LOCUS       NM_001278309            3334 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens A-kinase anchoring protein 3 (AKAP3), transcript
            variant 1, mRNA.
ACCESSION   NM_001278309
VERSION     NM_001278309.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3334)
  AUTHORS   Liu,C., Shen,Y., Tang,S., Wang,J., Zhou,Y., Tian,S., Wu,H.,
            Cong,J., He,X., Jin,L., Cao,Y., Yang,Y. and Zhang,F.
  TITLE     Homozygous variants in AKAP3 induce asthenoteratozoospermia and
            male infertility
  JOURNAL   J Med Genet 60 (2), 137-143 (2023)
   PUBMED   35228300
  REMARK    GeneRIF: Homozygous variants in AKAP3 induce
            asthenoteratozoospermia and male infertility.
REFERENCE   2  (bases 1 to 3334)
  AUTHORS   Zhan,C.H., Ding,D.S., Zhang,W., Wang,H.L., Mao,Z.Y. and Liu,G.J.
  TITLE     The cancer-testis antigen a-kinase anchor protein 3 facilitates
            breast cancer progression via activation of the PTEN/PI3K/AKT/mTOR
            signaling
  JOURNAL   Bioengineered 13 (4), 8478-8489 (2022)
   PUBMED   35322748
  REMARK    GeneRIF: The cancer-testis antigen a-kinase anchor protein 3
            facilitates breast cancer progression via activation of the
            PTEN/PI3K/AKT/mTOR signaling.
REFERENCE   3  (bases 1 to 3334)
  AUTHORS   Rafaee,A., Kashani-Amin,E., Meybodi,A.M., Ebrahim-Habibi,A. and
            Sabbaghian,M.
  TITLE     Structural modeling of human AKAP3 protein and in silico analysis
            of single nucleotide polymorphisms associated with sperm motility
  JOURNAL   Sci Rep 12 (1), 3656 (2022)
   PUBMED   35256641
  REMARK    GeneRIF: Structural modeling of human AKAP3 protein and in silico
            analysis of single nucleotide polymorphisms associated with sperm
            motility.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3334)
  AUTHORS   Zapata-Carmona,H., Baron,L., Kong,M. and Morales,P.
  TITLE     Protein Kinase A (PRKA) Activity Is Regulated by the Proteasome at
            the Onset of Human Sperm Capacitation
  JOURNAL   Cells 10 (12), 3501 (2021)
   PUBMED   34944009
  REMARK    GeneRIF: Protein Kinase A (PRKA) Activity Is Regulated by the
            Proteasome at the Onset of Human Sperm Capacitation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3334)
  AUTHORS   Michel,J.J. and Scott,J.D.
  TITLE     AKAP mediated signal transduction
  JOURNAL   Annu Rev Pharmacol Toxicol 42, 235-257 (2002)
   PUBMED   11807172
  REMARK    Review article
REFERENCE   6  (bases 1 to 3334)
  AUTHORS   Niu,J., Vaiskunaite,R., Suzuki,N., Kozasa,T., Carr,D.W., Dulin,N.
            and Voyno-Yasenetskaya,T.A.
  TITLE     Interaction of heterotrimeric G13 protein with an
            A-kinase-anchoring protein 110 (AKAP110) mediates cAMP-independent
            PKA activation
  JOURNAL   Curr Biol 11 (21), 1686-1690 (2001)
   PUBMED   11696326
REFERENCE   7  (bases 1 to 3334)
  AUTHORS   Carr,D.W., Fujita,A., Stentz,C.L., Liberty,G.A., Olson,G.E. and
            Narumiya,S.
  TITLE     Identification of sperm-specific proteins that interact with
            A-kinase anchoring proteins in a manner similar to the type II
            regulatory subunit of PKA
  JOURNAL   J Biol Chem 276 (20), 17332-17338 (2001)
   PUBMED   11278869
REFERENCE   8  (bases 1 to 3334)
  AUTHORS   Mandal,A., Naaby-Hansen,S., Wolkowicz,M.J., Klotz,K., Shetty,J.,
            Retief,J.D., Coonrod,S.A., Kinter,M., Sherman,N., Cesar,F.,
            Flickinger,C.J. and Herr,J.C.
  TITLE     FSP95, a testis-specific 95-kilodalton fibrous sheath antigen that
            undergoes tyrosine phosphorylation in capacitated human spermatozoa
  JOURNAL   Biol Reprod 61 (5), 1184-1197 (1999)
   PUBMED   10529264
REFERENCE   9  (bases 1 to 3334)
  AUTHORS   Lefevre,A., Duquenne,C., Rousseau-Merck,M.F., Rogier,E. and
            Finaz,C.
  TITLE     Cloning and characterization of SOB1, a new testis-specific cDNA
            encoding a human sperm protein probably involved in oocyte
            recognition
  JOURNAL   Biochem Biophys Res Commun 259 (1), 60-66 (1999)
   PUBMED   10334916
REFERENCE   10 (bases 1 to 3334)
  AUTHORS   Vijayaraghavan,S., Liberty,G.A., Mohan,J., Winfrey,V.P., Olson,G.E.
            and Carr,D.W.
  TITLE     Isolation and molecular characterization of AKAP110, a novel,
            sperm-specific protein kinase A-anchoring protein
  JOURNAL   Mol Endocrinol 13 (5), 705-717 (1999)
   PUBMED   10319321
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005832.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001278309.1.
            
            Summary: This gene encodes a member of A-kinase anchoring proteins
            (AKAPs), a family of functionally related proteins that target
            protein kinase A to discrete locations within the cell. The encoded
            protein is reported to participate in protein-protein interactions
            with the R-subunit of the protein kinase A as well as
            sperm-associated proteins. This protein is expressed in spermatozoa
            and localized to the acrosomal region of the sperm head as well as
            the length of the principal piece. It may function as a regulator
            of motility, capacitation, and the acrosome reaction. [provided by
            RefSeq, May 2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.215030.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000228850.6/ ENSP00000228850.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-307               AC005832.1         46055-46361
            308-445             AC005832.1         49914-50051
            446-551             AC005832.1         53102-53207
            552-647             AC005832.1         56910-57005
            648-2957            AC005832.1         66301-68610
            2958-3334           AC005832.1         79212-79588
FEATURES             Location/Qualifiers
     source          1..3334
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.32"
     gene            1..3334
                     /gene="AKAP3"
                     /gene_synonym="AKAP 110; AKAP110; CT82; FSP95; HEL159;
                     PRKA3; SOB1; SPGF82"
                     /note="A-kinase anchoring protein 3"
                     /db_xref="GeneID:10566"
                     /db_xref="HGNC:HGNC:373"
                     /db_xref="MIM:604689"
     exon            1..307
                     /gene="AKAP3"
                     /gene_synonym="AKAP 110; AKAP110; CT82; FSP95; HEL159;
                     PRKA3; SOB1; SPGF82"
                     /inference="alignment:Splign:2.1.0"
     exon            308..445
                     /gene="AKAP3"
                     /gene_synonym="AKAP 110; AKAP110; CT82; FSP95; HEL159;
                     PRKA3; SOB1; SPGF82"
                     /inference="alignment:Splign:2.1.0"
     exon            446..551
                     /gene="AKAP3"
                     /gene_synonym="AKAP 110; AKAP110; CT82; FSP95; HEL159;
                     PRKA3; SOB1; SPGF82"
                     /inference="alignment:Splign:2.1.0"
     CDS             552..3113
                     /gene="AKAP3"
                     /gene_synonym="AKAP 110; AKAP110; CT82; FSP95; HEL159;
                     PRKA3; SOB1; SPGF82"
                     /note="Fibrous Sheath Protein of 95 kDa; cancer/testis
                     antigen 82; sperm oocyte-binding protein 1; A-kinase
                     anchor protein, 110kDa; fibrousheathin I;
                     fibrousheathin-1; protein kinase A-anchoring protein 3;
                     protein kinase A binding protein AKAP 110; epididymis
                     luminal protein 159; A kinase (PRKA) anchor protein 3;
                     epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="A-kinase anchor protein 3"
                     /protein_id="NP_001265238.2"
                     /db_xref="CCDS:CCDS8531.1"
                     /db_xref="GeneID:10566"
                     /db_xref="HGNC:HGNC:373"
                     /db_xref="MIM:604689"
                     /translation="MSEKVDWLQSQNGVCKVDVYSPGDNQAQDWKMDTSTDPVRVLSW
                     LRRDLEKSTAEFQDVRFKPGESFGGETSNSGDPHKGFSVDYYNTTTKGTPERLHFEMT
                     HKEIPCQGPRAQLGNGSSVDEVSFYANRLTNLVIAMARKEINEKIDGSENKCVYQSLY
                     MGNEPTPTKSLSKIASELVNETVSACSRNAAPDKAPGSGDRVSGSSQSPPNLKYKSTL
                     KIKESTKERQGPDDKPPSKKSFFYKEVFESRNGDYAREGGRFFPRERKRFRGQERPDD
                     FTASVSEGIMTYANSVVSDMMVSIMKTLKIQVKDTTIATILLKKVLLKHAKEVVSDLI
                     DSFLRNLHSVTGTLMTDTQFVSAVKRTVFSHGSQKATDIMDAMLRKLYNVMFAKKVPE
                     HVRKAQDKAESYSLISMKGMGDPKNRNVNFAMKSETKLREKMYSEPKSEEETCAKTLG
                     EHIIKEGLTLWHKTQQKECKSLGFQHAAFEAPNTQRKPASDISFEYPEDIGNLSLPPY
                     PPEKPENFMYDSDSWAEDLIVSALLLIQYHLAQGGRRDARSFVEAAGTTNFPANEPPV
                     APDESCLKSAPIVGDQEQAEKKDLRSVFFNFIRNLLSETIFKRDQSPEPKVPEQPVKE
                     DRKLCERPLASSPPRLYEDDETPGALSGLTKMAVSQIDGHMSGQMVEHLMNSVMKLCV
                     IIAKSCDASLAELGDDKSGDASRLTSAFPDSLYECLPAKGTGSAEAVLQNAYQAIHNE
                     MRGTSGQPPEGCAAPTVIVSNHNLTDTVQNKQLQAVLQWVAASELNVPILYFAGDDEG
                     IQEKLLQLSAAAVDKGCSVGEVLQSVLRYEKERQLNEAVGNVTPLQLLDWLMVNL"
     exon            552..647
                     /gene="AKAP3"
                     /gene_synonym="AKAP 110; AKAP110; CT82; FSP95; HEL159;
                     PRKA3; SOB1; SPGF82"
                     /inference="alignment:Splign:2.1.0"
     exon            648..2957
                     /gene="AKAP3"
                     /gene_synonym="AKAP 110; AKAP110; CT82; FSP95; HEL159;
                     PRKA3; SOB1; SPGF82"
                     /inference="alignment:Splign:2.1.0"
     exon            2958..3334
                     /gene="AKAP3"
                     /gene_synonym="AKAP 110; AKAP110; CT82; FSP95; HEL159;
                     PRKA3; SOB1; SPGF82"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3315..3320
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AKAP3"
                     /gene_synonym="AKAP 110; AKAP110; CT82; FSP95; HEL159;
                     PRKA3; SOB1; SPGF82"
                     /note="hexamer: ATTAAA"
     polyA_site      3334
                     /gene="AKAP3"
                     /gene_synonym="AKAP 110; AKAP110; CT82; FSP95; HEL159;
                     PRKA3; SOB1; SPGF82"
                     /note="major polyA site"
ORIGIN      
        1 gcctgtctgc gcaagcgcta accaagaaac gacggtttcg ggtagattgt tggttaagaa
       61 gaaagctggg aaagtgaagg agagggggaa gaaaggaagt gaaaagactt tggctgttgg
      121 aatctcagat ctggaatagg ctgtataggc tatttataat ctctaattgc cgaggaacct
      181 gaagttcaga gttaaccagt gactgactca ggacatgcaa aatggcaaga cccgaggtag
      241 aagagctcac ctttcctgac tctcagtttc ctgttccctg aaaatgtaag ctaagctggc
      301 agccctgtcc cagcaagggg gaggtacatg gaaggccaca ggaagaaaca agatcttgag
      361 ctgagcaaga acatcccagc atcttcattg actttaaaag tatattctgg agtcttccgt
      421 ggttcactat tccagtacta cagagattcc ttatattaca tggcaggagg ggggtaaact
      481 gagggatagt gaagacaaca ataaattaat caagagcttt cctcatatct cagaacctat
      541 cctctgtaag aatgtcagaa aaggttgact ggttacaaag ccaaaatgga gtatgcaaag
      601 ttgatgtcta ttctcctgga gacaaccaag cccaggactg gaaaatggac acctccacgg
      661 atcctgtcag agtgctcagc tggctccgca gagacctgga gaagagtaca gcagagttcc
      721 aagatgttcg gttcaaaccc ggagaatcat ttggtgggga aacgtccaac tcaggagacc
      781 cacacaaagg tttctctgta gactattaca acaccaccac caagggcact ccagaaagat
      841 tgcattttga gatgactcac aaagagattc cttgccaggg ccccagggcc caacttggca
      901 acgggagttc agtagatgaa gtttccttct atgctaaccg cctcacgaat ctagtcatag
      961 ccatggcccg caaagagatc aatgagaaga tcgatggctc tgaaaacaaa tgtgtctatc
     1021 agtcattgta catggggaat gaacccacac ccaccaaaag cctcagtaag atagcatcag
     1081 agcttgtgaa tgagaccgtc tctgcatgtt ccaggaatgc tgccccagac aaggctcctg
     1141 gctctggaga cagagtctcg ggatcatcac aaagtccccc aaatttgaaa tacaagtcca
     1201 ctttgaagat caaggagagc accaaagaaa gacagggtcc agatgacaag cctccttcta
     1261 agaagtcttt cttctataag gaagtgtttg aatctcgtaa tggagattat gccagagagg
     1321 gtggaaggtt ctttcctcgg gagagaaaga ggtttcgagg gcaggaaagg cctgatgact
     1381 ttacggcttc tgttagtgaa gggatcatga cctatgctaa cagtgtggta tctgatatga
     1441 tggtctccat catgaagaca ctgaagatcc aagtgaaaga cacaaccatt gccaccatcc
     1501 tactgaagaa ggttctgctc aagcatgcaa aagaggtggt ctcggatctc atcgactcct
     1561 tcttgaggaa tctccacagc gtcacaggga ccctcatgac tgacacacag tttgtctcgg
     1621 ctgtgaaaag aactgtcttc tctcatggaa gccaaaaggc cacagatatc atggatgcca
     1681 tgctaaggaa gctgtacaat gtaatgtttg ccaagaaagt ccctgagcat gtcaggaaag
     1741 cccaagacaa ggctgagagt tattccctca tctccatgaa aggaatgggt gatcctaaaa
     1801 accgaaatgt gaactttgcc atgaaatctg aaactaaatt gagagaaaaa atgtattctg
     1861 aacccaaatc agaggaggag acttgtgcga aaactctggg tgagcacatt atcaaagagg
     1921 ggcttacctt gtggcataaa actcagcaga aagaatgtaa atctctaggt ttccagcatg
     1981 cagcatttga agctcccaac acacagcgta agcctgcatc agacatttcc tttgagtacc
     2041 ctgaagatat tggcaacctc agccttcctc catatcctcc agagaaacct gagaatttta
     2101 tgtatgattc agactcctgg gccgaggacc tgatcgtgtc tgccctgctt ctgattcaat
     2161 atcacctggc ccagggagga agaagggatg cacggagctt cgttgaagct gctggcacca
     2221 ccaactttcc tgccaatgaa cctcctgtag ctcccgatga atcttgcctt aagtctgctc
     2281 ccattgtagg tgaccaagaa caagcagaaa agaaggacct aaggagtgtt ttctttaatt
     2341 tcatccggaa cttacttagt gagaccattt tcaagcgtga ccagagccct gaacccaagg
     2401 tgccggaaca gccagttaag gaagatagga agttgtgtga aagaccgttg gcgtcttctc
     2461 cccccaggct atatgaggat gatgagaccc ctggtgccct ttctgggctg accaagatgg
     2521 ctgtcagcca gatagatggc cacatgagtg ggcagatggt agaacatctg atgaactcag
     2581 tgatgaagct gtgtgtcatc attgctaagt cctgtgatgc ttcgttggca gagctgggag
     2641 atgacaagtc tggagatgcc agtaggctaa cttcggcctt cccagatagt ttatatgagt
     2701 gcttaccagc caagggcaca gggtcagcag aagctgtcct gcagaatgcc tatcaagcta
     2761 tccataatga aatgagaggc acatcaggac agccccctga agggtgtgca gcacccacgg
     2821 tgattgtcag caatcacaac ctaacggaca cagttcagaa caagcaactc caagccgtcc
     2881 ttcaatgggt agctgcctct gagctcaatg tccctatttt gtattttgct ggtgatgatg
     2941 aagggatcca ggagaagcta cttcagctct cagctgctgc tgtggacaaa ggatgcagtg
     3001 tgggcgaggt tctgcagtcg gtgctgcgct atgagaagga gcgccagctg aatgaggcgg
     3061 tggggaatgt cacaccgctg cagctgctgg actggctgat ggtgaacctg taatcggcaa
     3121 ccccactgct ttcccctctt ctggcagtgg ggccggccct tatccccgcc cttctttctc
     3181 acttccacat ctccccctct atatcctcac agagccctaa cattatcttc acaccactct
     3241 catcaaagac atgtcatctt gtgctagcca ctggattttg cagattttcc tgtccatgca
     3301 agcaaggacg taaaattaaa aaattacaat taaa
//
