.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2384)
  AUTHORS   Christensen,J.R., Kendrick,A.A., Truong,J.B., Aguilar-Maldonado,A.,
            Adani,V., Dzieciatkowska,M. and Reck-Peterson,S.L.
  TITLE     Cytoplasmic dynein-1 cargo diversity is mediated by the
            combinatorial assembly of FTS-Hook-FHIP complexes
  JOURNAL   Elife 10, e74538 (2021)
   PUBMED   34882091
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2384)
  AUTHORS   Merigliano,C., Burla,R., La Torre,M., Del Giudice,S., Teo,H.,
            Liew,C.W., Chojnowski,A., Goh,W.I., Olmos,Y., Maccaroni,K.,
            Giubettini,M., Chiolo,I., Carlton,J.G., Raimondo,D., Verni,F.,
            Stewart,C.L., Rhodes,D., Wright,G.D., Burke,B.E. and Saggio,I.
  TITLE     AKTIP interacts with ESCRT I and is needed for the recruitment of
            ESCRT III subunits to the midbody
  JOURNAL   PLoS Genet 17 (8), e1009757 (2021)
   PUBMED   34449766
  REMARK    GeneRIF: AKTIP interacts with ESCRT I and is needed for the
            recruitment of ESCRT III subunits to the midbody.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2384)
  AUTHORS   Stelzl,U., Worm,U., Lalowski,M., Haenig,C., Brembeck,F.H.,
            Goehler,H., Stroedicke,M., Zenkner,M., Schoenherr,A., Koeppen,S.,
            Timm,J., Mintzlaff,S., Abraham,C., Bock,N., Kietzmann,S.,
            Goedde,A., Toksoz,E., Droege,A., Krobitsch,S., Korn,B.,
            Birchmeier,W., Lehrach,H. and Wanker,E.E.
  TITLE     A human protein-protein interaction network: a resource for
            annotating the proteome
  JOURNAL   Cell 122 (6), 957-968 (2005)
   PUBMED   16169070
REFERENCE   7  (bases 1 to 2384)
  AUTHORS   Remy,I. and Michnick,S.W.
  TITLE     Regulation of apoptosis by the Ft1 protein, a new modulator of
            protein kinase B/Akt
  JOURNAL   Mol Cell Biol 24 (4), 1493-1504 (2004)
   PUBMED   14749367
  REMARK    GeneRIF: Ft1 protein interacts directly with PKB, enhancing the
            phosphorylation of both of its regulatory sites by promoting its
            interaction with the upstream kinase PDK1
REFERENCE   8  (bases 1 to 2384)
  AUTHORS   Lesche,R. and Ruther,U.
  TITLE     Close linkage of p130 and Ft1 is conserved among mammals
  JOURNAL   Mamm Genome 9 (3), 253-255 (1998)
   PUBMED   9501314
REFERENCE   9  (bases 1 to 2384)
  AUTHORS   Lesche,R., Peetz,A., van der Hoeven,F. and Ruther,U.
  TITLE     Ft1, a novel gene related to ubiquitin-conjugating enzymes, is
            deleted in the Fused toes mouse mutation
  JOURNAL   Mamm Genome 8 (12), 879-883 (1997)
   PUBMED   9383278
REFERENCE   10 (bases 1 to 2384)
  AUTHORS   Aiyar,N., Rand,K., Elshourbagy,N.A., Zeng,Z., Adamou,J.E.,
            Bergsma,D.J. and Li,Y.
  TITLE     A cDNA encoding the calcitonin gene-related peptide type 1 receptor
  JOURNAL   J Biol Chem 271 (19), 11325-11329 (1996)
   PUBMED   8626685
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK023320.1, AC007342.6 and
            BM992149.1.
            
            On Nov 23, 2018 this sequence version replaced NM_022476.3.
            
            Summary: The mouse homolog of this gene produces fused toes and
            thymic hyperplasia in heterozygous mutant animals while homozygous
            mutants die in early development. This gene may play a role in
            apoptosis as these morphological abnormalities are caused by
            altered patterns of programmed cell death. The protein encoded by
            this gene is similar to the ubiquitin ligase domain of other
            ubiquitin-conjugating enzymes but lacks the conserved cysteine
            residue that enables those enzymes to conjugate ubiquitin to the
            target protein. This protein interacts directly with
            serine/threonine kinase protein kinase B (PKB)/Akt and modulates
            PKB activity by enhancing the phosphorylation of PKB's regulatory
            sites. Alternative splicing results in two transcript variants
            encoding the same protein. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 5' UTR compared to variant 1. Variants 1 and 2 encode the
            same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.178272.1,
                                           SRR1660803.122985.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394657.12/ ENSP00000378152.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1643              AK023320.1         31-1673
            1644-2100           AC007342.6         28204-28660
            2101-2384           BM992149.1         18-301              c
FEATURES             Location/Qualifiers
     source          1..2384
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q12.2"
     gene            1..2384
                     /gene="AKTIP"
                     /gene_synonym="FT1; FTS"
                     /note="AKT interacting protein"
                     /db_xref="GeneID:64400"
                     /db_xref="HGNC:HGNC:16710"
                     /db_xref="MIM:608483"
     exon            1..63
                     /gene="AKTIP"
                     /gene_synonym="FT1; FTS"
                     /inference="alignment:Splign:2.1.0"
     exon            64..175
                     /gene="AKTIP"
                     /gene_synonym="FT1; FTS"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..1012
                     /gene="AKTIP"
                     /gene_synonym="FT1; FTS"
                     /note="isoform 1 is encoded by transcript variant 2; fused
                     toes homolog"
                     /codon_start=1
                     /product="AKT-interacting protein isoform 1"
                     /protein_id="NP_071921.1"
                     /db_xref="CCDS:CCDS10749.1"
                     /db_xref="GeneID:64400"
                     /db_xref="HGNC:HGNC:16710"
                     /db_xref="MIM:608483"
                     /translation="MNPFWSMSTSSVRKRSEGEEKTLTGDVKTSPPRTAPKKQLPSIP
                     KNALPITKPTSPAPAAQSTNGTHASYGPFYLEYSLLAEFTLVVKQKLPGVYVQPSYRS
                     ALMWFGVIFIRHGLYQDGVFKFTVYIPDNYPDGDCPRLVFDIPVFHPLVDPTSGELDV
                     KRAFAKWRRNHNHIWQVLMYARRVFYKIDTASPLNPEAAVLYEKDIQLFKSKVVDSVK
                     VCTARLFDQPKIEDPYAISFSPWNPSVHDEAREKMLTQKKPEEQHNKSVHVAGLSWVK
                     PGSVQPFSKEEKTVAT"
     exon            176..381
                     /gene="AKTIP"
                     /gene_synonym="FT1; FTS"
                     /inference="alignment:Splign:2.1.0"
     exon            382..446
                     /gene="AKTIP"
                     /gene_synonym="FT1; FTS"
                     /inference="alignment:Splign:2.1.0"
     exon            447..547
                     /gene="AKTIP"
                     /gene_synonym="FT1; FTS"
                     /inference="alignment:Splign:2.1.0"
     exon            548..636
                     /gene="AKTIP"
                     /gene_synonym="FT1; FTS"
                     /inference="alignment:Splign:2.1.0"
     exon            637..735
                     /gene="AKTIP"
                     /gene_synonym="FT1; FTS"
                     /inference="alignment:Splign:2.1.0"
     exon            736..843
                     /gene="AKTIP"
                     /gene_synonym="FT1; FTS"
                     /inference="alignment:Splign:2.1.0"
     exon            844..904
                     /gene="AKTIP"
                     /gene_synonym="FT1; FTS"
                     /inference="alignment:Splign:2.1.0"
     exon            905..2384
                     /gene="AKTIP"
                     /gene_synonym="FT1; FTS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1098..1103
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AKTIP"
                     /gene_synonym="FT1; FTS"
                     /note="hexamer: AGTAAA"
     polyA_site      1119
                     /gene="AKTIP"
                     /gene_synonym="FT1; FTS"
                     /note="major polyA site"
     regulatory      2093..2098
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AKTIP"
                     /gene_synonym="FT1; FTS"
                     /note="hexamer: AATAAA"
     polyA_site      2114
                     /gene="AKTIP"
                     /gene_synonym="FT1; FTS"
                     /note="major polyA site"
     regulatory      2361..2366
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AKTIP"
                     /gene_synonym="FT1; FTS"
                     /note="hexamer: ATTAAA"
     polyA_site      2384
                     /gene="AKTIP"
                     /gene_synonym="FT1; FTS"
ORIGIN      
        1 gggagatgct gtcgggccgc ggcggcgctt ggcagccagg agctctgcat tgaaggcact
       61 ggggtaaagt gaatgccgaa gacagaagat ttggatgata caccactgac tttctttgtt
      121 tggaatacac gttatgaacc ctttctggag catgtctaca agctctgtac gcaaacgatc
      181 tgaaggtgaa gagaagacat taacagggga cgtgaaaacc agtcctccac gaactgcacc
      241 aaagaaacag ctgccttcta ttcccaaaaa tgctttgccc ataactaagc ctacatctcc
      301 tgccccagca gcacagtcaa caaatggcac gcatgcgtcc tatggaccct tctacctgga
      361 atactctctt cttgcagaat ttaccttggt tgtgaagcag aagctaccag gcgtctatgt
      421 gcagccatct tatcgctctg cattaatgtg gtttggagta atattcatac ggcatggact
      481 ttaccaagat ggcgtattta agtttacagt ttacatccct gataactatc cagatggtga
      541 ctgtccacgc ttggtgttcg atattcctgt ctttcacccg ctagttgatc ccacctcagg
      601 tgagctggat gtgaagagag catttgcaaa atggaggcgg aaccataatc atatttggca
      661 ggtattaatg tatgcaagga gagttttcta caagattgat acagcaagcc ccctgaaccc
      721 agaggctgca gtactgtatg aaaaagatat tcagcttttt aaaagtaaag ttgttgacag
      781 tgttaaggtg tgcactgctc gtttgtttga ccaacctaaa atagaagacc cctatgcaat
      841 tagcttttct ccatggaatc cttctgtaca tgatgaagcc agagaaaaga tgctgactca
      901 gaaaaagcct gaagaacagc acaataaaag tgttcatgtt gctggcctgt catgggtaaa
      961 gcctggctca gtacagcctt tcagtaaaga agagaaaaca gtggcgactt aagagatggt
     1021 gaatctggtg caccatgcac tttcctgcta gactctggcc tagttcaagc tgaccaatgg
     1081 cagaggactg cctgaagagt aaaactgtgt gaacaatgac tgactgccag tgttttccat
     1141 gtatgcatag gttctaacag cagggtttgg aaacctgtct ctaagtaatg cattacttct
     1201 gtcagaagtg tcttagggtg gttatctagt tcagtactcc aaattattgg ggaccttgag
     1261 gcttaagtaa gtatttttct gaatataatg ctaaaggtaa gttgcattca tttaaactaa
     1321 tagagcagac agaattcagc actacttaat agtttataaa tcagtggttt cagttgtata
     1381 tatgttagga aatggagagg tatagagaga gcaggttcca tagctcagca cttttaagtg
     1441 gaagatcatt tgaatctcag tcttcagcct gcactgattt gtagcctgca ctgtcttact
     1501 gatttacaaa ctgaaatcac tgagaaatgt ctttagttca gtgagaagaa accagaacac
     1561 ttgttcctag tgttgtgttg ttttttttaa gcaaattact tactgtattt ttatggcagg
     1621 agggagaaaa agtgttacaa cggtttctaa tgaagtccgg tatttaaatg ataaatgact
     1681 aatgtgttta gtagagacaa aataaaccaa taaatgattg ttctttgcca tttatgcagg
     1741 aaactaccct tttctcaata taaccaaaca aaggctaatt tataaatgct ttattgaaaa
     1801 atacacttat cttcatataa aattacagta gcagtatctt gagaagtttt ataaatattt
     1861 ttgcagaaca ctattctaat tgaacaatgt aagttccata tttctctcag caatatgaag
     1921 ttacctagta actttgttta tactgattca atttacaatt gaattttctc cctaataaga
     1981 ttattaattt gacttgaaaa ctgctggaac aatagtgatt aataaagata tgtatagata
     2041 attcagctgt taaataacat tttctaattt gtataaatgg tactatggta ctaataaaaa
     2101 cctaaattct ccaaccaatt tttttaaact gccaggaaca cccaaaaata tttttaaata
     2161 tatcacctta atagacattt cttttagata actccctcct aaaggaagag gtcataagtt
     2221 ttcatattaa tcccctcaat tcaacttgat taaaatcttt tcttagctgg ttgatcccta
     2281 tataacaaaa aactggagaa tttaaaacat tcccaaaagg tggctatagg ggttttaaca
     2341 ttttaaaaaa atataaaagc attaaagaaa atattggatg ttta
//
