LOCUS       NM_001317950            7454 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens AT-hook transcription factor (AKNA), transcript
            variant 1, mRNA.
ACCESSION   NM_001317950 XM_005252243
VERSION     NM_001317950.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7454)
  AUTHORS   Ramirez-Gonzalez,A., Avila-Lopez,P., Bahena-Roman,M.,
            Contreras-Ochoa,C.O., Lagunas-Martinez,A., Langley,E.,
            Manzo-Merino,J., Madrid-Marina,V. and Torres-Poveda,K.
  TITLE     Critical Role of the Transcription Factor AKNA in T-Cell
            Activation: An Integrative Bioinformatics Approach
  JOURNAL   Int J Mol Sci 24 (4), 4212 (2023)
   PUBMED   36835622
  REMARK    GeneRIF: Critical Role of the Transcription Factor AKNA in T-Cell
            Activation: An Integrative Bioinformatics Approach.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7454)
  AUTHORS   Ramirez-Gonzalez,A., Manzo-Merino,J., Contreras-Ochoa,C.O.,
            Bahena-Roman,M., Aguilar-Villasenor,J.M., Lagunas-Martinez,A.,
            Rosenstein,Y., Madrid Marina,V. and Torres-Poveda,K.
  TITLE     Functional Role of AKNA: A Scoping Review
  JOURNAL   Biomolecules 11 (11), 1709 (2021)
   PUBMED   34827707
  REMARK    GeneRIF: Functional Role of AKNA: A Scoping Review.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7454)
  AUTHORS   Waseem,S.S., Moawia,A., Budde,B., Tariq,M., Khan,A., Ali,Z.,
            Khan,S., Iqbal,M., Malik,N.A., Haque,S.U., Altmuller,J., Thiele,H.,
            Hussain,M.S., Cirak,S., Baig,S.M. and Nurnberg,P.
  TITLE     A Homozygous AKNA Frameshift Variant Is Associated with
            Microcephaly in a Pakistani Family
  JOURNAL   Genes (Basel) 12 (10), 1494 (2021)
   PUBMED   34680889
  REMARK    GeneRIF: A Homozygous AKNA Frameshift Variant Is Associated with
            Microcephaly in a Pakistani Family.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7454)
  AUTHORS   Zhao,T., Ma,C., Xie,B., Zhao,B., Wang,W. and Liu,J.
  TITLE     Evaluation of Common Variants in the AKNA Gene and Susceptibility
            to Knee Osteoarthritis Among the Han Chinese
  JOURNAL   Genet Test Mol Biomarkers 24 (7), 425-430 (2020)
   PUBMED   32460535
  REMARK    GeneRIF: Evaluation of Common Variants in the AKNA Gene and
            Susceptibility to Knee Osteoarthritis Among the Han Chinese.
REFERENCE   5  (bases 1 to 7454)
  AUTHORS   Wang,G., Sun,D., Li,W. and Xin,Y.
  TITLE     AKNA Is a Potential Prognostic Biomarker in Gastric Cancer and
            Function as a Tumor Suppressor by Modulating EMT-Related Pathways
  JOURNAL   Biomed Res Int 2020, 6726759 (2020)
   PUBMED   32462010
  REMARK    GeneRIF: AKNA Is a Potential Prognostic Biomarker in Gastric Cancer
            and Function as a Tumor Suppressor by Modulating EMT-Related
            Pathways.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7454)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 7454)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   8  (bases 1 to 7454)
  AUTHORS   Kofler,M., Motzny,K., Beyermann,M. and Freund,C.
  TITLE     Novel interaction partners of the CD2BP2-GYF domain
  JOURNAL   J Biol Chem 280 (39), 33397-33402 (2005)
   PUBMED   16000308
REFERENCE   9  (bases 1 to 7454)
  AUTHORS   Sims-Mourtada,J.C., Bruce,S., McKeller,M.R., Rangel,R.,
            Guzman-Rojas,L., Cain,K., Lopez,C., Zimonjic,D.B., Popescu,N.C.,
            Gordon,J., Wilkinson,M.F. and Martinez-Valdez,H.
  TITLE     The human AKNA gene expresses multiple transcripts and protein
            isoforms as a result of alternative promoter usage, splicing, and
            polyadenylation
  JOURNAL   DNA Cell Biol 24 (5), 325-338 (2005)
   PUBMED   15869410
  REMARK    GeneRIF: AKNA expresses multiple transcripts and protein isoforms
            as a result of alternative promoter usage, splicing, and
            polyadenylation.
REFERENCE   10 (bases 1 to 7454)
  AUTHORS   Siddiqa,A., Sims-Mourtada,J.C., Guzman-Rojas,L., Rangel,R.,
            Guret,C., Madrid-Marina,V., Sun,Y. and Martinez-Valdez,H.
  TITLE     Regulation of CD40 and CD40 ligand by the AT-hook transcription
            factor AKNA
  JOURNAL   Nature 410 (6826), 383-387 (2001)
   PUBMED   11268217
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL356796.16, AK131082.2, AY703040.1 and AL833220.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001317950.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1). Both variants 1 and
            2 encode the same protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK131082.2, AK160382.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374088.8/ ENSP00000363201.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AL356796.16        118145-118163       c
            20-2106             AK131082.2         1-2087
            2107-2632           AY703040.1         1646-2171
            2633-4256           AK131082.2         2614-4237
            4257-5239           AK131082.2         4239-5221
            5240-5240           AL356796.16        66551-66551         c
            5241-5472           AK131082.2         5223-5454
            5473-5483           AL833220.1         3876-3886
            5484-7454           AL356796.16        64337-66307         c
FEATURES             Location/Qualifiers
     source          1..7454
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q32"
     gene            1..7454
                     /gene="AKNA"
                     /note="AT-hook transcription factor"
                     /db_xref="GeneID:80709"
                     /db_xref="HGNC:HGNC:24108"
                     /db_xref="MIM:605729"
     exon            1..123
                     /gene="AKNA"
                     /inference="alignment:Splign:2.1.0"
     exon            124..510
                     /gene="AKNA"
                     /inference="alignment:Splign:2.1.0"
     CDS             237..4556
                     /gene="AKNA"
                     /note="isoform 1 is encoded by transcript variant 1;
                     AT-hook transcription factor AKNA; AT-hook-containing
                     transcription factor; AKNA transcript F2; microtubule
                     organization protein AKNA"
                     /codon_start=1
                     /product="microtubule organization protein AKNA isoform 1"
                     /protein_id="NP_001304879.1"
                     /db_xref="CCDS:CCDS6805.1"
                     /db_xref="GeneID:80709"
                     /db_xref="HGNC:HGNC:24108"
                     /db_xref="MIM:605729"
                     /translation="MASSETEIRWAEPGLGKGPQRRRWAWAEDKRDVDRSSSQSWEEE
                     RLFPNATSPELLEDFRLAQQHLPPLEWDPHPQPDGHQDSESGETSGEEAEAEDVDSPA
                     SSHEPLAWLPQQGRQLDMTEEEPDGTLGSLEVEEAGESSSRLGYEAGLSLEGHGNTSP
                     MALGHGQARGWVASGEQASGDKLSEHSEVNPSVELSPARSWSSGTVSLDHPSDSLDST
                     WEGETDGPQPTALAETLPEGPSHHLLSPDGRTGGSVARATPMEFQDSSAPPAQSPQHA
                     TDRWRRETTRFFCPQPKEHIWKQTKTSPKPLPSRFIGSISPLNPQPRPTRQGRPLPRQ
                     GATLAGRSSSNAPKYGRGQLNYPLPDFSKVGPRVRFPKDESYRPPKSRSHNRKPQAPA
                     RPLIFKSPAEIVQEVLLSSGEAALAKDTPPAHPITRVPQEFQTPEQATELVHQLQEDY
                     HRLLTKYAEAENTIDQLRLGAKVNLFSDPPQPNHSIHTGMVPQGTKVLSFTIPQPRSA
                     EWWPGPAEDPQASAASGWPSARGDLSPSSLTSMPTLGWLPENRDISEDQSSAEQTQAL
                     ASQASQFLAKVESFERLIQAGRLMPQDQVKGFQRLKAAHAALEEEYLKACREQHPAQP
                     LAGSKGTPGRFDPRRELEAEIYRLGSCLEELKEHIDQTQQEPEPPGSDSALDSTPALP
                     CLHQPTHLPAPSGQAPMPAIKTSCPEPATTTAAASTGPCPLHVNVEVSSGNSEVEDRP
                     QDPLARLRHKELQMEQVYHGLMERYLSVKSLPEAMRMEEEEEGEEEEEEEGGGDSLEV
                     DGVAATPGKAEATRVLPRQCPVQAEKSHGAPLEEATEKMVSMKPPGFQASLARDGHMS
                     GLGKAEAAPPGPGVPPHPPGTKSAASHQSSMTSLEGSGISERLPQKPLHRGGGPHLEE
                     TWMASPETDSGFVGSETSRVSPLTQTPEHRLSHISTAGTLAQPFAASVPRDGASYPKA
                     RGSLIPRRATEPSTPRSQAQRYLSSPSGPLRQRAPNFSLERTLAAEMAVPGSEFEGHK
                     RISEQPLPNKTISPPPAPAPAAAPLPCGPTETIPSFLLTRAGRDQAICELQEEVSRLR
                     LRLEDSLHQPLQGSPTRPASAFDRPARTRGRPADSPATWGSHYGSKSTERLPGEPRGE
                     EQIVPPGRQRARSSSVPREVLRLSLSSESELPSLPLFSEKSKTTKDSPQAARDGKRGV
                     GSAGWPDRVTFRGQYTGHEYHVLSPKAVPKGNGTVSCPHCRPIRTQDAGGAVTGDPLG
                     PPPADTLQCPLCGQVGSPPEADGPGSATSGAEKATTRRKASSTPSPKQRSKQAGSSPR
                     PPPGLWYLATAPPAPAPPAFAYISSVPIMPYPPAAVYYAPAGPTSAQPAAKWPPTASP
                     PPARRHRHSIQLDLGDLEELNKALSRAVQAAESVRSTTRQMRSSLSADLRQAHSLRGS
                     CLF"
     exon            511..1577
                     /gene="AKNA"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1652
                     /gene="AKNA"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1809
                     /gene="AKNA"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..1964
                     /gene="AKNA"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2024
                     /gene="AKNA"
                     /inference="alignment:Splign:2.1.0"
     exon            2025..2152
                     /gene="AKNA"
                     /inference="alignment:Splign:2.1.0"
     exon            2153..2360
                     /gene="AKNA"
                     /inference="alignment:Splign:2.1.0"
     exon            2361..2527
                     /gene="AKNA"
                     /inference="alignment:Splign:2.1.0"
     exon            2528..2728
                     /gene="AKNA"
                     /inference="alignment:Splign:2.1.0"
     exon            2729..2975
                     /gene="AKNA"
                     /inference="alignment:Splign:2.1.0"
     exon            2976..3082
                     /gene="AKNA"
                     /inference="alignment:Splign:2.1.0"
     exon            3083..3294
                     /gene="AKNA"
                     /inference="alignment:Splign:2.1.0"
     exon            3295..3457
                     /gene="AKNA"
                     /inference="alignment:Splign:2.1.0"
     exon            3458..3634
                     /gene="AKNA"
                     /inference="alignment:Splign:2.1.0"
     exon            3635..3750
                     /gene="AKNA"
                     /inference="alignment:Splign:2.1.0"
     exon            3751..3897
                     /gene="AKNA"
                     /inference="alignment:Splign:2.1.0"
     exon            3898..3993
                     /gene="AKNA"
                     /inference="alignment:Splign:2.1.0"
     exon            3994..4110
                     /gene="AKNA"
                     /inference="alignment:Splign:2.1.0"
     exon            4111..4303
                     /gene="AKNA"
                     /inference="alignment:Splign:2.1.0"
     exon            4304..7454
                     /gene="AKNA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5451..5456
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AKNA"
                     /note="hexamer: AAGAAA"
     polyA_site      5483
                     /gene="AKNA"
                     /note="major polyA site"
     polyA_site      6357
                     /gene="AKNA"
ORIGIN      
        1 agaacggcct ggaggtgggc cagggcgcaa tggagacagg gggctccctg ggtttggaac
       61 aaagaattca caggcaggtc ccctgaaact gggtcggcag gacggtggtg gagcccgaga
      121 gagggcacag gcaggatggc cgatgctgac aggaaccagc ggtgactctg gggcccctgg
      181 cagcagctct gtctcctgaa gatgaagtgg cccaggtgaa gcccaggcca gccccaatgg
      241 ccagctcgga gactgagatc cgctgggctg agcctggcct ggggaagggc ccccagcggc
      301 ggcgctgggc ctgggccgag gacaagaggg atgtggatag aagtagttca caaagctggg
      361 aagaagagag actctttccc aatgccacca gccccgagct cctagaggac ttccgcctgg
      421 cccagcagca cctgccgccc ctggagtggg acccacaccc gcagcccgat gggcatcagg
      481 attccgagtc aggagagact tcgggagaag aggctgaagc agaggatgtg gacagcccag
      541 caagttccca tgagcctctt gcctggctcc cccagcaggg ccgtcagctg gacatgactg
      601 aagaggagcc agatgggacc ctcggaagtc tggaggttga ggaggctgga gagagctcct
      661 caaggttggg gtatgaggct ggtctcagct tggaaggcca tggaaacacc agccccatgg
      721 ctcttgggca tggtcaggcc aggggctggg tggcttctgg cgaacaagcc agtggggaca
      781 aactttctga acattccgag gtcaacccat ccgttgaact cagcccggca aggtcctgga
      841 gcagtgggac agtgagcctc gaccacccta gtgacagcct tgattctacc tgggaaggag
      901 agaccgatgg cccccagccc actgccctgg cagaaacctt gccagagggc cccagccacc
      961 acctcctaag cccagatggc agaactggag gcagtgttgc tcgggcaacc cccatggaat
     1021 tccaggactc ctcagctccc ccagcccaga gtccgcagca tgccacagat agatggagga
     1081 gagaaacgac cagattcttc tgccctcagc ccaaggaaca catctggaag cagacaaaga
     1141 cgtcacctaa gccactccct tcccgattca ttggctccat cagccccctg aatccccagc
     1201 ccaggccaac gcggcagggc aggccgctgc ccagacaggg agccactctg gctggccgct
     1261 cctcttctaa tgcccccaag tatggccggg ggcagttgaa ctacccactc cctgatttct
     1321 ccaaggtagg gccccgggtg agattcccca aagatgagag ctaccgtccc cccaagtcca
     1381 gaagccacaa caggaagcct caggcccctg ccaggcccct catcttcaag tctccagctg
     1441 agattgtgca ggaggtgctg ttgagcagtg gagaagcagc cctggcaaag gacacgcctc
     1501 ctgcccaccc tatcaccagg gtaccccaag aatttcagac gcctgagcaa gccactgagc
     1561 tggtccatca gctccaggaa gactaccaca ggctcctcac caagtacgct gaggccgaga
     1621 acaccattga ccagctacgc ctcggggcca aggtgaacct gttctctgac ccaccccagc
     1681 ccaaccacag catccacacg ggaatggtgc cccaggggac caaggtcttg tccttcacca
     1741 tcccacagcc ccgctctgca gagtggtggc cgggcccggc cgaggacccc caggcctctg
     1801 cggcctcagg gtggccatca gctcgaggag acttgagccc ctcctcgctt accagcatgc
     1861 ccaccctggg gtggcttccg gagaaccggg acatctctga ggaccagtcc tcagcagagc
     1921 agacccaggc actggcttct caggccagcc agttcctggc caaggtggag tcctttgaaa
     1981 gactgataca ggcaggacgt ctcatgcccc aggaccaagt caagggcttc cagcggctga
     2041 aggctgccca cgcggcccta gaggaggagt acctgaaggc ttgtcgggag caacaccctg
     2101 cccagccgct tgccggctcc aaggggacgc ctggaagatt tgatcctcgc agggagctgg
     2161 aggcagagat ataccgtctg ggaagctgcc tggaagagct gaaggaacac atagaccaga
     2221 cccagcaaga gcctgagccg cccgggtcag actcagctct ggacagcacc ccagccctgc
     2281 cctgcctcca tcagccaacg cacctgcctg ctccttctgg acaagccccc atgccagcca
     2341 tcaagacctc ctgccctgag cctgctacca ccactgccgc cgccagcact ggcccctgcc
     2401 cattgcacgt aaatgtggag gtgagctctg gcaacagtga ggtggaggac aggccacagg
     2461 accccctggc ccgactcagg cacaaggagc tgcagatgga gcaagtttac catggcctca
     2521 tggagcggta cctcagtgtg aagtctctcc cagaagccat gagaatggag gaggaggaag
     2581 aaggagagga ggaggaggag gaagaggggg gaggtgactc cctggaagtt gatggggtgg
     2641 ctgcaactcc agggaaagca gaggccacca gggtcctccc aaggcagtgc ccggtgcagg
     2701 ctgagaaaag tcatggggct cccctggagg aggccacgga gaagatggta tctatgaagc
     2761 caccaggttt ccaggcatcc ctggctagag acgggcacat gtcaggcctg ggcaaggctg
     2821 aggcagcccc tccaggccct ggcgtgccac cccaccctcc aggcaccaag tccgcagcat
     2881 cccaccaaag tagtatgacc agcctggagg gaagcggcat ctctgagcgc cttccacaga
     2941 agcctttgca ccgaggcggt gggccccacc tggaggagac ctggatggcg tccccagaga
     3001 cagacagtgg ctttgtgggc tcagaaacaa gcagagtttc acccctcacc cagactccag
     3061 agcaccggct ctcccacatc agcacagcag gaacattagc ccagcccttt gctgcatctg
     3121 tgcccaggga tggagcttcc taccccaagg ccaggggttc tctgattccc agaagagcca
     3181 cagagcccag cacaccccgg agccaagcac agaggtacct ctccagccca agtgggcctc
     3241 tccggcagag ggcacccaac ttcagcctgg agcggacact ggcagccgag atggcggttc
     3301 ctggctcaga gtttgagggg cacaaacgga tttctgaaca gccccttccc aacaagacaa
     3361 tcagcccacc cccagccccc gcccctgccg ctgcgcctct accctgtgga ccaacagaga
     3421 ccatccccag cttcctgctc accagggcag ggcgagacca ggccatctgt gagctgcaag
     3481 aagaggtgtc ccggcttcgt ctgcggctgg aagacagcct gcaccagcca ctccagggca
     3541 gcccgacacg cccagcatct gcctttgacc gccccgcccg gacccgcggc cggccagcag
     3601 actccccagc cacctggggc tcccattatg gcagtaaatc cacagagaga ttgcctggtg
     3661 agcctagagg tgaagagcag attgtccctc caggaaggca gcgagccagg tcttcctcag
     3721 tgcctcggga ggtgctccga ctgtccctga gttcagaatc tgagctgccc tccctaccac
     3781 tgttctctga gaagagcaag accaccaagg acagtccaca ggcagctcgg gatggaaaga
     3841 gaggggtggg cagtgctgga tggccagaca gggtcacctt ccggggccaa tacacaggcc
     3901 acgaatacca tgttctgtcc cctaaggcgg tcccaaaagg caatggcaca gtctcctgtc
     3961 cccactgccg gcccattagg acccaggatg cgggtggtgc tgtcacaggg gacccactgg
     4021 gaccgcctcc cgctgatacc cttcagtgtc ccctgtgtgg tcaagttggg tctcccccag
     4081 aggcagatgg tccaggctca gccacctctg gggcagagaa ggccaccacg aggagaaaag
     4141 catcttcaac tcccagcccc aagcagagga gcaagcaggc ggggtcgtcg ccacgcccac
     4201 cccccggact gtggtatctg gcaacagcgc ccccagcacc agcccctcca gcctttgcct
     4261 acatctcctc ggttcccatc atgccttatc cacctgccgc tgtgtactat gcgcctgcag
     4321 gacctacctc agcccaacca gctgccaagt ggccgcccac agcctctccc ccaccagccc
     4381 ggagacaccg gcactccatc cagctcgacc tgggcgacct agaggagctc aacaaggccc
     4441 tgagccgggc cgtgcaggct gccgagagcg tccgctctac caccaggcag atgagaagct
     4501 cgctgtcagc cgacctgcgc caggctcaca gcctgcgggg ctcctgcctc ttctgacttc
     4561 actgggggcc cagaggcaga tgggtgggtg ggtgggcagg tggcctgcca ggccaggagt
     4621 gggctggagc tgctgaggcc cagaaggccc gcatagttcc tcaccaggag ggtctccctc
     4681 cagcacaggt cccgcctgct cagtccctgt gctttccaag tggagggggt gtcagctcgg
     4741 tcaccaagag aagtgacttc ccaggagcac cagtcccctc acagaggtgc tgtgagcgag
     4801 gcctccttcg gtccaggcag aacctcaggc agtctctcct ggtcctgcat gtgtgcaact
     4861 ccagctaata ataggtattt tatatacaga tggacagata tttttttaaa ctggggagtt
     4921 ttcctgatct tgggtcctct ttagggggcc agacaagaaa ggcctacggt ttctggagca
     4981 aacctgtccc ccacctgtga ccagtcactc tggggcaagc atcactggga agggcatagc
     5041 cggagacctt tctcctagtg actggtagtc agtggggcat tttaggatgt cagggcccca
     5101 gggtgacatg tgtccagctt ttctatggca gcagaggcct ttccctcaga caagctacaa
     5161 agtgcccagg atgccatcca ccatggtccc cttcagtacc tcacgcatgg tccccagctt
     5221 ctcctaggat cccagtggcg tttatcagtg gccagctacc tgccaggccc gggctggggc
     5281 acggtctgcg gccatgaggc caggccgcct cccgcacccc taccccgtgg cagcagcata
     5341 cctctgcatt tctggaatgt gtgtgcatca atgatgtttg tatatttgag gcatttaaaa
     5401 atctattttc gttacgaggg caaatgaaga atgaatattg atcttaaaaa aagaaaagaa
     5461 gacaaaaaaa atacccaaag ccatccgtgt ctctgctgta tgtcattaac ttttgccttc
     5521 aatgtcaagt ttatggggtg gtaggtttga tgcccagcca agccctttcc caggggacct
     5581 gttgggtgct ctgcctgcct ccctctggtg gcttctgttt ctccagtttt ccccctttgc
     5641 ctatctcaga accataaatc tttcaactgc ggagggcctt gaggtggggc tgcctagcca
     5701 agtccctttt gactgaggcc agagatgtaa atgaggcaca cagcaagttg ctgtctacaa
     5761 gagtatgcac ctggactctc cagtgctcct ttctttcttt tttttttctt ttttcttttt
     5821 cttttttttt ttttttttga gactgagttt tgctctggtt gcccaggctg gggtacagtg
     5881 gtggaatctc ggctcactgc aacctccgcc tcccgggttc aagtgattct cttgcctcag
     5941 cctcccgagt agctgggatt acaggcatgc accaccacgt ctggctaatt ttgtattttt
     6001 agtagagaca gggtttctcc atgttggtcg ggctgatctt gcactcccag cctcaggtga
     6061 tccacccacc tcagcctccc aaattgctgg gattacaggc gtgagccatg gcgcccagcc
     6121 ttccagtact ttcagtagca aacagcacct gccatttagg gagcacctgc tagaccctga
     6181 ttccggtgct aagcactggg cattgtctgc ttcacacagt ccatgtgcta accctcagga
     6241 ccctcactct gccccccttt tactgatgag gagagtgggg ttccaatggg ccatctgccc
     6301 aaactggttt gggagagaac ctggatttaa actcacattg gtctgaccca aagtccacat
     6361 tctttgttat gtgtgttttt tgcttcctct acctccatga ttctttttct cttgacctct
     6421 ggtttcttcc tcacgtggct ttttcttcca tgttccccac ttctcgtctc ccttgcttct
     6481 ccctgctctg cccatcatga ctcatttctg tttcattttt cagcggatcc tcctgagtat
     6541 ggttgaaaat ggtgtctcac tgaaagtaac actgaaatgg acaaacttcc tgtaggttct
     6601 gagccttcag ttccaggaca ttgtgggacc ccagaggctg tcctgtccac ttgccttctg
     6661 aggacatcag ctcggtgtcc ccagcctccg tgctgtgggc acagctgtgg tttgggtgct
     6721 gagcaaagga tgctgtagtc ttggccctgt ggagcttggc tgttgggaca ggaggtacaa
     6781 aggggagtgg tgcctgtgga cacaggacta gaccccagga catcagggcc tcgggctcat
     6841 ggtcctatca ccctggatgg tatacgcagc tgcacacgtg gaattgctca aacaattcag
     6901 gcccaacttt tctgccacgg aaggggtgct gcttccctca cgtaacaaga ggctgtcaat
     6961 cacgagcacc caggttgggg tgaggccggc cctttgtggc ttgtgccact gagtgggctg
     7021 tgcctcgggc ttggctccac ctcagggctc cacatttgca ggatgtcagc tgatttccag
     7081 ggaccagcct cacccttacg tgttatctcc ttcttctggg tctcccaggt gagcacccta
     7141 agaacacatc catggagaca cccagcccct ctggcctggg ccccaagccc tctgcatcac
     7201 cccagccctt ccctgccctg ccctgtcctg gcccaggcaa ccgcctcttg cctagttgcc
     7261 cacagcagcc ttcactcagg ccttcctgcc tccagcctgg tccccacaac gtgcctcccc
     7321 cgatggccat ggtaatactg gaataaggtc cttgtgatag gcaccacatg cctgaactct
     7381 ccccacccca tccaccttgt atttgtctgt tctcacattg ctataaagaa ctacctgaga
     7441 ctgggtagtt tatg
//
