LOCUS       NM_020299               1619 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens aldo-keto reductase family 1 member B10 (AKR1B10),
            mRNA.
ACCESSION   NM_020299 NM_004812
VERSION     NM_020299.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1619)
  AUTHORS   Shi,L., Du,X., Wang,B. and Zhang,G.
  TITLE     CircAKR1B10 interacts with EIF4A3 to stabilize AURKA and promotes
            IL-22-induced proliferation, migration and invasion in
            keratinocytes
  JOURNAL   Arch Dermatol Res 316 (8), 561 (2024)
   PUBMED   39177716
  REMARK    GeneRIF: CircAKR1B10 interacts with EIF4A3 to stabilize AURKA and
            promotes IL-22-induced proliferation, migration and invasion in
            keratinocytes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1619)
  AUTHORS   Kong,D., Wu,Y., Tong,B., Liang,Y., Xu,F., Chi,X., Ni,L., Tian,G.,
            Zhang,G. and Xu,Z.
  TITLE     CHES1 modulated tumorigenesis and senescence of pancreas cancer
            cells through repressing AKR1B10
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (6), 167214 (2024)
   PUBMED   38718846
  REMARK    GeneRIF: CHES1 modulated tumorigenesis and senescence of pancreas
            cancer cells through repressing AKR1B10.
REFERENCE   3  (bases 1 to 1619)
  AUTHORS   Tan,C., Zeng,X., Guo,X., Mo,M., Ma,X., Liu,B., Liu,S., Zeng,X.,
            Huang,D. and Qiu,X.
  TITLE     A Novel lncRNA lncRNA-4045 Promotes the Progression of
            Hepatocellular Carcinoma by Affecting the Expression of AKR1B10
  JOURNAL   Dig Dis Sci 69 (7), 2502-2521 (2024)
   PUBMED   38662158
  REMARK    GeneRIF: A Novel lncRNA lncRNA-4045 Promotes the Progression of
            Hepatocellular Carcinoma by Affecting the Expression of AKR1B10.
REFERENCE   4  (bases 1 to 1619)
  AUTHORS   Ma,L.N., Ma,Y., Luo,X., Ma,Z.M., Ma,L.N. and Ding,X.C.
  TITLE     AKR1B10 expression characteristics in hepatocellular carcinoma and
            its correlation with clinicopathological features and immune
            microenvironment
  JOURNAL   Sci Rep 14 (1), 12149 (2024)
   PUBMED   38802416
  REMARK    GeneRIF: AKR1B10 expression characteristics in hepatocellular
            carcinoma and its correlation with clinicopathological features and
            immune microenvironment.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1619)
  AUTHORS   Yao,H., Hu,J., Shao,Y., Shah,Q. and Zheng,S.
  TITLE     Aldo-keto Reductase 1B10 Restrains Cell Migration, Invasion, and
            Adhesion of Gastric Cancer via Regulating Integrin Subunit Alpha 5
  JOURNAL   Turk J Gastroenterol 34 (12), 1197-1205 (2023)
   PUBMED   37823316
  REMARK    GeneRIF: Aldo-keto Reductase 1B10 Restrains Cell Migration,
            Invasion, and Adhesion of Gastric Cancer via Regulating Integrin
            Subunit Alpha 5.
REFERENCE   6  (bases 1 to 1619)
  AUTHORS   Fanelli,A., Hadjadj,S., Gallois,Y., Fumeron,F., Betoule,D.,
            Grandchamp,B. and Marre,M.
  TITLE     [Polymorphism of aldose reductase gene and susceptibility to
            retinopathy and nephropathy in Caucasians with type 1 diabetes]
  JOURNAL   Arch Mal Coeur Vaiss 95 (7-8), 701-708 (2002)
   PUBMED   12365083
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 1619)
  AUTHORS   Neamat-Allah,M., Feeney,S.A., Savage,D.A., Maxwell,A.P.,
            Hanson,R.L., Knowler,W.C., El Nahas,A.M., Plater,M.E., Shaw,J.,
            Boulton,A.J., Duff,G.W. and Cox,A.
  TITLE     Analysis of the association between diabetic nephropathy and
            polymorphisms in the aldose reductase gene in Type 1 and Type 2
            diabetes mellitus
  JOURNAL   Diabet Med 18 (11), 906-914 (2001)
   PUBMED   11703436
  REMARK    GeneRIF: Meta-analysis of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 1619)
  AUTHORS   Hyndman,D.J. and Flynn,T.G.
  TITLE     Sequence and expression levels in human tissues of a new member of
            the aldo-keto reductase family
  JOURNAL   Biochim Biophys Acta 1399 (2-3), 198-202 (1998)
   PUBMED   9765596
REFERENCE   9  (bases 1 to 1619)
  AUTHORS   Cao,D., Fan,S.T. and Chung,S.S.
  TITLE     Identification and characterization of a novel human aldose
            reductase-like gene
  JOURNAL   J Biol Chem 273 (19), 11429-11435 (1998)
   PUBMED   9565553
REFERENCE   10 (bases 1 to 1619)
  AUTHORS   Scuric,Z., Stain,S.C., Anderson,W.F. and Hwang,J.J.
  TITLE     New member of aldose reductase family proteins overexpressed in
            human hepatocellular carcinoma
  JOURNAL   Hepatology 27 (4), 943-950 (1998)
   PUBMED   9537432
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC078847.2, AF524864.1,
            BC008837.2, AF052577.1 and BM975664.1.
            
            On Nov 22, 2018 this sequence version replaced NM_020299.4.
            
            Summary: This gene encodes a member of the aldo/keto reductase
            superfamily, which consists of more than 40 known enzymes and
            proteins. This member can efficiently reduce aliphatic and aromatic
            aldehydes, and it is less active on hexoses. It is highly expressed
            in adrenal gland, small intestine, and colon, and may play an
            important role in liver carcinogenesis. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF524864.1, ERR279856.2679.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359579.5/ ENSP00000352584.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                AC078847.2         74436-74460         c
            26-292              AF524864.1         1-267
            293-1281            BC008837.2         213-1201
            1282-1599           AF052577.1         976-1293
            1600-1619           BM975664.1         17-36               c
FEATURES             Location/Qualifiers
     source          1..1619
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q33"
     gene            1..1619
                     /gene="AKR1B10"
                     /gene_synonym="AKR1B11; AKR1B12; ALDRLn; ARL-1; ARL1; HIS;
                     HSI"
                     /note="aldo-keto reductase family 1 member B10"
                     /db_xref="GeneID:57016"
                     /db_xref="HGNC:HGNC:382"
                     /db_xref="MIM:604707"
     exon            1..411
                     /gene="AKR1B10"
                     /gene_synonym="AKR1B11; AKR1B12; ALDRLn; ARL-1; ARL1; HIS;
                     HSI"
                     /inference="alignment:Splign:2.1.0"
     CDS             346..1296
                     /gene="AKR1B10"
                     /gene_synonym="AKR1B11; AKR1B12; ALDRLn; ARL-1; ARL1; HIS;
                     HSI"
                     /EC_number="1.1.1.300"
                     /EC_number="1.1.1.54"
                     /note="aldose reductase-like 1; aldo-keto reductase family
                     1, member B11 (aldose reductase-like); aldose
                     reductase-like peptide; aldose reductase-related protein;
                     small intestine reductase; ARP; hARP; SI reductase;
                     aldo-keto reductase family 1, member B10 (aldose
                     reductase)"
                     /codon_start=1
                     /product="aldo-keto reductase family 1 member B10"
                     /protein_id="NP_064695.3"
                     /db_xref="CCDS:CCDS5832.1"
                     /db_xref="GeneID:57016"
                     /db_xref="HGNC:HGNC:382"
                     /db_xref="MIM:604707"
                     /translation="MATFVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHID
                     CAYVYQNEHEVGEAIQEKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKL
                     SYLDVYLIHWPQGFKSGDDLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVS
                     NFSHFQIEKLLNKPGLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDR
                     PWAKPEDPSLLEDPKIKEIAAKHKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQV
                     FDFKLSDEEMATILSFNRNWRACNVLQSSHLEDYPFNAEY"
     exon            412..579
                     /gene="AKR1B10"
                     /gene_synonym="AKR1B11; AKR1B12; ALDRLn; ARL-1; ARL1; HIS;
                     HSI"
                     /inference="alignment:Splign:2.1.0"
     exon            580..696
                     /gene="AKR1B10"
                     /gene_synonym="AKR1B11; AKR1B12; ALDRLn; ARL-1; ARL1; HIS;
                     HSI"
                     /inference="alignment:Splign:2.1.0"
     exon            697..774
                     /gene="AKR1B10"
                     /gene_synonym="AKR1B11; AKR1B12; ALDRLn; ARL-1; ARL1; HIS;
                     HSI"
                     /inference="alignment:Splign:2.1.0"
     exon            775..897
                     /gene="AKR1B10"
                     /gene_synonym="AKR1B11; AKR1B12; ALDRLn; ARL-1; ARL1; HIS;
                     HSI"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1004
                     /gene="AKR1B10"
                     /gene_synonym="AKR1B11; AKR1B12; ALDRLn; ARL-1; ARL1; HIS;
                     HSI"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1086
                     /gene="AKR1B10"
                     /gene_synonym="AKR1B11; AKR1B12; ALDRLn; ARL-1; ARL1; HIS;
                     HSI"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1170
                     /gene="AKR1B10"
                     /gene_synonym="AKR1B11; AKR1B12; ALDRLn; ARL-1; ARL1; HIS;
                     HSI"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1253
                     /gene="AKR1B10"
                     /gene_synonym="AKR1B11; AKR1B12; ALDRLn; ARL-1; ARL1; HIS;
                     HSI"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1619
                     /gene="AKR1B10"
                     /gene_synonym="AKR1B11; AKR1B12; ALDRLn; ARL-1; ARL1; HIS;
                     HSI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1593..1598
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AKR1B10"
                     /gene_synonym="AKR1B11; AKR1B12; ALDRLn; ARL-1; ARL1; HIS;
                     HSI"
                     /note="hexamer: AATAAA"
     regulatory      1605..1610
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AKR1B10"
                     /gene_synonym="AKR1B11; AKR1B12; ALDRLn; ARL-1; ARL1; HIS;
                     HSI"
                     /note="hexamer: AATAAT"
     polyA_site      1615
                     /gene="AKR1B10"
                     /gene_synonym="AKR1B11; AKR1B12; ALDRLn; ARL-1; ARL1; HIS;
                     HSI"
                     /note="major polyA site"
     polyA_site      1619
                     /gene="AKR1B10"
                     /gene_synonym="AKR1B11; AKR1B12; ALDRLn; ARL-1; ARL1; HIS;
                     HSI"
                     /note="major polyA site"
ORIGIN      
        1 cttcttaagc agcctgtggc cgggcacagt agctcacacc tgtaatccca gcactttgga
       61 aggccgaggt gggcggatca cctgagctca ggagtttgag accagcctgt ctctactaac
      121 aatataaaaa ttagctggga gtcacggtgg gcgcctgtaa tcccagctac tcgggaggct
      181 gaggcaggag aattgcttga acccaggaga cagaggttgt agtgagctga gatcgcacca
      241 ctgcactcta gccttggcaa cagtgcaaga ctgtctcaaa aacagcaaca gagagcagga
      301 cgtgagactt ctacctgctc actcagaatc atttctgcac caaccatggc cacgtttgtg
      361 gagctcagta ccaaagccaa gatgcccatt gtgggcctgg gcacttggaa gtctcctctt
      421 ggcaaagtga aagaagcagt gaaggtggcc attgatgcag gatatcggca cattgactgt
      481 gcctatgtct atcagaatga acatgaagtg ggggaagcca tccaagagaa gatccaagag
      541 aaggctgtga agcgggagga cctgttcatc gtcagcaagt tgtggcccac tttctttgag
      601 agaccccttg tgaggaaagc ctttgagaag accctcaagg acctgaagct gagctatctg
      661 gacgtctatc ttattcactg gccacaggga ttcaagtctg gggatgacct tttccccaaa
      721 gatgataaag gtaatgccat cggtggaaaa gcaacgttct tggatgcctg ggaggccatg
      781 gaggagctgg tggatgaggg gctggtgaaa gcccttgggg tctccaattt cagccacttc
      841 cagatcgaga agctcttgaa caaacctgga ctgaaatata aaccagtgac taaccaggtt
      901 gagtgtcacc catacctcac acaggagaaa ctgatccagt actgccactc caagggcatc
      961 accgttacgg cctacagccc cctgggctct ccggatagac cttgggccaa gccagaagac
     1021 ccttccctgc tggaggatcc caagattaag gagattgctg caaagcacaa aaaaaccgca
     1081 gcccaggttc tgatccgttt ccatatccag aggaatgtga ttgtcatccc caagtctgtg
     1141 acaccagcac gcattgttga gaacattcag gtctttgact ttaaattgag tgatgaggag
     1201 atggcaacca tactcagctt caacagaaac tggagggcct gtaacgtgtt gcaatcctct
     1261 catttggaag actatccctt caatgcagaa tattgaggtt gaatctcctg gtgagattat
     1321 acaggagatt ctctttcttc gctgaagtgt gactacctcc actcatgtcc cattttagcc
     1381 aagcttattt aagatcacag tgaacttagt cctgttatag acgagaatcg aggtgctgtt
     1441 ttagacattt atttctgtat gttcaactag gatcagaata tcacagaaaa gcatggcttg
     1501 aataaggaaa tgacaatttt ttccacttat ctgatcagaa caaatgttta ttaagcatca
     1561 gaaactctgc caacactgag gatgtaaaga tcaataaaaa aaataataat cataaccaa
//
