LOCUS       NM_005465               7281 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens AKT serine/threonine kinase 3 (AKT3), transcript
            variant 1, mRNA.
ACCESSION   NM_005465 XM_005272995
VERSION     NM_005465.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7281)
  AUTHORS   Xu,Y., Lu,R., Li,H., Feng,W. and Zhao,R.
  TITLE     A spectrum of AKT3 activating mutations cause focal malformations
            of cortical development (FMCDs) in cortical organoids
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (6), 167232 (2024)
   PUBMED   38759814
  REMARK    GeneRIF: A spectrum of AKT3 activating mutations cause focal
            malformations of cortical development (FMCDs) in cortical
            organoids.
REFERENCE   2  (bases 1 to 7281)
  AUTHORS   Corre,E., Soum,C., Pfeifer,R., Bessiere,C., Dailhau,S.,
            Marboeuf,C., Meggetto,F., Touriol,C., Recher,C., Bousquet,M. and
            Pyronnet,S.
  TITLE     Differential prognostic values of the three AKT isoforms in acute
            myeloid leukemia
  JOURNAL   Sci Rep 14 (1), 7070 (2024)
   PUBMED   38528080
  REMARK    GeneRIF: Differential prognostic values of the three AKT isoforms
            in acute myeloid leukemia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7281)
  AUTHORS   Jougasaki,M., Takenoshita,Y., Umebashi,K., Yamamoto,M., Sudou,K.,
            Nakashima,H., Sonoda,M. and Kinjo,T.
  TITLE     Autocrine Regulation of Interleukin-6 via the Activation of STAT3
            and Akt in Cardiac Myxoma Cells
  JOURNAL   Int J Mol Sci 25 (4), 2232 (2024)
   PUBMED   38396907
  REMARK    GeneRIF: Autocrine Regulation of Interleukin-6 via the Activation
            of STAT3 and Akt in Cardiac Myxoma Cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7281)
  AUTHORS   Murthy,S.S., Tosolini,A., Taguchi,T. and Testa,J.R.
  TITLE     Mapping of AKT3, encoding a member of the Akt/protein kinase B
            family, to human and rodent chromosomes by fluorescence in situ
            hybridization
  JOURNAL   Cytogenet Cell Genet 88 (1-2), 38-40 (2000)
   PUBMED   10773662
REFERENCE   5  (bases 1 to 7281)
  AUTHORS   Masure,S., Haefner,B., Wesselink,J.J., Hoefnagel,E., Mortier,E.,
            Verhasselt,P., Tuytelaars,A., Gordon,R. and Richardson,A.
  TITLE     Molecular cloning, expression and characterization of the human
            serine/threonine kinase Akt-3
  JOURNAL   Eur J Biochem 265 (1), 353-360 (1999)
   PUBMED   10491192
REFERENCE   6  (bases 1 to 7281)
  AUTHORS   Nakatani,K., Sakaue,H., Thompson,D.A., Weigel,R.J. and Roth,R.A.
  TITLE     Identification of a human Akt3 (protein kinase B gamma) which
            contains the regulatory serine phosphorylation site
  JOURNAL   Biochem Biophys Res Commun 257 (3), 906-910 (1999)
   PUBMED   10208883
REFERENCE   7  (bases 1 to 7281)
  AUTHORS   Brodbeck,D., Cron,P. and Hemmings,B.A.
  TITLE     A human protein kinase Bgamma with regulatory phosphorylation sites
            in the activation loop and in the C-terminal hydrophobic domain
  JOURNAL   J Biol Chem 274 (14), 9133-9136 (1999)
   PUBMED   10092583
REFERENCE   8  (bases 1 to 7281)
  AUTHORS   Walker,K.S., Deak,M., Paterson,A., Hudson,K., Cohen,P. and
            Alessi,D.R.
  TITLE     Activation of protein kinase B beta and gamma isoforms by insulin
            in vivo and by 3-phosphoinositide-dependent protein kinase-1 in
            vitro: comparison with protein kinase B alpha
  JOURNAL   Biochem J 331 (Pt 1) (Pt 1), 299-308 (1998)
   PUBMED   9512493
REFERENCE   9  (bases 1 to 7281)
  AUTHORS   Borgatti,P., Zauli,G., Colamussi,M.L., Gibellini,D., Previati,M.,
            Cantley,L.L. and Capitani,S.
  TITLE     Extracellular HIV-1 Tat protein activates phosphatidylinositol 3-
            and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells
  JOURNAL   Eur J Immunol 27 (11), 2805-2811 (1997)
   PUBMED   9394803
REFERENCE   10 (bases 1 to 7281)
  AUTHORS   Mirzaa,G.
  TITLE     MPPH Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   27854409
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL592151.13, AF135794.1,
            AC096539.2 and U79271.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Apr 25, 2019 this sequence version replaced NM_005465.6.
            
            Summary: The protein encoded by this gene is a member of the AKT,
            also called PKB,  serine/threonine protein kinase family. AKT
            kinases are known to be regulators of cell signaling in response to
            insulin and growth factors. They are involved in a wide variety of
            biological processes including cell proliferation, differentiation,
            apoptosis, tumorigenesis, as well as glycogen synthesis and glucose
            uptake. This kinase has been shown to be stimulated by
            platelet-derived growth factor (PDGF), insulin, and insulin-like
            growth factor 1 (IGF1). Alternatively splice transcript variants
            encoding distinct isoforms have been described. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853566.3023.1,
                                           SRR14038197.2205183.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000673466.1/ ENSP00000500582.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-204               AL592151.13        103174-103377       c
            205-316             AL592151.13        96305-96416         c
            317-3114            AF135794.1         1-2798
            3115-6101           AC096539.2         141495-144481       c
            6102-7281           U79271.1           1-1180
FEATURES             Location/Qualifiers
     source          1..7281
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q43-q44"
     gene            1..7281
                     /gene="AKT3"
                     /gene_synonym="MPPH; MPPH2; PKB-GAMMA; PKBG; PRKBG;
                     RAC-gamma; RAC-PK-gamma; STK-2"
                     /note="AKT serine/threonine kinase 3"
                     /db_xref="GeneID:10000"
                     /db_xref="HGNC:HGNC:393"
                     /db_xref="MIM:611223"
     exon            1..204
                     /gene="AKT3"
                     /gene_synonym="MPPH; MPPH2; PKB-GAMMA; PKBG; PRKBG;
                     RAC-gamma; RAC-PK-gamma; STK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            205..362
                     /gene="AKT3"
                     /gene_synonym="MPPH; MPPH2; PKB-GAMMA; PKBG; PRKBG;
                     RAC-gamma; RAC-PK-gamma; STK-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             317..1756
                     /gene="AKT3"
                     /gene_synonym="MPPH; MPPH2; PKB-GAMMA; PKBG; PRKBG;
                     RAC-gamma; RAC-PK-gamma; STK-2"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     RAC-gamma serine/threonine protein kinase; PKB gamma;
                     v-akt murine thymoma viral oncogene homolog 3 (protein
                     kinase B, gamma)"
                     /codon_start=1
                     /product="RAC-gamma serine/threonine-protein kinase
                     isoform 1"
                     /protein_id="NP_005456.1"
                     /db_xref="CCDS:CCDS31077.1"
                     /db_xref="GeneID:10000"
                     /db_xref="HGNC:HGNC:393"
                     /db_xref="MIM:611223"
                     /translation="MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQD
                     VDLPYPLNNFSVAKCQLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAI
                     QAVADRLQRQEEERMNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFG
                     KVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTK
                     DRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLEN
                     LMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGV
                     VMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGG
                     PDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPE
                     KYDEDGMDCMDNERRPHFPQFSYSASGRE"
     exon            363..488
                     /gene="AKT3"
                     /gene_synonym="MPPH; MPPH2; PKB-GAMMA; PKBG; PRKBG;
                     RAC-gamma; RAC-PK-gamma; STK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            489..600
                     /gene="AKT3"
                     /gene_synonym="MPPH; MPPH2; PKB-GAMMA; PKBG; PRKBG;
                     RAC-gamma; RAC-PK-gamma; STK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            601..745
                     /gene="AKT3"
                     /gene_synonym="MPPH; MPPH2; PKB-GAMMA; PKBG; PRKBG;
                     RAC-gamma; RAC-PK-gamma; STK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            746..877
                     /gene="AKT3"
                     /gene_synonym="MPPH; MPPH2; PKB-GAMMA; PKBG; PRKBG;
                     RAC-gamma; RAC-PK-gamma; STK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            878..943
                     /gene="AKT3"
                     /gene_synonym="MPPH; MPPH2; PKB-GAMMA; PKBG; PRKBG;
                     RAC-gamma; RAC-PK-gamma; STK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1012
                     /gene="AKT3"
                     /gene_synonym="MPPH; MPPH2; PKB-GAMMA; PKBG; PRKBG;
                     RAC-gamma; RAC-PK-gamma; STK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1135
                     /gene="AKT3"
                     /gene_synonym="MPPH; MPPH2; PKB-GAMMA; PKBG; PRKBG;
                     RAC-gamma; RAC-PK-gamma; STK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1264
                     /gene="AKT3"
                     /gene_synonym="MPPH; MPPH2; PKB-GAMMA; PKBG; PRKBG;
                     RAC-gamma; RAC-PK-gamma; STK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1479
                     /gene="AKT3"
                     /gene_synonym="MPPH; MPPH2; PKB-GAMMA; PKBG; PRKBG;
                     RAC-gamma; RAC-PK-gamma; STK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1567
                     /gene="AKT3"
                     /gene_synonym="MPPH; MPPH2; PKB-GAMMA; PKBG; PRKBG;
                     RAC-gamma; RAC-PK-gamma; STK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1670
                     /gene="AKT3"
                     /gene_synonym="MPPH; MPPH2; PKB-GAMMA; PKBG; PRKBG;
                     RAC-gamma; RAC-PK-gamma; STK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..7281
                     /gene="AKT3"
                     /gene_synonym="MPPH; MPPH2; PKB-GAMMA; PKBG; PRKBG;
                     RAC-gamma; RAC-PK-gamma; STK-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5218..5223
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AKT3"
                     /gene_synonym="MPPH; MPPH2; PKB-GAMMA; PKBG; PRKBG;
                     RAC-gamma; RAC-PK-gamma; STK-2"
                     /note="hexamer: AATAAA"
     polyA_site      5242
                     /gene="AKT3"
                     /gene_synonym="MPPH; MPPH2; PKB-GAMMA; PKBG; PRKBG;
                     RAC-gamma; RAC-PK-gamma; STK-2"
                     /note="major polyA site"
     regulatory      7261..7266
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AKT3"
                     /gene_synonym="MPPH; MPPH2; PKB-GAMMA; PKBG; PRKBG;
                     RAC-gamma; RAC-PK-gamma; STK-2"
                     /note="hexamer: AATAAA"
     polyA_site      7281
                     /gene="AKT3"
                     /gene_synonym="MPPH; MPPH2; PKB-GAMMA; PKBG; PRKBG;
                     RAC-gamma; RAC-PK-gamma; STK-2"
ORIGIN      
        1 gcagcccttc gcttgccctc ccgccggccg caccgggctc caggaggcca gaggctctgt
       61 ggggtggggg gaggacagga ggggaggagg agggaggggg gacccccgag tcgccccctc
      121 tcctcccccc gccccccccc ggctccatcc tccgccgccg cccgagcagc tgcggggccg
      181 ccaccgccgc cgccgccgtt gcaggctgag tcatcactag agagtgggaa gggcagcagc
      241 agcagagaat ccaaacccta aagctgatat cacaaagtac catttctcca agttgggggc
      301 tcagagggga gtcatcatga gcgatgttac cattgtgaaa gaaggttggg ttcagaagag
      361 gggagaatat ataaaaaact ggaggccaag atacttcctt ttgaagacag atggctcatt
      421 cataggatat aaagagaaac ctcaagatgt ggatttacct tatcccctca acaacttttc
      481 agtggcaaaa tgccagttaa tgaaaacaga acgaccaaag ccaaacacat ttataatcag
      541 atgtctccag tggactactg ttatagagag aacatttcat gtagatactc cagaggaaag
      601 ggaagaatgg acagaagcta tccaggctgt agcagacaga ctgcagaggc aagaagagga
      661 gagaatgaat tgtagtccaa cttcacaaat tgataatata ggagaggaag agatggatgc
      721 ctctacaacc catcataaaa gaaagacaat gaatgatttt gactatttga aactactagg
      781 taaaggcact tttgggaaag ttattttggt tcgagagaag gcaagtggaa aatactatgc
      841 tatgaagatt ctgaagaaag aagtcattat tgcaaaggat gaagtggcac acactctaac
      901 tgaaagcaga gtattaaaga acactagaca tcccttttta acatccttga aatattcctt
      961 ccagacaaaa gaccgtttgt gttttgtgat ggaatatgtt aatgggggcg agctgttttt
     1021 ccatttgtcg agagagcggg tgttctctga ggaccgcaca cgtttctatg gtgcagaaat
     1081 tgtctctgcc ttggactatc tacattccgg aaagattgtg taccgtgatc tcaagttgga
     1141 gaatctaatg ctggacaaag atggccacat aaaaattaca gattttggac tttgcaaaga
     1201 agggatcaca gatgcagcca ccatgaagac attctgtggc actccagaat atctggcacc
     1261 agaggtgtta gaagataatg actatggccg agcagtagac tggtggggcc taggggttgt
     1321 catgtatgaa atgatgtgtg ggaggttacc tttctacaac caggaccatg agaaactttt
     1381 tgaattaata ttaatggaag acattaaatt tcctcgaaca ctctcttcag atgcaaaatc
     1441 attgctttca gggctcttga taaaggatcc aaataaacgc cttggtggag gaccagatga
     1501 tgcaaaagaa attatgagac acagtttctt ctctggagta aactggcaag atgtatatga
     1561 taaaaagctt gtacctcctt ttaaacctca agtaacatct gagacagata ctagatattt
     1621 tgatgaagaa tttacagctc agactattac aataacacca cctgaaaaat atgatgagga
     1681 tggtatggac tgcatggaca atgagaggcg gccgcatttc cctcaatttt cctactctgc
     1741 aagtggacga gaataagtct ctttcattct gctacttcac tgtcatcttc aatttattac
     1801 tgaaaatgat tcctggacat caccagtcct agctcttaca catagcaggg gcaccttccg
     1861 acatcccaga ccagccaagg gtcctcaccc ctcgccacct ttcaccctca tgaaaacaca
     1921 catacacgca aatacactcc agtttttgtt tttgcatgaa attgtatctc agtctaaggt
     1981 ctcatgctgt tgctgctact gtcttactat tatagcaact ttaagaagta attttccaac
     2041 ctttggaagt catgagccca ccattgttca tttgtgcacc aattatcatc ttttgatctt
     2101 ttagtttttc cctcagtgaa ggctaaatga gatacactga ttctaggtac attttttaac
     2161 tttctagaag agaaaaacta actagactaa gaagatttag tttataaatt cagaacaagc
     2221 aattgtggaa gggtggtggc gtgcatatgt aaagcacatc agatccgtgc gtgaagtagg
     2281 catatatcac taagctgtgg ctggaattga ttaggaagca tttggtagaa ggactgaaca
     2341 actgttggga tatatatata tatatataat tttttttttt taaattcctg gtggatactg
     2401 tagaagaagc ccatatcaca tgtggatgtc gagacttcac gggcaatcat gagcaagtga
     2461 acactgttct accaagaact gaaggcatat gcacagtcaa ggtcacttaa agggtcttat
     2521 gaaacaattt gagccagaga gcatctttcc cctgtgcttg gaaacctttt ttccttcttg
     2581 acatttatca cctctgatgg ctgaagaatg tagacaggta taatgatact gcttttcacc
     2641 aaaatttcta caccaaggta aacaggtgtt tgccttattt aattttttac tttcagttct
     2701 acgtgaatta gctttttctc agatgttgaa actttgaatg tccttttatg attttgttta
     2761 tattgcagta gtatttattt tttagtgatg agaattgtat gtcatgttag caaacgcagc
     2821 tccaacttat ataaaataga cttactgcag ttacttttga cccatgtgca aggattgtac
     2881 acgctgatga gaatcatgca ctttttctcc tctgttaaaa aaaatgataa ggctctgaaa
     2941 tggaatatat tggttagaat ttggctttgg gagaagagat gctgccattt aaccccttgg
     3001 tactgaaaat gagaaaatcc ccaactatgc atgccaaggg gttaatgaaa caaatagctg
     3061 ttgacgtttg ctcatttaag aatttgaaac gttatgatga cctggcaaca aaaagtaatg
     3121 aagaaaattg agacctgagt gaagataaga aatgatcttt acgtggcaaa atgaacacat
     3181 cttgagtatt taggaaatgg gcagtgaagg ctaagaacct ggtgtgtttc ttgggatcat
     3241 ggtacattta tcactgaatt aagccatcag ggaaaaaaca acaaaaaaag agaacacctc
     3301 cagcttttct ttttctgtat atactcatgt cccccagatt ccaacatttc tcactgaaag
     3361 ggggcatgta tgcaaacctc atctttctcc ttcattaatg atgatcttca gattaaaccc
     3421 tttggtgcta ggagctgaca atttccaaag cagcctgtga agtcctaggg gctgggggcc
     3481 actcttgcgg caagcagaag gccatcctac tccgcggagt gatcatggaa atgtatttta
     3541 gttaaactct gacagctccc aaacggaaga ctacagcatg acgtagtatt atgattgcat
     3601 tgtatgaaag agcaagtgac tttctaagta ggatgaatca tattcatatg cagatgtctt
     3661 agcctcttga cgctggaagt gtggatttat agctatgaaa ccactgctgg cagtgggtgg
     3721 gccactggga ctgacggggg ttaaagggca ttttactaag gcagctaaga catattcaga
     3781 catcaacgtt atccttcttt ttcatatttc tacctgagtg aagttcatcc ttagtattga
     3841 gtaggaagtt acagtaaatg gtagttcatt cttacttaca cacatagcta atcttttttt
     3901 tttcacttgg aattatgttg aatgtttcat tttgacaaaa aagtagacta gaaggtatgt
     3961 tctttaagtt gtcttgcatc cattatataa gaaagaaaca ggtgagagga agagcagaaa
     4021 gctgagactg gctgatgttc agagcactta ctcctctaga gggaaagcat gacaccgaac
     4081 actaagcaca cagctttttg ttgttttggt tttttctccc gcaaatctta aagtgattcc
     4141 catgaccttg gccaaggaca cttcttaaag attaatgact ggcactgaca ttgccccagg
     4201 cgggccactc ctcacactgg ctctcagttc ccagccatgc ctggggctca gtcacttcta
     4261 ttccaccctc tgagactcca ttggtgtcac acaaggtgtc ttcttggctt tgattttgag
     4321 aatcccctat tttcacttcc agatctgtca gctgccatgg aggaataata gaaaaccaga
     4381 aatgcgtgta gagggagatt tctaaaactt cccttgtgtc gcccatagtt gtagttttgg
     4441 gttctggcag gtggaacacc ctgaaacctg gaatcattct atgagaatac agttcagact
     4501 ttgcagactc cagcccatac taactgtcat gaagcttgac ttcttgtcat aatgcagcca
     4561 tcttggagga aattggccat ttctgcttag atggttggca gggtcgcgct cagctttgct
     4621 ttctacacta attacatagc attattcaag tattgttttc catttcccat ccctgatttc
     4681 cagcttctta aagctgactg ttcttgcagg ggccacttgc ttctcctaga gtacaaaagt
     4741 aagggccttc cttactaact gcagggtctc tctattacac ctcaacatac acactttgct
     4801 gctactgttt gtactgtcta cagtagaatt tccttatctt gctcctggta gtgcattaca
     4861 ggcaagcatg aaatgtaaag tatttattta aataaaaaga aaacctctaa attggtaatt
     4921 gaattacctc cctgtagctt tatagtttgt gacatttctt gaccttgcta gttctttcat
     4981 tagatctgcg caagatctag tcatctggtt aaggatttta agcagatgca actataaacc
     5041 caagaaactg tattactatt actgttggtc atactaaacc tgtctatttc ctgaagtata
     5101 tgacccacaa ggatgtggaa taactaggag aaactgtttt tgtacactgt acatccttag
     5161 tatttttaca cgtatatgat agggatgaac atgattttcc ttcgtacaga cagcttaaat
     5221 aaagcactat gtcaatctgc tacttctctg tttattgttg ttggatgtgg ttctataatc
     5281 cccccaaatt aaatcttctt taatgaaaac atgattttta atagccccag ctggtattaa
     5341 cctaccttgt ataaaatgtg acaggaaaat atagaaataa ttccttgtag ctcacacaca
     5401 cacacatagg ggatcatttt tacttcagtg aaatggcagt agtgcggttg tgcaaacttt
     5461 gatgaacggc tgcttctgag gggaaacgct gacctctcag cactggattt aggatggatg
     5521 tactgtgaag ccagggatga aggaggtctc agaccctggg gacattcaga cccgaatcat
     5581 ctatacaaca cacggtttgg acccagaatc tgaaggaatg tagcttttca ttaacgtctt
     5641 cctgataatg tactgctctg catatttcct ttcttagagt gtatttctaa caacatgtca
     5701 tggcaaatta acaaacttag acgtgggtga tgtagatggg taggatggct ggactgcagt
     5761 ctgacttcac gttgaatcat tctggatggg gcctttttct gattttacct cataaagcta
     5821 ctattgtaga aacttggctt tgctcctgtg acgaagccag acagaggaat ggcttttggg
     5881 accagagtga gtcaagcatg tatgtgtatg tcacacggcc aaatttgagg gcattctcac
     5941 atgtgctctt ctctcaaaac cactggggtt gacagatcca ggaggctaaa aaaaagtgac
     6001 ctctataatt ctttaaaggt gctattttta gaatattgta taatttattc acagtatatc
     6061 taaaacagaa ttaaggacaa ttaaaatatc ttatgtgaca gcctttatgt ctagcacatt
     6121 tgatgaaata aaaaacttct gaatctgaat agaagttcta ctgtttcagg cttgaacctt
     6181 ttacatgctc aagagattca aatggtctct gtgtgtagat catgccaccg cctccaaagc
     6241 ctaatccaca tcacttctga gaggcaaggc tgagcatatg gtgacatcag ctctgtgttg
     6301 agatggtgat gaggatgatg gctcgctggc caggcagggc agccgaaggt cagggacctg
     6361 tcctaactaa ctgcagcctt gcctttagtg tttgtcattc tcagatacaa cacggtatgt
     6421 ccagtgtccg tttttattac tttaaagcat ttgagggctt aattgtgtat agtagaaata
     6481 ctattttaga caaataatta tctgtgtaca gatatttgat atactctaag taaattttct
     6541 aatttcacta agtacgtttt taggctcctc tcaaatactg cgtattgaag aaaaaaatct
     6601 gacaccaccg agccaaagat gcttttttgt ctgttttcgt tgtttaacag aatggaaaga
     6661 gtaatgcata gtgcttcctg gtgtctcctg attgattgat tgtgcacaaa gtaggacgat
     6721 aaataaataa aatggagtct gatgggacat tgattaaagg tgaaggatga ttgatatata
     6781 gatcatgaaa agaaaaatga atggcaggaa aaaaagtttg gtccttaata tactttggcc
     6841 tagttaaaat atgtgccttt ttggtgtgtt ttgttcatca ctacaagata aaaaggaaac
     6901 attacaactc aagtctttaa aaagttcatt tattgaaaat catatgtata acctagcata
     6961 cgaatgagca gatttaaaca cataacttca agccatttct gaaaacatac accaggagct
     7021 ctgctcagct agagtcagac tccagctcca gcccgactgc gtgcggggac agcgcccgcg
     7081 ttgatgagga ccagccccac tgcaggctga ggcggtgtca ccctgggaag gtcgtggtgc
     7141 gttgtggcat attaagtcta aaccagatga atgtaaatat ctctttgtaa atcatttatt
     7201 tcactctgtt ccatccaggt cagcaatcag attgtggcat gctgggtaac tggaaaaaat
     7261 aataaaaagt aagtttcaat a
//
