LOCUS       NM_024595               2688 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens akirin 1 (AKIRIN1), transcript variant 1, mRNA.
ACCESSION   NM_024595 XM_941120
VERSION     NM_024595.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2688)
  AUTHORS   Coulibaly,A., Velasquez,S.Y., Sticht,C., Figueiredo,A.S.,
            Himmelhan,B.S., Schulte,J., Sturm,T., Centner,F.S., Schottler,J.J.,
            Thiel,M. and Lindner,H.A.
  TITLE     AKIRIN1: A Potential New Reference Gene in Human Natural Killer
            Cells and Granulocytes in Sepsis
  JOURNAL   Int J Mol Sci 20 (9), 2290 (2019)
   PUBMED   31075840
  REMARK    GeneRIF: Inspection of external neutrophil transcriptome datasets
            further support unchanged AKIRIN1 expression in human systemic
            inflammation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2688)
  AUTHORS   Macqueen,D.J. and Johnston,I.A.
  TITLE     Evolution of the multifaceted eukaryotic akirin gene family
  JOURNAL   BMC Evol Biol 9, 34 (2009)
   PUBMED   19200367
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2688)
  AUTHORS   Goto,A., Matsushita,K., Gesellchen,V., El Chamy,L.,
            Kuttenkeuler,D., Takeuchi,O., Hoffmann,J.A., Akira,S., Boutros,M.
            and Reichhart,J.M.
  TITLE     Akirins are highly conserved nuclear proteins required for
            NF-kappaB-dependent gene expression in drosophila and mice
  JOURNAL   Nat Immunol 9 (1), 97-104 (2008)
   PUBMED   18066067
  REMARK    Erratum:[Nat Immunol. 2008 Feb;9(2):216]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB727813.1, BC119745.1 and AL606465.21.
            
            On Nov 23, 2018 this sequence version replaced NM_024595.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK223276.1, BC001498.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000432648.8/ ENSP00000392678.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                DB727813.1         54-112
            60-730              BC119745.1         9-679
            731-2688            AL606465.21        48590-50547
FEATURES             Location/Qualifiers
     source          1..2688
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.3"
     gene            1..2688
                     /gene="AKIRIN1"
                     /gene_synonym="C1orf108; STRF2"
                     /note="akirin 1"
                     /db_xref="GeneID:79647"
                     /db_xref="HGNC:HGNC:25744"
                     /db_xref="MIM:615164"
     exon            1..325
                     /gene="AKIRIN1"
                     /gene_synonym="C1orf108; STRF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..684
                     /gene="AKIRIN1"
                     /gene_synonym="C1orf108; STRF2"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="akirin-1 isoform 1"
                     /protein_id="NP_078871.1"
                     /db_xref="CCDS:CCDS433.1"
                     /db_xref="GeneID:79647"
                     /db_xref="HGNC:HGNC:25744"
                     /db_xref="MIM:615164"
                     /translation="MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAE
                     PPPPFQTQTPPQSLQQPAPPGSERRLPTPEQIFQNIKQEYSRYQRWRHLEVVLNQSEA
                     CASESQPHSSALTAPSSPGSSWMKKDQPTFTLRQVGIICERLLKDYEDKIREEYEQIL
                     NTKLAEQYESFVKFTHDQIMRRYGTRPTSYVS"
     exon            326..466
                     /gene="AKIRIN1"
                     /gene_synonym="C1orf108; STRF2"
                     /inference="alignment:Splign:2.1.0"
     exon            467..601
                     /gene="AKIRIN1"
                     /gene_synonym="C1orf108; STRF2"
                     /inference="alignment:Splign:2.1.0"
     exon            602..673
                     /gene="AKIRIN1"
                     /gene_synonym="C1orf108; STRF2"
                     /inference="alignment:Splign:2.1.0"
     exon            674..2688
                     /gene="AKIRIN1"
                     /gene_synonym="C1orf108; STRF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2495..2500
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AKIRIN1"
                     /gene_synonym="C1orf108; STRF2"
                     /note="hexamer: AATAAA"
     polyA_site      2520
                     /gene="AKIRIN1"
                     /gene_synonym="C1orf108; STRF2"
                     /note="major polyA site"
     regulatory      2665..2670
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AKIRIN1"
                     /gene_synonym="C1orf108; STRF2"
                     /note="hexamer: ATTAAA"
     polyA_site      2688
                     /gene="AKIRIN1"
                     /gene_synonym="C1orf108; STRF2"
ORIGIN      
        1 gctggaggcg ccattggagc cggcttggct ggcgagcccg gctgaggagc ctcttgggcc
       61 gcacttaccg ccgcgtccgc tcccggtccc tggcccctca gcggcatggc gtgcggggcg
      121 acgctgaagc ggcccatgga gttcgaggcg gcgctgctga gccccggctc cccgaagcgg
      181 cggcgctgcg cccctctgcc cggccccact ccgggcctca ggcccccgga cgccgagccg
      241 ccgccgccgt ttcagacgca gaccccaccg cagagtctgc agcagcccgc cccgcccggc
      301 agcgagcggc gccttccaac tccggagcaa atttttcaga acataaaaca agaatatagt
      361 cgttatcaga ggtggagaca tttagaagtt gttcttaatc agagtgaagc ttgtgcttcg
      421 gaaagtcaac ctcactcctc agcactcaca gcacctagct ctccaggttc ctcatggatg
      481 aagaaggacc agcccacatt taccctccga caagttggca taatatgtga gcgcctctta
      541 aaagactatg aagataaaat tcgggaggag tatgagcaaa tcctcaatac caaactagca
      601 gaacaatatg aatcttttgt gaaattcaca catgatcaga ttatgcgacg gtatgggaca
      661 aggccaacaa gctatgtgtc atgaagcttt gtcacatatc tgggtaccag gtttgacctc
      721 aagagatggc tgctgtacac tttttgcaac tggtttgatg tcacatttca gctccaactt
      781 tgcatcctga gaacacttaa acgtttctgc aggtccattt tatacaactt gaaagaccgt
      841 aaaactttct ggttgccaca agcatatctt tcttttctgc tcatccaata aacagctgtg
      901 ccctactgtg atagattttc caaacaaaaa tacctggagc agcagtttag caaaatatgc
      961 cttcagtggc attcaacaaa tggagtttcc ccaagcacag ttctgtaaga agtgcgtgtg
     1021 agagtgtgtg tatatgtgtg tatgtgtatt ttaagttatt atttgtattg tgcaaaaatt
     1081 tttttttgat cttggggatt ctggctgtga atttggtgca cgacaattat ggtaaaaaaa
     1141 catttgcttg gtctaaagaa gatcattaat gttttgtgac catacaagtt gtaacagtgg
     1201 attgttttta tgtgtaggta ttgttaaata cagggactgt ttccaggcac agaatatgaa
     1261 tcgtaagtta ggatggacat tagatgtgat tatgatgata aagcgaaggt ctgcggtcct
     1321 atatctacag acacgtggtg agaaattaga acaaactgga gacgggccat tgacacatgg
     1381 actctgcctg ggcatgttag gttaattctt tgactccaag ccttaaaata ctcacatgga
     1441 gtcagcgctc acctcattca cacaattatc atagagctcc ctggacactg aacctctaaa
     1501 gggaaaaggt ctaccctgga gccaggagca tcagggttgg cttgggagca tgagaggtga
     1561 gcccagggct aggcctgggc caggccccgg cagcactgct acttgggagg agccacttca
     1621 cctttgtatt agttattaaa aaatataatt tgggctgggc gcagtggctc acgcctgtaa
     1681 tcccagcact ttgggagtcc gaggcatgcg gatcacttga ggtcaggagt tcgagaccac
     1741 cctggccaat atggtgaaac cccatctcta ctaaaaatac aacaaagtta gccgggcgtg
     1801 gtggcaggcg tctgtaatcc cagctgcttg ggaggctgag gcaggagaat cacttgaacc
     1861 ctggaggtgg cggttgcagt gagcacagat catgccactg cactccagcc tgggcaacaa
     1921 aacgagactt cgtctcaaaa aaaaaaaaaa aacatagaat ttggatcctt tggtcgggtt
     1981 ctcccaaatt cttttgaggt gtccatggtc aactgcttca gctttgtttt ggcaaccccc
     2041 tgcccgaagt cgcatatagg ctgttcttca ccttgtttcc aaggctgagg aacagaaagt
     2101 agcctctgtt ttgaggaggt ggaagttaag tatacattta ttttttactg tgacttgttc
     2161 aggaccacat tttacaaaat gccttgtttc cttcattgtt tctggaaagg aaagttctat
     2221 taatattgtt ttactttgaa tatagaatag tttttttaat tagggcttat tttgaaaaat
     2281 tctgagttta attcaaatgt atgccaatac cttccaaagt aaggtaatat tcagagacag
     2341 ttgttgtgat cagatggctt agagaaattt ctggaatatt cacattcgaa gattccttat
     2401 taatgaatgt ctttgactta aatctaacca aaaactgcaa cattattctt tgtacatttt
     2461 cattatatag tgttaacaag cttagttgca aacaaataaa atacttaagc tatttgttta
     2521 ccttgccttc ttaatactgt gataatgttt attaattcaa ataacttatg tgagagctgc
     2581 tataaccatt tccccagttc aacattgcat tgaaaattta tggaccttta aaaaaaaaag
     2641 cccaacagtg attttttttt aataattaaa gaatgatttt actttgta
//
