LOCUS       NM_012067               1215 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens aldo-keto reductase family 7 member A3 (AKR7A3), mRNA.
ACCESSION   NM_012067
VERSION     NM_012067.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1215)
  AUTHORS   Lim,S.H., Snider,J., Birimberg-Schwartz,L., Ip,W., Serralha,J.C.,
            Botelho,H.M., Lopes-Pacheco,M., Pinto,M.C., Moutaoufik,M.T.,
            Zilocchi,M., Laselva,O., Esmaeili,M., Kotlyar,M., Lyakisheva,A.,
            Tang,P., Lopez Vazquez,L., Akula,I., Aboualizadeh,F., Wong,V.,
            Grozavu,I., Opacak-Bernardi,T., Yao,Z., Mendoza,M., Babu,M.,
            Jurisica,I., Gonska,T., Bear,C.E., Amaral,M.D. and Stagljar,I.
  TITLE     CFTR interactome mapping using the mammalian membrane two-hybrid
            high-throughput screening system
  JOURNAL   Mol Syst Biol 18 (2), e10629 (2022)
   PUBMED   35156780
REFERENCE   2  (bases 1 to 1215)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1215)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1215)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1215)
  AUTHORS   Torres-Mena,J.E., Salazar-Villegas,K.N., Sanchez-Rodriguez,R.,
            Lopez-Gabino,B., Del Pozo-Yauner,L., Arellanes-Robledo,J.,
            Villa-Trevino,S., Gutierrez-Nava,M.A. and Perez-Carreon,J.I.
  TITLE     Aldo-Keto Reductases as Early Biomarkers of Hepatocellular
            Carcinoma: A Comparison Between Animal Models and Human HCC
  JOURNAL   Dig Dis Sci 63 (4), 934-944 (2018)
   PUBMED   29383608
  REMARK    GeneRIF: Results demonstrate that Akr7a3 mRNA and protein levels
            are consistently co-expressed along with Akr1b10, in both
            experimental rat liver carcinogenesis and some human hepatocellular
            carcinoma samples.
REFERENCE   6  (bases 1 to 1215)
  AUTHORS   Liu,C.Y., Wu,M.C., Chen,F., Ter-Minassian,M., Asomaning,K.,
            Zhai,R., Wang,Z., Su,L., Heist,R.S., Kulke,M.H., Lin,X., Liu,G. and
            Christiani,D.C.
  TITLE     A Large-scale genetic association study of esophageal
            adenocarcinoma risk
  JOURNAL   Carcinogenesis 31 (7), 1259-1263 (2010)
   PUBMED   20453000
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 1215)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   8  (bases 1 to 1215)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   9  (bases 1 to 1215)
  AUTHORS   Praml,C., Savelyeva,L. and Schwab,M.
  TITLE     Aflatoxin B1 aldehyde reductase (AFAR) genes cluster at 1p35-1p36.1
            in a region frequently altered in human tumour cells
  JOURNAL   Oncogene 22 (30), 4765-4773 (2003)
   PUBMED   12879023
REFERENCE   10 (bases 1 to 1215)
  AUTHORS   Knight,L.P., Primiano,T., Groopman,J.D., Kensler,T.W. and
            Sutter,T.R.
  TITLE     cDNA cloning, expression and activity of a second human aflatoxin
            B1-metabolizing member of the aldo-keto reductase superfamily,
            AKR7A3
  JOURNAL   Carcinogenesis 20 (7), 1215-1223 (1999)
   PUBMED   10383892
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM855386.1, BM920315.1, BC031562.1 and BG747063.1.
            
            On Nov 23, 2018 this sequence version replaced NM_012067.2.
            
            Summary: Aldo-keto reductases, such as AKR7A3, are involved in the
            detoxification of aldehydes and ketones.[supplied by OMIM, Apr
            2004].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF040639.1, BC025709.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2152474 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361640.5/ ENSP00000355377.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-275               BM855386.1         29-303
            276-703             BM920315.1         256-683
            704-999             BC031562.1         662-957
            1000-1215           BG747063.1         249-464
FEATURES             Location/Qualifiers
     source          1..1215
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.13"
     gene            1..1215
                     /gene="AKR7A3"
                     /gene_synonym="AFAR2"
                     /note="aldo-keto reductase family 7 member A3"
                     /db_xref="GeneID:22977"
                     /db_xref="HGNC:HGNC:390"
                     /db_xref="MIM:608477"
     exon            1..275
                     /gene="AKR7A3"
                     /gene_synonym="AFAR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..1057
                     /gene="AKR7A3"
                     /gene_synonym="AFAR2"
                     /EC_number="1.1.1.n11"
                     /note="aflatoxin B1 aldehyde reductase 2; aflatoxin
                     aldehyde reductase; AFB1-AR 2; AFB1 aldehyde reductase 2;
                     epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="aflatoxin B1 aldehyde reductase member 3"
                     /protein_id="NP_036199.2"
                     /db_xref="CCDS:CCDS193.1"
                     /db_xref="GeneID:22977"
                     /db_xref="HGNC:HGNC:390"
                     /db_xref="MIM:608477"
                     /translation="MSRQLSRARPATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEID
                     TAFVYSEGQSETILGGLGLRLGGSDCRVKIDTKAIPLFGNSLKPDSLRFQLETSLKRL
                     QCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSN
                     GWILPTVYQGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGKYKYEDKNGKQ
                     PVGRFFGNTWAEMYRNRYWKEHHFEGIALVEKALQAAYGASAPSMTSATLRWMYHHSQ
                     LQGAHGDAVILGMSSLEQLEQNLAAAEEGPLEPAVVDAFNQAWHLVTHECPNYFR"
     exon            276..463
                     /gene="AKR7A3"
                     /gene_synonym="AFAR2"
                     /inference="alignment:Splign:2.1.0"
     exon            464..568
                     /gene="AKR7A3"
                     /gene_synonym="AFAR2"
                     /inference="alignment:Splign:2.1.0"
     exon            569..665
                     /gene="AKR7A3"
                     /gene_synonym="AFAR2"
                     /inference="alignment:Splign:2.1.0"
     exon            666..765
                     /gene="AKR7A3"
                     /gene_synonym="AFAR2"
                     /inference="alignment:Splign:2.1.0"
     exon            766..895
                     /gene="AKR7A3"
                     /gene_synonym="AFAR2"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1215
                     /gene="AKR7A3"
                     /gene_synonym="AFAR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1203..1208
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AKR7A3"
                     /gene_synonym="AFAR2"
                     /note="hexamer: AATAAA"
     polyA_site      1215
                     /gene="AKR7A3"
                     /gene_synonym="AFAR2"
                     /note="major polyA site"
ORIGIN      
        1 ctggtgcttc cgaccgctgc gcgcggctcc tgggctgtca cagtctcccg ttgccgccgt
       61 catgtcccgg cagctgtcgc gggcccggcc agccacggtg ctgggcgcca tggagatggg
      121 gcgccgcatg gacgcgccca ccagcgccgc agtcacgcgc gccttcctgg agcgcggcca
      181 caccgagata gacacggcct tcgtgtacag cgagggccag tccgagacca tccttggcgg
      241 cctggggctc cggctgggcg gcagcgactg cagagtgaaa attgatacca aggccattcc
      301 actgtttggg aactccctga agcctgacag tctccggttc cagctggaga cgtcactgaa
      361 gcggctgcag tgtccccgag tggacctctt ctacctgcat atgccagacc acagcacccc
      421 ggtggaagag acactgcgtg cctgccacca gctgcaccag gagggcaagt tcgtggagct
      481 tggcctctcc aactatgcag cctgggaagt ggccgagatc tgtaccctct gcaagagcaa
      541 cggctggatc ctgcccactg tgtaccaggg catgtacaat gccatcaccc ggcaggtgga
      601 aacggagctc ttcccctgcc tcaggcactt tggactgagg ttctatgcct tcaaccctct
      661 ggctgggggc ctgctgaccg gcaagtacaa gtatgaggac aagaatggga aacagcccgt
      721 gggccgcttc tttgggaata cctgggcaga gatgtacagg aatcgctact ggaaggagca
      781 ccactttgag ggcattgccc tggtggagaa ggccctgcag gccgcgtatg gcgccagcgc
      841 ccccagcatg acctcggcca ccctccggtg gatgtaccac cactcacagc tgcagggtgc
      901 ccacggggac gcggtcatcc tgggcatgtc cagcctggag cagctggagc agaacttggc
      961 agcggcagag gaagggcccc tggagccggc tgtcgtggac gcctttaatc aagcctggca
     1021 tttggttact cacgaatgtc ccaactactt ccgctaggcc catcgtttct caggctgccc
     1081 aaggctcttc tgtaacatct tttgttactc acattttctt taatttagaa ctgcctcagt
     1141 aaattcttag ggatggaagt atttggacaa aaacctaata gaagagtcac caccaaatga
     1201 agaataaaac tccca
//
