LOCUS       NM_001382430            2957 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens AKT serine/threonine kinase 1 (AKT1), transcript
            variant 4, mRNA.
ACCESSION   NM_001382430
VERSION     NM_001382430.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2957)
  AUTHORS   Sun,X., Moreno Caceres,S., Yegambaram,M., Lu,Q., Pokharel,M.D.,
            Boehme,J.T., Datar,S.A., Aggarwal,S., Wang,T., Fineman,J.R. and
            Black,S.M.
  TITLE     The mitochondrial redistribution of ENOS is regulated by AKT1 and
            dimer status
  JOURNAL   Nitric Oxide 152, 90-100 (2024)
   PUBMED   39332480
  REMARK    GeneRIF: The mitochondrial redistribution of ENOS is regulated by
            AKT1 and dimer status.
REFERENCE   2  (bases 1 to 2957)
  AUTHORS   Zakaria,M.F., Kato,H., Sonoda,S., Kato,K., Uehara,N.,
            Kyumoto-Nakamura,Y., Sharifa,M.M., Yu,L., Dai,L., Yamaza,H.,
            Kajioka,S., Nishimura,F. and Yamaza,T.
  TITLE     NaV1.1 contributes to the cell cycle of human mesenchymal stem
            cells by regulating AKT and CDK2
  JOURNAL   J Cell Sci 137 (19) (2024)
   PUBMED   39258309
  REMARK    GeneRIF: NaV1.1 contributes to the cell cycle of human mesenchymal
            stem cells by regulating AKT and CDK2.
REFERENCE   3  (bases 1 to 2957)
  AUTHORS   Han,X., Zhang,A., Wang,P., Bi,H., Ren,K., Li,E., Yang,X.,
            Aydemir,I., Tao,K., Lin,J., Abdulkadir,S.A., Yang,J. and Ji,P.
  TITLE     Pleckstrin-2 Mediates the Activation of AKT in Prostate Cancer and
            Is Repressed by Androgen Receptor
  JOURNAL   Am J Pathol 194 (10), 1986-1996 (2024)
   PUBMED   39069167
  REMARK    GeneRIF: Pleckstrin-2 Mediates the Activation of AKT in Prostate
            Cancer and Is Repressed by Androgen Receptor.
REFERENCE   4  (bases 1 to 2957)
  AUTHORS   Xiang,C., Chen,L., Zhu,S., Chen,Y., Huang,H., Yang,C., Chi,Y.,
            Wang,Y., Lei,Y. and Cai,X.
  TITLE     CRLF1 bridges AKT and mTORC2 through SIN1 to inhibit pyroptosis and
            enhance chemo-resistance in ovarian cancer
  JOURNAL   Cell Death Dis 15 (9), 662 (2024)
   PUBMED   39256356
  REMARK    GeneRIF: CRLF1 bridges AKT and mTORC2 through SIN1 to inhibit
            pyroptosis and enhance chemo-resistance in ovarian cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2957)
  AUTHORS   Chen,J., Zeng,Q., Wang,X., Xu,R., Wang,W., Huang,Y., Sun,Q.,
            Yuan,W., Wang,P., Chen,D., Tong,P. and Jin,H.
  TITLE     Aberrant methylation and expression of TNXB promote chondrocyte
            apoptosis and extracullar matrix degradation in hemophilic
            arthropathy via AKT signaling
  JOURNAL   Elife 13, 93087 (2024)
   PUBMED   38819423
  REMARK    GeneRIF: Aberrant methylation and expression of TNXB promote
            chondrocyte apoptosis and extracullar matrix degradation in
            hemophilic arthropathy via AKT signaling.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2957)
  AUTHORS   Biesecker,L.G. and Sapp,J.C.
  TITLE     Proteus Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   22876373
REFERENCE   7  (bases 1 to 2957)
  AUTHORS   Coffer,P.J. and Woodgett,J.R.
  TITLE     Molecular cloning and characterisation of a novel putative
            protein-serine kinase related to the cAMP-dependent and protein
            kinase C families
  JOURNAL   Eur J Biochem 205 (3), 1217 (1992)
   PUBMED   1533586
  REMARK    Correction to:[Eur J Biochem. 1991 Oct 15;201(2):475-81. doi:
            10.1111/j.1432-1033.1991.tb16305.x. PMID: 1718748]
REFERENCE   8  (bases 1 to 2957)
  AUTHORS   Coffer,P.J. and Woodgett,J.R.
  TITLE     Molecular cloning and characterisation of a novel putative
            protein-serine kinase related to the cAMP-dependent and protein
            kinase C families
  JOURNAL   Eur J Biochem 201 (2), 475-481 (1991)
   PUBMED   1718748
  REMARK    Erratum:[Eur J Biochem. 1992 May 1;205(3):1217.. PMID: 1533586]
REFERENCE   9  (bases 1 to 2957)
  AUTHORS   Jones,P.F., Jakubowicz,T., Pitossi,F.J., Maurer,F. and
            Hemmings,B.A.
  TITLE     Molecular cloning and identification of a serine/threonine protein
            kinase of the second-messenger subfamily
  JOURNAL   Proc Natl Acad Sci U S A 88 (10), 4171-4175 (1991)
   PUBMED   1851997
REFERENCE   10 (bases 1 to 2957)
  AUTHORS   Staal,S.P.
  TITLE     Molecular cloning of the akt oncogene and its human homologues AKT1
            and AKT2: amplification of AKT1 in a primary human gastric
            adenocarcinoma
  JOURNAL   Proc Natl Acad Sci U S A 84 (14), 5034-5037 (1987)
   PUBMED   3037531
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL590327.3 and AL583722.6.
            
            Summary: This gene encodes one of the three members of the human
            AKT serine-threonine protein kinase family which are often referred
            to as protein kinase B alpha, beta, and gamma. These highly similar
            AKT proteins all have an N-terminal pleckstrin homology domain, a
            serine/threonine-specific kinase domain and a C-terminal regulatory
            domain. These proteins are phosphorylated by phosphoinositide
            3-kinase (PI3K). AKT/PI3K forms a key component of many signalling
            pathways that involve the binding of membrane-bound ligands such as
            receptor tyrosine kinases, G-protein coupled receptors, and
            integrin-linked kinase. These AKT proteins therefore regulate a
            wide variety of cellular functions including cell proliferation,
            survival, metabolism, and angiogenesis in both normal and malignant
            cells. AKT proteins are recruited to the cell membrane by
            phosphatidylinositol 3,4,5-trisphosphate (PIP3) after
            phosphorylation of phosphatidylinositol 4,5-bisphosphate (PIP2) by
            PI3K. Subsequent phosphorylation of both threonine residue 308 and
            serine residue 473 is required for full activation of the AKT1
            protein encoded by this gene. Phosphorylation of additional
            residues also occurs, for example, in response to insulin growth
            factor-1 and epidermal growth factor. Protein phosphatases act as
            negative regulators of AKT proteins by dephosphorylating AKT or
            PIP3. The PI3K/AKT signalling pathway is crucial for tumor cell
            survival. Survival factors can suppress apoptosis in a
            transcription-independent manner by activating AKT1 which then
            phosphorylates and inactivates components of the apoptotic
            machinery. AKT proteins also participate in the mammalian target of
            rapamycin (mTOR) signalling pathway which controls the assembly of
            the eukaryotic translation initiation factor 4F (eIF4E) complex and
            this pathway, in addition to responding to extracellular signals
            from growth factors and cytokines, is disregulated in many cancers.
            Mutations in this gene are associated with multiple types of cancer
            and excessive tissue growth including Proteus syndrome and Cowden
            syndrome 6, and breast, colorectal, and ovarian cancers. Multiple
            alternatively spliced transcript variants have been found for this
            gene. [provided by RefSeq, Jul 2020].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.4133176.1,
                                           SRR18074969.138080.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000649815.2/ ENSP00000497822.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-265               AL590327.3         28391-28655
            266-443             AL590327.3         30835-31012
            444-568             AL590327.3         31417-31541
            569-697             AL583722.6         187038-187166       c
            698-809             AL583722.6         183609-183720       c
            810-957             AL583722.6         182602-182749       c
            958-1089            AL583722.6         182026-182157       c
            1090-1155           AL583722.6         181888-181953       c
            1156-1224           AL583722.6         180862-180930       c
            1225-1350           AL583722.6         180405-180530       c
            1351-1479           AL583722.6         180201-180329       c
            1480-1694           AL583722.6         179828-180042       c
            1695-1782           AL583722.6         179315-179402       c
            1783-1885           AL583722.6         177695-177797       c
            1886-2957           AL583722.6         176299-177370       c
FEATURES             Location/Qualifiers
     source          1..2957
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.33"
     gene            1..2957
                     /gene="AKT1"
                     /gene_synonym="AKT; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA"
                     /note="AKT serine/threonine kinase 1"
                     /db_xref="GeneID:207"
                     /db_xref="HGNC:HGNC:391"
                     /db_xref="MIM:164730"
     exon            1..265
                     /gene="AKT1"
                     /gene_synonym="AKT; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            266..443
                     /gene="AKT1"
                     /gene_synonym="AKT; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            444..568
                     /gene="AKT1"
                     /gene_synonym="AKT; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            569..697
                     /gene="AKT1"
                     /gene_synonym="AKT; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            698..809
                     /gene="AKT1"
                     /gene_synonym="AKT; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            810..957
                     /gene="AKT1"
                     /gene_synonym="AKT; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1089
                     /gene="AKT1"
                     /gene_synonym="AKT; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1155
                     /gene="AKT1"
                     /gene_synonym="AKT; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1224
                     /gene="AKT1"
                     /gene_synonym="AKT; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1350
                     /gene="AKT1"
                     /gene_synonym="AKT; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1479
                     /gene="AKT1"
                     /gene_synonym="AKT; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1694
                     /gene="AKT1"
                     /gene_synonym="AKT; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1782
                     /gene="AKT1"
                     /gene_synonym="AKT; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1885
                     /gene="AKT1"
                     /gene_synonym="AKT; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..2957
                     /gene="AKT1"
                     /gene_synonym="AKT; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2938..2943
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AKT1"
                     /gene_synonym="AKT; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA"
                     /note="hexamer: AATAAA"
     polyA_site      2957
                     /gene="AKT1"
                     /gene_synonym="AKT; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA"
                     /note="major polyA site"
ORIGIN      
        1 ggcggcggca ggaccgagcg cggcaggcgg ctggcccagc gcacgcagcg cggcccgaag
       61 acgggagcag gcggccgagc accgagcgct gggcaccggg caccgagcgg cggcggcacg
      121 cgaggcccgg ccccgagcag cgcccccgcc cgccgcggcc tccagcccgg ccccgcccag
      181 cgccggcccg cggggatgcg gagcggcggg cgccggaggc cgcggcccgg ctaggcccgc
      241 gctcgcgccc ggacgcggcg gcccgtctgg ggagcaggga ggagccctgt gccctgtccc
      301 aggatccatg ggtaggaaca ccatggacag ggagagcaaa cggggccatc tgtcaccagg
      361 ggcttaggga aggccgagcc agcctgggtc aaagaagtca aaggggctgc ctggaggagg
      421 cagcctgtca gctggtgcat cagaggctgt ggccaggcca gctgggctcg gggagcgcca
      481 gcctgagagg agcgcgtgag cgtcgcggga gcctcgggca ccatgagcga cgtggctatt
      541 gtgaaggagg gttggctgca caaacgaggg gagtacatca agacctggcg gccacgctac
      601 ttcctcctca agaatgatgg caccttcatt ggctacaagg agcggccgca ggatgtggac
      661 caacgtgagg ctcccctcaa caacttctct gtggcgcagt gccagctgat gaagacggag
      721 cggccccggc ccaacacctt catcatccgc tgcctgcagt ggaccactgt catcgaacgc
      781 accttccatg tggagactcc tgaggagcgg gaggagtgga caaccgccat ccagactgtg
      841 gctgacggcc tcaagaagca ggaggaggag gagatggact tccggtcggg ctcacccagt
      901 gacaactcag gggctgaaga gatggaggtg tccctggcca agcccaagca ccgcgtgacc
      961 atgaacgagt ttgagtacct gaagctgctg ggcaagggca ctttcggcaa ggtgatcctg
     1021 gtgaaggaga aggccacagg ccgctactac gccatgaaga tcctcaagaa ggaagtcatc
     1081 gtggccaagg acgaggtggc ccacacactc accgagaacc gcgtcctgca gaactccagg
     1141 caccccttcc tcacagccct gaagtactct ttccagaccc acgaccgcct ctgctttgtc
     1201 atggagtacg ccaacggggg cgagctgttc ttccacctgt cccgggagcg tgtgttctcc
     1261 gaggaccggg cccgcttcta tggcgctgag attgtgtcag ccctggacta cctgcactcg
     1321 gagaagaacg tggtgtaccg ggacctcaag ctggagaacc tcatgctgga caaggacggg
     1381 cacattaaga tcacagactt cgggctgtgc aaggagggga tcaaggacgg tgccaccatg
     1441 aagacctttt gcggcacacc tgagtacctg gcccccgagg tgctggagga caatgactac
     1501 ggccgtgcag tggactggtg ggggctgggc gtggtcatgt acgagatgat gtgcggtcgc
     1561 ctgcccttct acaaccagga ccatgagaag ctttttgagc tcatcctcat ggaggagatc
     1621 cgcttcccgc gcacgcttgg tcccgaggcc aagtccttgc tttcagggct gctcaagaag
     1681 gaccccaagc agaggcttgg cgggggctcc gaggacgcca aggagatcat gcagcatcgc
     1741 ttctttgccg gtatcgtgtg gcagcacgtg tacgagaaga agctcagccc acccttcaag
     1801 ccccaggtca cgtcggagac tgacaccagg tattttgatg aggagttcac ggcccagatg
     1861 atcaccatca caccacctga ccaagatgac agcatggagt gtgtggacag cgagcgcagg
     1921 ccccacttcc cccagttctc ctactcggcc agcggcacgg cctgaggcgg cggtggactg
     1981 cgctggacga tagcttggag ggatggagag gcggcctcgt gccatgatct gtatttaatg
     2041 gtttttattt ctcgggtgca tttgagagaa gccacgctgt cctctcgagc ccagatggaa
     2101 agacgttttt gtgctgtggg cagcaccctc ccccgcagcg gggtagggaa gaaaactatc
     2161 ctgcgggttt taatttattt catccagttt gttctccggg tgtggcctca gccctcagaa
     2221 caatccgatt cacgtaggga aatgttaagg acttctgcag ctatgcgcaa tgtggcattg
     2281 gggggccggg caggtcctgc ccatgtgtcc cctcactctg tcagccagcc gccctgggct
     2341 gtctgtcacc agctatctgt catctctctg gggccctggg cctcagttca acctggtggc
     2401 accagatgca acctcactat ggtatgctgg ccagcaccct ctcctggggg tggcaggcac
     2461 acagcagccc cccagcacta aggccgtgtc tctgaggacg tcatcggagg ctgggcccct
     2521 gggatgggac cagggatggg ggatgggcca gggtttaccc agtgggacag aggagcaagg
     2581 tttaaatttg ttattgtgta ttatgttgtt caaatgcatt ttgggggttt ttaatctttg
     2641 tgacaggaaa gccctccccc ttccccttct gtgtcacagt tcttggtgac tgtcccaccg
     2701 ggagcctccc cctcagatga tctctccacg gtagcacttg accttttcga cgcttaacct
     2761 ttccgctgtc gccccaggcc ctccctgact ccctgtgggg gtggccatcc ctgggcccct
     2821 ccacgcctcc tggccagacg ctgccgctgc cgctgcacca cggcgttttt ttacaacatt
     2881 caactttagt atttttacta ttataatata atatggaacc ttccctccaa attcttcaat
     2941 aaaagttgct tttcaaa
//
