LOCUS       NM_001080538            1641 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens aldo-keto reductase family 1 member B15 (AKR1B15),
            transcript variant 1, mRNA.
ACCESSION   NM_001080538 XM_930548
VERSION     NM_001080538.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1641)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1641)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1641)
  AUTHORS   Gimenez-Dejoz,J., Kolar,M.H., Ruiz,F.X., Crespo,I.,
            Cousido-Siah,A., Podjarny,A., Barski,O.A., Fanfrlik,J., Pares,X.,
            Farres,J. and Porte,S.
  TITLE     Substrate Specificity, Inhibitor Selectivity and Structure-Function
            Relationships of Aldo-Keto Reductase 1B15: A Novel Human
            Retinaldehyde Reductase
  JOURNAL   PLoS One 10 (7), e0134506 (2015)
   PUBMED   26222439
  REMARK    GeneRIF: Amino acid substitutions clustered in loops A and C result
            in a smaller more hydrophobic and more rigid active site in AKR1B15
            compared with the AKR1B10 pocket, consistent with distinct
            substrate specificity and narrower inhibitor selectivity for
            AKR1B15.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1641)
  AUTHORS   Weber,S., Salabei,J.K., Moller,G., Kremmer,E., Bhatnagar,A.,
            Adamski,J. and Barski,O.A.
  TITLE     Aldo-keto Reductase 1B15 (AKR1B15): a mitochondrial human aldo-keto
            reductase with activity toward steroids and 3-keto-acyl-CoA
            conjugates
  JOURNAL   J Biol Chem 290 (10), 6531-6545 (2015)
   PUBMED   25577493
  REMARK    GeneRIF: AKR1B15.2 localizes to the cytosol and displays no
            enzymatic activity with the substrates tested.
REFERENCE   5  (bases 1 to 1641)
  AUTHORS   Jagoe,W.N., Howe,K., O'Brien,S.C. and Carroll,J.
  TITLE     Identification of a role for a mouse sperm surface aldo-keto
            reductase (AKR1B7) and its human analogue in the detoxification of
            the reactive aldehyde, acrolein
  JOURNAL   Andrologia 45 (5), 326-331 (2013)
   PUBMED   22970857
  REMARK    GeneRIF: human sperm possess an aldo-keto reductase on their
            membrane surface and are thus enzymatically protected against
            reactive aldehyde species both in the male and female reproductive
            tract
REFERENCE   6  (bases 1 to 1641)
  AUTHORS   Calvo,S.E., Compton,A.G., Hershman,S.G., Lim,S.C., Lieber,D.S.,
            Tucker,E.J., Laskowski,A., Garone,C., Liu,S., Jaffe,D.B.,
            Christodoulou,J., Fletcher,J.M., Bruno,D.L., Goldblatt,J.,
            Dimauro,S., Thorburn,D.R. and Mootha,V.K.
  TITLE     Molecular diagnosis of infantile mitochondrial disease with
            targeted next-generation sequencing
  JOURNAL   Sci Transl Med 4 (118), 118ra10 (2012)
   PUBMED   22277967
  REMARK    GeneRIF: Strong candidate gene for mitochondrial disease, based on
            recessive mutations detected in infantile patients
REFERENCE   7  (bases 1 to 1641)
  AUTHORS   Salabei,J.K., Li,X.P., Petrash,J.M., Bhatnagar,A. and Barski,O.A.
  TITLE     Functional expression of novel human and murine AKR1B genes
  JOURNAL   Chem Biol Interact 191 (1-3), 177-184 (2011)
   PUBMED   21276782
  REMARK    GeneRIF: AKR1B15 and Akr1b16 genes are expressed as functional
            proteins in human and murine tissues
REFERENCE   8  (bases 1 to 1641)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1641)
  AUTHORS   Yashin,A.I., Wu,D., Arbeev,K.G. and Ukraintseva,S.V.
  TITLE     Joint influence of small-effect genetic variants on human longevity
  JOURNAL   Aging (Albany NY) 2 (9), 612-620 (2010)
   PUBMED   20834067
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX335355.2 and AC078847.2.
            
            On Nov 22, 2018 this sequence version replaced NM_001080538.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a). Variants 1 and 2 both encode the same isoform (a).
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000457545.7/ ENSP00000389289.1
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                BX335355.2         14-39
            27-140              AC078847.2         52778-52891         c
            141-264             AC078847.2         45168-45291         c
            265-436             AC078847.2         37258-37429         c
            437-604             AC078847.2         33702-33869         c
            605-721             AC078847.2         32498-32614         c
            722-799             AC078847.2         30346-30423         c
            800-922             AC078847.2         26485-26607         c
            923-1029            AC078847.2         26100-26206         c
            1030-1111           AC078847.2         25597-25678         c
            1112-1195           AC078847.2         24981-25064         c
            1196-1278           AC078847.2         24241-24323         c
            1279-1641           AC078847.2         22158-22520         c
FEATURES             Location/Qualifiers
     source          1..1641
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q33"
     gene            1..1641
                     /gene="AKR1B15"
                     /gene_synonym="AK1R1B7; AKR1B10L; AKR1R1B7"
                     /note="aldo-keto reductase family 1 member B15"
                     /db_xref="GeneID:441282"
                     /db_xref="HGNC:HGNC:37281"
                     /db_xref="MIM:616336"
     exon            1..140
                     /gene="AKR1B15"
                     /gene_synonym="AK1R1B7; AKR1B10L; AKR1R1B7"
                     /inference="alignment:Splign:2.1.0"
     exon            141..264
                     /gene="AKR1B15"
                     /gene_synonym="AK1R1B7; AKR1B10L; AKR1R1B7"
                     /inference="alignment:Splign:2.1.0"
     exon            265..436
                     /gene="AKR1B15"
                     /gene_synonym="AK1R1B7; AKR1B10L; AKR1R1B7"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..1321
                     /gene="AKR1B15"
                     /gene_synonym="AK1R1B7; AKR1B10L; AKR1R1B7"
                     /EC_number="1.1.1.64"
                     /EC_number="1.1.1.300"
                     /EC_number="1.1.1.216"
                     /EC_number="1.1.1.54"
                     /note="isoform a is encoded by transcript variant 1;
                     putative aldo-keto reductase family 1 member B15;
                     estradiol 17-beta-dehydrogenase AKR1B15; farnesol
                     dehydrogenase; testosterone 17beta-dehydrogenase"
                     /codon_start=1
                     /product="aldo-keto reductase family 1 member B15 isoform
                     a"
                     /protein_id="NP_001074007.2"
                     /db_xref="CCDS:CCDS47715.2"
                     /db_xref="GeneID:441282"
                     /db_xref="HGNC:HGNC:37281"
                     /db_xref="MIM:616336"
                     /translation="MVLQMEPQVNSTNNFHQGPLDQPVGPLTGLKSSLLKDTTSAGPL
                     LRPYPASLLGKVKEAVKVAIDAEYRHIDCAYFYENQHEVGEAIQEKIQEKAVMREDLF
                     IVSKVWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKTGDDFFPKDDKGNMI
                     SGKGTFLDAWEAMEELVDEGLVKALGVSNFNHFQIERLLNKPGLKYKPVTNQVECHPY
                     LTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAKHKKTTAQV
                     LIRFHIQRNVTVIPKSMTPAHIVENIQVFDFKLSDEEMATILSFNRNWRAFDFKEFSH
                     LEDFPFDAEY"
     exon            437..604
                     /gene="AKR1B15"
                     /gene_synonym="AK1R1B7; AKR1B10L; AKR1R1B7"
                     /inference="alignment:Splign:2.1.0"
     exon            605..721
                     /gene="AKR1B15"
                     /gene_synonym="AK1R1B7; AKR1B10L; AKR1R1B7"
                     /inference="alignment:Splign:2.1.0"
     exon            722..799
                     /gene="AKR1B15"
                     /gene_synonym="AK1R1B7; AKR1B10L; AKR1R1B7"
                     /inference="alignment:Splign:2.1.0"
     exon            800..922
                     /gene="AKR1B15"
                     /gene_synonym="AK1R1B7; AKR1B10L; AKR1R1B7"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1029
                     /gene="AKR1B15"
                     /gene_synonym="AK1R1B7; AKR1B10L; AKR1R1B7"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1111
                     /gene="AKR1B15"
                     /gene_synonym="AK1R1B7; AKR1B10L; AKR1R1B7"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1195
                     /gene="AKR1B15"
                     /gene_synonym="AK1R1B7; AKR1B10L; AKR1R1B7"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1278
                     /gene="AKR1B15"
                     /gene_synonym="AK1R1B7; AKR1B10L; AKR1R1B7"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1641
                     /gene="AKR1B15"
                     /gene_synonym="AK1R1B7; AKR1B10L; AKR1R1B7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1621..1626
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AKR1B15"
                     /gene_synonym="AK1R1B7; AKR1B10L; AKR1R1B7"
                     /note="hexamer: AATAAA"
     polyA_site      1641
                     /gene="AKR1B15"
                     /gene_synonym="AK1R1B7; AKR1B10L; AKR1R1B7"
                     /note="major polyA site"
ORIGIN      
        1 agacagacag ctggcttaca gggccacctg aagacgttcc agggctccac aggccactgt
       61 cttctggagg ggaacggatc gactgccggt gcgcccagcc aaattcaact cctgagtcct
      121 cagtctctag tcccgggaag gtttcaccga gctgccctac tccttgtacc ccttctagct
      181 ggccttagca tagctacgtc agcagctatt ggcacgactg ccctgattca aggagaaact
      241 ggactaatat cactatctca acaggatcga ggccatcaag ctacagatgg tcttacaaat
      301 ggaaccccaa gtgaactcaa ctaacaactt ccaccaagga cccctggacc aacccgttgg
      361 ccctttgact ggcctaaaga gttcccttct gaaggacact acaagtgcag ggccccttct
      421 tcgcccctat ccagcatctc ttctcggcaa agtgaaagaa gcggtgaagg tggccattga
      481 tgcagaatat cgccacattg actgtgccta tttctatgag aatcaacatg aggtgggaga
      541 agccatccaa gagaagatcc aagagaaggc tgtgatgcgg gaggacctgt tcatcgtcag
      601 caaggtgtgg cccactttct ttgagagacc ccttgtgagg aaagcctttg agaagaccct
      661 caaggacctg aagctgagct atctggacgt ctatcttatt cactggccac agggattcaa
      721 gactggggat gactttttcc ccaaagatga taaaggtaat atgatcagtg gaaaaggaac
      781 gttcttggat gcctgggagg ccatggagga gctggtggac gaggggctgg tgaaagccct
      841 tggggtctca aatttcaacc acttccagat cgagaggctc ttgaacaaac ctggactgaa
      901 atataaacca gtgactaacc aggttgagtg tcacccatac ctcacgcagg agaaactgat
      961 ccagtactgc cactccaagg gcatcaccgt tacggcctac agccccctgg gctctccgga
     1021 tagaccttgg gccaaacctg aggacccttc cctgctggag gatcccaaga ttaaggagat
     1081 tgctgcaaag cacaaaaaaa ccacagccca ggttctgatc cgtttccata tccagaggaa
     1141 tgtgacagtg atccccaagt ctatgacacc agcacacatt gttgagaaca ttcaggtctt
     1201 tgactttaaa ttgagtgatg aggagatggc aaccatactc agcttcaaca gaaactggag
     1261 ggcctttgac ttcaaggaat tctctcattt ggaggacttt cccttcgatg cagaatattg
     1321 aggttgaatc tcctggtgag attacacagg ggattctctt tcttcgctga agtgtgactg
     1381 tctccactca agaactattt tagccaagct tatctgagat cacagtgaac tttgtcctgt
     1441 tgtagaccag aatggaggtg ctgttttaga catgtatttc tgtatgttca actaggataa
     1501 gaatatcaca gaaaagcatg gcctgaataa gcaaatgaca attttttcca cttatctgat
     1561 ctgatcaaat gtctgttaag caccagaaac tctgccaaca ctgaggatgt aaagataaat
     1621 aataaaaaat aatgacttta a
//
