LOCUS       NM_014371               2078 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens A-kinase anchoring protein 8 like (AKAP8L), transcript
            variant 1, mRNA.
ACCESSION   NM_014371
VERSION     NM_014371.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2078)
  AUTHORS   Zhou,L., Mei,J., Cao,R., Liu,X., Fu,B., Ma,M., Gong,B., Luo,L.,
            Liu,Y., Zhu,Q. and Meng,X.
  TITLE     Integrative analysis identifies AKAP8L as an immunological and
            prognostic biomarker of pan-cancer
  JOURNAL   Aging (Albany NY) 15 (17), 8851-8872 (2023)
   PUBMED   37683130
  REMARK    GeneRIF: Integrative analysis identifies AKAP8L as an immunological
            and prognostic biomarker of pan-cancer.
REFERENCE   2  (bases 1 to 2078)
  AUTHORS   Pintacuda,G., Hsu,Y.H., Tsafou,K., Li,K.W., Martin,J.M.,
            Riseman,J., Biagini,J.C., Ching,J.K.T., Mena,D.,
            Gonzalez-Lozano,M.A., Egri,S.B., Jaffe,J., Smit,A.B., Fornelos,N.,
            Eggan,K.C. and Lage,K.
  TITLE     Protein interaction studies in human induced neurons indicate
            convergent biology underlying autism spectrum disorders
  JOURNAL   Cell Genom 3 (3), 100250 (2023)
   PUBMED   36950384
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2078)
  AUTHORS   Zhang,R., Liu,L., Wang,F., Zhao,W., Liu,K., Yu,H., Zhao,S., Xu,B.,
            Zhang,X., Chai,J. and Hao,J.
  TITLE     AKAP8L enhances the stemness and chemoresistance of gastric cancer
            cells by stabilizing SCD1 mRNA
  JOURNAL   Cell Death Dis 13 (12), 1041 (2022)
   PUBMED   36522343
  REMARK    GeneRIF: AKAP8L enhances the stemness and chemoresistance of
            gastric cancer cells by stabilizing SCD1 mRNA.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2078)
  AUTHORS   Luo,Q.Y., Di,T., Chen,Z.G., Peng,J.H., Sun,J., Xia,Z.F., Pan,W.T.,
            Luo,F., Lu,F.T., Sun,Y.T., Yang,L.Q., Zhang,L., Qiu,M.Z. and
            Yang,D.J.
  TITLE     Novel prognostic model predicts overall survival in colon cancer
            based on RNA splicing regulation gene expression
  JOURNAL   Cancer Sci 113 (10), 3330-3346 (2022)
   PUBMED   35792657
  REMARK    GeneRIF: Novel prognostic model predicts overall survival in colon
            cancer based on RNA splicing regulation gene expression.
REFERENCE   5  (bases 1 to 2078)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 2078)
  AUTHORS   Yang,J.P., Tang,H., Reddy,T.R. and Wong-Staal,F.
  TITLE     Mapping the functional domains of HAP95, a protein that binds RNA
            helicase A and activates the constitutive transport element of type
            D retroviruses
  JOURNAL   J Biol Chem 276 (33), 30694-30700 (2001)
   PUBMED   11402034
REFERENCE   7  (bases 1 to 2078)
  AUTHORS   Martins,S.B., Eide,T., Steen,R.L., Jahnsen,T., Skalhegg,B. S and
            Collas,P.
  TITLE     HA95 is a protein of the chromatin and nuclear matrix regulating
            nuclear envelope dynamics
  JOURNAL   J Cell Sci 113 Pt 21, 3703-3713 (2000)
   PUBMED   11034899
REFERENCE   8  (bases 1 to 2078)
  AUTHORS   Westberg,C., Yang,J.P., Tang,H., Reddy,T.R. and Wong-Staal,F.
  TITLE     A novel shuttle protein binds to RNA helicase A and activates the
            retroviral constitutive transport element
  JOURNAL   J Biol Chem 275 (28), 21396-21401 (2000)
   PUBMED   10748171
REFERENCE   9  (bases 1 to 2078)
  AUTHORS   Orstavik,S., Eide,T., Collas,P., Han,I.O., Tasken,K., Kieff,E.,
            Jahnsen,T. and Skalhegg,B.S.
  TITLE     Identification, cloning and characterization of a novel nuclear
            protein, HA95, homologous to A-kinase anchoring protein 95
  JOURNAL   Biol Cell 92 (1), 27-37 (2000)
   PUBMED   10761695
REFERENCE   10 (bases 1 to 2078)
  AUTHORS   Seki,N., Ueki,N., Yano,K., Saito,T., Masuho,Y. and Muramatsu,M.
  TITLE     cDNA cloning of a novel human gene NAKAP95, neighbor of A-kinase
            anchoring protein 95 (AKAP95) on chromosome 19p13.11-p13.12 region
  JOURNAL   J Hum Genet 45 (1), 31-37 (2000)
   PUBMED   10697960
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA315789.1, AJ243467.1 and BQ006924.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014371.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK225291.1, SRR3476690.695137.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397410.10/ ENSP00000380557.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                DA315789.1         118-136
            20-2077             AJ243467.1         1-2058
            2078-2078           BQ006924.1         21-21               c
FEATURES             Location/Qualifiers
     source          1..2078
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.12"
     gene            1..2078
                     /gene="AKAP8L"
                     /gene_synonym="HA95; HAP95; NAKAP; NAKAP95"
                     /note="A-kinase anchoring protein 8 like"
                     /db_xref="GeneID:26993"
                     /db_xref="HGNC:HGNC:29857"
                     /db_xref="MIM:609475"
     exon            1..78
                     /gene="AKAP8L"
                     /gene_synonym="HA95; HAP95; NAKAP; NAKAP95"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..2006
                     /gene="AKAP8L"
                     /gene_synonym="HA95; HAP95; NAKAP; NAKAP95"
                     /note="isoform 1 is encoded by transcript variant 1;
                     helicase A-binding protein 95 kDa; neighbor of A-kinase
                     anchoring protein 95; A-kinase anchor protein 8-like;
                     AKAP8-like protein; neighbor of AKAP95; homologous to
                     AKAP95 protein; A kinase (PRKA) anchor protein 8-like;
                     testis tissue sperm-binding protein Li 90mP"
                     /codon_start=1
                     /product="A-kinase anchor protein 8-like isoform 1"
                     /protein_id="NP_055186.3"
                     /db_xref="CCDS:CCDS46005.1"
                     /db_xref="GeneID:26993"
                     /db_xref="HGNC:HGNC:29857"
                     /db_xref="MIM:609475"
                     /translation="MSYTGFVQGSETTLQSTYSDTSAQPTCDYGYGTWNSGTNRGYEG
                     YGYGYGYGQDNTTNYGYGMATSHSWEMPSSDTNANTSASGSASADSVLSRINQRLDMV
                     PHLETDMMQGGVYGSGGERYDSYESCDSRAVLSERDLYRSGYDYSELDPEMEMAYEGQ
                     YDAYRDQFRMRGNDTFGPRAQGWARDARSGRPMASGYGRMWEDPMGARGQCMSGASRL
                     PSLFSQNIIPEYGMFQGMRGGGAFPGGSRFGFGFGNGMKQMRRTWKTWTTADFRTKKK
                     KRKQGGSPDEPDSKATRTDCSDNSDSDNDEGTEGEATEGLEGTEAVEKGSRVDGEDEE
                     GKEDGREEGKEDPEKGALTTQDENGQTKRKLQAGKKSQDKQKKRQRDRMVERIQFVCS
                     LCKYRTFYEDEMASHLDSKFHKEHFKYVGTKLPKQTADFLQEYVTNKTKKTEELRKTV
                     EDLDGLIQQIYRDQDLTQEIAMEHFVKKVEAAHCAACDLFIPMQFGIIQKHLKTMDHN
                     RNRRLMMEQSKKSSLMVARSILNNKLISKKLERYLKGENPFTDSPEEEKEQEEAEGGA
                     LDEGAQGEAAGISEGAEGVPAQPPVPPEPAPGAVSPPPPPPPEEEEEGAVPLLGGALQ
                     RQIRGIPGLDVEDDEEGGGGAP"
     exon            79..153
                     /gene="AKAP8L"
                     /gene_synonym="HA95; HAP95; NAKAP; NAKAP95"
                     /inference="alignment:Splign:2.1.0"
     exon            154..186
                     /gene="AKAP8L"
                     /gene_synonym="HA95; HAP95; NAKAP; NAKAP95"
                     /inference="alignment:Splign:2.1.0"
     exon            187..427
                     /gene="AKAP8L"
                     /gene_synonym="HA95; HAP95; NAKAP; NAKAP95"
                     /inference="alignment:Splign:2.1.0"
     exon            428..881
                     /gene="AKAP8L"
                     /gene_synonym="HA95; HAP95; NAKAP; NAKAP95"
                     /inference="alignment:Splign:2.1.0"
     exon            882..978
                     /gene="AKAP8L"
                     /gene_synonym="HA95; HAP95; NAKAP; NAKAP95"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1049
                     /gene="AKAP8L"
                     /gene_synonym="HA95; HAP95; NAKAP; NAKAP95"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1113
                     /gene="AKAP8L"
                     /gene_synonym="HA95; HAP95; NAKAP; NAKAP95"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1222
                     /gene="AKAP8L"
                     /gene_synonym="HA95; HAP95; NAKAP; NAKAP95"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1364
                     /gene="AKAP8L"
                     /gene_synonym="HA95; HAP95; NAKAP; NAKAP95"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1470
                     /gene="AKAP8L"
                     /gene_synonym="HA95; HAP95; NAKAP; NAKAP95"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1601
                     /gene="AKAP8L"
                     /gene_synonym="HA95; HAP95; NAKAP; NAKAP95"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1697
                     /gene="AKAP8L"
                     /gene_synonym="HA95; HAP95; NAKAP; NAKAP95"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..2078
                     /gene="AKAP8L"
                     /gene_synonym="HA95; HAP95; NAKAP; NAKAP95"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2059..2064
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AKAP8L"
                     /gene_synonym="HA95; HAP95; NAKAP; NAKAP95"
                     /note="hexamer: AATAAA"
     polyA_site      2078
                     /gene="AKAP8L"
                     /gene_synonym="HA95; HAP95; NAKAP; NAKAP95"
                     /note="major polyA site"
ORIGIN      
        1 atcgcagcgt cggatgttca gagcagcaga agccggcgtc gtcggatgtt gtgttgcccg
       61 ccaccatgag ctacacaggc tttgtccagg gatctgaaac cactttgcag tcgacatact
      121 cggataccag cgctcagccc acctgtgatt atggatatgg aacttggaac tctgggacaa
      181 atagaggcta cgagggctat ggctatggct atggctatgg ccaggataac accaccaact
      241 atgggtatgg tatggccact tcacactctt gggaaatgcc tagctctgac acaaatgcaa
      301 acactagtgc ctcgggtagc gccagtgccg attccgtttt atccagaatt aaccagcgct
      361 tagatatggt gccgcatttg gagacagaca tgatgcaagg aggcgtgtac ggctcaggtg
      421 gagaaaggta tgactcttat gagtcctgcg actcgagggc cgtcctgagt gagcgcgacc
      481 tgtaccggtc aggctatgac tacagcgagc ttgaccctga gatggaaatg gcctatgagg
      541 gccaatacga tgcctaccgc gaccagttcc gcatgcgtgg caacgacacc ttcggtccca
      601 gggcacaggg ctgggcccgg gatgcccgga gcggccggcc aatggcctca ggctatgggc
      661 gcatgtggga agaccccatg ggggcccggg gccagtgcat gtctggtgcc tctcggctgc
      721 cctccctctt ctcccagaac atcatccccg agtacggcat gttccagggc atgcgaggtg
      781 ggggcgcctt cccgggcggc tcccgctttg gtttcgggtt tggcaatggc atgaagcaga
      841 tgaggcggac ctggaagacc tggaccacag ccgacttccg aaccaagaag aagaagagaa
      901 agcagggcgg cagtcctgat gagccagata gcaaagccac ccgcacggac tgctcggaca
      961 acagcgactc agacaatgat gagggcaccg agggggaagc cacagagggc cttgaaggca
     1021 ccgaggctgt ggagaagggc tccagagtgg acggagagga tgaggaggga aaagaggatg
     1081 ggagagaaga aggcaaagag gatccagaga agggggccct aaccacccag gatgaaaatg
     1141 gccagaccaa gcgcaagttg caggcaggca agaagagtca ggacaagcag aaaaagcggc
     1201 agcgagaccg catggtggaa aggatccagt ttgtgtgttc tctgtgcaaa taccggacct
     1261 tctatgagga cgagatggcc agccatcttg acagcaagtt ccacaaggaa cactttaagt
     1321 acgtaggcac caagctccct aagcagacgg ctgactttct gcaggagtac gtcactaaca
     1381 agaccaagaa gacagaggag ctccgaaaaa ccgtggagga ccttgatggc ctcatccagc
     1441 aaatctacag agaccaggat ctgacccagg aaattgccat ggagcatttt gtgaagaagg
     1501 tggaggcagc ccattgtgca gcctgcgacc tcttcattcc catgcagttt gggatcatcc
     1561 agaagcatct gaagaccatg gatcacaacc ggaaccgcag gctcatgatg gagcagtcca
     1621 agaagtcctc cctcatggtg gcccgcagta ttctcaacaa caagctcatc agcaagaagc
     1681 tggagcgcta cctgaagggc gagaaccctt tcaccgacag ccccgaggag gagaaggagc
     1741 aggaggaggc tgagggcggt gccctggacg agggggcgca gggcgaagcg gcagggatct
     1801 cggagggcgc agagggcgtg ccggcgcagc ctcccgtgcc cccagagcca gcccccgggg
     1861 ccgtgtcgcc gccaccgccg ccgcccccag aggaggagga ggagggcgcc gtgcccttgc
     1921 tgggaggggc gctgcaacgc cagatccgcg gcatcccggg cctcgacgtg gaggacgacg
     1981 aggagggcgg cgggggcgcc ccgtgacccg agctcggggc gggcggagcc cgcgtggccg
     2041 aagctggaaa ccaaacctaa taaagttttc ccatccca
//
