LOCUS       NM_178813                921 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens A-kinase anchoring protein 14 (AKAP14), transcript
            variant 1, mRNA.
ACCESSION   NM_178813
VERSION     NM_178813.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 921)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 921)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 921)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 921)
  AUTHORS   Kultgen,P.L., Byrd,S.K., Ostrowski,L.E. and Milgram,S.L.
  TITLE     Characterization of an A-kinase anchoring protein in human ciliary
            axonemes
  JOURNAL   Mol Biol Cell 13 (12), 4156-4166 (2002)
   PUBMED   12475942
  REMARK    GeneRIF: AKAP28 likely plays a role in the signaling necessary for
            efficient modulation of ciliary beat frequency
REFERENCE   5  (bases 1 to 921)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC002477.1 and BC066357.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_178813.5.
            
            Summary: The A-kinase anchor proteins (AKAPs) are a group of
            structurally diverse proteins, which have the common function of
            binding to the regulatory subunit of protein kinase A (PKA) and
            confining the holoenzyme to discrete locations within the cell.
            This gene encodes a member of the AKAP family. The protein anchors
            PKA in ciliary axonemes and, in this way, may play a role in
            regulating ciliary beat frequency. Alternate transcriptional splice
            variants, encoding different isoforms, have been characterized.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066357.1, BI559462.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371431.8/ ENSP00000360485.3
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                AC002477.1         72418-72497
            81-921              BC066357.1         138-978
FEATURES             Location/Qualifiers
     source          1..921
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq24"
     gene            1..921
                     /gene="AKAP14"
                     /gene_synonym="AKAP28; PRKA14"
                     /note="A-kinase anchoring protein 14"
                     /db_xref="GeneID:158798"
                     /db_xref="HGNC:HGNC:24061"
                     /db_xref="MIM:300462"
     exon            1..95
                     /gene="AKAP14"
                     /gene_synonym="AKAP28; PRKA14"
                     /inference="alignment:Splign:2.1.0"
     exon            96..208
                     /gene="AKAP14"
                     /gene_synonym="AKAP28; PRKA14"
                     /inference="alignment:Splign:2.1.0"
     exon            209..387
                     /gene="AKAP14"
                     /gene_synonym="AKAP28; PRKA14"
                     /inference="alignment:Splign:2.1.0"
     CDS             219..812
                     /gene="AKAP14"
                     /gene_synonym="AKAP28; PRKA14"
                     /note="isoform a is encoded by transcript variant 1;
                     A-kinase anchoring protein 28; A-kinase anchor protein 14;
                     AKAP 28; AKAP-14; A-kinase anchor protein 28 kDa; protein
                     kinase A-anchoring protein 14; A kinase (PRKA) anchor
                     protein 14"
                     /codon_start=1
                     /product="A-kinase anchor protein 14 isoform a"
                     /protein_id="NP_848928.1"
                     /db_xref="CCDS:CCDS14591.1"
                     /db_xref="GeneID:158798"
                     /db_xref="HGNC:HGNC:24061"
                     /db_xref="MIM:300462"
                     /translation="MSETQNSTSQKAMDEDNKAASQTMPNTQDKNYEDELTQVALALV
                     EDVINYAVKIVEEERNPLKNIKWMTHGEFTVEKGLKQIDEYFSKCVSKKCWAHGVEFV
                     ERKDLIHSFLYIYYVHWSISTADLPVARISAGTYFTMKVSKTKPPDAPIVVSYVGDHQ
                     ALVHRPGMVRFRENWQKNLTDAKYSFMESFPFLFNRV"
     exon            388..479
                     /gene="AKAP14"
                     /gene_synonym="AKAP28; PRKA14"
                     /inference="alignment:Splign:2.1.0"
     exon            480..659
                     /gene="AKAP14"
                     /gene_synonym="AKAP28; PRKA14"
                     /inference="alignment:Splign:2.1.0"
     exon            660..712
                     /gene="AKAP14"
                     /gene_synonym="AKAP28; PRKA14"
                     /inference="alignment:Splign:2.1.0"
     exon            713..921
                     /gene="AKAP14"
                     /gene_synonym="AKAP28; PRKA14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      902..907
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AKAP14"
                     /gene_synonym="AKAP28; PRKA14"
                     /note="hexamer: AATAAA"
     polyA_site      921
                     /gene="AKAP14"
                     /gene_synonym="AKAP28; PRKA14"
                     /note="major polyA site"
ORIGIN      
        1 atagggatgc ccaatacata ccagctgtga ggcttatcac cactgttctt cctggcatgg
       61 ccctgtaagc tcatcttcgg ctgaagagaa gctagcactt gcaaacattc catctggcaa
      121 tctgagagaa gctactgaga gaatcctgag acatccccag ccacctacca ctgctcctgt
      181 tccaagcaaa gaagatctgc tcactccgga aaaagaaaat gagtgagact caaaattcaa
      241 caagccagaa agcaatggat gaggataaca aagccgcaag ccaaacaatg ccgaatacac
      301 aagacaagaa ctacgaggat gaattgactc aagtagctct agctctggtt gaggatgtca
      361 tcaattatgc tgttaagatt gtggaagagg agcgaaaccc tttgaaaaac atcaagtgga
      421 tgactcacgg tgaattcact gtggaaaagg gtcttaaaca aattgacgaa tatttttcga
      481 agtgtgtttc taaaaaatgc tgggcacatg gcgtagagtt tgtagagagg aaagacttaa
      541 ttcacagctt cctctacatc tactatgtac actggagtat ctcaactgct gacctacccg
      601 tagcacgaat ctctgctggt acctacttca ccatgaaggt ctccaaaacc aaaccaccgg
      661 atgcacccat tgttgtttct tatgtaggtg accaccaagc attagttcac agaccaggaa
      721 tggttcgctt tcgagaaaac tggcagaaga atcttactga tgccaaatat agtttcatgg
      781 agtcattccc cttcttattc aatcgtgtct gatacttaca ggatgtctta ggattgtttt
      841 tctcatcagg atacattaaa aatacaatac agcacgtcaa accacagaat atttattgag
      901 taataaactt gtggcacaca a
//
