LOCUS       NM_018064               1898 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens akirin 2 (AKIRIN2), mRNA.
ACCESSION   NM_018064
VERSION     NM_018064.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1898)
  AUTHORS   de Almeida,M., Hinterndorfer,M., Brunner,H., Grishkovskaya,I.,
            Singh,K., Schleiffer,A., Jude,J., Deswal,S., Kalis,R., Vunjak,M.,
            Lendl,T., Imre,R., Roitinger,E., Neumann,T., Kandolf,S.,
            Schutzbier,M., Mechtler,K., Versteeg,G.A., Haselbach,D. and
            Zuber,J.
  TITLE     AKIRIN2 controls the nuclear import of proteasomes in vertebrates
  JOURNAL   Nature 599 (7885), 491-496 (2021)
   PUBMED   34711951
  REMARK    GeneRIF: AKIRIN2 controls the nuclear import of proteasomes in
            vertebrates.
REFERENCE   2  (bases 1 to 1898)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1898)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1898)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1898)
  AUTHORS   Leng,K., Xu,Y., Kang,P., Qin,W., Cai,H., Wang,H., Ji,D., Jiang,X.,
            Li,J., Li,Z., Huang,L., Zhong,X., Sun,X., Wang,Z. and Cui,Y.
  TITLE     Akirin2 is modulated by miR-490-3p and facilitates angiogenesis in
            cholangiocarcinoma through the IL-6/STAT3/VEGFA signaling pathway
  JOURNAL   Cell Death Dis 10 (4), 262 (2019)
   PUBMED   30886152
  REMARK    GeneRIF: Akirin2 expression is negatively controlled by miR-490-3p
            in cholangiocarcinoma (CCA) cells, and miR-490-3p attenuated cell
            migration and angiogenesis in CCA cells by silencing Akirin2.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1898)
  AUTHORS   Krossa,S., Schmitt,A.D., Hattermann,K., Fritsch,J., Scheidig,A.J.,
            Mehdorn,H.M. and Held-Feindt,J.
  TITLE     Down regulation of Akirin-2 increases chemosensitivity in human
            glioblastomas more efficiently than Twist-1
  JOURNAL   Oncotarget 6 (25), 21029-21045 (2015)
   PUBMED   26036627
  REMARK    GeneRIF: Akirin-2 downregulation increases chemosensitivity in
            human glioblastomas more efficiently than Twist-1
REFERENCE   7  (bases 1 to 1898)
  AUTHORS   Armour,S.M., Bennett,E.J., Braun,C.R., Zhang,X.Y., McMahon,S.B.,
            Gygi,S.P., Harper,J.W. and Sinclair,D.A.
  TITLE     A high-confidence interaction map identifies SIRT1 as a mediator of
            acetylation of USP22 and the SAGA coactivator complex
  JOURNAL   Mol Cell Biol 33 (8), 1487-1502 (2013)
   PUBMED   23382074
REFERENCE   8  (bases 1 to 1898)
  AUTHORS   Macqueen,D.J. and Johnston,I.A.
  TITLE     Evolution of the multifaceted eukaryotic akirin gene family
  JOURNAL   BMC Evol Biol 9, 34 (2009)
   PUBMED   19200367
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1898)
  AUTHORS   Komiya,Y., Kurabe,N., Katagiri,K., Ogawa,M., Sugiyama,A.,
            Kawasaki,Y. and Tashiro,F.
  TITLE     A novel binding factor of 14-3-3beta functions as a transcriptional
            repressor and promotes anchorage-independent growth,
            tumorigenicity, and metastasis
  JOURNAL   J Biol Chem 283 (27), 18753-18764 (2008)
   PUBMED   18460465
REFERENCE   10 (bases 1 to 1898)
  AUTHORS   Goto,A., Matsushita,K., Gesellchen,V., El Chamy,L.,
            Kuttenkeuler,D., Takeuchi,O., Hoffmann,J.A., Akira,S., Boutros,M.
            and Reichhart,J.M.
  TITLE     Akirins are highly conserved nuclear proteins required for
            NF-kappaB-dependent gene expression in drosophila and mice
  JOURNAL   Nat Immunol 9 (1), 97-104 (2008)
   PUBMED   18066067
  REMARK    Erratum:[Nat Immunol. 2008 Feb;9(2):216]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK001204.1, BC000764.2 and BM996262.1.
            
            On Nov 23, 2018 this sequence version replaced NM_018064.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC000764.2, AK222701.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000257787.6/ ENSP00000257787.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-194               AK001204.1         35-228
            195-1502            BC000764.2         170-1477
            1503-1898           BM996262.1         17-412              c
FEATURES             Location/Qualifiers
     source          1..1898
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q15"
     gene            1..1898
                     /gene="AKIRIN2"
                     /gene_synonym="C6orf166; dJ486L4.2; FBI1"
                     /note="akirin 2"
                     /db_xref="GeneID:55122"
                     /db_xref="HGNC:HGNC:21407"
                     /db_xref="MIM:615165"
     exon            1..784
                     /gene="AKIRIN2"
                     /gene_synonym="C6orf166; dJ486L4.2; FBI1"
                     /inference="alignment:Splign:2.1.0"
     CDS             550..1161
                     /gene="AKIRIN2"
                     /gene_synonym="C6orf166; dJ486L4.2; FBI1"
                     /note="fourteen-three-three beta interactant 1"
                     /codon_start=1
                     /product="akirin-2"
                     /protein_id="NP_060534.1"
                     /db_xref="CCDS:CCDS5013.1"
                     /db_xref="GeneID:55122"
                     /db_xref="HGNC:HGNC:21407"
                     /db_xref="MIM:615165"
                     /translation="MACGATLKRTLDFDPLLSPASPKRRRCAPLSAPTSAAASPLSAA
                     AATAASFSAAAASPQKYLRMEPSPFGDVSSRLTTEQILYNIKQEYKRMQKRRHLETSF
                     QQTDPCCTSDAQPHAFLLSGPASPGTSSAASSPLKKEQPLFTLRQVGMICERLLKERE
                     EKVREEYEEILNTKLAEQYDAFVKFTHDQIMRRYGEQPASYVS"
     exon            785..928
                     /gene="AKIRIN2"
                     /gene_synonym="C6orf166; dJ486L4.2; FBI1"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1078
                     /gene="AKIRIN2"
                     /gene_synonym="C6orf166; dJ486L4.2; FBI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1150
                     /gene="AKIRIN2"
                     /gene_synonym="C6orf166; dJ486L4.2; FBI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1898
                     /gene="AKIRIN2"
                     /gene_synonym="C6orf166; dJ486L4.2; FBI1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1483..1488
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AKIRIN2"
                     /gene_synonym="C6orf166; dJ486L4.2; FBI1"
                     /note="hexamer: AATAAA"
     polyA_site      1507
                     /gene="AKIRIN2"
                     /gene_synonym="C6orf166; dJ486L4.2; FBI1"
                     /note="major polyA site"
     regulatory      1814..1819
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AKIRIN2"
                     /gene_synonym="C6orf166; dJ486L4.2; FBI1"
                     /note="hexamer: AATAAA"
     polyA_site      1832
                     /gene="AKIRIN2"
                     /gene_synonym="C6orf166; dJ486L4.2; FBI1"
                     /note="major polyA site"
     regulatory      1873..1878
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AKIRIN2"
                     /gene_synonym="C6orf166; dJ486L4.2; FBI1"
                     /note="hexamer: AATAAA"
     polyA_site      1898
                     /gene="AKIRIN2"
                     /gene_synonym="C6orf166; dJ486L4.2; FBI1"
                     /note="major polyA site"
ORIGIN      
        1 agagttctac gagggagggg aagcggttgg acgtgttcgc ttgggttcct gctgcggcag
       61 ctacctcgca atctctctgc atcgatcgcc gctcgcaagc tactgaccgt actcgggcgt
      121 attaggagcc gcgttccagc ctcacacccc acggtgctgt tttcgacttc agaaaggatc
      181 tagtctcagc acagaagcgc ctcaggcgcg gcgcaaagct cgagcggacg gcgggggcgg
      241 ccggagcctc tctcggggga gccgcgcctg aggaggcgga agaacccccc tgacgcgact
      301 ggcgtgtgct tctgcccgcc accgcccctc ccgctctcac ccgggccgtc cctggccact
      361 gcccctgccg cggaggcagc ggcggcagcg gctctccttt ccacagccgg cgctccgcga
      421 cccgcttggc tcctgagccc gtcgggtagg ctctcctcga gttcccgctc ttcacccctt
      481 ccctcaccct cttctttcgt cacccgtccc cgaccccacc cgagcccggc gcctcagctg
      541 cccccggcca tggcgtgcgg agccactctg aaaaggactc tggatttcga cccgctgttg
      601 agcccggcgt ccccgaagcg caggcgatgt gcgccattgt cggcgcccac ctcggccgct
      661 gcctccccgt tgtcggcggc cgcggccacc gccgcctcct tctccgctgc ggccgcctcg
      721 ccgcagaagt atctccgaat ggagccatcc cccttcggcg acgtctcctc ccgcctcacc
      781 acagaacaaa ttctgtacaa cataaaacaa gagtataaac gaatgcagaa gagaagacat
      841 ttagaaacga gtttccaaca gacagatccg tgttgtactt ctgatgcaca gccacatgca
      901 tttctcctca gtggaccagc ttcaccaggg acttcatctg cagcatcctc accattaaaa
      961 aaagaacagc ccttatttac tctacggcag gttgggatga tctgtgaacg tttgttgaaa
     1021 gaacgtgaag agaaagttcg agaagaatat gaagaaatat tgaacacaaa acttgcagaa
     1081 caatatgatg cgtttgtgaa gtttacgcat gatcaaataa tgcgacgata tggagaacag
     1141 cctgctagct atgtttcatg aatcacgtat cctgcatttg tgggctgcct tgttccttgt
     1201 tgagttgttg caagaggtcc caattatgac atgcagcaat gccaataccc cttctgtgaa
     1261 tacaggttat ttcaagcttt cgtcagtggc aaccactctt aggcagcagc aactggtttt
     1321 ggaaatttcc ctgatgtcag taccacctgg atgtggacct ttgctacctg tattaatacc
     1381 agtggcctca ttttgctgta tcattacaat ttggcttctt atattaatgt ttgaaaagga
     1441 ttaaagctgg tattctagaa catgcccttc actggttgtg taaataaaac tgtagaatga
     1501 cacttcagat gaagttagtg tgattttaat tgtgcactac aaccgagctg taaccagtta
     1561 ctaattttag aatgtaatcc caggacaata ttaagcaaat agcctgcagt gcttcctgtg
     1621 aaatagtgaa ggaggagggc atttctgtat tccaggactt cttggggttt cagaatgggt
     1681 ttgtatgatt tttttttttt ttgtagtttt atttattcta tcagtctttt taacaaatgt
     1741 ttattgctgc attttttttt ttccagtgta tcattgtttt actgcccttg tagtactgga
     1801 atttagttgg aagaataaaa catttacttc tattttgctt gtttcttaat gtacagatgg
     1861 ggttagtatt tgaataaagt tggtgtttta aaacgtaa
//
