LOCUS       NM_153326               1407 bp    mRNA    linear   PRI 02-JUN-2024
DEFINITION  Homo sapiens aldo-keto reductase family 1 member A1 (AKR1A1),
            transcript variant 2, mRNA.
ACCESSION   NM_153326
VERSION     NM_153326.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1407)
  AUTHORS   Chiang,C.H., Lin,Y.H., Kao,Y.C., Weng,S.C., Chen,C.M. and Liou,Y.M.
  TITLE     Mechanistic study of the Aldo-keto reductase family 1 member A1 in
            regulating mesenchymal stem cell fate decision toward adipogenesis
            and osteogenesis
  JOURNAL   Life Sci 336, 122336 (2024)
   PUBMED   38092142
  REMARK    GeneRIF: Mechanistic study of the Aldo-keto reductase family 1
            member A1 in regulating mesenchymal stem cell fate decision toward
            adipogenesis and osteogenesis.
REFERENCE   2  (bases 1 to 1407)
  AUTHORS   Chen,H., Zhang,X., Zhang,X., Liu,W., Lei,Y., Zhu,C. and Ma,B.
  TITLE     (5-Hydroxy-4-oxo-2-styryl-4H-pyridin-1-yl)-acetic Acid Derivatives
            as Multifunctional Aldose Reductase Inhibitors
  JOURNAL   Molecules 25 (21), 5135 (2020)
   PUBMED   33158254
  REMARK    GeneRIF: (5-Hydroxy-4-oxo-2-styryl-4H-pyridin-1-yl)-acetic Acid
            Derivatives as Multifunctional Aldose Reductase Inhibitors.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1407)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 1407)
  AUTHORS   Stomberski,C.T., Zhou,H.L., Wang,L., van den Akker,F. and
            Stamler,J.S.
  TITLE     Molecular recognition of S-nitrosothiol substrate by its cognate
            protein denitrosylase
  JOURNAL   J Biol Chem 294 (5), 1568-1578 (2019)
   PUBMED   30538128
REFERENCE   5  (bases 1 to 1407)
  AUTHORS   Homma,T., Shirato,T., Akihara,R., Kobayashi,S., Lee,J.,
            Yamada,K.I., Miyata,S., Takahashi,M. and Fujii,J.
  TITLE     Mice deficient in aldo-keto reductase 1a (Akr1a) are resistant to
            thioacetamide-induced liver injury
  JOURNAL   Toxicol Lett 294, 37-43 (2018)
   PUBMED   29763686
  REMARK    GeneRIF: Data (including data from studies in knockout and
            transgenic mice) suggest that AKR1A1 in liver is involved in
            bioactivation of xenobiotic/carcinogen thioacetamide (TAA);
            Akr1a-/- knockout mice are resistant to TAA-induced liver
            injury/hepatotoxicity.
REFERENCE   6  (bases 1 to 1407)
  AUTHORS   Barski,O.A., Gabbay,K.H., Grimshaw,C.E. and Bohren,K.M.
  TITLE     Mechanism of human aldehyde reductase: characterization of the
            active site pocket
  JOURNAL   Biochemistry 34 (35), 11264-11275 (1995)
   PUBMED   7669785
REFERENCE   7  (bases 1 to 1407)
  AUTHORS   Tanimoto,T., Ohta,M., Tanaka,A., Ikemoto,I. and Machida,T.
  TITLE     Purification and characterization of human testis aldose and
            aldehyde reductase
  JOURNAL   Int J Biochem 23 (4), 421-428 (1991)
   PUBMED   1901806
REFERENCE   8  (bases 1 to 1407)
  AUTHORS   Vander Jagt,D.L., Hunsaker,L.A., Robinson,B., Stangebye,L.A. and
            Deck,L.M.
  TITLE     Aldehyde and aldose reductases from human placenta. Heterogeneous
            expression of multiple enzyme forms
  JOURNAL   J Biol Chem 265 (19), 10912-10918 (1990)
   PUBMED   2113526
REFERENCE   9  (bases 1 to 1407)
  AUTHORS   Bohren,K.M., Bullock,B., Wermuth,B. and Gabbay,K.H.
  TITLE     The aldo-keto reductase superfamily. cDNAs and deduced amino acid
            sequences of human aldehyde and aldose reductases
  JOURNAL   J Biol Chem 264 (16), 9547-9551 (1989)
   PUBMED   2498333
REFERENCE   10 (bases 1 to 1407)
  AUTHORS   Wermuth,B., Omar,A., Forster,A., di Francesco,C., Wolf,M., von
            Wartburg,J.P., Bullock,B. and Gabbay,K.H.
  TITLE     Primary structure of aldehyde reductase from human liver
  JOURNAL   Prog Clin Biol Res 232, 297-307 (1987)
   PUBMED   3615425
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI549149.1, DA550374.1,
            BT007003.1 and BU631634.1.
            
            On Jun 2, 2019 this sequence version replaced NM_153326.2.
            
            Summary: This gene encodes a member of the aldo/keto reductase
            superfamily, which consists of more than 40 known enzymes and
            proteins. This member, also known as aldehyde reductase, is
            involved in the reduction of biogenic and xenobiotic aldehydes and
            is present in virtually every tissue. Multiple alternatively
            spliced transcript variants of this gene exist, all encoding the
            same protein. [provided by RefSeq, Jan 2011].
            
            Transcript Variant: This variant (2) lacks an alternate exon in the
            5' UTR, compared to variant 1. All variants encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU794588.1, EU668319.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000351829.9/ ENSP00000312606.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                BI549149.1         49-63
            16-576              DA550374.1         1-561
            577-1312            BT007003.1         241-976
            1313-1407           BU631634.1         20-114              c
FEATURES             Location/Qualifiers
     source          1..1407
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.1"
     gene            1..1407
                     /gene="AKR1A1"
                     /gene_synonym="ALDR1; ALR; ARM; DD3; HEL-S-6"
                     /note="aldo-keto reductase family 1 member A1"
                     /db_xref="GeneID:10327"
                     /db_xref="HGNC:HGNC:380"
                     /db_xref="MIM:103830"
     exon            1..330
                     /gene="AKR1A1"
                     /gene_synonym="ALDR1; ALR; ARM; DD3; HEL-S-6"
                     /inference="alignment:Splign:2.1.0"
     exon            331..420
                     /gene="AKR1A1"
                     /gene_synonym="ALDR1; ALR; ARM; DD3; HEL-S-6"
                     /inference="alignment:Splign:2.1.0"
     CDS             337..1314
                     /gene="AKR1A1"
                     /gene_synonym="ALDR1; ALR; ARM; DD3; HEL-S-6"
                     /EC_number="1.1.1.2"
                     /EC_number="1.1.1.54"
                     /EC_number="1.1.1.19"
                     /EC_number="1.1.1.20"
                     /EC_number="1.1.1.372"
                     /note="dihydrodiol dehydrogenase 3; aldehyde reductase;
                     alcohol dehydrogenase; epididymis secretory protein Li 6;
                     HEL-S-165mP; epididymis secretory sperm binding protein Li
                     165mP; glucuronate reductase; glucuronolactone reductase;
                     scorR; S-nitroso-CoA reductase"
                     /codon_start=1
                     /product="aldo-keto reductase family 1 member A1"
                     /protein_id="NP_697021.1"
                     /db_xref="CCDS:CCDS523.1"
                     /db_xref="GeneID:10327"
                     /db_xref="HGNC:HGNC:380"
                     /db_xref="MIM:103830"
                     /translation="MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHI
                     DCAAIYGNEPEIGEALKEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADL
                     QLEYLDLYLMHWPYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALG
                     LSNFNSRQIDDILSVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDR
                     AWRDPDEPVLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKV
                     FDFTFSPEEMKQLNALNKNWRYIVPMLTVDGKRVPRDAGHPLYPFNDPY"
     exon            421..540
                     /gene="AKR1A1"
                     /gene_synonym="ALDR1; ALR; ARM; DD3; HEL-S-6"
                     /inference="alignment:Splign:2.1.0"
     exon            541..692
                     /gene="AKR1A1"
                     /gene_synonym="ALDR1; ALR; ARM; DD3; HEL-S-6"
                     /inference="alignment:Splign:2.1.0"
     exon            693..888
                     /gene="AKR1A1"
                     /gene_synonym="ALDR1; ALR; ARM; DD3; HEL-S-6"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1088
                     /gene="AKR1A1"
                     /gene_synonym="ALDR1; ALR; ARM; DD3; HEL-S-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1161
                     /gene="AKR1A1"
                     /gene_synonym="ALDR1; ALR; ARM; DD3; HEL-S-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1248
                     /gene="AKR1A1"
                     /gene_synonym="ALDR1; ALR; ARM; DD3; HEL-S-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1407
                     /gene="AKR1A1"
                     /gene_synonym="ALDR1; ALR; ARM; DD3; HEL-S-6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1386..1391
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AKR1A1"
                     /gene_synonym="ALDR1; ALR; ARM; DD3; HEL-S-6"
                     /note="hexamer: AATAAA"
     polyA_site      1407
                     /gene="AKR1A1"
                     /gene_synonym="ALDR1; ALR; ARM; DD3; HEL-S-6"
                     /note="major polyA site"
ORIGIN      
        1 agcgccacct gcctcattgt gcccaggagt tctccaaacc cgcgctgcgg agtgagtgac
       61 caagttccgg ccagttcgac ctcgaggatc cagaggtgga gacggtacta cctcccagct
      121 ctgttttcca tccccttcag gtccttcctc gggaggcggc gaaggcggtc caccctgcgc
      181 gtgatccttt atgcccggcc cctgcccctc cctccgggtg gaacttcccc ctcaccgcca
      241 gacttaagct gaggatcgtt ggatctctgg cggggtgcag aactgagccc aggccacagt
      301 accctattca cgctctgtgc ttgtgccaag ggggcaatgg cggcttcctg tgttctactg
      361 cacactgggc agaagatgcc tctgattggt ctgggtacct ggaagagtga gcctggtcag
      421 gtaaaagcag ctgttaagta tgcccttagc gtaggctacc gccacattga ttgtgctgct
      481 atctacggca atgagcctga gattggggag gccctgaagg aggacgtggg accaggcaag
      541 gcggtgcctc gggaggagct gtttgtgaca tccaagctgt ggaacaccaa gcaccacccc
      601 gaggatgtgg agcctgccct ccggaagact ctggctgacc tccagctgga gtatctggac
      661 ctgtacctga tgcactggcc ttatgccttt gagcggggag acaacccctt ccccaagaat
      721 gctgatggga ctatatgcta cgactccacc cactacaagg agacttggaa ggctctggag
      781 gcactggtgg ctaaggggct ggtgcaggcg ctgggcctgt ccaacttcaa cagtcggcag
      841 attgatgaca tactcagtgt ggcctccgtg cgtccagctg tcttgcaggt ggaatgccac
      901 ccatacttgg ctcaaaatga gctaattgcc cactgccaag cacgtggcct ggaggtaact
      961 gcttatagcc ctttgggctc ctctgatcgt gcatggcgtg atcctgatga gcctgtcctg
     1021 ctggaggaac cagtagtcct ggcattggct gaaaagtatg gccgatctcc agctcagatc
     1081 ttgctcaggt ggcaggtcca gcggaaagtg atctgcatcc ccaaaagtat cactccttct
     1141 cgaatccttc agaacatcaa ggtgtttgac ttcaccttta gcccagaaga gatgaagcag
     1201 ctaaatgccc tgaacaaaaa ttggagatat attgtgccta tgcttacggt ggatgggaag
     1261 agagtcccaa gggatgcagg gcatcctctg taccccttta atgacccgta ctgagaccac
     1321 agcttcttgg cctcccttcc agctctgcag ctaatgaggt cctgccacaa cggaaagagg
     1381 gagttaataa agccattgga gcatcca
//
