LOCUS       NM_001395972            1247 bp    mRNA    linear   PRI 28-OCT-2022
DEFINITION  Homo sapiens aldo-keto reductase family 1 member C8 (AKR1C8),
            transcript variant 1, mRNA.
ACCESSION   NM_001395972
VERSION     NM_001395972.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1247)
  AUTHORS   Haenig C, Atias N, Taylor AK, Mazza A, Schaefer MH, Russ J,
            Riechers SP, Jain S, Coughlin M, Fontaine JF, Freibaum BD,
            Brusendorf L, Zenkner M, Porras P, Stroedicke M, Schnoegl S,
            Arnsburg K, Boeddrich A, Pigazzini L, Heutink P, Taylor JP,
            Kirstein J, Andrade-Navarro MA, Sharan R and Wanker EE.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1247)
  AUTHORS   Deloukas P, Earthrowl ME, Grafham DV, Rubenfield M, French L,
            Steward CA, Sims SK, Jones MC, Searle S, Scott C, Howe K, Hunt SE,
            Andrews TD, Gilbert JG, Swarbreck D, Ashurst JL, Taylor A, Battles
            J, Bird CP, Ainscough R, Almeida JP, Ashwell RI, Ambrose KD,
            Babbage AK, Bagguley CL, Bailey J, Banerjee R, Bates K, Beasley H,
            Bray-Allen S, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J,
            Cahill P, Camire D, Carter NP, Chapman JC, Clark SY, Clarke G, Clee
            CM, Clegg S, Corby N, Coulson A, Dhami P, Dutta I, Dunn M, Faulkner
            L, Frankish A, Frankland JA, Garner P, Garnett J, Gribble S,
            Griffiths C, Grocock R, Gustafson E, Hammond S, Harley JL, Hart E,
            Heath PD, Ho TP, Hopkins B, Horne J, Howden PJ, Huckle E, Hynds C,
            Johnson C, Johnson D, Kana A, Kay M, Kimberley AM, Kershaw JK,
            Kokkinaki M, Laird GK, Lawlor S, Lee HM, Leongamornlert DA, Laird
            G, Lloyd C, Lloyd DM, Loveland J, Lovell J, McLaren S, McLay KE,
            McMurray A, Mashreghi-Mohammadi M, Matthews L, Milne S, Nickerson
            T, Nguyen M, Overton-Larty E, Palmer SA, Pearce AV, Peck AI, Pelan
            S, Phillimore B, Porter K, Rice CM, Rogosin A, Ross MT, Sarafidou
            T, Sehra HK, Shownkeen R, Skuce CD, Smith M, Standring L, Sycamore
            N, Tester J, Thorpe A, Torcasso W, Tracey A, Tromans A, Tsolas J,
            Wall M, Walsh J, Wang H, Weinstock K, West AP, Willey DL, Whitehead
            SL, Wilming L, Wray PW, Young L, Chen Y, Lovering RC, Moschonas NK,
            Siebert R, Fechtel K, Bentley D, Durbin R, Hubbard T,
            Doucette-Stamm L, Beck S, Smith DR and Rogers J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL355303.17.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1966682, SAMEA1968968
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000648824.2/ ENSP00000496804.1
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               AL355303.17        43548-43686         c
            140-307             AL355303.17        21389-21556         c
            308-424             AL355303.17        20392-20508         c
            425-502             AL355303.17        19348-19425         c
            503-625             AL355303.17        18419-18541         c
            626-735             AL355303.17        17136-17245         c
            736-901             AL355303.17        16171-16336         c
            902-984             AL355303.17        14211-14293         c
            985-1247            AL355303.17        12456-12718         c
FEATURES             Location/Qualifiers
     source          1..1247
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p15.1"
     gene            1..1247
                     /gene="AKR1C8"
                     /gene_synonym="AKR1C8P; AKR1CL1"
                     /note="aldo-keto reductase family 1 member C8"
                     /db_xref="GeneID:340811"
                     /db_xref="HGNC:HGNC:23469"
     exon            1..139
                     /gene="AKR1C8"
                     /gene_synonym="AKR1C8P; AKR1CL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..1027
                     /gene="AKR1C8"
                     /gene_synonym="AKR1C8P; AKR1CL1"
                     /note="protein RAKc; aldo-keto reductase family 1, member
                     C-like 1; aldo-keto reductase family 1 member C-like
                     protein 1; aldo-keto reductase family 1 member C8,
                     pseudogene"
                     /codon_start=1
                     /product="putative aldo-keto reductase family 1 member C8"
                     /protein_id="NP_001382901.1"
                     /db_xref="CCDS:CCDS91207.1"
                     /db_xref="GeneID:340811"
                     /db_xref="HGNC:HGNC:23469"
                     /translation="MMTDLKQSHSVRLNDGPFMPVLGFGTYAPDHTPKSQAAEATKVA
                     IDVGFRHIDSAYLYQNEEEVGQAIWEKIADGTVKREEIFYTIKLWATFFRAELVHPAL
                     ERSLKKLGPDYVDLFIIHVPFAMKPGKELLPKDASGEIILETVELCDTWEALEKCKEA
                     GLTRSIGVSNFNHKLLELILNKPGLKYKPTCNQVECHPYLNQSKLLEFCKSKDIVLVA
                     YSALGSQRDPQWVDPDCPHLLEEPILKSIAKKHSGSPGQVALRYQLQRGVVVLAKSFS
                     QERIKENFQIFDFELTPEDMKAIDGLNRNLRYDKLQFAANHPYFPFSEEY"
     exon            140..307
                     /gene="AKR1C8"
                     /gene_synonym="AKR1C8P; AKR1CL1"
                     /inference="alignment:Splign:2.1.0"
     exon            308..424
                     /gene="AKR1C8"
                     /gene_synonym="AKR1C8P; AKR1CL1"
                     /inference="alignment:Splign:2.1.0"
     exon            425..502
                     /gene="AKR1C8"
                     /gene_synonym="AKR1C8P; AKR1CL1"
                     /inference="alignment:Splign:2.1.0"
     exon            503..625
                     /gene="AKR1C8"
                     /gene_synonym="AKR1C8P; AKR1CL1"
                     /inference="alignment:Splign:2.1.0"
     exon            626..735
                     /gene="AKR1C8"
                     /gene_synonym="AKR1C8P; AKR1CL1"
                     /inference="alignment:Splign:2.1.0"
     exon            736..901
                     /gene="AKR1C8"
                     /gene_synonym="AKR1C8P; AKR1CL1"
                     /inference="alignment:Splign:2.1.0"
     exon            902..984
                     /gene="AKR1C8"
                     /gene_synonym="AKR1C8P; AKR1CL1"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1247
                     /gene="AKR1C8"
                     /gene_synonym="AKR1C8P; AKR1CL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1227..1232
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AKR1C8"
                     /gene_synonym="AKR1C8P; AKR1CL1"
                     /note="hexamer: AATAAA"
     polyA_site      1247
                     /gene="AKR1C8"
                     /gene_synonym="AKR1C8P; AKR1CL1"
                     /note="major polyA site"
ORIGIN      
        1 actgggctgt cagtgaggaa aaggaggaaa gacaggttag ctggggatga tgacggatct
       61 gaagcaaagc cattcagtga ggctgaatga tggacccttc atgccagtgc tgggatttgg
      121 cacttatgct cctgatcata ctcccaaaag ccaggctgcc gaggccacca aagtggctat
      181 tgacgtaggc ttccgccata ttgattcagc atacttatac caaaatgagg aggaggttgg
      241 acaggccatt tgggagaaga tcgctgatgg taccgtcaag agagaggaaa tattctacac
      301 catcaagctt tgggctactt tctttcgggc agaattggtt cacccggccc tagaaaggtc
      361 actgaagaaa cttggaccgg actatgtaga tctcttcatt attcatgtac catttgctat
      421 gaagcctggg aaagaattac tgccaaagga tgccagtgga gagattattt tagaaactgt
      481 ggagctttgt gacacttggg aggccctgga gaagtgcaaa gaagcaggtt taaccaggtc
      541 cattggggtg tccaatttca atcacaagct gctggaactc atcctcaaca agccagggct
      601 caagtacaag cccacctgca accaggtgga atgtcaccct tacctcaacc agagcaaact
      661 cctggagttc tgcaagtcca aggacattgt tctagttgcc tacagtgccc tgggatccca
      721 aagagaccca cagtgggtgg atcccgactg cccacatctc ttggaggagc cgatcttgaa
      781 atccattgcc aagaaacaca gtggaagccc aggccaggtc gccctgcgct accagctgca
      841 gcggggagtg gtggtgctgg ccaagagctt ctctcaggag agaatcaaag agaacttcca
      901 gatttttgac tttgagttga ctccagagga catgaaagcc attgatggcc tcaacagaaa
      961 tctccgatat gacaagttac aatttgctgc taatcaccct tattttccat tttctgaaga
     1021 atattgacca tgagctattg aacattacca ccacaatttc ctccttttag gtgacagaga
     1081 gaggatttca gtatttgata gaggagtagg aagtaggatc tgtagttgca ggttgcttgc
     1141 ctttctttat tttatgaaat gaagacttta acaagaagat gtttgttttt cctgattatt
     1201 aaagtaatac ccataaattt tagaaaaata aaaaatacaa aaaaaga
//
