LOCUS       NM_001393392            3215 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens aldo-keto reductase family 1 member C2 (AKR1C2),
            transcript variant 5, mRNA.
ACCESSION   NM_001393392
VERSION     NM_001393392.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3215)
  AUTHORS   Xiao,Y., Shen,Y., Song,H., Gao,F., Mao,Z., Lv,Q., Qin,C., Yuan,L.,
            Wu,D., Chu,H., Wang,M., Du,M., Zheng,R. and Zhang,Z.
  TITLE     AKR1C2 genetic variants mediate tobacco carcinogens metabolism
            involving bladder cancer susceptibility
  JOURNAL   Arch Toxicol 98 (7), 2269-2279 (2024)
   PUBMED   38662237
  REMARK    GeneRIF: AKR1C2 genetic variants mediate tobacco carcinogens
            metabolism involving bladder cancer susceptibility.
REFERENCE   2  (bases 1 to 3215)
  AUTHORS   Wang,Z., Feng,Y., Song,J., Sun,D. and Zhang,Y.Y.
  TITLE     Function, drug resistance and prognostic effect of AKR1C2 in human
            cancer
  JOURNAL   Neoplasma 70 (3), 319-332 (2023)
   PUBMED   37498066
  REMARK    GeneRIF: Function, drug resistance and prognostic effect of AKR1C2
            in human cancer.
REFERENCE   3  (bases 1 to 3215)
  AUTHORS   Liu,W., Zhang,F., Yang,K. and Yan,Y.
  TITLE     Comprehensive analysis regarding the prognostic significance of
            downregulated ferroptosis-related gene AKR1C2 in gastric cancer and
            its underlying roles in immune response
  JOURNAL   PLoS One 18 (1), e0280989 (2023)
   PUBMED   36701414
  REMARK    GeneRIF: Comprehensive analysis regarding the prognostic
            significance of downregulated ferroptosis-related gene AKR1C2 in
            gastric cancer and its underlying roles in immune response.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3215)
  AUTHORS   Ostinelli,G., Vijay,J., Vohl,M.C., Grundberg,E. and Tchernof,A.
  TITLE     AKR1C2 and AKR1C3 expression in adipose tissue: Association with
            body fat distribution and regulatory variants
  JOURNAL   Mol Cell Endocrinol 527, 111220 (2021)
   PUBMED   33675863
  REMARK    GeneRIF: AKR1C2 and AKR1C3 expression in adipose tissue:
            Association with body fat distribution and regulatory variants.
REFERENCE   5  (bases 1 to 3215)
  AUTHORS   Zhang,Z.F., Huang,T.J., Zhang,X.K., Xie,Y.J., Lin,S.T., Luo,F.F.,
            Meng,D.F., Hu,H., Wang,J., Peng,L.X., Qian,C.N., Cheng,C. and
            Huang,B.J.
  TITLE     AKR1C2 acts as a targetable oncogene in esophageal squamous cell
            carcinoma via activating PI3K/AKT signaling pathway
  JOURNAL   J Cell Mol Med 24 (17), 9999-10012 (2020)
   PUBMED   32678482
  REMARK    GeneRIF: AKR1C2 acts as a targetable oncogene in esophageal
            squamous cell carcinoma via activating PI3K/AKT signaling pathway.
REFERENCE   6  (bases 1 to 3215)
  AUTHORS   Khanna,M., Qin,K.N., Klisak,I., Belkin,S., Sparkes,R.S. and
            Cheng,K.C.
  TITLE     Localization of multiple human dihydrodiol dehydrogenase (DDH1 and
            DDH2) and chlordecone reductase (CHDR) genes in chromosome 10 by
            the polymerase chain reaction and fluorescence in situ
            hybridization
  JOURNAL   Genomics 25 (2), 588-590 (1995)
   PUBMED   7789999
REFERENCE   7  (bases 1 to 3215)
  AUTHORS   Qin,K.N., Khanna,M. and Cheng,K.C.
  TITLE     Structure of a gene coding for human dihydrodiol dehydrogenase/bile
            acid-binding protein
  JOURNAL   Gene 149 (2), 357-361 (1994)
   PUBMED   7959017
REFERENCE   8  (bases 1 to 3215)
  AUTHORS   Ciaccio,P.J. and Tew,K.D.
  TITLE     cDNA and deduced amino acid sequences of a human colon dihydrodiol
            dehydrogenase
  JOURNAL   Biochim Biophys Acta 1186 (1-2), 129-132 (1994)
   PUBMED   8011662
REFERENCE   9  (bases 1 to 3215)
  AUTHORS   Winters,C.J., Molowa,D.T. and Guzelian,P.S.
  TITLE     Isolation and characterization of cloned cDNAs encoding human liver
            chlordecone reductase
  JOURNAL   Biochemistry 29 (4), 1080-1087 (1990)
   PUBMED   2187532
REFERENCE   10 (bases 1 to 3215)
  AUTHORS   Zachmann,M., Vollmin,J.A., Hamilton,W. and Prader,A.
  TITLE     Steroid 17,20-desmolase deficiency: a new cause of male
            pseudohermaphroditism
  JOURNAL   Clin Endocrinol (Oxf) 1 (4), 369-385 (1972)
   PUBMED   4352099
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL391427.10 and AL713867.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene encodes a member of the aldo/keto reductase
            superfamily, which consists of more than 40 known enzymes and
            proteins. These enzymes catalyze the conversion of aldehydes and
            ketones to their corresponding alcohols using NADH and/or NADPH as
            cofactors. The enzymes display overlapping but distinct substrate
            specificity. This enzyme binds bile acid with high affinity, and
            shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This
            gene shares high sequence identity with three other gene members
            and is clustered with those three genes at chromosome 10p15-p14.
            Three transcript variants encoding two different isoforms have been
            found for this gene. [provided by RefSeq, Dec 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.4338682.1,
                                           SRR14038194.3704554.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380753.9/ ENSP00000370129.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-106               AL391427.10        10019-10124         c
            107-274             AL391427.10        7781-7948           c
            275-391             AL391427.10        6817-6933           c
            392-469             AL391427.10        5467-5544           c
            470-592             AL391427.10        4892-5014           c
            593-702             AL391427.10        2023-2132           c
            703-868             AL713867.6         26985-27150         c
            869-951             AL713867.6         23497-23579         c
            952-3215            AL713867.6         19441-21704         c
FEATURES             Location/Qualifiers
     source          1..3215
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p15.1"
     gene            1..3215
                     /gene="AKR1C2"
                     /gene_synonym="AKR1C-pseudo; BABP; DD; DD-2; DD/BABP; DD2;
                     DDH2; HAKRD; HBAB; MCDR2; SRXY8; TDD"
                     /note="aldo-keto reductase family 1 member C2"
                     /db_xref="GeneID:1646"
                     /db_xref="HGNC:HGNC:385"
                     /db_xref="MIM:600450"
     exon            1..106
                     /gene="AKR1C2"
                     /gene_synonym="AKR1C-pseudo; BABP; DD; DD-2; DD/BABP; DD2;
                     DDH2; HAKRD; HBAB; MCDR2; SRXY8; TDD"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..994
                     /gene="AKR1C2"
                     /gene_synonym="AKR1C-pseudo; BABP; DD; DD-2; DD/BABP; DD2;
                     DDH2; HAKRD; HBAB; MCDR2; SRXY8; TDD"
                     /EC_number="1.1.1.62"
                     /EC_number="1.3.1.20"
                     /EC_number="1.1.1.112"
                     /EC_number="1.1.1.209"
                     /EC_number="1.1.1.357"
                     /EC_number="1.1.1.53"
                     /note="isoform 1 is encoded by transcript variant 5; type
                     II dihydrodiol dehydrogenase;
                     trans-1,2-dihydrobenzene-1,2-diol dehydrogenase;
                     pseudo-chlordecone reductase; dihydrodiol dehydrogenase 2;
                     bile acid binding protein; 3-alpha hydroxysteroid
                     dehydrogenase, type III; testicular 17,20-desmolase
                     deficiency; 3-alpha-HSD3; chlordecone reductase homolog
                     HAKRD"
                     /codon_start=1
                     /product="aldo-keto reductase family 1 member C2 isoform
                     1"
                     /protein_id="NP_001380321.1"
                     /db_xref="CCDS:CCDS7062.1"
                     /db_xref="GeneID:1646"
                     /db_xref="HGNC:HGNC:385"
                     /db_xref="MIM:600450"
                     /translation="MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEA
                     GFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERS
                     LKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLA
                     KSIGVSNFNHRLLEMILNKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSA
                     LGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQR
                     IRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTLDIFAGPPNYPFSDEY"
     exon            107..274
                     /gene="AKR1C2"
                     /gene_synonym="AKR1C-pseudo; BABP; DD; DD-2; DD/BABP; DD2;
                     DDH2; HAKRD; HBAB; MCDR2; SRXY8; TDD"
                     /inference="alignment:Splign:2.1.0"
     exon            275..391
                     /gene="AKR1C2"
                     /gene_synonym="AKR1C-pseudo; BABP; DD; DD-2; DD/BABP; DD2;
                     DDH2; HAKRD; HBAB; MCDR2; SRXY8; TDD"
                     /inference="alignment:Splign:2.1.0"
     exon            392..469
                     /gene="AKR1C2"
                     /gene_synonym="AKR1C-pseudo; BABP; DD; DD-2; DD/BABP; DD2;
                     DDH2; HAKRD; HBAB; MCDR2; SRXY8; TDD"
                     /inference="alignment:Splign:2.1.0"
     exon            470..592
                     /gene="AKR1C2"
                     /gene_synonym="AKR1C-pseudo; BABP; DD; DD-2; DD/BABP; DD2;
                     DDH2; HAKRD; HBAB; MCDR2; SRXY8; TDD"
                     /inference="alignment:Splign:2.1.0"
     exon            593..702
                     /gene="AKR1C2"
                     /gene_synonym="AKR1C-pseudo; BABP; DD; DD-2; DD/BABP; DD2;
                     DDH2; HAKRD; HBAB; MCDR2; SRXY8; TDD"
                     /inference="alignment:Splign:2.1.0"
     exon            703..868
                     /gene="AKR1C2"
                     /gene_synonym="AKR1C-pseudo; BABP; DD; DD-2; DD/BABP; DD2;
                     DDH2; HAKRD; HBAB; MCDR2; SRXY8; TDD"
                     /inference="alignment:Splign:2.1.0"
     exon            869..951
                     /gene="AKR1C2"
                     /gene_synonym="AKR1C-pseudo; BABP; DD; DD-2; DD/BABP; DD2;
                     DDH2; HAKRD; HBAB; MCDR2; SRXY8; TDD"
                     /inference="alignment:Splign:2.1.0"
     exon            952..3215
                     /gene="AKR1C2"
                     /gene_synonym="AKR1C-pseudo; BABP; DD; DD-2; DD/BABP; DD2;
                     DDH2; HAKRD; HBAB; MCDR2; SRXY8; TDD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1185..1190
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AKR1C2"
                     /gene_synonym="AKR1C-pseudo; BABP; DD; DD-2; DD/BABP; DD2;
                     DDH2; HAKRD; HBAB; MCDR2; SRXY8; TDD"
                     /note="hexamer: ATTAAA"
     polyA_site      1217
                     /gene="AKR1C2"
                     /gene_synonym="AKR1C-pseudo; BABP; DD; DD-2; DD/BABP; DD2;
                     DDH2; HAKRD; HBAB; MCDR2; SRXY8; TDD"
                     /note="major polyA site"
     regulatory      3193..3198
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AKR1C2"
                     /gene_synonym="AKR1C-pseudo; BABP; DD; DD-2; DD/BABP; DD2;
                     DDH2; HAKRD; HBAB; MCDR2; SRXY8; TDD"
                     /note="hexamer: TATAAA"
     polyA_site      3215
                     /gene="AKR1C2"
                     /gene_synonym="AKR1C-pseudo; BABP; DD; DD-2; DD/BABP; DD2;
                     DDH2; HAKRD; HBAB; MCDR2; SRXY8; TDD"
ORIGIN      
        1 gctaaccagg ccagtgacag aaatggattc gaaataccag tgtgtgaagc tgaatgatgg
       61 tcacttcatg cctgtcctgg gatttggcac ctatgcgcct gcagaggttc ctaaaagtaa
      121 agctctagag gccgtcaaat tggcaataga agccgggttc caccatattg attctgcaca
      181 tgtttacaat aatgaggagc aggttggact ggccatccga agcaagattg cagatggcag
      241 tgtgaagaga gaagacatat tctacacttc aaagctttgg agcaattccc atcgaccaga
      301 gttggtccga ccagccttgg aaaggtcact gaaaaatctt caattggact atgttgacct
      361 ctatcttatt cattttccag tgtctgtaaa gccaggtgag gaagtgatcc caaaagatga
      421 aaatggaaaa atactatttg acacagtgga tctctgtgcc acatgggagg ccatggagaa
      481 gtgtaaagat gcaggattgg ccaagtccat cggggtgtcc aacttcaacc acaggctgct
      541 ggagatgatc ctcaacaagc cagggctcaa gtacaagcct gtctgcaacc aggtggaatg
      601 tcatccttac ttcaaccaga gaaaactgct ggatttctgc aagtcaaaag acattgttct
      661 ggttgcctat agtgctctgg gatcccatcg agaagaacca tgggtggacc cgaactcccc
      721 ggtgctcttg gaggacccag tcctttgtgc cttggcaaaa aagcacaagc gaaccccagc
      781 cctgattgcc ctgcgctacc agctgcagcg tggggttgtg gtcctggcca agagctacaa
      841 tgagcagcgc atcagacaga acgtgcaggt gtttgaattc cagttgactt cagaggagat
      901 gaaagccata gatggcctaa acagaaatgt gcgatatttg acccttgata tttttgctgg
      961 cccccctaat tatccatttt ctgatgaata ttaacatgga gggcattgca tgaggtctgc
     1021 cagaaggccc tgcgtgtgga tggtgacaca gaggatggct ctatgctggt gactggacac
     1081 atcgcctctg gttaaatctc tcctgcttgg cgacttcagt aagctacagc taagcccatc
     1141 ggccggaaaa gaaagacaat aattttgttt ttcattttga aaaaattaaa tgctctctcc
     1201 taaagattct tcacctactt tggtctccat aacttctatg ttttctctcc ttctgacaca
     1261 ctagtgcccc caaattgtga tttgcctata cgtttagggc cggggttgga agatgttaac
     1321 aaccatttaa gattcatttc tgcagtggga gtgggtggag tttcaccctc tgggaaaggg
     1381 gcaggtgaca ggtatttatc agtcagtgcc tctctagctc ttgtaggaag aagcacacgc
     1441 aggatggagt ctagaggatg agcgatattg actagcaatt catgggctcc ctccagcagt
     1501 gcgagggtca gagtttctgg agccttggga ggaggcatcc ctgtgagggg gggttaggga
     1561 gatgggaggg caccaggaaa agtgattaga agtcaggtat gggaaggcta aataggacag
     1621 agtcgagtac atctctgctt ggaaaaacat atcaacaccc ttttttttga tcattatatc
     1681 ttgttcataa aagaaaactt tccacattgt tttaacaaac cccacagctg agagtcaggc
     1741 ctgaatcttt gatgtgtgcc cattcacaac gttgacccta ttggtttgtg gtggggcagg
     1801 acatcgaaga tatcattgac tcatcacatt cccctgaata gctcatattt agaaaatatt
     1861 cttagattgt aaaaatgtac tgttcatttg ttatatgcaa tcttttaaat gttttatact
     1921 ttaaacaagg catagttaca agtataaaac ataaatatcc caaagccatt atgcatggca
     1981 ctcaagatta aaatgggaaa taatacatct aataaatcaa atgttccaag acttcaaatg
     2041 tcttttggaa acaggctatg taaaacagca cactggtttc aaactttggt aaattttaag
     2101 aagaactctt acaaaggcat ttaattctta tacataattt tcaggggaac taatcaaatc
     2161 agctaatcat gaagacatga ttttcgtttt agaaaacact tttgaaaact tgggataatc
     2221 tcatgtctta atgatcaaag cattatgaga aggacagtgg ttttttacct gggcacactt
     2281 tctaacacat ttactctcca ctattcgtac tctggtagcc atgttaaccc catcagagat
     2341 tccttctcaa gccatgtctc agagctgata ggcatcccag caagttttgc agctcacaat
     2401 ttttctgtaa attacttatt ctataaaatt ggaagaggcc ataaactttg gagggcccta
     2461 gaccaatttt ttggattatt tctggtctac tctcattccg ttgatgatct tagatattct
     2521 ctgcattaaa tatcacctct aggctgagaa atccaccaaa aaatatttct agctcagcgt
     2581 tttcctccaa atcttcaatg gaagatcata atgtgaactc tgcatctcca tgttaaagtt
     2641 taatggacat tcacacttag catgtctcaa agaaatctca tgtaaaccat ggccatcctg
     2701 ttctacctta actttctgag tctatggaat gataatttca catctcataa acttgactga
     2761 tgtaagtgtc aagaaaagat tgacattttg ttaaaacttc gtagccaagt gtgtaacgct
     2821 taagcagact ttcatatttc aaatctctat agcacgtgta actctttttt caagatgtga
     2881 aataatcatt aggtcagtca tttgtaaata gtacggctgc tgtgggcttt ttccagttct
     2941 tcaccatcca tttttataaa actcttattg ttaaaaaaaa aaagttactc agaatttcat
     3001 aaagccaaac acctgatttc aggaacactt gagatgtaag aaaattttat agggacctcc
     3061 aatcactaat tttcctattt tttctctcaa agaaatgctg aagggaggaa ttcaggttga
     3121 atgaaaggaa atagtaactt acagccatat agagttataa agacttcttg taaatgtgaa
     3181 catatggtaa aatataaaaa catgtatttt tgaaa
//
