LOCUS       NM_001379277            7474 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens A-kinase anchoring protein 9 (AKAP9), transcript
            variant 6, mRNA.
ACCESSION   NM_001379277 XM_017011660
VERSION     NM_001379277.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7474)
  AUTHORS   Li,B., Karlova,M., Zhang,H., Pustovit,O.B., Mai,L.,
            Novoseletsky,V., Podolyak,D., Zaklyazminskaya,E.V.,
            Abramochkin,D.V. and Sokolova,O.S.
  TITLE     A mutation in the cardiac KV7.1 channel possibly disrupts
            interaction with Yotiao protein
  JOURNAL   Biochem Biophys Res Commun 714, 149947 (2024)
   PUBMED   38657442
  REMARK    GeneRIF: A mutation in the cardiac KV7.1 channel possibly disrupts
            interaction with Yotiao protein.
REFERENCE   2  (bases 1 to 7474)
  AUTHORS   Soboska,K., Kusinski,M., Pawelczyk,K., Migdalska-Sek,M.,
            Brzezianska-Lasota,E. and Czarnecka-Chrebelska,K.H.
  TITLE     Expression of RASSF1A, DIRAS3, and AKAP9 Genes in Thyroid Lesions:
            Implications for Differential Diagnosis and Prognosis of Thyroid
            Carcinomas
  JOURNAL   Int J Mol Sci 25 (1), 562 (2024)
   PUBMED   38203733
  REMARK    GeneRIF: Expression of RASSF1A, DIRAS3, and AKAP9 Genes in Thyroid
            Lesions: Implications for Differential Diagnosis and Prognosis of
            Thyroid Carcinomas.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7474)
  AUTHORS   Zhou,Y., Liu,Y., Gupta,S., Paramo,M.I., Hou,Y., Mao,C., Luo,Y.,
            Judd,J., Wierbowski,S., Bertolotti,M., Nerkar,M., Jehi,L.,
            Drayman,N., Nicolaescu,V., Gula,H., Tay,S., Randall,G., Wang,P.,
            Lis,J.T., Feschotte,C., Erzurum,S.C., Cheng,F. and Yu,H.
  TITLE     A comprehensive SARS-CoV-2-human protein-protein interactome
            reveals COVID-19 pathobiology and potential host therapeutic
            targets
  JOURNAL   Nat Biotechnol 41 (1), 128-139 (2023)
   PUBMED   36217030
REFERENCE   4  (bases 1 to 7474)
  AUTHORS   You,Y., Hersh,S.W., Aslebagh,R., Shaffer,S.A., Ikezu,S., Mez,J.,
            Lunetta,K.L., Logue,M.W., Farrer,L.A. and Ikezu,T.
  TITLE     Alzheimer's disease associated AKAP9 I2558M mutation alters
            posttranslational modification and interactome of tau and cellular
            functions in CRISPR-edited human neuronal cells
  JOURNAL   Aging Cell 21 (6), e13617 (2022)
   PUBMED   35567427
  REMARK    GeneRIF: Alzheimer's disease associated AKAP9 I2558M mutation
            alters posttranslational modification and interactome of tau and
            cellular functions in CRISPR-edited human neuronal cells.
REFERENCE   5  (bases 1 to 7474)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 7474)
  AUTHORS   Witczak,O., Skalhegg,B.S., Keryer,G., Bornens,M., Tasken,K.,
            Jahnsen,T. and Orstavik,S.
  TITLE     Cloning and characterization of a cDNA encoding an A-kinase
            anchoring protein located in the centrosome, AKAP450
  JOURNAL   EMBO J 18 (7), 1858-1868 (1999)
   PUBMED   10202149
REFERENCE   7  (bases 1 to 7474)
  AUTHORS   Schmidt,P.H., Dransfield,D.T., Claudio,J.O., Hawley,R.G.,
            Trotter,K.W., Milgram,S.L. and Goldenring,J.R.
  TITLE     AKAP350, a multiply spliced protein kinase A-anchoring protein
            associated with centrosomes
  JOURNAL   J Biol Chem 274 (5), 3055-3066 (1999)
   PUBMED   9915845
REFERENCE   8  (bases 1 to 7474)
  AUTHORS   Lin,J.W., Wyszynski,M., Madhavan,R., Sealock,R., Kim,J.U. and
            Sheng,M.
  TITLE     Yotiao, a novel protein of neuromuscular junction and brain that
            interacts with specific splice variants of NMDA receptor subunit
            NR1
  JOURNAL   J Neurosci 18 (6), 2017-2027 (1998)
   PUBMED   9482789
  REMARK    Review article
REFERENCE   9  (bases 1 to 7474)
  AUTHORS   Golsteyn,R.M., Mundt,K.E., Fry,A.M. and Nigg,E.A.
  TITLE     Cell cycle regulation of the activity and subcellular localization
            of Plk1, a human protein kinase implicated in mitotic spindle
            function
  JOURNAL   J Cell Biol 129 (6), 1617-1628 (1995)
   PUBMED   7790358
REFERENCE   10 (bases 1 to 7474)
  AUTHORS   Groffen,A.J., Bikker,H. and Christiaans,I.
  TITLE     Long QT Syndrome Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301308
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004013.1 and AC000120.1.
            
            On Mar 27, 2020 this sequence version replaced XM_017011660.2.
            
            Summary: The A-kinase anchor proteins (AKAPs) are a group of
            structurally diverse proteins which have the common function of
            binding to the regulatory subunit of protein kinase A (PKA) and
            confining the holoenzyme to discrete locations within the cell.
            This gene encodes a member of the AKAP family. Alternate splicing
            of this gene results in at least two isoforms that localize to the
            centrosome and the Golgi apparatus, and interact with numerous
            signaling proteins from multiple signal transduction pathways.
            These signaling proteins include type II protein kinase A,
            serine/threonine kinase protein kinase N, protein phosphatase 1,
            protein phosphatase 2a, protein kinase C-epsilon and
            phosphodiesterase 4D3. [provided by RefSeq, Aug 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.316730.1,
                                           SRR1803612.12153.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-837               AC004013.1         8120-8956
            838-1000            AC004013.1         11802-11964
            1001-1213           AC004013.1         12816-13028
            1214-1446           AC004013.1         15773-16005
            1447-1566           AC004013.1         16969-17088
            1567-1743           AC004013.1         20572-20748
            1744-1848           AC004013.1         21447-21551
            1849-2001           AC004013.1         27397-27549
            2002-2181           AC004013.1         28238-28417
            2182-3255           AC004013.1         29621-30694
            3256-3396           AC004013.1         33064-33204
            3397-3882           AC004013.1         33712-34197
            3883-3946           AC004013.1         35182-35245
            3947-4068           AC004013.1         35361-35482
            4069-4260           AC004013.1         36037-36228
            4261-4449           AC004013.1         36770-36958
            4450-4594           AC004013.1         39927-40071
            4595-4814           AC004013.1         43639-43858
            4815-4965           AC004013.1         45565-45715
            4966-5634           AC004013.1         47231-47899
            5635-5843           AC004013.1         48128-48336
            5844-5949           AC004013.1         48651-48756
            5950-6132           AC004013.1         50229-50411
            6133-6333           AC004013.1         51398-51598
            6334-6566           AC004013.1         53136-53368
            6567-6652           AC004013.1         56220-56305
            6653-6782           AC004013.1         57835-57964
            6783-6922           AC000120.1         131-270
            6923-7474           AC000120.1         1759-2310
FEATURES             Location/Qualifiers
     source          1..7474
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.2"
     gene            1..7474
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /note="A-kinase anchoring protein 9"
                     /db_xref="GeneID:10142"
                     /db_xref="HGNC:HGNC:379"
                     /db_xref="MIM:604001"
     exon            1..837
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     CDS             592..6960
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /note="isoform 4 is encoded by transcript variant 6;
                     kinase N-associated protein; protein kinase A anchoring
                     protein 9; A kinase (PRKA) anchor protein 9; AKAP9-BRAF
                     fusion protein; protein yotiao; protein hyperion; AKAP
                     120-like protein; A-kinase anchor protein 350 kDa; A
                     kinase (PRKA) anchor protein (yotiao) 9; centrosome- and
                     golgi-localized protein kinase N-associated protein;
                     A-kinase anchor protein 450 kDa; centrosome- and
                     Golgi-localized PKN-associated protein; protein
                     phosphatase 1, regulatory subunit 45"
                     /codon_start=1
                     /product="A-kinase anchor protein 9 isoform 4"
                     /protein_id="NP_001366206.1"
                     /db_xref="CCDS:CCDS94142.1"
                     /db_xref="GeneID:10142"
                     /db_xref="HGNC:HGNC:379"
                     /db_xref="MIM:604001"
                     /translation="MDSYSTYLATVKVSGSWLEEQDEDIYEVESRVPLPHPFPLCEHL
                     DENNSVIVNTSIFHFIHKRNGHILKLISKISLPTPPYSLEHAKVTQTELMRESFRQKQ
                     EATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDII
                     DRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMK
                     EKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQ
                     LEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLK
                     EKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFG
                     AVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEI
                     QKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVE
                     IDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQ
                     LNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEM
                     TFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEV
                     VLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDM
                     QEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPER
                     TNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEK
                     KLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESV
                     ATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETE
                     VQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSE
                     EVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKA
                     VIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEE
                     SESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYIN
                     TISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRT
                     ELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRK
                     ITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAE
                     LKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQ
                     WALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIES
                     QRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRP
                     PLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQ
                     EANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEK
                     RESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHE
                     LEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQG
                     EEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTG
                     AGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSL
                     LQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKKYLLLLLGGFQECEDATLALLARM
                     GGQPAFTDLEVITNRPKGFTRFRSAVRVSIAISRMKFLVRRWHRVTGSVSININRDGF
                     GLNQGAEKTDSFYHSSGGLELYGEPRHTTYRSRSDLDYIRSPLPFQNRYPGTPADFNP
                     GSLACSQLQNYDPDRALTDYITRLEALQRRLGTIQSGSTTQFHAGMRR"
     exon            838..1000
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1213
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1446
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1566
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1743
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1848
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..2001
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2181
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            2182..3255
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            3256..3396
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            3397..3882
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            3883..3946
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            3947..4068
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            4069..4260
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            4261..4449
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            4450..4594
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            4595..4814
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            4815..4965
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            4966..5634
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            5635..5843
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            5844..5949
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            5950..6132
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            6133..6333
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            6334..6566
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            6567..6652
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            6653..6782
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            6783..6922
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     exon            6923..7474
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7445..7450
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /note="hexamer: AATAAA"
     polyA_site      7474
                     /gene="AKAP9"
                     /gene_synonym="AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION;
                     LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO"
                     /note="major polyA site"
ORIGIN      
        1 ggctcagcat gagaggctat ttgaatagct cagttcagaa gagcttttcc ttttgaatag
       61 agtgaagcag caagagcaag agaaataatg ttacaactgc atttctcaag actgctgcta
      121 tggagatttc aaacttgacc ttccctgcca ggttctgctt tgaaggctta cttattacta
      181 cagacatcgc tgatattaaa agcagtttta ttgctcgtct aattagatgt ttatattttt
      241 attcttctct tcaaggactt aattatgcta gtttaaaagg tgtttttgtt tgcttgcttt
      301 tatttttgtt ttttgatttt ttttggtttt tgttttggtt tgggtttttt tgagggggca
      361 tcaagattga tagagaccta agttttttta gatttgtagt ttttttcctg gactttcccc
      421 ttccttttat tgtgcagttg tatgaattaa ttttataaca tttatttgat agtgctaaaa
      481 aagaaacttt ttatactgct atggtagatc ttgataaact aaaaagaact ttttaatgta
      541 ttagaaaatt gataaagcaa attaggaatc tcggcagctg tatcttctgg gatggattct
      601 tatagcacct atttggcaac tgtcaaagtc agtggctcgt ggttagaaga gcaagatgaa
      661 gacatttatg aggttgaatc tcgcgtgcct ttaccacatc cttttcctct ttgtgaacat
      721 ttggatgaaa ataactcagt aattgttaat acttctattt tccattttat tcataaaaga
      781 aacgggcata tattaaagct tatttctaaa atttcactgc ctacccctcc ttattcactt
      841 gaacatgcga aagtgacaca gacagagttg atgcgtgagt catttagaca gaaacaagaa
      901 gcaacagagt cccttaagtg ccaagaggaa cttcgagagc gccttcatga ggagtccagg
      961 gccagagaac agctagctgt ggagctcagt aaggctgagg gcgtcattga tggctatgca
     1021 gatgaaaaaa ctctttttga aaggcaaatt caggaaaaaa ctgatataat agatcgtctt
     1081 gagcaggagt tgttatgtgc aagtaacagg ttgcaagaat tggaggcaga gcaacagcag
     1141 atccaagaag aaagagaatt actgtccaga caaaaggaag ctatgaaagc agaggcaggc
     1201 ccagttgaac aacaattact acaggagaca gaaaaattaa tgaaggaaaa actagaagta
     1261 caatgtcaag ctgaaaaagt acgtgatgac cttcaaaaac aagtgaaagc tctagaaata
     1321 gatgtggaag aacaagtcag taggtttata gagctggaac aagaaaaaaa tactgaacta
     1381 atggatttaa gacagcaaaa ccaagcattg gaaaagcagt tagaaaaaat gagaaaattt
     1441 ttagatgagc aagccattga cagagaacat gagagagatg tattccaaca ggaaatacag
     1501 aaactagaac agcaacttaa ggttgttcct cgattccagc ctatcagtga acatcaaact
     1561 agagaggttg aacagttagc aaatcatctg aaagaaaaaa cagacaaatg cagtgagctt
     1621 ttgctctcta aagagcagct tcaaagggat atacaagaaa ggaatgaaga aatagagaaa
     1681 ctggagttca gagtaagaga actggagcag gcgcttcttg tgagtgcaga tacttttcaa
     1741 aaggtagagg accgaaaaca ctttggagct gtagaagcta aaccagaatt gtccctagaa
     1801 gtacaattgc aggctgaacg agatgccata gacagaaagg aaaaagagat tacaaactta
     1861 gaagagcaat tagaacagtt tagagaagaa ctggaaaata agaatgaaga agttcaacaa
     1921 ttacatatgc aattagaaat acagaaaaag gaatctacta cccgcctaca agaacttgaa
     1981 caggaaaaca aattatttaa ggatgacatg gagaaactgg gacttgccat aaaggaatct
     2041 gatgccatgt ctactcaaga ccaacatgtg ctatttggga aatttgctca aataatacag
     2101 gaaaaagagg tagaaattga ccaattaaat gaacaagtta cgaaactcca gcagcaactt
     2161 aaaattacaa cagataacaa ggttattgaa gaaaaaaatg aactgataag ggatcttgaa
     2221 acccaaatag aatgtttgat gagtgatcaa gaatgtgtga agagaaatag agaagaagaa
     2281 atagagcagc tcaatgaagt gattgaaaaa cttcaacagg aattggcaaa tattggacag
     2341 aagacatcaa tgaatgctca ttccctctca gaagaagcag acagtttaaa acatcaattg
     2401 gatgtggtta tagctgaaaa gctggccttg gaacagcaag tagaaaccgc taatgaagaa
     2461 atgaccttca tgaaaaatgt acttaaagaa accaatttta aaatgaatca gctaacacag
     2521 gaattattca gcttaaagag agaacgtgaa agtgtggaaa agattcaaag cataccagag
     2581 aatagtgtta acgtggctat agatcatctg agcaaagaca aacctgaact agaagtagtc
     2641 cttacagagg atgctcttaa atccctagaa aatcagacat acttcaaatc ttttgaagaa
     2701 aatggcaaag gttccataat taatttggaa acaaggttgc tacaacttga gagcactgtt
     2761 agtgcaaagg acttagaact tacccagtgt tataaacaaa taaaagacat gcaagaacaa
     2821 ggccagtttg aaacagaaat gcttcaaaag aagattgtaa acctacagaa aatagttgaa
     2881 gaaaaagtgg ctgctgctct tgtcagtcaa atccaacttg aggcagttca ggaatatgca
     2941 aaattctgtc aagataatca aacaatttca tcagaacctg aaagaacaaa tattcagaat
     3001 ttaaatcaac taagagaaga tgagttgggg tcagatatat cagcattaac cttgagaata
     3061 tcagaattag aaagccaggt tgttgaaatg catactagtt tgattttaga aaaagaacaa
     3121 gtagaaattg cagaaaaaaa tgttttagaa aaagaaaaga agctgctaga actacagaag
     3181 ctattggagg gcaatgagaa aaaacagaga gagaaagaaa agaaaagaag ccctcaagat
     3241 gttgaagttc tcaagacaac tactgagcta tttcatagca atgaagaaag tggatttttt
     3301 aatgaactcg aggctcttag agctgaatca gtggctacca aagcagaact tgccagttat
     3361 aaagaaaagg ctgaaaaact tcaagaagag cttttggtaa aagaaacaaa tatgacatct
     3421 cttcagaaag acttaagcca agttagggat cacctcgcag aggcaaaaga gaaattgtcc
     3481 attttagaaa aagaagatga gactgaggta caagaaagca aaaaggcctg catgtttgag
     3541 ccacttccta taaaactgag taagagcatt gcatcccaga cagatgggac tctgaagatc
     3601 agtagcagca atcagactcc acaaattctt gttaaaaatg caggaataca aattaattta
     3661 cagagtgaat gttcctcaga agaagttact gaaataatca gtcagtttac tgaaaaaatt
     3721 gagaagatgc aagaactaca tgctgctgaa attttggaca tggaatccag acatatttca
     3781 gaaactgaaa ccttaaagag ggaacactat gttgccgttc agttactgaa agaggaatgt
     3841 ggtaccttga aggcagtgat acagtgtctg agaagtaaag agggatcctc aattcctgag
     3901 ctagcacatt ctgatgctta ccagactaga gaaatatgct ccagtgattc tggatcagac
     3961 tggggtcagg gaatttatct tacacacagt cagggatttg acatagcatc agaaggccga
     4021 ggagaagaaa gtgaaagtgc aacagattcc tttccaaaga aaataaaggg attactgaga
     4081 gctgtccata atgaaggcat gcaggtgctt tctctcactg agtctcccta tagtgatgga
     4141 gaggaccatt ctattcagca ggtttcagaa ccttggctag aagagagaaa agcttacatc
     4201 aatacaatct catctctaaa ggatttaatt acaaagatgc aactgcaaag agaagccgag
     4261 gtttatgata gttctcaatc tcatgagagc ttctcagact ggcgaggtga actactgctt
     4321 gcccttcaac aagttttctt agaagagcgt agtgttttac tagcagcatt tcggacggag
     4381 ctgacagctc taggtactac agatgcagtt ggtttactaa actgtttgga acagagaata
     4441 caagaacagg gtgttgaata tcaagcagct atggaatgcc tccagaaagc agatagaagg
     4501 agtttgttat ctgaaattca ggcactgcat gcacaaatga atggtaggaa aattactctg
     4561 aaaagagaac aagagagtga gaaaccaagc caagaactct tggaatataa tatacagcag
     4621 aagcagtctc aaatgctgga gatgcaagtg gagctcagca gtatgaaaga cagagcaacg
     4681 gaactgcagg agcagctgag ttctgagaaa atggtggttg ctgaactgaa gagtgagctt
     4741 gcacaaacta aattggaact agaaacaaca ctcaaggcac agcataaaca cctaaaagaa
     4801 ttggaggctt tcaggttgga agttaaagat aagacagatg aagtacattt gcttaatgac
     4861 acattagcaa gtgaacagaa aaaatcaaga gagctccagt gggctttgga gaaagagaaa
     4921 gccaagttgg gacgcagtga agaacgggat aaagaagaac ttgaggatct gaagttttca
     4981 cttgagagtc agaaacaaag gaatcttcag ctaaatctac ttttggaaca acagaaacaa
     5041 ctactgaacg aatcccagca aaaaatagaa tcacagagaa tgctatatga tgcccagttg
     5101 tcagaagaac aaggtcgaaa cttagagctt caggtacttc ttgaatctga gaaagttcga
     5161 attcgggaaa tgagtagtac cctagatagg gagcgggaat tgcacgcaca gctgcagagc
     5221 agtgatggta ctggacagtc tcggccaccc ttgccctcag aggacctact gaaagagctg
     5281 cagaaacagc tagaggaaaa acacagtcgc atagtagaat tgttaaatga gactgaaaaa
     5341 tataaactgg attctttgca aacacgacag caaatggaaa aagataggca ggttcacagg
     5401 aaaacactgc agacagaaca ggaggccaac actgagggac agaaaaaaat gcatgagctc
     5461 cagtccaaag tggaagatct tcagcgccag ctggaagaga aaagacaaca agtttataag
     5521 ttagaccttg aaggacagcg actacaagga atcatgcagg aattccagaa gcaagaacta
     5581 gaacgagaag aaaaacgaga aagtagaaga attctgtatc agaaccttaa tgagccaacc
     5641 acgtggagct taaccagtga tagaactaga aattgggttc ttcaacagaa aatagaagga
     5701 gaaacaaaag aatcaaacta cgctaaattg attgaaatga atggaggagg aaccggctgt
     5761 aatcatgaat tagaaatgat cagacaaaag cttcaatgtg tagcttcaaa actacaggtt
     5821 ctaccccaga aagcctctga gagactacag tttgaaacag cagatgatga agatttcatt
     5881 tgggttcagg aaaatattga tgaaattatt ttacaactac agaaattaac tggccagcaa
     5941 ggtgaagagc ccagcttggt gtccccaagt acttcttgtg gctcattgac tgaaagacta
     6001 ctgagacaaa atgctgagct gacagggcat atcagtcaac tgactgaaga gaagaatgac
     6061 ttaaggaaca tggttatgaa gctggaagag cagatcaggt ggtatcgaca gacaggagct
     6121 ggtagagata attcttccag gttttcattg aatggtggtg ccaacattga agccatcatt
     6181 gcctctgaaa aagaagtatg gaacagagaa aaattgactc tccagaaatc tttgaaaagg
     6241 gcagaggctg aagtatacaa actgaaagct gaactaagaa atgactcttt acttcaaact
     6301 ctgagccctg attctgaaca tgtcacttta aagagaattt atggtaaata cttgagggca
     6361 gaaagttttc gaaaggctct catttaccag aagaaatacc tgctgctgtt actgggtggg
     6421 ttccaggaat gtgaagatgc caccttggcc ctgcttgccc ggatgggggg gcagccagct
     6481 ttcacggatc tagaggtgat caccaatcgc ccaaagggct tcaccaggtt tcggtcggcc
     6541 gtcagagtat ccattgcaat ttccagaatg aaatttttgg ttcgacggtg gcatcgagtc
     6601 acaggttctg tttccatcaa tattaacaga gatggctttg gactgaatca aggtgcagaa
     6661 aagactgact cattttatca ttcttctggt gggctggagt tatatggaga accaagacat
     6721 actacgtatc gctcaagatc agatctggac tatattaggt cccctttacc atttcagaat
     6781 aggtacccag gcactccagc tgatttcaat cctggttctt tagcatgttc tcagcttcag
     6841 aattacgatc ctgacagagc cctaacagat tatatcactc ggctagaggc actgcaaaga
     6901 cgacttggaa ctatacagtc aggttcaact actcaatttc atgctggcat gagaagataa
     6961 tcctttgaaa catcattaat tgaagtgatt ttaaatagat ttccttttgt aaatcaatgg
     7021 ttcttttgtg cttttgtatt gtgaatattc aatgggacca atatgaacac agcttatgat
     7081 tgtatacaaa tcccttgcca gcacatgaaa acaaactgga atttgtatat ataagcattg
     7141 tgtatgtatt catgcacaat aattattgaa ttacctgtat atttgtggaa tgctaattta
     7201 aaacattaaa ttataaacct tgtgtattta tcaaatgggt gaaaagatta aacttttacg
     7261 cattacaata ctgctgaatg tgtagctcga ggtgtcctgc acttttctta taaggctact
     7321 gaagttacat gttttgccta atatattcta ctggtgatga agacagataa tatcacttgt
     7381 agagacctat ttttgtataa tggtagaagt tttgaatttt atggggtatt ttgtcaagta
     7441 ctgaaataaa aatgacttca ccattttcac caca
//
