LOCUS       NM_005751              12476 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens A-kinase anchoring protein 9 (AKAP9), transcript
            variant 2, mRNA.
ACCESSION   NM_005751
VERSION     NM_005751.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12476)
  AUTHORS   Li,B., Karlova,M., Zhang,H., Pustovit,O.B., Mai,L.,
            Novoseletsky,V., Podolyak,D., Zaklyazminskaya,E.V.,
            Abramochkin,D.V. and Sokolova,O.S.
  TITLE     A mutation in the cardiac KV7.1 channel possibly disrupts
            interaction with Yotiao protein
  JOURNAL   Biochem Biophys Res Commun 714, 149947 (2024)
   PUBMED   38657442
  REMARK    GeneRIF: A mutation in the cardiac KV7.1 channel possibly disrupts
            interaction with Yotiao protein.
REFERENCE   2  (bases 1 to 12476)
  AUTHORS   Soboska,K., Kusinski,M., Pawelczyk,K., Migdalska-Sek,M.,
            Brzezianska-Lasota,E. and Czarnecka-Chrebelska,K.H.
  TITLE     Expression of RASSF1A, DIRAS3, and AKAP9 Genes in Thyroid Lesions:
            Implications for Differential Diagnosis and Prognosis of Thyroid
            Carcinomas
  JOURNAL   Int J Mol Sci 25 (1), 562 (2024)
   PUBMED   38203733
  REMARK    GeneRIF: Expression of RASSF1A, DIRAS3, and AKAP9 Genes in Thyroid
            Lesions: Implications for Differential Diagnosis and Prognosis of
            Thyroid Carcinomas.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 12476)
  AUTHORS   Zhou,Y., Liu,Y., Gupta,S., Paramo,M.I., Hou,Y., Mao,C., Luo,Y.,
            Judd,J., Wierbowski,S., Bertolotti,M., Nerkar,M., Jehi,L.,
            Drayman,N., Nicolaescu,V., Gula,H., Tay,S., Randall,G., Wang,P.,
            Lis,J.T., Feschotte,C., Erzurum,S.C., Cheng,F. and Yu,H.
  TITLE     A comprehensive SARS-CoV-2-human protein-protein interactome
            reveals COVID-19 pathobiology and potential host therapeutic
            targets
  JOURNAL   Nat Biotechnol 41 (1), 128-139 (2023)
   PUBMED   36217030
REFERENCE   4  (bases 1 to 12476)
  AUTHORS   You,Y., Hersh,S.W., Aslebagh,R., Shaffer,S.A., Ikezu,S., Mez,J.,
            Lunetta,K.L., Logue,M.W., Farrer,L.A. and Ikezu,T.
  TITLE     Alzheimer's disease associated AKAP9 I2558M mutation alters
            posttranslational modification and interactome of tau and cellular
            functions in CRISPR-edited human neuronal cells
  JOURNAL   Aging Cell 21 (6), e13617 (2022)
   PUBMED   35567427
  REMARK    GeneRIF: Alzheimer's disease associated AKAP9 I2558M mutation
            alters posttranslational modification and interactome of tau and
            cellular functions in CRISPR-edited human neuronal cells.
REFERENCE   5  (bases 1 to 12476)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 12476)
  AUTHORS   Witczak,O., Skalhegg,B.S., Keryer,G., Bornens,M., Tasken,K.,
            Jahnsen,T. and Orstavik,S.
  TITLE     Cloning and characterization of a cDNA encoding an A-kinase
            anchoring protein located in the centrosome, AKAP450
  JOURNAL   EMBO J 18 (7), 1858-1868 (1999)
   PUBMED   10202149
REFERENCE   7  (bases 1 to 12476)
  AUTHORS   Schmidt,P.H., Dransfield,D.T., Claudio,J.O., Hawley,R.G.,
            Trotter,K.W., Milgram,S.L. and Goldenring,J.R.
  TITLE     AKAP350, a multiply spliced protein kinase A-anchoring protein
            associated with centrosomes
  JOURNAL   J Biol Chem 274 (5), 3055-3066 (1999)
   PUBMED   9915845
REFERENCE   8  (bases 1 to 12476)
  AUTHORS   Lin,J.W., Wyszynski,M., Madhavan,R., Sealock,R., Kim,J.U. and
            Sheng,M.
  TITLE     Yotiao, a novel protein of neuromuscular junction and brain that
            interacts with specific splice variants of NMDA receptor subunit
            NR1
  JOURNAL   J Neurosci 18 (6), 2017-2027 (1998)
   PUBMED   9482789
  REMARK    Review article
REFERENCE   9  (bases 1 to 12476)
  AUTHORS   Golsteyn,R.M., Mundt,K.E., Fry,A.M. and Nigg,E.A.
  TITLE     Cell cycle regulation of the activity and subcellular localization
            of Plk1, a human protein kinase implicated in mitotic spindle
            function
  JOURNAL   J Cell Biol 129 (6), 1617-1628 (1995)
   PUBMED   7790358
REFERENCE   10 (bases 1 to 12476)
  AUTHORS   Groffen,A.J., Bikker,H. and Christiaans,I.
  TITLE     Long QT Syndrome Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301308
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC003086.1, AC000066.1,
            AC004013.1 and AC000120.1.
            
            On Mar 27, 2020 this sequence version replaced NM_005751.4.
            
            Summary: The A-kinase anchor proteins (AKAPs) are a group of
            structurally diverse proteins which have the common function of
            binding to the regulatory subunit of protein kinase A (PKA) and
            confining the holoenzyme to discrete locations within the cell.
            This gene encodes a member of the AKAP family. Alternate splicing
            of this gene results in at least two isoforms that localize to the
            centrosome and the Golgi apparatus, and interact with numerous
            signaling proteins from multiple signal transduction pathways.
            These signaling proteins include type II protein kinase A,
            serine/threonine kinase protein kinase N, protein phosphatase 1,
            protein phosphatase 2a, protein kinase C-epsilon and
            phosphodiesterase 4D3. [provided by RefSeq, Aug 2008].
            
            Transcript Variant: This variant (2) represents the longer
            transcript and encodes the longer isoform (2).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ131693.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356239.8/ ENSP00000348573.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-286               AC003086.1         96358-96643
            287-544             AC000066.1         19013-19270
            545-589             AC000066.1         25591-25635
            590-643             AC000066.1         37460-37513
            644-814             AC000066.1         38187-38357
            815-970             AC000066.1         39923-40078
            971-1168            AC000066.1         40905-41102
            1169-3556           AC000066.1         46150-48537
            3557-3770           AC000066.1         57731-57944
            3771-3850           AC000066.1         59551-59630
            3851-3989           AC000066.1         61431-61569
            3990-4075           AC000066.1         62319-62404
            4076-4190           AC000066.1         67540-67654
            4191-4386           AC000066.1         68116-68311
            4387-4483           AC000066.1         75197-75293
            4484-4576           AC000066.1         76814-76906
            4577-4930           AC000066.1         83721-84074
            4931-5155           AC000066.1         85976-86200
            5156-5296           AC000066.1         87348-87488
            5297-5400           AC000066.1         87970-88073
            5401-5606           AC000066.1         90310-90515
            5607-5839           AC004013.1         3268-3500
            5840-6002           AC004013.1         11802-11964
            6003-6215           AC004013.1         12816-13028
            6216-6448           AC004013.1         15773-16005
            6449-6568           AC004013.1         16969-17088
            6569-6745           AC004013.1         20572-20748
            6746-6850           AC004013.1         21447-21551
            6851-7003           AC004013.1         27397-27549
            7004-7183           AC004013.1         28238-28417
            7184-8257           AC004013.1         29621-30694
            8258-8398           AC004013.1         33064-33204
            8399-8884           AC004013.1         33712-34197
            8885-8948           AC004013.1         35182-35245
            8949-9070           AC004013.1         35361-35482
            9071-9262           AC004013.1         36037-36228
            9263-9451           AC004013.1         36770-36958
            9452-9596           AC004013.1         39927-40071
            9597-9816           AC004013.1         43639-43858
            9817-9967           AC004013.1         45565-45715
            9968-10636          AC004013.1         47231-47899
            10637-10845         AC004013.1         48128-48336
            10846-10951         AC004013.1         48651-48756
            10952-11134         AC004013.1         50229-50411
            11135-11335         AC004013.1         51398-51598
            11336-11568         AC004013.1         53136-53368
            11569-11654         AC004013.1         56220-56305
            11655-11784         AC004013.1         57835-57964
            11785-11924         AC000120.1         131-270
            11925-12476         AC000120.1         1759-2310
FEATURES             Location/Qualifiers
     source          1..12476
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.2"
     gene            1..12476
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /note="A-kinase anchoring protein 9"
                     /db_xref="GeneID:10142"
                     /db_xref="HGNC:HGNC:379"
                     /db_xref="MIM:604001"
     exon            1..286
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     CDS             239..11962
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /note="isoform 2 is encoded by transcript variant 2;
                     kinase N-associated protein; protein kinase A anchoring
                     protein 9; A kinase (PRKA) anchor protein 9; AKAP9-BRAF
                     fusion protein; protein yotiao; protein hyperion; AKAP
                     120-like protein; A-kinase anchor protein 350 kDa; A
                     kinase (PRKA) anchor protein (yotiao) 9; centrosome- and
                     golgi-localized protein kinase N-associated protein;
                     A-kinase anchor protein 450 kDa; centrosome- and
                     Golgi-localized PKN-associated protein; protein
                     phosphatase 1, regulatory subunit 45"
                     /codon_start=1
                     /product="A-kinase anchor protein 9 isoform 2"
                     /protein_id="NP_005742.4"
                     /db_xref="CCDS:CCDS5622.1"
                     /db_xref="GeneID:10142"
                     /db_xref="HGNC:HGNC:379"
                     /db_xref="MIM:604001"
                     /translation="MEDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSS
                     SKHDVSAHHDLNIDQSQCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVE
                     LESEISTTADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMM
                     ESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQAR
                     REKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQ
                     LEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEEL
                     NTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSE
                     EIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQ
                     ELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQ
                     KEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLS
                     TVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELER
                     LRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQ
                     FEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGT
                     LEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVS
                     QEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKN
                     FEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKS
                     SVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGE
                     ISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRG
                     AEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQ
                     PSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSL
                     KEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQ
                     TLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNK
                     VTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVN
                     HKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSES
                     TVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQY
                     QEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLS
                     QDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEM
                     FSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQ
                     AHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSL
                     AGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQK
                     ANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVH
                     EEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEEL
                     MLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELR
                     ERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNR
                     LQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVR
                     DDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAI
                     DREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSK
                     EQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQ
                     LQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELE
                     QENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQ
                     QLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELA
                     NIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFK
                     MNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQ
                     TYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQK
                     KIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDE
                     LGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNE
                     KKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKA
                     EKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPL
                     PIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKI
                     EKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSI
                     PELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIK
                     GLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQ
                     LQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGL
                     LNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPS
                     QELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELE
                     TTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRS
                     EERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQ
                     GRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQK
                     QLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHEL
                     QSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNE
                     PTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVAS
                     KLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCG
                     SLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNG
                     GANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSPDSEHVTL
                     KRIYGKYLRAESFRKALIYQKKYLLLLLGGFQECEDATLALLARMGGQPAFTDLEVIT
                     NRPKGFTRFRSAVRVSIAISRMKFLVRRWHRVTGSVSININRDGFGLNQGAEKTDSFY
                     HSSGGLELYGEPRHTTYRSRSDLDYIRSPLPFQNRYPGTPADFNPGSLACSQLQNYDP
                     DRALTDYITRLEALQRRLGTIQSGSTTQFHAGMRR"
     exon            287..544
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            545..589
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            590..643
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            644..814
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            815..970
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1168
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..3556
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            3557..3770
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            3771..3850
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            3851..3989
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            3990..4075
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            4076..4190
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            4191..4386
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            4387..4483
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            4484..4576
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            4577..4930
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            4931..5155
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            5156..5296
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            5297..5400
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            5401..5606
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            5607..5839
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            5840..6002
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            6003..6215
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            6216..6448
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            6449..6568
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            6569..6745
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            6746..6850
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            6851..7003
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            7004..7183
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            7184..8257
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            8258..8398
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            8399..8884
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            8885..8948
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            8949..9070
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            9071..9262
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            9263..9451
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            9452..9596
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            9597..9816
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            9817..9967
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            9968..10636
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            10637..10845
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            10846..10951
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            10952..11134
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            11135..11335
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            11336..11568
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            11569..11654
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            11655..11784
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            11785..11924
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            11925..12476
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     regulatory      12447..12452
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /note="hexamer: AATAAA"
     polyA_site      12476
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /note="major polyA site"
ORIGIN      
        1 gtgtttacgt ggagacgaag atggcggcgg cggcggcggt gacggcgctt cccgtgcggc
       61 tgaggacgat ccgccagtga gcgcggagac tgcttccact tcgggcgggg gagcgccgga
      121 ccgaatcggc tctctaggcc gtggagcttg ccgtcccacc tccgtccaaa tcgacctttc
      181 ctttctatcc ccaaccaccc ctcaacccct gttttcccct gccttccttg cagaggccat
      241 ggaggacgag gagagacaga agaagctgga ggccggcaaa gccaagcttg cccagtttcg
      301 acaaagaaaa gctcagtcgg atgggcagag tccttccaag aagcagaaaa aaaagagaaa
      361 aacgtcaagc agtaaacatg atgtgtcagc acaccatgat ttgaatattg atcaatcaca
      421 gtgtaatgaa atgtacataa atagttctca gagagtagaa tcaactgtga ttcctgaatc
      481 tacaataatg agaactctac atagtggaga aataaccagt catgagcagg gcttctctgt
      541 ggaactggaa agtgaaattt caaccacagc agatgactgc agttcagagg taaatggttg
      601 cagttttgtg atgagaacag gaaagcctac aaatttatta agggaagaag aatttggtgt
      661 tgatgattct tattctgaac aaggagcaca agacagtccg actcatctag agatgatgga
      721 aagtgagttg gctgggaagc agcatgagat tgaagagcta aacagagagc tggaagaaat
      781 gagggttacc tatgggactg aaggactgca gcagttacaa gaatttgaag ctgccattaa
      841 acaaagagat ggcattataa cccagctcac tgctaattta caacaagcaa gaagagaaaa
      901 ggatgagaca atgagagaat ttttagagtt gacagaacag agtcaaaaat tacagattca
      961 atttcagcaa ttacaggcta gtgaaactct gagaaacagc actcatagta gcacagctgc
     1021 agacttacta caagccaaac aacagatcct cactcatcaa cagcagcttg aagaacaaga
     1081 ccacttatta gaagattatc agaaaaagaa agaagacttc acaatgcaaa ttagtttctt
     1141 gcaagagaaa attaaagtat atgaaatgga acaagataaa aaagtagaaa actcaaataa
     1201 agaagaaata caggaaaagg agacaatcat tgaagaatta aacacaaaaa taatagaaga
     1261 agaaaagaaa actcttgagc taaaggataa attaacaact gctgataaat tactaggaga
     1321 attacaagaa cagattgtgc aaaagaacca agaaataaaa aacatgaaat tagagctgac
     1381 taattctaag caaaaagaaa gacagtcttc tgaagaaata aaacagttaa tggggacagt
     1441 cgaagaactt cagaagagaa atcataaaga cagccagttc gaaactgata tagtacaacg
     1501 aatggaacaa gaaacacaaa gaaagttaga acaactccgg gcagagctgg atgagatgta
     1561 tgggcagcag atagtgcaaa tgaaacaaga attaataaga caacacatgg cacagatgga
     1621 ggaaatgaaa acacggcata agggagaaat ggagaatgct ttaaggtcat attcaaatat
     1681 tacagttaat gaagatcaga taaagttaat gaatgtggca ataaatgaac tgaatataaa
     1741 attgcaagat actaactctc aaaaggaaaa actcaaggaa gaactaggac taattttaga
     1801 agaaaagtgt gctctacaga gacagcttga agaccttgtt gaagaattga gcttttcaag
     1861 ggaacagatt cagagagcta gacagacaat agctgaacaa gaaagtaaac ttaatgaagc
     1921 acataagtcc cttagtacag tggaagattt gaaagctgag attgtttctg catctgaatc
     1981 cagaaaggaa ctagaattaa aacatgaagc agaagttaca aattacaaga taaaacttga
     2041 aatgttagaa aaagaaaaga atgctgtgtt agacagaatg gctgaatcac aagaagctga
     2101 attagagagg ctgagaacac agcttctatt tagtcacgaa gaagagcttt ccaaactgaa
     2161 ggaagattta gaaattgaac atcgaataaa tattgaaaaa cttaaagata atttaggcat
     2221 tcactataaa cagcagatag atggtttaca gaatgaaatg agtcaaaaga tagaaaccat
     2281 gcagtttgaa aaggacaatt tgataactaa gcagaatcaa ttaattttgg aaatttcaaa
     2341 gctaaaagat ttacagcagt ctcttgtaaa ttcaaagtca gaagaaatga ctcttcaaat
     2401 caatgaactt caaaaagaaa ttgaaatact cagacaagaa gaaaaagaaa agggtacact
     2461 tgaacaagaa gttcaagaat tacaacttaa aacagaattg ttagaaaaac agatgaagga
     2521 aaaagagaat gatcttcaag aaaaatttgc acaacttgaa gcagagaata gcattcttaa
     2581 agatgaaaag aaaacccttg aagacatgtt gaaaatacat actcctgtta gccaagaaga
     2641 aagattgatt ttcttagact ccattaagtc caaatccaaa gactctgtgt gggaaaaaga
     2701 aatagaaata cttatagagg aaaatgagga cctcaaacaa caatgtattc agctaaatga
     2761 agagattgaa aagcaaagga acactttttc atttgctgaa aaaaactttg aagttaacta
     2821 tcaagagtta caagaggagt atgcttgcct tctcaaagta aaagatgatt tagaagacag
     2881 taaaaataaa caggaattag agtataaaag taaacttaaa gcacttaatg aagagcttca
     2941 tttgcaaaga ataaatccaa ctacagtgaa aatgaaaagt tctgtctttg atgaagacaa
     3001 aacttttgta gcagaaacat tggaaatggg tgaggttgtt gaaaaggata caacagaact
     3061 catggaaaaa cttgaggtaa ccaagcgaga gaaattagag ctgtcacaga gactgtctga
     3121 tctttctgaa caattgaaac agaaacatgg tgagattagt tttctaaatg aagaagttaa
     3181 atctttaaag caagagaaag aacaagtttc attgagatgt agagagctag aaatcattat
     3241 taaccacaac agggcagaaa atgtacagtc atgtgatact caagtaagct ctttattaga
     3301 tggagttgtg accatgacaa gcaggggtgc tgaaggatca gtttctaaag taaataaaag
     3361 ttttggtgaa gaatcaaaaa taatggtgga agataaagtt tcttttgaaa atatgactgt
     3421 tggagaagaa agtaagcaag aacagttgat tttggatcac ttaccatctg taacaaagga
     3481 atcatcactt agagcaactc aaccaagtga aaatgataaa cttcagaaag aactcaatgt
     3541 acttaaatca gaacagaatg atttaaggct acagatggaa gcccaacgca tttgcctctc
     3601 tctggtttat tcaactcatg tggatcaggt tcgtgaatat atggaaaatg aaaaagataa
     3661 agctctttgc agtcttaaag aagagcttat ttttgctcaa gaggaaaaga tcaaggaact
     3721 tcagaaaata caccagttag aactacagac tatgaaaaca caagaaacag gtgatgaagg
     3781 aaagccttta catctgctca ttggaaaact tcaaaaggca gtgtctgaag aatgttctta
     3841 ttttttacag actttatgca gtgtccttgg tgaatattat actcctgctt taaaatgtga
     3901 agtaaatgca gaagacaaag agaattctgg tgattacatt tctgaaaatg aagatccaga
     3961 attacaagat tatagatatg aagttcaaga ctttcaagaa aatatgcaca ctcttctcaa
     4021 caaagtaaca gaagaataca acaaactctt ggtacttcaa acacgactaa gcaagatctg
     4081 gggacagcag acagatggta tgaaacttga atttggagaa gaaaaccttc caaaagagga
     4141 aacagagttt ttatcaatcc attctcagat gaccaatttg gaagacattg atgtcaatca
     4201 taaaagcaag ttatcttctc tgcaagatct tgaaaaaact aaacttgaag aacaagttca
     4261 agaattagaa agcctcatat cctctttgca gcaacagttg aaagaaactg aacaaaacta
     4321 tgaggcagag atccactgtt tacagaagag gcttcaagct gttagtgagt ccacggttcc
     4381 gccaagctta cctgttgatt cggtggtaat tacagaatct gatgcacaga gaacaatgta
     4441 ccctggaagt tgtgtgaaaa agaatattga tggtacaata gagttttctg gtgaatttgg
     4501 agtgaaagag gaaacaaata tcgttaagtt gcttgaaaaa caataccaag aacaattaga
     4561 agaagaagta gctaaggtta ttgtgtcaat gagtatagca tttgctcaac aaactgaact
     4621 gtctagaata tctgggggaa aagaaaatac tgcatcatca aagcaagcac atgctgtgtg
     4681 tcagcaagaa caacattatt ttaatgaaat gaaattatca caggatcaaa ttggttttca
     4741 gacttttgag acagtggatg tgaaatttaa agaagaattt aaaccactta gtaaagagtt
     4801 aggagaacat ggaaaggaaa ttttattatc aaatagtgat ccccatgata taccagaatc
     4861 aaaggactgt gtgctgacta tttcagaaga aatgttctcc aaagataaaa catttatagt
     4921 tagacagtct attcatgatg agatttcagt gtcaagcatg gatgcttcta gacaactaat
     4981 gttgaatgaa gaacagttgg aagatatgag acaggaactt gtacgacaat accaagaaca
     5041 tcaacaggca acggaattgt taaggcaagc acatatgcgg caaatggaga gacagcgaga
     5101 agaccaggaa cagctacaag aagagattaa gagacttaat agacaattag cccagagatc
     5161 ctccatagat aatgaaaacc tggtttcaga gagagagagg gtgcttttag aggagctgga
     5221 agcactaaag cagctgtctt tagctggaag agagaagctg tgttgtgagc tgcgcaacag
     5281 cagtacgcaa acacagaatg gaaatgaaaa ccaaggagaa gttgaagaac aaacatttaa
     5341 agaaaaggaa ttagacagaa aacctgaaga tgtgcctcct gagattttgt ctaatgaaag
     5401 gtatgcactc cagaaagcta ataatagact tttgaagatc ctcttagaag ttgtaaagac
     5461 aacagcagct gttgaagaaa caattggtcg ccatgtcctt gggattctag atagatctag
     5521 taaaagccag tcatctgcca gcctaatttg gaggtcagaa gcagaggcat ctgtaaagtc
     5581 atgtgtccat gaggaacata caagagttac agatgaatcc attccctctt attctggaag
     5641 tgatatgcca agaaatgaca ttaacatgtg gtcaaaagta actgaggaag gaacagagct
     5701 gtcacaacga cttgtgagga gtggttttgc tggaactgaa atagaccctg aaaatgaaga
     5761 acttatgctg aacattagct ctcgactaca agcagcagtt gaaaaactcc tagaagccat
     5821 aagtgaaact agcagtcagc ttgaacatgc gaaagtgaca cagacagagt tgatgcgtga
     5881 gtcatttaga cagaaacaag aagcaacaga gtcccttaag tgccaagagg aacttcgaga
     5941 gcgccttcat gaggagtcca gggccagaga acagctagct gtggagctca gtaaggctga
     6001 gggcgtcatt gatggctatg cagatgaaaa aactcttttt gaaaggcaaa ttcaggaaaa
     6061 aactgatata atagatcgtc ttgagcagga gttgttatgt gcaagtaaca ggttgcaaga
     6121 attggaggca gagcaacagc agatccaaga agaaagagaa ttactgtcca gacaaaagga
     6181 agctatgaaa gcagaggcag gcccagttga acaacaatta ctacaggaga cagaaaaatt
     6241 aatgaaggaa aaactagaag tacaatgtca agctgaaaaa gtacgtgatg accttcaaaa
     6301 acaagtgaaa gctctagaaa tagatgtgga agaacaagtc agtaggttta tagagctgga
     6361 acaagaaaaa aatactgaac taatggattt aagacagcaa aaccaagcat tggaaaagca
     6421 gttagaaaaa atgagaaaat ttttagatga gcaagccatt gacagagaac atgagagaga
     6481 tgtattccaa caggaaatac agaaactaga acagcaactt aaggttgttc ctcgattcca
     6541 gcctatcagt gaacatcaaa ctagagaggt tgaacagtta gcaaatcatc tgaaagaaaa
     6601 aacagacaaa tgcagtgagc ttttgctctc taaagagcag cttcaaaggg atatacaaga
     6661 aaggaatgaa gaaatagaga aactggagtt cagagtaaga gaactggagc aggcgcttct
     6721 tgtgagtgca gatacttttc aaaaggtaga ggaccgaaaa cactttggag ctgtagaagc
     6781 taaaccagaa ttgtccctag aagtacaatt gcaggctgaa cgagatgcca tagacagaaa
     6841 ggaaaaagag attacaaact tagaagagca attagaacag tttagagaag aactggaaaa
     6901 taagaatgaa gaagttcaac aattacatat gcaattagaa atacagaaaa aggaatctac
     6961 tacccgccta caagaacttg aacaggaaaa caaattattt aaggatgaca tggagaaact
     7021 gggacttgcc ataaaggaat ctgatgccat gtctactcaa gaccaacatg tgctatttgg
     7081 gaaatttgct caaataatac aggaaaaaga ggtagaaatt gaccaattaa atgaacaagt
     7141 tacgaaactc cagcagcaac ttaaaattac aacagataac aaggttattg aagaaaaaaa
     7201 tgaactgata agggatcttg aaacccaaat agaatgtttg atgagtgatc aagaatgtgt
     7261 gaagagaaat agagaagaag aaatagagca gctcaatgaa gtgattgaaa aacttcaaca
     7321 ggaattggca aatattggac agaagacatc aatgaatgct cattccctct cagaagaagc
     7381 agacagttta aaacatcaat tggatgtggt tatagctgaa aagctggcct tggaacagca
     7441 agtagaaacc gctaatgaag aaatgacctt catgaaaaat gtacttaaag aaaccaattt
     7501 taaaatgaat cagctaacac aggaattatt cagcttaaag agagaacgtg aaagtgtgga
     7561 aaagattcaa agcataccag agaatagtgt taacgtggct atagatcatc tgagcaaaga
     7621 caaacctgaa ctagaagtag tccttacaga ggatgctctt aaatccctag aaaatcagac
     7681 atacttcaaa tcttttgaag aaaatggcaa aggttccata attaatttgg aaacaaggtt
     7741 gctacaactt gagagcactg ttagtgcaaa ggacttagaa cttacccagt gttataaaca
     7801 aataaaagac atgcaagaac aaggccagtt tgaaacagaa atgcttcaaa agaagattgt
     7861 aaacctacag aaaatagttg aagaaaaagt ggctgctgct cttgtcagtc aaatccaact
     7921 tgaggcagtt caggaatatg caaaattctg tcaagataat caaacaattt catcagaacc
     7981 tgaaagaaca aatattcaga atttaaatca actaagagaa gatgagttgg ggtcagatat
     8041 atcagcatta accttgagaa tatcagaatt agaaagccag gttgttgaaa tgcatactag
     8101 tttgatttta gaaaaagaac aagtagaaat tgcagaaaaa aatgttttag aaaaagaaaa
     8161 gaagctgcta gaactacaga agctattgga gggcaatgag aaaaaacaga gagagaaaga
     8221 aaagaaaaga agccctcaag atgttgaagt tctcaagaca actactgagc tatttcatag
     8281 caatgaagaa agtggatttt ttaatgaact cgaggctctt agagctgaat cagtggctac
     8341 caaagcagaa cttgccagtt ataaagaaaa ggctgaaaaa cttcaagaag agcttttggt
     8401 aaaagaaaca aatatgacat ctcttcagaa agacttaagc caagttaggg atcacctcgc
     8461 agaggcaaaa gagaaattgt ccattttaga aaaagaagat gagactgagg tacaagaaag
     8521 caaaaaggcc tgcatgtttg agccacttcc tataaaactg agtaagagca ttgcatccca
     8581 gacagatggg actctgaaga tcagtagcag caatcagact ccacaaattc ttgttaaaaa
     8641 tgcaggaata caaattaatt tacagagtga atgttcctca gaagaagtta ctgaaataat
     8701 cagtcagttt actgaaaaaa ttgagaagat gcaagaacta catgctgctg aaattttgga
     8761 catggaatcc agacatattt cagaaactga aaccttaaag agggaacact atgttgccgt
     8821 tcagttactg aaagaggaat gtggtacctt gaaggcagtg atacagtgtc tgagaagtaa
     8881 agagggatcc tcaattcctg agctagcaca ttctgatgct taccagacta gagaaatatg
     8941 ctccagtgat tctggatcag actggggtca gggaatttat cttacacaca gtcagggatt
     9001 tgacatagca tcagaaggcc gaggagaaga aagtgaaagt gcaacagatt cctttccaaa
     9061 gaaaataaag ggattactga gagctgtcca taatgaaggc atgcaggtgc tttctctcac
     9121 tgagtctccc tatagtgatg gagaggacca ttctattcag caggtttcag aaccttggct
     9181 agaagagaga aaagcttaca tcaatacaat ctcatctcta aaggatttaa ttacaaagat
     9241 gcaactgcaa agagaagccg aggtttatga tagttctcaa tctcatgaga gcttctcaga
     9301 ctggcgaggt gaactactgc ttgcccttca acaagttttc ttagaagagc gtagtgtttt
     9361 actagcagca tttcggacgg agctgacagc tctaggtact acagatgcag ttggtttact
     9421 aaactgtttg gaacagagaa tacaagaaca gggtgttgaa tatcaagcag ctatggaatg
     9481 cctccagaaa gcagatagaa ggagtttgtt atctgaaatt caggcactgc atgcacaaat
     9541 gaatggtagg aaaattactc tgaaaagaga acaagagagt gagaaaccaa gccaagaact
     9601 cttggaatat aatatacagc agaagcagtc tcaaatgctg gagatgcaag tggagctcag
     9661 cagtatgaaa gacagagcaa cggaactgca ggagcagctg agttctgaga aaatggtggt
     9721 tgctgaactg aagagtgagc ttgcacaaac taaattggaa ctagaaacaa cactcaaggc
     9781 acagcataaa cacctaaaag aattggaggc tttcaggttg gaagttaaag ataagacaga
     9841 tgaagtacat ttgcttaatg acacattagc aagtgaacag aaaaaatcaa gagagctcca
     9901 gtgggctttg gagaaagaga aagccaagtt gggacgcagt gaagaacggg ataaagaaga
     9961 acttgaggat ctgaagtttt cacttgagag tcagaaacaa aggaatcttc agctaaatct
    10021 acttttggaa caacagaaac aactactgaa cgaatcccag caaaaaatag aatcacagag
    10081 aatgctatat gatgcccagt tgtcagaaga acaaggtcga aacttagagc ttcaggtact
    10141 tcttgaatct gagaaagttc gaattcggga aatgagtagt accctagata gggagcggga
    10201 attgcacgca cagctgcaga gcagtgatgg tactggacag tctcggccac ccttgccctc
    10261 agaggaccta ctgaaagagc tgcagaaaca gctagaggaa aaacacagtc gcatagtaga
    10321 attgttaaat gagactgaaa aatataaact ggattctttg caaacacgac agcaaatgga
    10381 aaaagatagg caggttcaca ggaaaacact gcagacagaa caggaggcca acactgaggg
    10441 acagaaaaaa atgcatgagc tccagtccaa agtggaagat cttcagcgcc agctggaaga
    10501 gaaaagacaa caagtttata agttagacct tgaaggacag cgactacaag gaatcatgca
    10561 ggaattccag aagcaagaac tagaacgaga agaaaaacga gaaagtagaa gaattctgta
    10621 tcagaacctt aatgagccaa ccacgtggag cttaaccagt gatagaacta gaaattgggt
    10681 tcttcaacag aaaatagaag gagaaacaaa agaatcaaac tacgctaaat tgattgaaat
    10741 gaatggagga ggaaccggct gtaatcatga attagaaatg atcagacaaa agcttcaatg
    10801 tgtagcttca aaactacagg ttctacccca gaaagcctct gagagactac agtttgaaac
    10861 agcagatgat gaagatttca tttgggttca ggaaaatatt gatgaaatta ttttacaact
    10921 acagaaatta actggccagc aaggtgaaga gcccagcttg gtgtccccaa gtacttcttg
    10981 tggctcattg actgaaagac tactgagaca aaatgctgag ctgacagggc atatcagtca
    11041 actgactgaa gagaagaatg acttaaggaa catggttatg aagctggaag agcagatcag
    11101 gtggtatcga cagacaggag ctggtagaga taattcttcc aggttttcat tgaatggtgg
    11161 tgccaacatt gaagccatca ttgcctctga aaaagaagta tggaacagag aaaaattgac
    11221 tctccagaaa tctttgaaaa gggcagaggc tgaagtatac aaactgaaag ctgaactaag
    11281 aaatgactct ttacttcaaa ctctgagccc tgattctgaa catgtcactt taaagagaat
    11341 ttatggtaaa tacttgaggg cagaaagttt tcgaaaggct ctcatttacc agaagaaata
    11401 cctgctgctg ttactgggtg ggttccagga atgtgaagat gccaccttgg ccctgcttgc
    11461 ccggatgggg gggcagccag ctttcacgga tctagaggtg atcaccaatc gcccaaaggg
    11521 cttcaccagg tttcggtcgg ccgtcagagt atccattgca atttccagaa tgaaattttt
    11581 ggttcgacgg tggcatcgag tcacaggttc tgtttccatc aatattaaca gagatggctt
    11641 tggactgaat caaggtgcag aaaagactga ctcattttat cattcttctg gtgggctgga
    11701 gttatatgga gaaccaagac atactacgta tcgctcaaga tcagatctgg actatattag
    11761 gtccccttta ccatttcaga ataggtaccc aggcactcca gctgatttca atcctggttc
    11821 tttagcatgt tctcagcttc agaattacga tcctgacaga gccctaacag attatatcac
    11881 tcggctagag gcactgcaaa gacgacttgg aactatacag tcaggttcaa ctactcaatt
    11941 tcatgctggc atgagaagat aatcctttga aacatcatta attgaagtga ttttaaatag
    12001 atttcctttt gtaaatcaat ggttcttttg tgcttttgta ttgtgaatat tcaatgggac
    12061 caatatgaac acagcttatg attgtataca aatcccttgc cagcacatga aaacaaactg
    12121 gaatttgtat atataagcat tgtgtatgta ttcatgcaca ataattattg aattacctgt
    12181 atatttgtgg aatgctaatt taaaacatta aattataaac cttgtgtatt tatcaaatgg
    12241 gtgaaaagat taaactttta cgcattacaa tactgctgaa tgtgtagctc gaggtgtcct
    12301 gcacttttct tataaggcta ctgaagttac atgttttgcc taatatattc tactggtgat
    12361 gaagacagat aatatcactt gtagagacct atttttgtat aatggtagaa gttttgaatt
    12421 ttatggggta ttttgtcaag tactgaaata aaaatgactt caccattttc accaca
//
