LOCUS       NM_005088               3199 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens A-kinase anchoring protein 17A (AKAP17A), transcript
            variant 1, mRNA.
ACCESSION   NM_005088
VERSION     NM_005088.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3199)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3199)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3199)
  AUTHORS   Lee,B.P., Pilling,L.C., Bandinelli,S., Ferrucci,L., Melzer,D. and
            Harries,L.W.
  TITLE     The transcript expression levels of HNRNPM, HNRNPA0 and AKAP17A
            splicing factors may be predictively associated with ageing
            phenotypes in human peripheral blood
  JOURNAL   Biogerontology 20 (5), 649-663 (2019)
   PUBMED   31292793
  REMARK    GeneRIF: The expression of splicing factor gene AKAP17A was
            associated with Cognitive Decline as measured by the Mini-Mental
            State Examinations and also with a decline in Physical Ability as
            measured by hand-grip strength in ageing human population.
REFERENCE   4  (bases 1 to 3199)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3199)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 3199)
  AUTHORS   Jarnaess,E., Stokka,A.J., Kvissel,A.K., Skalhegg,B.S.,
            Torgersen,K.M., Scott,J.D., Carlson,C.R. and Tasken,K.
  TITLE     Splicing factor arginine/serine-rich 17A (SFRS17A) is an A-kinase
            anchoring protein that targets protein kinase A to splicing factor
            compartments
  JOURNAL   J Biol Chem 284 (50), 35154-35164 (2009)
   PUBMED   19840947
REFERENCE   7  (bases 1 to 3199)
  AUTHORS   Mangs,A.H., Speirs,H.J., Goy,C., Adams,D.J., Markus,M.A. and
            Morris,B.J.
  TITLE     XE7: a novel splicing factor that interacts with ASF/SF2 and ZNF265
  JOURNAL   Nucleic Acids Res 34 (17), 4976-4986 (2006)
   PUBMED   16982639
  REMARK    GeneRIF: The spliceosomal component XE7 resembles an SR-related
            splicing protein, and can influence alternative splicing.
REFERENCE   8  (bases 1 to 3199)
  AUTHORS   Ried,K., Rao,E., Schiebel,K. and Rappold,G.A.
  TITLE     Gene duplications as a recurrent theme in the evolution of the
            human pseudoautosomal region 1: isolation of the gene ASMTL
  JOURNAL   Hum Mol Genet 7 (11), 1771-1778 (1998)
   PUBMED   9736779
REFERENCE   9  (bases 1 to 3199)
  AUTHORS   Ellison,J.W., Ramos,C., Yen,P.H. and Shapiro,L.J.
  TITLE     Structure and expression of the human pseudoautosomal gene XE7
  JOURNAL   Hum Mol Genet 1 (9), 691-696 (1992)
   PUBMED   1302606
REFERENCE   10 (bases 1 to 3199)
  AUTHORS   Voland,J.R., Wyzykowski,R.J., Huang,M. and Dutton,R.W.
  TITLE     Cloning and sequencing of a trophoblast-endothelial-activated
            lymphocyte surface protein: cDNA sequence and genomic structure
  JOURNAL   Proc Natl Acad Sci U S A 89 (21), 10425-10429 (1992)
   PUBMED   1438229
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC016935.1, BC028151.1,
            BC015800.1, BM713425.1, M99578.1 and BM046630.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_005088.2.
            
            Summary: This locus encodes a protein kinase A anchoring protein.
            The encoded protein is part of the spliceosome complex and is
            involved in the regulation of alternate splicing in some mRNA
            precursors. Alternatively spliced transcript variants have been
            identified for this gene.[provided by RefSeq, Sep 2010].
            
            Transcript Variant: This variant (1) encodes the functional
            protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.115823.1,
                                           SRR3476690.948348.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000313871.9/ ENSP00000324827.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-850               BC016935.1         12-861
            851-1096            BC028151.1         830-1075
            1097-1682           BC015800.1         1018-1603
            1683-1762           BM713425.1         484-563
            1763-2637           M99578.1           1745-2619
            2638-3193           BC015800.1         2559-3114
            3194-3199           BM046630.1         456-461
FEATURES             Location/Qualifiers
     source          1..3199
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /chromosome="Y"
                     /map="X"
                     /map="Y"
     gene            1..3199
                     /gene="AKAP17A"
                     /gene_synonym="721P; AKAP-17A; CCDC133; CXYorf3; DXYS155E;
                     PRKA17A; SFRS17A; XE7; XE7Y"
                     /note="A-kinase anchoring protein 17A"
                     /db_xref="GeneID:8227"
                     /db_xref="HGNC:HGNC:18783"
                     /db_xref="MIM:312095"
                     /db_xref="MIM:465000"
     exon            1..166
                     /gene="AKAP17A"
                     /gene_synonym="721P; AKAP-17A; CCDC133; CXYorf3; DXYS155E;
                     PRKA17A; SFRS17A; XE7; XE7Y"
                     /inference="alignment:Splign:2.1.0"
     exon            167..947
                     /gene="AKAP17A"
                     /gene_synonym="721P; AKAP-17A; CCDC133; CXYorf3; DXYS155E;
                     PRKA17A; SFRS17A; XE7; XE7Y"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..2273
                     /gene="AKAP17A"
                     /gene_synonym="721P; AKAP-17A; CCDC133; CXYorf3; DXYS155E;
                     PRKA17A; SFRS17A; XE7; XE7Y"
                     /note="isoform 1 is encoded by transcript variant 1;
                     splicing factor, arginine/serine-rich 17A; A-kinase anchor
                     protein 17A; B-lymphocyte surface antigen; pseudoautosomal
                     gene XE7; protein kinase A-anchoring protein 17A; A kinase
                     (PRKA) anchor protein 17A"
                     /codon_start=1
                     /product="A-kinase anchor protein 17A isoform 1"
                     /protein_id="NP_005079.2"
                     /db_xref="CCDS:CCDS14116.1"
                     /db_xref="GeneID:8227"
                     /db_xref="HGNC:HGNC:18783"
                     /db_xref="MIM:312095"
                     /db_xref="MIM:465000"
                     /translation="MAAATIVHDTSEAVELCPAYGLYLKPITKMTISVALPQLKQPGK
                     SISNWEVMERLKGMVQNHQFSTLRISKSTMDFIRFEGEVENKSLVKSFLACLDGKTIK
                     LSGFSDILKVRAAEFKIDFPTRHDWDSFFRDAKDMNETLPGERPDTIHLEGLPCKWFA
                     LKESGSEKPSEDVLVKVFEKFGEIRNVDIPMLDPYREEMTGRNFHTFSFGGHLNFEAY
                     VQYREYMGFIQAMSALRGMKLMYKGEDGKAVACNIKVSFDSTKHLSDASIKKRQLERQ
                     KLQELEQQREEQKRREKEAEERQRAEERKQKELEELERERKREEKLRKREQKQRDREL
                     RRNQKKLEKLQAEEQKQLQEKIKLEERKLLLAQRNLQSIRLIAELLSRAKAVKLREQE
                     QKEEKLRLQQQEERRRLQEAELRRVEEEKERALGLQRKERELRERLLSILLSKKPDDS
                     HTHDELGVAHADLLQPVLDILQTVSSGCVSATTLHPLGGQPPAGAPKESPAHPEADGA
                     PKSVNGSVAEEAPCKEVQSSCRVVPEDGSPEKRCPGGVLSCIPDNNQQPKGIPACEQN
                     VSRKDTRSEQDKCNREPSKGRGRATGDGLADRHKRERSRARRASSREDGRPRKERRPH
                     KKHAYKDDSPRRRSTSPDHTRSRRSHSKDRHRRERSRERRGSASRKHSRHRRRSERSR
                     SRSPSRHRSTWNR"
     exon            948..1096
                     /gene="AKAP17A"
                     /gene_synonym="721P; AKAP-17A; CCDC133; CXYorf3; DXYS155E;
                     PRKA17A; SFRS17A; XE7; XE7Y"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1337
                     /gene="AKAP17A"
                     /gene_synonym="721P; AKAP-17A; CCDC133; CXYorf3; DXYS155E;
                     PRKA17A; SFRS17A; XE7; XE7Y"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..3199
                     /gene="AKAP17A"
                     /gene_synonym="721P; AKAP-17A; CCDC133; CXYorf3; DXYS155E;
                     PRKA17A; SFRS17A; XE7; XE7Y"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3172..3177
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AKAP17A"
                     /gene_synonym="721P; AKAP-17A; CCDC133; CXYorf3; DXYS155E;
                     PRKA17A; SFRS17A; XE7; XE7Y"
                     /note="hexamer: AATAAA"
     polyA_site      3199
                     /gene="AKAP17A"
                     /gene_synonym="721P; AKAP-17A; CCDC133; CXYorf3; DXYS155E;
                     PRKA17A; SFRS17A; XE7; XE7Y"
                     /note="major polyA site"
ORIGIN      
        1 gtcatagagg gcgggcggcg acggcggtgg cggcgtcgga ggcgcctccg ggggacggtg
       61 gcggctcccg gcggtgaggc cgcgcctgtc cggggatcgt cgagggacgg cgggagcttg
      121 ggccagcggc ggcggcggcc tgggacgcag gcggagcccc gcgcaggccc aaggtcccgg
      181 aggctatggc agcggctacc atcgtgcacg acacgtctga ggccgtggag ctctgccctg
      241 cttacggctt gtacctgaag cccatcacca agatgaccat cagcgtggca ctcccgcagc
      301 tgaagcagcc ggggaagtcc atctccaact gggaggtgat ggagaggctg aagggcatgg
      361 tgcagaacca ccagttctcc acgctgcgta tttccaagag caccatggac ttcatccgct
      421 tcgaggggga ggtggagaac aagagcctgg tcaagtcttt tctggcctgc ctggacggca
      481 agaccatcaa gctcagcggc ttctccgaca tcctgaaggt gcgcgcggcc gagttcaaga
      541 tcgacttccc cacccgccac gactgggact ccttcttccg cgacgccaag gacatgaacg
      601 agaccctgcc gggggagcgg ccggacacca tccacctgga ggggctgccc tgcaagtggt
      661 tcgccctgaa ggagtcgggc tccgagaagc ccagcgagga cgtcctggtc aaggtgtttg
      721 agaagttcgg ggagatccgg aatgtggaca tccccatgct ggacccctac cgggaggaga
      781 tgacgggccg caacttccac accttcagtt tcggggggca cttgaacttc gaggcctatg
      841 tgcagtaccg cgagtacatg ggcttcatcc aggccatgag cgccctgcgc gggatgaaac
      901 tcatgtacaa gggcgaggac ggcaaggccg tggcctgcaa catcaaggtt tcttttgatt
      961 cgaccaaaca cctgagtgat gcctcaatta agaagcggca gctggagagg cagaagcttc
     1021 aggaactgga gcagcaaaga gaagaacaaa agcgcagaga gaaggaagcg gaggagaggc
     1081 agcgagcgga ggaaaggaaa caaaaggagc tggaagagct ggagcgagag aggaaaagag
     1141 aagagaagct tcgcaagagg gagcagaagc agagggaccg tgagctgcgc cggaatcaga
     1201 agaagctgga gaagctgcag gcggaggagc agaagcagct gcaggagaag atcaagctgg
     1261 aggagcgcaa gctgctgctg gcccagagga acctgcagtc catccggctc atcgccgagc
     1321 tgctcagcag agccaaggct gtgaagctac gggaacagga gcagaaggag gagaagctga
     1381 ggctccagca gcaggaggag cggcggcggc tgcaggaggc cgagctgcgg cgcgtggagg
     1441 aggagaagga gcgcgcgctg ggcctgcagc ggaaagagcg ggagctgcgc gagcggctgc
     1501 tgagcatcct gctgagcaag aagccggacg acagccacac acacgacgag ctgggcgtgg
     1561 cacacgccga cctgctgcag cccgtcctgg acatcctgca gaccgtgtcg tccggctgtg
     1621 tgagcgccac cacgctgcac cccctcgggg gccagccccc ggccggtgcc cccaaggaga
     1681 gcccggccca cccagaggcc gacggcgctc ccaaaagcgt gaacgggagc gtggccgagg
     1741 aggccccatg caaggaggtt cagagctcct gtcgtgtggt ccccgaggat ggctctccag
     1801 agaagaggtg cccgggcggc gtcctctcct gcattcctga caacaaccaa cagcccaagg
     1861 gcatccctgc ctgcgagcag aatgtctcca gaaaggacac ccggtcagaa caggacaagt
     1921 gcaaccggga gcccagcaag ggccggggcc gggccaccgg agacgggctt gctgaccggc
     1981 acaagcggga gaggagccgg gccaggcggg ccagcagcag ggaggacggg aggccacgca
     2041 aggagcggcg gccccacaag aagcacgcct acaaggatga cagcccccgc cggcgcagca
     2101 cgagcccgga ccacacccgg tcccggaggt cccacagcaa agacaggcac cggagggagc
     2161 ggagccggga gcggaggggc agcgccagca ggaagcacag ccgccaccgc cgccgaagcg
     2221 agcggtcgcg ctcccggtcc ccgagcaggc accgcagtac ctggaacagg taatgacggg
     2281 cacggcctcc ccacggcctg tccgggaaag accaggacct gctcgagcct cctggccgct
     2341 ccttggccgc tctccgtcca cccctgcaaa gccaagaccc ttctgcagcc acgaatgtcc
     2401 acggagcccg ccggcaggaa ggaagacacc atgctttaga gatccatctt tctccactca
     2461 ccgcagcgta cttggcactt cagtttcaaa cacgtagtcc tttaaaactt gatccgatag
     2521 ctttaatgcg gccggtcctc tctcagtcag gaaaattgca cagaccgaca gtcgtgagga
     2581 tggcagagct gctgcattcc cccacacggg gatttctgtg tctgcttggc gacctccctg
     2641 cgtgcacggc ctaggaggtg cacgggccac catagtcaca ctggcactga aaagaaagcg
     2701 ttgccctggt gattctttcc cccccgtttg taatgttaac tgatcaggaa gtgcagtttg
     2761 ggtgggatgc cgaatcgtcg tgctgacatt gagtcacgga tgaggaaggt acaagtcctt
     2821 taagatcaaa actcaaacgg gccgttcttt ctaaggtgtc ggtatgtggg gagtggtaca
     2881 aaatggtctg atgctccttc aaaaacattc actttttaca acgtcaagga attaagcata
     2941 aaaaagattg gttaaaagct ttggtttcta gtaaaggtta gtgtgtgtgg tttttttaag
     3001 aagctgtttt gctaaattat ttttacttgg aatgtttcaa acagatttca ggctgcaaac
     3061 ttgttttata atcgtttgct tctccaagtg aagctcagaa atacctaaaa atagctgtaa
     3121 cgttcgcgtt aggaaagatg gtgtttattc cagtttgcat ttttatggtg aaataaaatc
     3181 cttttccaat gaactaaaa
//
