LOCUS       NM_001136275            2553 bp    mRNA    linear   PRI 02-JUN-2024
DEFINITION  Homo sapiens akirin 1 (AKIRIN1), transcript variant 2, mRNA.
ACCESSION   NM_001136275
VERSION     NM_001136275.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2553)
  AUTHORS   Coulibaly,A., Velasquez,S.Y., Sticht,C., Figueiredo,A.S.,
            Himmelhan,B.S., Schulte,J., Sturm,T., Centner,F.S., Schottler,J.J.,
            Thiel,M. and Lindner,H.A.
  TITLE     AKIRIN1: A Potential New Reference Gene in Human Natural Killer
            Cells and Granulocytes in Sepsis
  JOURNAL   Int J Mol Sci 20 (9), 2290 (2019)
   PUBMED   31075840
  REMARK    GeneRIF: Inspection of external neutrophil transcriptome datasets
            further support unchanged AKIRIN1 expression in human systemic
            inflammation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2553)
  AUTHORS   Macqueen,D.J. and Johnston,I.A.
  TITLE     Evolution of the multifaceted eukaryotic akirin gene family
  JOURNAL   BMC Evol Biol 9, 34 (2009)
   PUBMED   19200367
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2553)
  AUTHORS   Goto,A., Matsushita,K., Gesellchen,V., El Chamy,L.,
            Kuttenkeuler,D., Takeuchi,O., Hoffmann,J.A., Akira,S., Boutros,M.
            and Reichhart,J.M.
  TITLE     Akirins are highly conserved nuclear proteins required for
            NF-kappaB-dependent gene expression in drosophila and mice
  JOURNAL   Nat Immunol 9 (1), 97-104 (2008)
   PUBMED   18066067
  REMARK    Erratum:[Nat Immunol. 2008 Feb;9(2):216]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB727813.1, AK303098.1 and AL606465.21.
            
            On Aug 13, 2020 this sequence version replaced NM_001136275.1.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon compared to variant 1. The resulting isoform (2) has the same
            N- and C-termini but is shorter compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853560.873.1,
                                           SRR14038191.581788.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                DB727813.1         54-112
            60-1185             AK303098.1         48-1173
            1186-2553           AL606465.21        49180-50547
FEATURES             Location/Qualifiers
     source          1..2553
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.3"
     gene            1..2553
                     /gene="AKIRIN1"
                     /gene_synonym="C1orf108; STRF2"
                     /note="akirin 1"
                     /db_xref="GeneID:79647"
                     /db_xref="HGNC:HGNC:25744"
                     /db_xref="MIM:615164"
     exon            1..325
                     /gene="AKIRIN1"
                     /gene_synonym="C1orf108; STRF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..549
                     /gene="AKIRIN1"
                     /gene_synonym="C1orf108; STRF2"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="akirin-1 isoform 2"
                     /protein_id="NP_001129747.1"
                     /db_xref="CCDS:CCDS44113.1"
                     /db_xref="GeneID:79647"
                     /db_xref="HGNC:HGNC:25744"
                     /db_xref="MIM:615164"
                     /translation="MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAE
                     PPPPFQTQTPPQSLQQPAPPGSERRLPTPEQIFQNIKQEYSRYQRWRHLEVVLNQSEA
                     CASESQPHSSALTAPSSPEQYESFVKFTHDQIMRRYGTRPTSYVS"
     exon            326..466
                     /gene="AKIRIN1"
                     /gene_synonym="C1orf108; STRF2"
                     /inference="alignment:Splign:2.1.0"
     exon            467..538
                     /gene="AKIRIN1"
                     /gene_synonym="C1orf108; STRF2"
                     /inference="alignment:Splign:2.1.0"
     exon            539..2553
                     /gene="AKIRIN1"
                     /gene_synonym="C1orf108; STRF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2360..2365
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AKIRIN1"
                     /gene_synonym="C1orf108; STRF2"
                     /note="hexamer: AATAAA"
     polyA_site      2385
                     /gene="AKIRIN1"
                     /gene_synonym="C1orf108; STRF2"
                     /note="major polyA site"
     regulatory      2530..2535
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AKIRIN1"
                     /gene_synonym="C1orf108; STRF2"
                     /note="hexamer: ATTAAA"
     polyA_site      2553
                     /gene="AKIRIN1"
                     /gene_synonym="C1orf108; STRF2"
ORIGIN      
        1 gctggaggcg ccattggagc cggcttggct ggcgagcccg gctgaggagc ctcttgggcc
       61 gcacttaccg ccgcgtccgc tcccggtccc tggcccctca gcggcatggc gtgcggggcg
      121 acgctgaagc ggcccatgga gttcgaggcg gcgctgctga gccccggctc cccgaagcgg
      181 cggcgctgcg cccctctgcc cggccccact ccgggcctca ggcccccgga cgccgagccg
      241 ccgccgccgt ttcagacgca gaccccaccg cagagtctgc agcagcccgc cccgcccggc
      301 agcgagcggc gccttccaac tccggagcaa atttttcaga acataaaaca agaatatagt
      361 cgttatcaga ggtggagaca tttagaagtt gttcttaatc agagtgaagc ttgtgcttcg
      421 gaaagtcaac ctcactcctc agcactcaca gcacctagct ctccagaaca atatgaatct
      481 tttgtgaaat tcacacatga tcagattatg cgacggtatg ggacaaggcc aacaagctat
      541 gtgtcatgaa gctttgtcac atatctgggt accaggtttg acctcaagag atggctgctg
      601 tacacttttt gcaactggtt tgatgtcaca tttcagctcc aactttgcat cctgagaaca
      661 cttaaacgtt tctgcaggtc cattttatac aacttgaaag accgtaaaac tttctggttg
      721 ccacaagcat atctttcttt tctgctcatc caataaacag ctgtgcccta ctgtgataga
      781 ttttccaaac aaaaatacct ggagcagcag tttagcaaaa tatgccttca gtggcattca
      841 acaaatggag tttccccaag cacagttctg taagaagtgc gtgtgagagt gtgtgtatat
      901 gtgtgtatgt gtattttaag ttattatttg tattgtgcaa aaattttttt ttgatcttgg
      961 ggattctggc tgtgaatttg gtgcacgaca attatggtaa aaaaacattt gcttggtcta
     1021 aagaagatca ttaatgtttt gtgaccatac aagttgtaac agtggattgt ttttatgtgt
     1081 aggtattgtt aaatacaggg actgtttcca ggcacagaat atgaatcgta agttaggatg
     1141 gacattagat gtgattatga tgataaagcg aaggtctgcg gtcctatatc tacagacacg
     1201 tggtgagaaa ttagaacaaa ctggagacgg gccattgaca catggactct gcctgggcat
     1261 gttaggttaa ttctttgact ccaagcctta aaatactcac atggagtcag cgctcacctc
     1321 attcacacaa ttatcataga gctccctgga cactgaacct ctaaagggaa aaggtctacc
     1381 ctggagccag gagcatcagg gttggcttgg gagcatgaga ggtgagccca gggctaggcc
     1441 tgggccaggc cccggcagca ctgctacttg ggaggagcca cttcaccttt gtattagtta
     1501 ttaaaaaata taatttgggc tgggcgcagt ggctcacgcc tgtaatccca gcactttggg
     1561 agtccgaggc atgcggatca cttgaggtca ggagttcgag accaccctgg ccaatatggt
     1621 gaaaccccat ctctactaaa aatacaacaa agttagccgg gcgtggtggc aggcgtctgt
     1681 aatcccagct gcttgggagg ctgaggcagg agaatcactt gaaccctgga ggtggcggtt
     1741 gcagtgagca cagatcatgc cactgcactc cagcctgggc aacaaaacga gacttcgtct
     1801 caaaaaaaaa aaaaaaacat agaatttgga tcctttggtc gggttctccc aaattctttt
     1861 gaggtgtcca tggtcaactg cttcagcttt gttttggcaa ccccctgccc gaagtcgcat
     1921 ataggctgtt cttcaccttg tttccaaggc tgaggaacag aaagtagcct ctgttttgag
     1981 gaggtggaag ttaagtatac atttattttt tactgtgact tgttcaggac cacattttac
     2041 aaaatgcctt gtttccttca ttgtttctgg aaaggaaagt tctattaata ttgttttact
     2101 ttgaatatag aatagttttt ttaattaggg cttattttga aaaattctga gtttaattca
     2161 aatgtatgcc aataccttcc aaagtaaggt aatattcaga gacagttgtt gtgatcagat
     2221 ggcttagaga aatttctgga atattcacat tcgaagattc cttattaatg aatgtctttg
     2281 acttaaatct aaccaaaaac tgcaacatta ttctttgtac attttcatta tatagtgtta
     2341 acaagcttag ttgcaaacaa ataaaatact taagctattt gtttaccttg ccttcttaat
     2401 actgtgataa tgtttattaa ttcaaataac ttatgtgaga gctgctataa ccatttcccc
     2461 agttcaacat tgcattgaaa atttatggac ctttaaaaaa aaaagcccaa cagtgatttt
     2521 tttttaataa ttaaagaatg attttacttt gta
//
