LOCUS       NM_001628               1361 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens aldo-keto reductase family 1 member B (AKR1B1),
            transcript variant 1, mRNA.
ACCESSION   NM_001628
VERSION     NM_001628.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1361)
  AUTHORS   Yu,P.C., Hou,D., Chang,B., Liu,N., Xu,C.H., Chen,X., Hu,C.L.,
            Liu,T., Wang,X., Zhang,Q., Liu,P., Jiang,Y., Fei,M.Y., Zong,L.J.,
            Zhang,J.Y., Liu,H., Chen,B.Y., Chen,S.B., Wang,Y., Li,Z.J., Li,X.,
            Deng,C.H., Ren,Y.Y., Zhao,M., Jiang,S., Wang,R., Jin,J., Yang,S.,
            Xue,K., Shi,J., Chang,C.K., Shen,S., Wang,Z., He,P.C., Chen,Z.,
            Chen,S.J., Sun,X.J. and Wang,L.
  TITLE     SMARCA5 reprograms AKR1B1-mediated fructose metabolism to control
            leukemogenesis
  JOURNAL   Dev Cell 59 (15), 1954-1971 (2024)
   PUBMED   38776924
  REMARK    GeneRIF: SMARCA5 reprograms AKR1B1-mediated fructose metabolism to
            control leukemogenesis.
REFERENCE   2  (bases 1 to 1361)
  AUTHORS   Rao,M. and Chang,K.C.
  TITLE     Aldose reductase is a potential therapeutic target for
            neurodegeneration
  JOURNAL   Chem Biol Interact 389, 110856 (2024)
   PUBMED   38185272
  REMARK    GeneRIF: Aldose reductase is a potential therapeutic target for
            neurodegeneration.
            Review article
REFERENCE   3  (bases 1 to 1361)
  AUTHORS   Meng,M., Yang,L., Zhou,H., Cheng,Q., Peng,R., Wang,Z., Liang,X.,
            Wen,J., Nie,J., Hu,Z., Zhang,L. and Liu,Z.
  TITLE     LINC00978 regulates metabolic rewiring to promote the malignancy of
            glioblastoma through AKR1B1
  JOURNAL   Cancer Lett 567, 216277 (2023)
   PUBMED   37336288
  REMARK    GeneRIF: LINC00978 regulates metabolic rewiring to promote the
            malignancy of glioblastoma through AKR1B1.
REFERENCE   4  (bases 1 to 1361)
  AUTHORS   Zhao,Z., Hao,Z., Zhang,Z. and Zhan,X.
  TITLE     Bioinformatics Analysis Reveals the Vital Role of AKR1B1 in Immune
            Infiltration and Clinical Outcomes of Gastric Cancer
  JOURNAL   DNA Cell Biol 42 (7), 372-389 (2023)
   PUBMED   37285280
  REMARK    GeneRIF: Bioinformatics Analysis Reveals the Vital Role of AKR1B1
            in Immune Infiltration and Clinical Outcomes of Gastric Cancer.
REFERENCE   5  (bases 1 to 1361)
  AUTHORS   Maqsood,M., Waheed,P., Rashid,A., Majeed,A. and Mukhtar,A.
  TITLE     Aldose reductase gene polymorphism rs752010122 and retinopathy in
            type 2 diabetics
  JOURNAL   J Pak Med Assoc 73 (5), 978-982 (2023)
   PUBMED   37218221
  REMARK    GeneRIF: Aldose reductase gene polymorphism rs752010122 and
            retinopathy in type 2 diabetics.
REFERENCE   6  (bases 1 to 1361)
  AUTHORS   Borhani,D.W., Harter,T.M. and Petrash,J.M.
  TITLE     The crystal structure of the aldose reductase.NADPH binary complex
  JOURNAL   J Biol Chem 267 (34), 24841-24847 (1992)
   PUBMED   1447221
REFERENCE   7  (bases 1 to 1361)
  AUTHORS   Grimshaw,C.E.
  TITLE     Aldose reductase: model for a new paradigm of enzymic perfection in
            detoxification catalysts
  JOURNAL   Biochemistry 31 (42), 10139-10145 (1992)
   PUBMED   1420136
  REMARK    Review article
REFERENCE   8  (bases 1 to 1361)
  AUTHORS   Wilson,D.K., Bohren,K.M., Gabbay,K.H. and Quiocho,F.A.
  TITLE     An unlikely sugar substrate site in the 1.65 A structure of the
            human aldose reductase holoenzyme implicated in diabetic
            complications
  JOURNAL   Science 257 (5066), 81-84 (1992)
   PUBMED   1621098
REFERENCE   9  (bases 1 to 1361)
  AUTHORS   Graham,A., Brown,L., Hedge,P.J., Gammack,A.J. and Markham,A.F.
  TITLE     Structure of the human aldose reductase gene
  JOURNAL   J Biol Chem 266 (11), 6872-6877 (1991)
   PUBMED   1901857
REFERENCE   10 (bases 1 to 1361)
  AUTHORS   Graham,A., Heath,P., Morten,J.E. and Markham,A.F.
  TITLE     The human aldose reductase gene maps to chromosome region 7q35
  JOURNAL   Hum Genet 86 (5), 509-514 (1991)
   PUBMED   1901827
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC000260.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001628.3.
            
            Summary: This gene encodes a member of the aldo/keto reductase
            superfamily, which consists of more than 40 known enzymes and
            proteins. This member catalyzes the reduction of a number of
            aldehydes, including the aldehyde form of glucose, and is thereby
            implicated in the development of diabetic complications by
            catalyzing the reduction of glucose to sorbitol. Multiple
            pseudogenes have been identified for this gene. The nomenclature
            system used by the HUGO Gene Nomenclature Committee to define human
            aldo-keto reductase family members is known to differ from that
            used by the Mouse Genome Informatics database. [provided by RefSeq,
            Feb 2009].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1030648.1,
                                           SRR3476690.1147323.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145544, SAMEA2162841
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000285930.9/ ENSP00000285930.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1361              BC000260.1         37-1397
FEATURES             Location/Qualifiers
     source          1..1361
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q33"
     gene            1..1361
                     /gene="AKR1B1"
                     /gene_synonym="ADR; ALDR1; ALR2; AR"
                     /note="aldo-keto reductase family 1 member B"
                     /db_xref="GeneID:231"
                     /db_xref="HGNC:HGNC:381"
                     /db_xref="MIM:103880"
     exon            1..104
                     /gene="AKR1B1"
                     /gene_synonym="ADR; ALDR1; ALR2; AR"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..989
                     /gene="AKR1B1"
                     /gene_synonym="ADR; ALDR1; ALR2; AR"
                     /EC_number="1.1.1.21"
                     /EC_number="1.1.1.300"
                     /EC_number="1.1.1.54"
                     /EC_number="1.1.1.372"
                     /note="isoform 1 is encoded by transcript variant 1; low
                     Km aldose reductase; Lii5-2 CTCL tumor antigen; aldehyde
                     reductase 1; aldo-keto reductase family 1 member B1"
                     /codon_start=1
                     /product="aldo-keto reductase family 1 member B1 isoform
                     1"
                     /protein_id="NP_001619.1"
                     /db_xref="CCDS:CCDS5831.1"
                     /db_xref="GeneID:231"
                     /db_xref="HGNC:HGNC:381"
                     /db_xref="MIM:103880"
                     /translation="MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHID
                     CAHVYQNENEVGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKL
                     DYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGIS
                     NFNHLQVEMILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDR
                     PWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKV
                     FDFELSSQDMTTLLSYNRNWRVCALLSCTSHKDYPFHEEF"
     exon            105..272
                     /gene="AKR1B1"
                     /gene_synonym="ADR; ALDR1; ALR2; AR"
                     /inference="alignment:Splign:2.1.0"
     exon            273..389
                     /gene="AKR1B1"
                     /gene_synonym="ADR; ALDR1; ALR2; AR"
                     /inference="alignment:Splign:2.1.0"
     exon            390..467
                     /gene="AKR1B1"
                     /gene_synonym="ADR; ALDR1; ALR2; AR"
                     /inference="alignment:Splign:2.1.0"
     exon            468..590
                     /gene="AKR1B1"
                     /gene_synonym="ADR; ALDR1; ALR2; AR"
                     /inference="alignment:Splign:2.1.0"
     exon            591..697
                     /gene="AKR1B1"
                     /gene_synonym="ADR; ALDR1; ALR2; AR"
                     /inference="alignment:Splign:2.1.0"
     exon            698..779
                     /gene="AKR1B1"
                     /gene_synonym="ADR; ALDR1; ALR2; AR"
                     /inference="alignment:Splign:2.1.0"
     exon            780..863
                     /gene="AKR1B1"
                     /gene_synonym="ADR; ALDR1; ALR2; AR"
                     /inference="alignment:Splign:2.1.0"
     exon            864..946
                     /gene="AKR1B1"
                     /gene_synonym="ADR; ALDR1; ALR2; AR"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1361
                     /gene="AKR1B1"
                     /gene_synonym="ADR; ALDR1; ALR2; AR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1342..1347
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AKR1B1"
                     /gene_synonym="ADR; ALDR1; ALR2; AR"
                     /note="hexamer: AATAAA"
     polyA_site      1361
                     /gene="AKR1B1"
                     /gene_synonym="ADR; ALDR1; ALR2; AR"
                     /note="major polyA site"
ORIGIN      
        1 gcaccgtact gggcgggggt ctggggagcg cagcagccat ggcaagccgt ctcctgctca
       61 acaacggcgc caagatgccc atcctggggt tgggtacctg gaagtcccct ccagggcagg
      121 tgactgaggc cgtgaaggtg gccattgacg tcgggtaccg ccacatcgac tgtgcccatg
      181 tgtaccagaa tgagaatgag gtgggggtgg ccattcagga gaagctcagg gagcaggtgg
      241 tgaagcgtga ggagctcttc atcgtcagca agctgtggtg cacgtaccat gagaagggcc
      301 tggtgaaagg agcctgccag aagacactca gcgacctgaa gctggactac ctggacctct
      361 accttattca ctggccgact ggctttaagc ctgggaagga atttttccca ttggatgagt
      421 cgggcaatgt ggttcccagt gacaccaaca ttctggacac gtgggcggcc atggaagagc
      481 tggtggatga agggctggtg aaagctattg gcatctccaa cttcaaccat ctccaggtgg
      541 agatgatctt aaacaaacct ggcttgaagt ataagcctgc agttaaccag attgagtgcc
      601 acccatatct cactcaggag aagttaatcc agtactgcca gtccaaaggc atcgtggtga
      661 ccgcctacag ccccctcggc tctcctgaca ggccctgggc caagcccgag gacccttctc
      721 tcctggagga tcccaggatc aaggcgatcg cagccaagca caataaaact acagcccagg
      781 tcctgatccg gttccccatg cagaggaact tggtggtgat ccccaagtct gtgacaccag
      841 aacgcattgc tgagaacttt aaggtctttg actttgaact gagcagccag gatatgacca
      901 ccttactcag ctacaacagg aactggaggg tctgtgcctt gttgagctgt acctcccaca
      961 aggattaccc cttccatgaa gagttttgaa gctgtggttg cctgctcgtc cccaagtgac
     1021 ctatacctgt gtttcttgcc tcattttttt ccttgcaaat gtagtatggc ctgtgtcact
     1081 cagcagtggg acagcaacct gtagagtggc cagcgagggc gtgtctagct tgatgttgga
     1141 tctcaagagc cctgtcagta gagtagaagt ctcttccagt ttgctttgcc cttctttcta
     1201 ccctgctggg gaaagtacaa cctgaatacc cttttctgac caaagagaag caaaatctac
     1261 caggtcaaaa tagtgccact aacggttgag ttttgactgc ttggaactgg aatcctttca
     1321 gcaagacttc tctttgcctc aaataaaaag tgcttttgtg a
//
