LOCUS       NM_020642               1273 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens A-kinase interacting protein 1 (AKIP1), transcript
            variant 1, mRNA.
ACCESSION   NM_020642
VERSION     NM_020642.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1273)
  AUTHORS   Zhu,L., Gao,T., Huang,Y., Jin,J., Wang,D., Zhang,L., Jin,Y., Li,P.,
            Hu,Y., Wu,Y., Liu,H., Dong,Q., Wang,G., Zheng,T., Song,C., Bai,Y.,
            Zhang,X., Liu,Y., Yang,W., Xu,K., Zou,G., Zhao,L., Cao,R.,
            Zhong,W., Xia,X., Xiao,G., Liu,X. and Cao,C.
  TITLE     Ebola virus VP35 hijacks the PKA-CREB1 pathway for replication and
            pathogenesis by AKIP1 association
  JOURNAL   Nat Commun 13 (1), 2256 (2022)
   PUBMED   35474062
  REMARK    GeneRIF: Ebola virus VP35 hijacks the PKA-CREB1 pathway for
            replication and pathogenesis by AKIP1 association.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1273)
  AUTHORS   Chen,Z., Wen,H., Zhang,J., Zou,X. and Wu,S.
  TITLE     Silencing of AKIP1 Suppresses the Proliferation, Migration, and
            Epithelial-Mesenchymal Transition Process of Glioma Cells by
            Upregulating DLG2
  JOURNAL   Biomed Res Int 2022, 5648011 (2022)
   PUBMED   35111846
  REMARK    GeneRIF: Silencing of AKIP1 Suppresses the Proliferation,
            Migration, and Epithelial-Mesenchymal Transition Process of Glioma
            Cells by Upregulating DLG2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1273)
  AUTHORS   Yulia,A., Singh,N., Varley,A.J., Lei,K., Markovic,D., Sooranna,S.R.
            and Johnson,M.R.
  TITLE     PKA and AKIP1 interact to mediate cAMP-driven COX-2 expression: A
            potentially pivotal interaction in preterm and term labour
  JOURNAL   PLoS One 16 (6), e0252720 (2021)
   PUBMED   34166397
  REMARK    GeneRIF: PKA and AKIP1 interact to mediate cAMP-driven COX-2
            expression: A potentially pivotal interaction in preterm and term
            labour.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1273)
  AUTHORS   Sun,Y., Shi,G., Ma,C., Jiao,J., Liu,Y., Gao,Q., Zhang,X. and
            Feng,Q.
  TITLE     Upregulation of a kinase interacting protein 1 in tongue squamous
            cell carcinoma correlates with lymph node metastasis and poor
            overall survival
  JOURNAL   Medicine (Baltimore) 100 (14), e25278 (2021)
   PUBMED   33832094
  REMARK    GeneRIF: Upregulation of a kinase interacting protein 1 in tongue
            squamous cell carcinoma correlates with lymph node metastasis and
            poor overall survival.
REFERENCE   5  (bases 1 to 1273)
  AUTHORS   Shen,S. and Yao,Y.
  TITLE     A-kinase interacting protein 1 is sufficiently expressed and
            positively associates with WHO grade, meanwhile predicts
            unfavorable overall survival independently in glioma patients
  JOURNAL   Medicine (Baltimore) 100 (4), e20426 (2021)
   PUBMED   33530151
  REMARK    GeneRIF: A-kinase interacting protein 1 is sufficiently expressed
            and positively associates with WHO grade, meanwhile predicts
            unfavorable overall survival independently in glioma patients.
REFERENCE   6  (bases 1 to 1273)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 1273)
  AUTHORS   Gao,N., Asamitsu,K., Hibi,Y., Ueno,T. and Okamoto,T.
  TITLE     AKIP1 enhances NF-kappaB-dependent gene expression by promoting the
            nuclear retention and phosphorylation of p65
  JOURNAL   J Biol Chem 283 (12), 7834-7843 (2008)
   PUBMED   18178962
  REMARK    GeneRIF: AKIP1 colocalized with p65 within the cells and appeared
            to retain p65 in nucleus.
REFERENCE   8  (bases 1 to 1273)
  AUTHORS   Sastri,M., Barraclough,D.M., Carmichael,P.T. and Taylor,S.S.
  TITLE     A-kinase-interacting protein localizes protein kinase A in the
            nucleus
  JOURNAL   Proc Natl Acad Sci U S A 102 (2), 349-354 (2005)
   PUBMED   15630084
  REMARK    GeneRIF: AKIP1 describes a PKA-interacting protein that can
            contribute to localization by a mechanism that is distinct from
            A-kinase anchoring proteins that interact with the regulatory
            subunits.
REFERENCE   9  (bases 1 to 1273)
  AUTHORS   Kitching,R., Li,H., Wong,M.J., Kanaganayakam,S., Kahn,H. and
            Seth,A.
  TITLE     Characterization of a novel human breast cancer associated gene
            (BCA3) encoding an alternatively spliced proline-rich protein
  JOURNAL   Biochim Biophys Acta 1625 (1), 116-121 (2003)
   PUBMED   12527432
  REMARK    GeneRIF: characterization of the BCA3 gene; BCA3 is expressed in
            breast tumor cells in vivo, and not in surrounding stromal tissue
REFERENCE   10 (bases 1 to 1273)
  AUTHORS   Amid,C., Bahr,A., Mujica,A., Sampson,N., Bikar,S.E.,
            Winterpacht,A., Zabel,B., Hankeln,T. and Schmidt,E.R.
  TITLE     Comparative genomic sequencing reveals a strikingly similar
            architecture of a conserved syntenic region on human chromosome
            11p15.3 (including gene ST5) and mouse chromosome 7
  JOURNAL   Cytogenet Cell Genet 93 (3-4), 284-290 (2001)
   PUBMED   11528127
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF493783.1 and AC026894.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_020642.3.
            
            Summary: This gene encodes a nuclear protein that interacts with
            protein kinase A catalytic subunit, and regulates the effect of the
            cAMP-dependent protein kinase signaling pathway on the NF-kappa-B
            activation cascade. Alternatively spliced transcript variants have
            been described for this gene. [provided by RefSeq, Oct 2011].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF493783.1, SRR7346977.237944.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000309377.9/ ENSP00000310459.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1028              AF493783.1         36-1063
            1029-1273           AC026894.7         67948-68192         c
FEATURES             Location/Qualifiers
     source          1..1273
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..1273
                     /gene="AKIP1"
                     /gene_synonym="BCA3; C11orf17"
                     /note="A-kinase interacting protein 1"
                     /db_xref="GeneID:56672"
                     /db_xref="HGNC:HGNC:1170"
                     /db_xref="MIM:609191"
     exon            1..35
                     /gene="AKIP1"
                     /gene_synonym="BCA3; C11orf17"
                     /inference="alignment:Splign:2.1.0"
     exon            36..263
                     /gene="AKIP1"
                     /gene_synonym="BCA3; C11orf17"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..674
                     /gene="AKIP1"
                     /gene_synonym="BCA3; C11orf17"
                     /note="isoform a is encoded by transcript variant 1;
                     breast cancer associated gene 3; proline-rich protein
                     BCA3; koyt binding protein 1; koyt binding protein 2; koyt
                     binding protein 3; A kinase (PRKA) interacting protein 1"
                     /codon_start=1
                     /product="A-kinase-interacting protein 1 isoform a"
                     /protein_id="NP_065693.2"
                     /db_xref="CCDS:CCDS7793.1"
                     /db_xref="GeneID:56672"
                     /db_xref="HGNC:HGNC:1170"
                     /db_xref="MIM:609191"
                     /translation="MDNCLAAAALNGVDRRSLQRSARLALEVLERAKRRAVDWHALER
                     PKGCMGVLAREAPHLEKQPAAGPQRVLPGEREERPPTLSASFRTMAEFMDYTSSQCGK
                     YYSSVPEEGGATHVYRYHRGESKLHMCLDIGNGQRKDRKKTSLGPGGSYQISEHAPEA
                     SQPAENISKDLYIEVYPGTYSVTVGSNDLTKKTHVVAVDSGQSVDLVFPV"
     exon            264..344
                     /gene="AKIP1"
                     /gene_synonym="BCA3; C11orf17"
                     /inference="alignment:Splign:2.1.0"
     exon            345..449
                     /gene="AKIP1"
                     /gene_synonym="BCA3; C11orf17"
                     /inference="alignment:Splign:2.1.0"
     exon            450..530
                     /gene="AKIP1"
                     /gene_synonym="BCA3; C11orf17"
                     /inference="alignment:Splign:2.1.0"
     exon            531..1273
                     /gene="AKIP1"
                     /gene_synonym="BCA3; C11orf17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      720..725
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AKIP1"
                     /gene_synonym="BCA3; C11orf17"
                     /note="hexamer: AATAAA"
     polyA_site      746
                     /gene="AKIP1"
                     /gene_synonym="BCA3; C11orf17"
                     /note="major polyA site"
     regulatory      1252..1257
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AKIP1"
                     /gene_synonym="BCA3; C11orf17"
                     /note="hexamer: AATAAA"
     polyA_site      1273
                     /gene="AKIP1"
                     /gene_synonym="BCA3; C11orf17"
                     /note="major polyA site"
ORIGIN      
        1 agcgttgcgc gcatgcgcct tgacgagtga gccggggagc catggacaac tgtttggcgg
       61 ccgcagcgct gaatggggtg gaccgacgtt ccctgcagcg ttcagcaagg ctggctctag
      121 aagtgctgga gagggccaag aggagggcgg tggactggca tgccctggag cgtcccaaag
      181 gctgcatggg ggtccttgcc cgggaggcgc cccacctaga gaaacagccg gcagccggcc
      241 cgcagcgcgt tctcccggga gagagagaag agagaccccc aacccttagt gcttccttca
      301 gaacaatggc tgaattcatg gactatactt caagtcagtg tgggaaatat tattcatctg
      361 tgccagagga aggaggggca acccatgtct atcgttatca cagaggcgag tcgaagctgc
      421 acatgtgctt ggacataggg aatggtcaga gaaaagacag aaaaaagaca tcccttggtc
      481 ctggaggcag ctatcaaata tcagagcatg ctccagaggc atcccagcct gctgagaaca
      541 tctctaagga cctctacata gaagtatatc cagggaccta ttctgtcact gtgggctcaa
      601 atgacttaac caagaagact catgtggtag cagttgattc tggacaaagc gtggacctgg
      661 tcttccctgt gtgatgttga ccatcactgc catcacatca ccttttttta agtagtaaga
      721 ataaagccac tgtatgattc tcttaatagc tatacattaa tcctgttttt agtgctgact
      781 gggtcagcct tccgggaact ggagtctgtc tctttcagtg cttttttgtt tgtttggttg
      841 gttttttttt gagacagtct cactctgttg cccaggctgg agtgcagtgg cgtgatctcg
      901 gctcactgca agttccgcct cccgggttca caccattctc ctgcctcagc ctcccgagta
      961 gctggcacta caggcacccg ccaccatgcc cggctatttt ttttgtattt ttagtagaga
     1021 cggggtttca ccatgttggc caggatggtc tcgatctctt gacctcgtga tccacccacc
     1081 ttggcctccc aaagtgttgg gattacaggc gtgagccacc gcgcccggcc tcagtgcctt
     1141 ttttaacttg agggtgtaga ggtcctccac gcttgtttgc ctgaaagtaa tataatgatg
     1201 ctgtctgaac aggttttact gcttgctttc caagtaaagg ttaattatga taataaagag
     1261 atttggaaat gaa
//
