LOCUS       NM_003739               1186 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens aldo-keto reductase family 1 member C3 (AKR1C3),
            transcript variant 1, mRNA.
ACCESSION   NM_003739
VERSION     NM_003739.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1186)
  AUTHORS   Gao,Y., Tao,W., Wang,S., Duan,R. and Zhang,Z.
  TITLE     AKR1C3 silencing inhibits autophagy-dependent glycolysis in thyroid
            cancer cells by inactivating ERK signaling
  JOURNAL   Drug Dev Res 85 (1), e22142 (2024)
   PUBMED   38349266
  REMARK    GeneRIF: AKR1C3 silencing inhibits autophagy-dependent glycolysis
            in thyroid cancer cells by inactivating ERK signaling.
REFERENCE   2  (bases 1 to 1186)
  AUTHORS   Himura,R., Kawano,S., Nagata,Y., Kawai,M., Ota,A., Kudo,Y.,
            Yoshino,Y., Fujimoto,N., Miyamoto,H., Endo,S. and Ikari,A.
  TITLE     Inhibition of aldo-keto reductase 1C3 overcomes
            gemcitabine/cisplatin resistance in bladder cancer
  JOURNAL   Chem Biol Interact 388, 110840 (2024)
   PUBMED   38122923
  REMARK    GeneRIF: Inhibition of aldo-keto reductase 1C3 overcomes
            gemcitabine/cisplatin resistance in bladder cancer.
REFERENCE   3  (bases 1 to 1186)
  AUTHORS   Jeng,K.S., Cheng,P.Y., Lin,Y.H., Liu,P.C., Tseng,P.H., Wang,Y.C.,
            Chang,C.F. and Leu,C.M.
  TITLE     Aldo-keto reductase family member C3 (AKR1C3) promotes
            hepatocellular carcinoma cell growth by producing prostaglandin
            F2alpha
  JOURNAL   Oncol Res 32 (1), 163-174 (2023)
   PUBMED   38188684
  REMARK    GeneRIF: Aldo-keto reductase family member C3 (AKR1C3) promotes
            hepatocellular carcinoma cell growth by producing prostaglandin
            F2alpha.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1186)
  AUTHORS   Lazzarini,R., Tartaglione,M.F., Ciarapica,V., Piva,F.,
            Giulietti,M., Fulgenzi,G., Martelli,M., Ledda,C., Vitale,E.,
            Malavolta,M., Santarelli,L. and Bracci,M.
  TITLE     Keratinocytes Exposed to Blue or Red Light: Proteomic
            Characterization Showed Cytoplasmic Thioredoxin Reductase 1 and
            Aldo-Keto Reductase Family 1 Member C3 Triggered Expression
  JOURNAL   Int J Mol Sci 24 (22), 16189 (2023)
   PUBMED   38003379
  REMARK    GeneRIF: Keratinocytes Exposed to Blue or Red Light: Proteomic
            Characterization Showed Cytoplasmic Thioredoxin Reductase 1 and
            Aldo-Keto Reductase Family 1 Member C3 Triggered Expression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1186)
  AUTHORS   Takano,S., Fukami,T., Ichida,H., Suzuki,K., Nakano,M. and
            Nakajima,M.
  TITLE     In Vitro Evaluation of the Reductase Activities of Human AKR1C3
            Allelic Variants
  JOURNAL   Drug Metab Dispos 51 (9), 1188-1195 (2023)
   PUBMED   37344179
  REMARK    GeneRIF: In Vitro Evaluation of the Reductase Activities of Human
            AKR1C3 Allelic Variants.
REFERENCE   6  (bases 1 to 1186)
  AUTHORS   Bennett,M.J., Schlegel,B.P., Jez,J.M., Penning,T.M. and Lewis,M.
  TITLE     Structure of 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase
            complexed with NADP+
  JOURNAL   Biochemistry 35 (33), 10702-10711 (1996)
   PUBMED   8718859
REFERENCE   7  (bases 1 to 1186)
  AUTHORS   Khanna,M., Qin,K.N., Wang,R.W. and Cheng,K.C.
  TITLE     Substrate specificity, gene structure, and tissue-specific
            distribution of multiple human 3 alpha-hydroxysteroid
            dehydrogenases
  JOURNAL   J Biol Chem 270 (34), 20162-20168 (1995)
   PUBMED   7650035
REFERENCE   8  (bases 1 to 1186)
  AUTHORS   Khanna,M., Qin,K.N. and Cheng,K.C.
  TITLE     Distribution of 3 alpha-hydroxysteroid dehydrogenase in rat brain
            and molecular cloning of multiple cDNAs encoding structurally
            related proteins in humans
  JOURNAL   J Steroid Biochem Mol Biol 53 (1-6), 41-46 (1995)
   PUBMED   7626489
REFERENCE   9  (bases 1 to 1186)
  AUTHORS   Khanna,M., Qin,K.N., Klisak,I., Belkin,S., Sparkes,R.S. and
            Cheng,K.C.
  TITLE     Localization of multiple human dihydrodiol dehydrogenase (DDH1 and
            DDH2) and chlordecone reductase (CHDR) genes in chromosome 10 by
            the polymerase chain reaction and fluorescence in situ
            hybridization
  JOURNAL   Genomics 25 (2), 588-590 (1995)
   PUBMED   7789999
REFERENCE   10 (bases 1 to 1186)
  AUTHORS   Qin,K.N., New,M.I. and Cheng,K.C.
  TITLE     Molecular cloning of multiple cDNAs encoding human enzymes
            structurally related to 3 alpha-hydroxysteroid dehydrogenase
  JOURNAL   J Steroid Biochem Mol Biol 46 (6), 673-679 (1993)
   PUBMED   8274401
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AV761799.2 and BC019230.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_003739.5.
            
            Summary: This gene encodes a member of the aldo/keto reductase
            superfamily, which consists of more than 40 known enzymes and
            proteins. These enzymes catalyze the conversion of aldehydes and
            ketones to their corresponding alcohols by utilizing NADH and/or
            NADPH as cofactors. The enzymes display overlapping but distinct
            substrate specificity. This enzyme catalyzes the reduction of
            prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the
            oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important
            role in the pathogenesis of allergic diseases such as asthma, and
            may also have a role in controlling cell growth and/or
            differentiation. This gene shares high sequence identity with three
            other gene members and is clustered with those three genes at
            chromosome 10p15-p14. Three transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Dec
            2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes one of the larger isoforms (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC001479.2, AB018580.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380554.5/ ENSP00000369927.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AV761799.2         41-48
            9-1186              BC019230.1         4-1181
FEATURES             Location/Qualifiers
     source          1..1186
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p15.1"
     gene            1..1186
                     /gene="AKR1C3"
                     /gene_synonym="DD3; DDX; HA1753; HAKRB; HAKRe; hluPGFS;
                     HSD17B5; PGFS"
                     /note="aldo-keto reductase family 1 member C3"
                     /db_xref="GeneID:8644"
                     /db_xref="HGNC:HGNC:386"
                     /db_xref="MIM:603966"
     exon            1..115
                     /gene="AKR1C3"
                     /gene_synonym="DD3; DDX; HA1753; HAKRB; HAKRe; hluPGFS;
                     HSD17B5; PGFS"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..1003
                     /gene="AKR1C3"
                     /gene_synonym="DD3; DDX; HA1753; HAKRB; HAKRe; hluPGFS;
                     HSD17B5; PGFS"
                     /EC_number="1.1.1.62"
                     /EC_number="1.1.1.188"
                     /EC_number="1.1.1.239"
                     /EC_number="1.1.1.64"
                     /EC_number="1.1.1.357"
                     /EC_number="1.1.1.210"
                     /EC_number="1.1.1.53"
                     /note="isoform 1 is encoded by transcript variant 1;
                     dihydrodiol dehydrogenase X; type IIb 3-alpha
                     hydroxysteroid dehydrogenase; prostaglandin F synthase;
                     trans-1,2-dihydrobenzene-1,2-diol dehydrogenase;
                     dihydrodiol dehydrogenase 3; 3-alpha hydroxysteroid
                     dehydrogenase, type II; indanol dehydrogenase; 3-alpha-HSD
                     type II, brain; chlordecone reductase homolog HAKRb;
                     testosterone 17-beta-dehydrogenase 5"
                     /codon_start=1
                     /product="aldo-keto reductase family 1 member C3 isoform
                     1"
                     /protein_id="NP_003730.4"
                     /db_xref="CCDS:CCDS7063.1"
                     /db_xref="GeneID:8644"
                     /db_xref="HGNC:HGNC:386"
                     /db_xref="MIM:603966"
                     /translation="MDSKHQCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEA
                     GFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENS
                     LKKAQLDYVDLYLIHSPMSLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLA
                     KSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSA
                     LGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQR
                     IRQNVQVFEFQLTAEDMKAIDGLDRNLHYFNSDSFASHPNYPYSDEY"
     exon            116..283
                     /gene="AKR1C3"
                     /gene_synonym="DD3; DDX; HA1753; HAKRB; HAKRe; hluPGFS;
                     HSD17B5; PGFS"
                     /inference="alignment:Splign:2.1.0"
     exon            284..400
                     /gene="AKR1C3"
                     /gene_synonym="DD3; DDX; HA1753; HAKRB; HAKRe; hluPGFS;
                     HSD17B5; PGFS"
                     /inference="alignment:Splign:2.1.0"
     exon            401..478
                     /gene="AKR1C3"
                     /gene_synonym="DD3; DDX; HA1753; HAKRB; HAKRe; hluPGFS;
                     HSD17B5; PGFS"
                     /inference="alignment:Splign:2.1.0"
     exon            479..601
                     /gene="AKR1C3"
                     /gene_synonym="DD3; DDX; HA1753; HAKRB; HAKRe; hluPGFS;
                     HSD17B5; PGFS"
                     /inference="alignment:Splign:2.1.0"
     exon            602..711
                     /gene="AKR1C3"
                     /gene_synonym="DD3; DDX; HA1753; HAKRB; HAKRe; hluPGFS;
                     HSD17B5; PGFS"
                     /inference="alignment:Splign:2.1.0"
     exon            712..877
                     /gene="AKR1C3"
                     /gene_synonym="DD3; DDX; HA1753; HAKRB; HAKRe; hluPGFS;
                     HSD17B5; PGFS"
                     /inference="alignment:Splign:2.1.0"
     exon            878..960
                     /gene="AKR1C3"
                     /gene_synonym="DD3; DDX; HA1753; HAKRB; HAKRe; hluPGFS;
                     HSD17B5; PGFS"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1186
                     /gene="AKR1C3"
                     /gene_synonym="DD3; DDX; HA1753; HAKRB; HAKRe; hluPGFS;
                     HSD17B5; PGFS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1161..1166
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AKR1C3"
                     /gene_synonym="DD3; DDX; HA1753; HAKRB; HAKRe; hluPGFS;
                     HSD17B5; PGFS"
                     /note="hexamer: AATAAA"
     polyA_site      1186
                     /gene="AKR1C3"
                     /gene_synonym="DD3; DDX; HA1753; HAKRB; HAKRe; hluPGFS;
                     HSD17B5; PGFS"
                     /note="major polyA site"
ORIGIN      
        1 aaacatttgc tagtcagaca agtgacaggg aatggattcc aaacaccagt gtgtaaagct
       61 aaatgatggc cacttcatgc ctgtattggg atttggcacc tatgcacctc cagaggttcc
      121 gagaagtaaa gctttggagg tcacaaaatt agcaatagaa gctgggttcc gccatataga
      181 ttctgctcat ttatacaata atgaggagca ggttggactg gccatccgaa gcaagattgc
      241 agatggcagt gtgaagagag aagacatatt ctacacttca aagctttggt ccacttttca
      301 tcgaccagag ttggtccgac cagccttgga aaactcactg aagaaagctc aattggacta
      361 tgttgacctc tatcttattc attctccaat gtctctaaag ccaggtgagg aactttcacc
      421 aacagatgaa aatggaaaag taatatttga catagtggat ctctgtacca cctgggaggc
      481 catggagaag tgtaaggatg caggattggc caagtccatt ggggtgtcaa acttcaaccg
      541 caggcagctg gagatgatcc tcaacaagcc aggactcaag tacaagcctg tctgcaacca
      601 ggtagaatgt catccgtatt tcaaccggag taaattgcta gatttctgca agtcgaaaga
      661 tattgttctg gttgcctata gtgctctggg atctcaacga gacaaacgat gggtggaccc
      721 gaactccccg gtgctcttgg aggacccagt cctttgtgcc ttggcaaaaa agcacaagcg
      781 aaccccagcc ctgattgccc tgcgctacca gctgcagcgt ggggttgtgg tcctggccaa
      841 gagctacaat gagcagcgca tcagacagaa cgtgcaggtt tttgagttcc agttgactgc
      901 agaggacatg aaagccatag atggcctaga cagaaatctc cactatttta acagtgatag
      961 ttttgctagc caccctaatt atccatattc agatgaatat taacatggag ggctttgcct
     1021 gatgtctacc agaagccctg tgtgtggatg gtgacgcaga ggacgtctct atgccggtga
     1081 ctggacatat cacctctact taaatccgtc ctgtttagcg acttcagtca actacagctg
     1141 agtccatagg ccagaaagac aataaatttt tatcattttg aaataa
//
