LOCUS       NM_016248               9915 bp    mRNA    linear   PRI 03-MAY-2024
DEFINITION  Homo sapiens A-kinase anchoring protein 11 (AKAP11), mRNA.
ACCESSION   NM_016248
VERSION     NM_016248.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9915)
  AUTHORS   Hsu,Y.H., Pintacuda,G., Liu,R., Nacu,E., Kim,A., Tsafou,K.,
            Petrossian,N., Crotty,W., Suh,J.M., Riseman,J., Martin,J.M.,
            Biagini,J.C., Mena,D., Ching,J.K.T., Malolepsza,E., Li,T.,
            Singh,T., Ge,T., Egri,S.B., Tanenbaum,B., Stanclift,C.R.,
            Apffel,A.M., Carr,S.A., Schenone,M., Jaffe,J., Fornelos,N.,
            Huang,H., Eggan,K.C. and Lage,K.
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium;
            Stanley Global Asia Initiatives
  TITLE     Using brain cell-type-specific protein interactomes to interpret
            neurodevelopmental genetic signals in schizophrenia
  JOURNAL   iScience 26 (5), 106701 (2023)
   PUBMED   37207277
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9915)
  AUTHORS   Palmer,D.S., Howrigan,D.P., Chapman,S.B., Adolfsson,R., Bass,N.,
            Blackwood,D., Boks,M.P.M., Chen,C.Y., Churchhouse,C., Corvin,A.P.,
            Craddock,N., Curtis,D., Di Florio,A., Dickerson,F., Freimer,N.B.,
            Goes,F.S., Jia,X., Jones,I., Jones,L., Jonsson,L., Kahn,R.S.,
            Landen,M., Locke,A.E., McIntosh,A.M., McQuillin,A., Morris,D.W.,
            O'Donovan,M.C., Ophoff,R.A., Owen,M.J., Pedersen,N.L., Posthuma,D.,
            Reif,A., Risch,N., Schaefer,C., Scott,L., Singh,T., Smoller,J.W.,
            Solomonson,M., Clair,D.S., Stahl,E.A., Vreeker,A., Walters,J.T.R.,
            Wang,W., Watts,N.A., Yolken,R., Zandi,P.P. and Neale,B.M.
  TITLE     Exome sequencing in bipolar disorder identifies AKAP11 as a risk
            gene shared with schizophrenia
  JOURNAL   Nat Genet 54 (5), 541-547 (2022)
   PUBMED   35410376
  REMARK    GeneRIF: Exome sequencing in bipolar disorder identifies AKAP11 as
            a risk gene shared with schizophrenia.
REFERENCE   3  (bases 1 to 9915)
  AUTHORS   Deng,Z., Li,X., Blanca Ramirez,M., Purtell,K., Choi,I., Lu,J.H.,
            Yu,Q. and Yue,Z.
  TITLE     Selective autophagy of AKAP11 activates cAMP/PKA to fuel
            mitochondrial metabolism and tumor cell growth
  JOURNAL   Proc Natl Acad Sci U S A 118 (14) (2021)
   PUBMED   33785595
  REMARK    GeneRIF: Selective autophagy of AKAP11 activates cAMP/PKA to fuel
            mitochondrial metabolism and tumor cell growth.
REFERENCE   4  (bases 1 to 9915)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 9915)
  AUTHORS   Correa-Rodriguez,M., Schmidt Rio-Valle,J. and Rueda-Medina,B.
  TITLE     AKAP11 gene polymorphism is associated with bone mass measured by
            quantitative ultrasound in young adults
  JOURNAL   Int J Med Sci 15 (10), 999-1004 (2018)
   PUBMED   30013441
  REMARK    GeneRIF: AKAP11 gene (rs9533090) influences QUS trait in a
            population of Caucasian young adults. The rs9533090 SNP may be
            considered a factor affecting peak bone mass acquisition.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9915)
  AUTHORS   Schillace,R.V., Voltz,J.W., Sim,A.T., Shenolikar,S. and Scott,J.D.
  TITLE     Multiple interactions within the AKAP220 signaling complex
            contribute to protein phosphatase 1 regulation
  JOURNAL   J Biol Chem 276 (15), 12128-12134 (2001)
   PUBMED   11152471
REFERENCE   7  (bases 1 to 9915)
  AUTHORS   Reinton,N., Collas,P., Haugen,T.B., Skalhegg,B.S., Hansson,V.,
            Jahnsen,T. and Tasken,K.
  TITLE     Localization of a novel human A-kinase-anchoring protein, hAKAP220,
            during spermatogenesis
  JOURNAL   Dev Biol 223 (1), 194-204 (2000)
   PUBMED   10864471
REFERENCE   8  (bases 1 to 9915)
  AUTHORS   Schillace,R.V. and Scott,J.D.
  TITLE     Association of the type 1 protein phosphatase PP1 with the A-kinase
            anchoring protein AKAP220
  JOURNAL   Curr Biol 9 (6), 321-324 (1999)
   PUBMED   10209101
REFERENCE   9  (bases 1 to 9915)
  AUTHORS   Lester,L.B. and Scott,J.D.
  TITLE     Anchoring and scaffold proteins for kinases and phosphatases
  JOURNAL   Recent Prog Horm Res 52, 409-29 (1997)
   PUBMED   9238861
  REMARK    Review article
REFERENCE   10 (bases 1 to 9915)
  AUTHORS   Lester,L.B., Coghlan,V.M., Nauert,B. and Scott,J.D.
  TITLE     Cloning and characterization of a novel A-kinase anchoring protein.
            AKAP 220, association with testicular peroxisomes
  JOURNAL   J Biol Chem 271 (16), 9460-9465 (1996)
   PUBMED   8621616
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL136527.9, AF176555.1,
            DA780016.1, BE694434.1 and BE670178.1.
            
            On Nov 24, 2018 this sequence version replaced NM_016248.3.
            
            Summary: The A-kinase anchor proteins (AKAPs) are a group of
            structurally diverse proteins, which have the common function of
            binding to the regulatory subunit of protein kinase A (PKA) and
            confining the holoenzyme to discrete locations within the cell.
            This gene encodes a member of the AKAP family. The encoded protein
            is expressed at high levels throughout spermatogenesis and in
            mature sperm. It binds the RI and RII subunits of PKA in testis. It
            may serve a function in cell cycle control of both somatic cells
            and germ cells in addition to its putative role in spermatogenesis
            and sperm function. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF176555.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000025301.4/ ENSP00000025301.2
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AL136527.9         97002-97002         c
            2-4558              AF176555.1         1-4557
            4559-4977           DA780016.1         141-559
            4978-5323           AF176555.1         4977-5322
            5324-5589           BE694434.1         180-445
            5590-6367           AF176555.1         5589-6366
            6368-9893           AL136527.9         45915-49440         c
            9894-9915           BE670178.1         13-34               c
FEATURES             Location/Qualifiers
     source          1..9915
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.11"
     gene            1..9915
                     /gene="AKAP11"
                     /gene_synonym="AKAP-11; AKAP220; PPP1R44; PRKA11"
                     /note="A-kinase anchoring protein 11"
                     /db_xref="GeneID:11215"
                     /db_xref="HGNC:HGNC:369"
                     /db_xref="MIM:604696"
     exon            1..77
                     /gene="AKAP11"
                     /gene_synonym="AKAP-11; AKAP220; PPP1R44; PRKA11"
                     /inference="alignment:Splign:2.1.0"
     exon            78..127
                     /gene="AKAP11"
                     /gene_synonym="AKAP-11; AKAP220; PPP1R44; PRKA11"
                     /inference="alignment:Splign:2.1.0"
     exon            128..227
                     /gene="AKAP11"
                     /gene_synonym="AKAP-11; AKAP220; PPP1R44; PRKA11"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..5882
                     /gene="AKAP11"
                     /gene_synonym="AKAP-11; AKAP220; PPP1R44; PRKA11"
                     /note="A-kinase anchoring protein, 220kDa; A kinase (PRKA)
                     anchor protein 11; protein kinase A anchoring protein 11;
                     a kinase anchor protein 220 kDa; A-kinase anchor protein
                     220 kDa; protein phosphatase 1, regulatory subunit 44"
                     /codon_start=1
                     /product="A-kinase anchor protein 11"
                     /protein_id="NP_057332.1"
                     /db_xref="CCDS:CCDS9383.1"
                     /db_xref="GeneID:11215"
                     /db_xref="HGNC:HGNC:369"
                     /db_xref="MIM:604696"
                     /translation="MATFRNNHMKTKASVRKSFSEDVFQSVKSLLQSQKELCSVTAED
                     CLQQDEHANLTEVTFLGFNEETDAAHIQDLAAVSLELPDILNSLHFCSLNENEIICMK
                     NINKPLDISSDPLNQSHPSGMLCVMRVSPTSPRLRIDFIFSLLSKYATGIRYTLDTFL
                     HQKHQLETTDEDDDDTNQSVSSIEDDFVTAFEHLEEEETSKPYNDGMNITVLRSQCDA
                     ASQTVTGHHLETHDLKILISSGQQKSLAKPSTSSVNVLGHKELPSVKTSVTTSISEPW
                     TQRSFYRSSNASDKDSDLQKTFFSSSPAYSSESECSSPSPVIFLDEEGYQKSLKAKLE
                     LPKIPVMKDDIEDSDSEVSEFFDSFDQFDELEQTLETCLFNKDPVIGKSSQRKGHKHG
                     KSCMNPQKFKFDRPALPANVRKPTPRKPESPYGNLCDAPDSPRPVKASREDSGLFSPI
                     RSSAFSPLGGCTPAECFCQTDIGGDRIHENHDSVYYTYEDYAKSISCEVLGSVLRTHH
                     TNTLSNINSIKHGENKTVTFKHGNLDQKNKSKNKSLMIKDSIQKFAADLVEKSFGSAF
                     KDLQKGVSSCTNALYHLAIKLTSSVLQMAFDELRRQRAFSLKERAISGLANFLVSEAL
                     SNALKDLQYVKKQIFTNTVARFAADLAEELVFEGIMEVCQFSYPQTPASPQCGSFDFE
                     DKVVKLYAKDLSESVIQEAFIELSQVDVTFTTKAAVSVSTDNIKYVSAESVVPSTQAV
                     TFSPSFHNQAIMVTKPVQEYKKEYTVQQALFCTSGIVTSIPVPLAGSALLPYHISSTA
                     CQAKAHLSSDDSNSNGDSAQVHIATKNREEKAACLRNICLPSEHNPGNQNDFKPTNDD
                     IEMQSSSKLPNDPAIISNFSAAVVHTIVNETLESMTSLEVTKMVDERTDYLTKSLKEK
                     TPPFSHCDQAVLQCSEASSNKDMFADRLSKSIIKHSIDKSKSVIPNIDKNAVYKESLP
                     VSGEESQLTPEKSPKFPDSQNQLTHCSLSAAKDCVPECKVSMVHGSSLETLPSCPAVT
                     GQKSDLKESAKDQPLKKHNLNSTSLEALSFGQENPFPHSHTFSSTALTCVDGLHVEDK
                     QKVRDRNVIPDTPPSTPLVPSRASSEWDIKKLTKKLKGELAKEFAPATPPSTPHNSSV
                     GSLSENEQNTIEKEEFMLKLMRSLSEEVESSESGELPEVDVKSEHSGKKVQFAEALAT
                     HILSLATEMAASHLDNKIIQEPKVKNPCLNVQSQRSVSPTFLNPSDENLKTLCNFAGD
                     LAAEVITEAEKIAKVRNCMLFKQKKNSCYADGDEDYKVEEKLDIEAVVHPREVDPFIL
                     SLPPSSCMSGLMYKYPSCESVTDEYAGHLIQILKQEGGNSELIMDQYANRLAYRSVKS
                     GLQEAAKTTKVQCNSRMFPVPSSQVKTNKELLMFSNKEHHQEADKKRQSKRNEGYFCK
                     NQTCERTLDPYRNEVSQLYSFSTSLVHSITKDAKEELTASLVGLPKSLTDSCLFEKSG
                     YEEDNECHVTPELPKSLQPSSQNHRFYHSTGSLNGYGCGDNVVQAVEQYAKKVVDDTL
                     ELTLGSTVFRVSETTKSADRVTYAEKLSPLTGQACRYCDLKELHNCTGNSSQHFFRQG
                     SLASSKPASNPKFSSRYQKSRIFHLSVPQIHVNLDKKAVLAEKIVAEAIEKAERELSS
                     TSLAADSGIGQEGASFAESLATETMTAAVTNVGHAVSSSKEIEDFQSTESVSSQQMNL
                     SIGDDSTGSWSNLSFEDEHQDESSSFHHLSESNGNSSSWSSLGLEGDLYEDNLSFPTS
                     DSDGPDDKDEEHEDEVEGLGQDGKTLLITNIDMEPCTVDPQLRIILQWLIASEAEVAE
                     LYFHDSANKEFMLLSKQLQEKGWKVGDLLQAVLQYYEVMEKASSEERCKSLFDWLLEN
                     A"
     exon            228..344
                     /gene="AKAP11"
                     /gene_synonym="AKAP-11; AKAP220; PPP1R44; PRKA11"
                     /inference="alignment:Splign:2.1.0"
     exon            345..392
                     /gene="AKAP11"
                     /gene_synonym="AKAP-11; AKAP220; PPP1R44; PRKA11"
                     /inference="alignment:Splign:2.1.0"
     exon            393..527
                     /gene="AKAP11"
                     /gene_synonym="AKAP-11; AKAP220; PPP1R44; PRKA11"
                     /inference="alignment:Splign:2.1.0"
     exon            528..792
                     /gene="AKAP11"
                     /gene_synonym="AKAP-11; AKAP220; PPP1R44; PRKA11"
                     /inference="alignment:Splign:2.1.0"
     exon            793..5293
                     /gene="AKAP11"
                     /gene_synonym="AKAP-11; AKAP220; PPP1R44; PRKA11"
                     /inference="alignment:Splign:2.1.0"
     exon            5294..5449
                     /gene="AKAP11"
                     /gene_synonym="AKAP-11; AKAP220; PPP1R44; PRKA11"
                     /inference="alignment:Splign:2.1.0"
     exon            5450..5533
                     /gene="AKAP11"
                     /gene_synonym="AKAP-11; AKAP220; PPP1R44; PRKA11"
                     /inference="alignment:Splign:2.1.0"
     exon            5534..5580
                     /gene="AKAP11"
                     /gene_synonym="AKAP-11; AKAP220; PPP1R44; PRKA11"
                     /inference="alignment:Splign:2.1.0"
     exon            5581..5741
                     /gene="AKAP11"
                     /gene_synonym="AKAP-11; AKAP220; PPP1R44; PRKA11"
                     /inference="alignment:Splign:2.1.0"
     exon            5742..9915
                     /gene="AKAP11"
                     /gene_synonym="AKAP-11; AKAP220; PPP1R44; PRKA11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9899..9904
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AKAP11"
                     /gene_synonym="AKAP-11; AKAP220; PPP1R44; PRKA11"
                     /note="hexamer: AATAAA"
     polyA_site      9915
                     /gene="AKAP11"
                     /gene_synonym="AKAP-11; AKAP220; PPP1R44; PRKA11"
                     /note="major polyA site"
ORIGIN      
        1 agcttgcttg cccggctcgc tcacgggtcg ttgaggccgg tgacatgtct gtgagctgcg
       61 gaggctgcgg cccccagatc tttctctttg acactttgca ataaaaaagg gcagtgagat
      121 tgaataggtg ttttgtggat taactcttca ttgattatat acaacaaaaa atagttatgg
      181 cgactttcag aaacaatcac atgaagacta aagcatctgt cagaaaaagc ttcagtgaag
      241 atgtgttcca gtctgtaaag tctttattgc agagtcagaa ggaactatgc agtgtaacag
      301 cagaggactg tttacagcag gatgagcatg ccaatttaac tgaggtcaca tttctgggtt
      361 ttaatgaaga gacagatgct gctcatatac aggatttagc tgcagtttct ttggaacttc
      421 cagatattct gaattcactc cacttctgca gtctaaatga aaatgaaatt atttgtatga
      481 agaatataaa taaaccatta gatataagca gtgatcctct aaatcagagt catccttctg
      541 gaatgctttg tgtcatgaga gtgtcaccta catcaccaag acttaggatt gattttatct
      601 ttagtctcct aagtaaatat gctactggta taaggtacac cttggacaca ttcttgcatc
      661 agaagcacca acttgagacc actgatgaag atgatgatga tactaaccag tctgtgtcat
      721 ccatagagga tgactttgtc actgcttttg agcacttaga agaggaagag acttcaaagc
      781 catacaatga tggaatgaac attactgtgc taaggagcca gtgtgatgct gcttcccaga
      841 cggttactgg tcatcattta gaaacccatg atttaaagat tctcattagc tctggacagc
      901 agaagtcatt ggctaaaccc tcaacttcct cagtgaatgt cctgggacat aaagaactac
      961 cttctgtgaa aacttcagtc acaacatcaa tttcagagcc ttggacccaa aggagtttct
     1021 ataggtcatc taatgcttca gataaagata gtgatttaca gaaaacattt ttttcgtctt
     1081 ctcctgccta ctcatctgaa tcagaatgtt caagtccaag tcctgttatt ttcttggatg
     1141 aagagggata tcaaaaaagc ttaaaagcaa aacttgagct gcctaaaatt cctgtgatga
     1201 aagatgatat agaggattca gactcagaag taagtgaatt ttttgatagt tttgatcagt
     1261 ttgatgaact agaacaaact ttagagactt gcctgtttaa caaagatccc gtcataggga
     1321 agtcatcgca gaggaaaggg cacaaacatg gaaagtcatg tatgaatcct caaaaattca
     1381 agtttgatcg tccagctctc ccagctaatg ttagaaagcc aactcctcgt aaaccagaat
     1441 ctccatatgg taacctgtgt gatgctccgg attctcctcg cccagtgaag gcatcaaggg
     1501 aagatagtgg tttatttagt cctattcgat cctctgcttt tagtcctctt ggaggctgta
     1561 ctccagctga atgtttttgc caaacagata ttggtggaga taggattcat gaaaatcatg
     1621 attctgttta ttacacctat gaagactatg caaaaagcat ttcatgtgaa gtactaggct
     1681 cagttcttcg tacccaccat actaataccc tatcaaatat taacagtatt aaacatggag
     1741 aaaataaaac tgtaactttt aagcatggaa accttgatca aaaaaataaa tctaaaaata
     1801 aatccttaat gattaaagat agcattcaaa aatttgcagc agatcttgtg gaaaaaagtt
     1861 ttggcagtgc atttaaagac ttacagaaag gagtctcttc atgtaccaat gctttgtacc
     1921 acttagccat caaattgaca tcatctgttt tgcagatggc atttgatgag ctgagaaggc
     1981 agcgtgcatt ttcactaaaa gaacgtgcca ttagtggcct ggctaacttt ttggtgagtg
     2041 aagctttatc aaatgcctta aaagatttac agtatgtaaa gaagcagata ttcacaaaca
     2101 cagttgctag gtttgctgca gatcttgctg aagagcttgt ttttgaaggc atcatggagg
     2161 tgtgtcagtt ttcatatcct caaacgcctg catctccaca gtgtgggtcg tttgactttg
     2221 aagacaaagt agtgaagttg tatgcaaaag atttgtctga atctgtaata caggaagcat
     2281 tcattgagct atcacaagtt gatgtgacct ttacaacaaa ggcagcagtt agtgtctcta
     2341 cggataatat caagtatgtg agtgcagaaa gtgtagtgcc atcgacacag gctgtcacgt
     2401 tttccccttc ttttcacaat caagcaatta tggtgacaaa accagtgcag gaatataaaa
     2461 aggaatacac agtgcagcag gccttgtttt gtacttctgg aattgttact tctataccgg
     2521 tgcccttggc aggaagtgcc cttctcccat atcatatttc atctactgca tgtcaggcca
     2581 aggctcatct gtcatctgat gatagtaatt caaatggtga ttctgcccaa gtgcatattg
     2641 ccacaaaaaa cagagaagaa aaagcagctt gtctcagaaa tatttgttta ccttcagaac
     2701 acaatccagg taatcagaat gattttaaac caactaatga cgatattgaa atgcagagtt
     2761 cctcaaaatt accaaatgat cctgcaatta ttagcaactt ttctgcagca gtggtgcata
     2821 cgatagtaaa tgaaacttta gagtcaatga catcattgga agttacaaaa atggttgatg
     2881 aacgtacaga ttatttaact aaatctttaa aggagaaaac ccctccattt tcccactgtg
     2941 atcaggcagt gctgcaatgc agtgaagcta gtagcaataa ggacatgttt gctgaccggt
     3001 tatctaaatc tattattaaa cattccatag ataagagcaa atcagtgatc ccaaatatag
     3061 ataaaaatgc agtatacaag gaaagcttgc ctgtttctgg agaagaatca cagttgacac
     3121 cagaaaagtc tcccaaattt cctgactctc agaatcagtt aactcactgc tcactttcag
     3181 ctgcaaagga ttgtgttcca gaatgtaaag tttctatggt tcatggatcc tccctagaga
     3241 cactgccatc ttgtccagct gtgacaggtc agaaatctga cttgaaggaa tctgctaagg
     3301 atcaaccact gaaaaagcat aacttgaata gtacatcact tgaggccttg tcttttggac
     3361 aggaaaaccc ctttcctcat tcacatactt tctcatctac agcacttacc tgtgtagatg
     3421 gtttgcatgt ggaagataaa cagaaagtca gagacagaaa tgtaatacct gatactcctc
     3481 catcaactcc tctagtacca tcccgggcta gttctgaatg ggatatcaag aagttaacta
     3541 aaaagctcaa gggagaatta gccaaagagt ttgcacctgc tacaccacct tctactccac
     3601 acaactcatc tgttggtagt ttgtctgaga atgaacaaaa tactatagaa aaagaagagt
     3661 tcatgttgaa actcatgcga tctctttctg aagaagttga gagtagtgaa agtggagagc
     3721 tcccagaagt ggatgtgaag tcggagcact cagggaagaa ggttcagttt gcagaagcat
     3781 tagctacaca catcctttct cttgcaactg aaatggcagc ttcccattta gataacaaaa
     3841 taattcaaga acccaaggtt aaaaaccctt gcttaaatgt gcaaagtcaa agaagtgtgt
     3901 cgcctacttt tttaaacccc tcagacgaaa atttgaaaac attatgcaat tttgcgggtg
     3961 atctggcagc agaagtcatt acagaagctg agaaaatagc aaaagtccga aattgtatgc
     4021 ttttcaagca aaagaagaac agttgttatg ctgatggtga cgaagattat aaagtagaag
     4081 agaagttgga tatagaggct gtagtgcacc caagagaagt ggatccgttt attctttcat
     4141 taccaccaag ttcttgtatg tcaggtctga tgtataagta tcccagctgt gaaagtgtga
     4201 cagatgaata tgcaggtcac cttattcaga tactaaaaca ggaaggtggt aatagtgagt
     4261 tgataatgga tcagtatgcc aataggcttg cctaccgatc tgttaaatca ggattacagg
     4321 aagcagctaa gacaaccaaa gtgcagtgca actcaagaat gttccctgtg ccaagttcac
     4381 aagtgaaaac aaacaaggaa ctgttaatgt tttcaaacaa agagcaccac caagaagcag
     4441 acaaaaagag acaaagtaaa agaaatgaag gttacttttg taaaaatcaa acttgtgaaa
     4501 ggaccctgga tccatataga aatgaggtct cccaactgta tagtttttca acctctctgg
     4561 ttcacagcat aacaaaagat gctaaggaag agttgacagc ctctctagtt ggcctaccaa
     4621 aatccttaac agattcttgc ttgtttgaaa aatctggata tgaagaagat aatgagtgtc
     4681 acgttacacc agaattgcct aagtctcttc agccttcctc acaaaatcac aggttttacc
     4741 acagcactgg cagtttaaat ggatatggtt gtggagacaa tgttgttcaa gctgtagaac
     4801 agtatgccaa aaaagtagtg gatgacactc tagagctaac tctaggatct acagtgttcc
     4861 gagtgtctga gaccacaaaa tcagcagaca gggtcactta tgcagaaaag ttgtcacctc
     4921 ttacaggtca agcttgcaga tactgtgacc ttaaagaact ccacaattgc actggaaatt
     4981 catctcagca ctttttcaga cagggttctc tcgccagtag taagccagct tctaatccaa
     5041 aatttagcag ccgctatcag aaatctagga tttttcatct cagtgtccct cagattcatg
     5101 ttaatcttga taagaaggca gtgcttgctg agaagatagt tgctgaagcc attgaaaaag
     5161 ctgagcgaga gctgagcagt accagcctgg cagccgacag tgggatcgga caggagggtg
     5221 ccagctttgc tgaaagcctt gccacagaaa ccatgacagc agctgtcaca aatgttgggc
     5281 atgctgttag cagttcaaaa gaaatagaag actttcagtc aaccgagtct gtcagtagcc
     5341 agcagatgaa cctcagtatt ggtgatgaca gcactggtag ctggtccaat ttaagttttg
     5401 aagatgaaca ccaagatgaa agcagcagtt ttcatcatct aagtgaaagt aatggtaaca
     5461 gcagtagctg gagcagtctt ggtttagaag gagatttgta tgaggacaat ttatcctttc
     5521 caacatcaga cagtgatgga ccagatgata aagatgaaga gcatgaggac gaagtagaag
     5581 gtttggggca agatggaaag acactgctaa ttacgaatat tgacatggag ccatgcacgg
     5641 tagaccccca gctaaggatt attcttcagt ggctcattgc ctctgaggct gaagttgcag
     5701 aactttattt tcatgactct gcaaataagg agtttatgct actttcaaaa caattacaag
     5761 agaaaggatg gaaagtggga gacctcctgc aggctgtgct tcaatactat gaagtgatgg
     5821 aaaaagcttc cagtgaggag agatgcaagt cgctgtttga ttggctcttg gaaaatgcat
     5881 agagcaaacc ccaaaccagt atattttagt atttgtttgg ggaggggaac aagccaataa
     5941 agatgtttag gataaaattt gaatagtgaa tattaacatc gtaagtcagt tgggaggcaa
     6001 gtaaatatag ctttctgagc gctttgtgtt atcactcggt gtatatagtt catacttttg
     6061 taatctgtca aaatactacc ttcatttatt cttctataca catgtgtagt gtgtcaagac
     6121 cctaagaaca tgtatttgaa ggaaggtcta accagggggt tttcaggggc attgtctgac
     6181 cacattcttt ttgtatccaa atagtgctgc tagaaactgc actgaagtgg ctgaggatag
     6241 gttccagtga tagagttata attttgctcc tttgcaaaca aatggtatct aattaataac
     6301 tagtctgaca tcagaaaata aaattgaggc tgatttttaa aaatttctag tagatttttg
     6361 gcctttcctg tttttaaaaa tcagtttcat tttcatattt catagatcag ctattggtag
     6421 ctttttgatt tccccaaact atttaatttc ttagcagaaa cattagtatt ttaggtttct
     6481 ataaacacta taagtgatag tttcccccat cctttcattg acattatttg ccaatgctgc
     6541 cagtcattct ggcatgaaag gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     6601 gtgtaaggga gtactttaac cttgccagtt tgttccctct tttattttac tgttttcttt
     6661 ttagaaaccc actgttaaaa tttaaaaagg tgctttaaaa taaaacgcct ataaagattg
     6721 tgcagtaaga atttttattg acaataatta aaattttttt tgacaatttt gggttcccaa
     6781 cttatcttac aagtgaaaac ttaaattgta aaacatgttg aaattttaaa aattaatgtt
     6841 aatatggaaa tgcatttaga gaagcccagt agtttttatt gttggatttt tgaaaaaacc
     6901 tctaccaaga atgtggtgtt ttttttgttt gtttgtttgt ttgttttaga aaaattggga
     6961 tttcccccca ccccgcccca cccagataaa ctatatctac actgtctcgt caagttctct
     7021 gacacgatct ttctgggctc tacatttcct actagtttgt gtccagaaac tgcaagttga
     7081 catgaataga ggacaaaggt tgtgtcttgc ttttgtctct ctcttccctc cctgcaactc
     7141 tctctcccct cctcccactc tcttccccct cccccctcct cccactgtct ctcacctccc
     7201 ccacccccca ctctctctca tctctcgctg tgtcctgtgt atgtgtgggt gtgtgtgtat
     7261 ttgggtgtgt aaatgttggt tcttccacta ctggattttg taatctagga taaatcactt
     7321 tttttgggga ctttgatttt gctccattac gttttcattt tttctgagca ctgactgttc
     7381 tgaaagctgc acaaaacgta gaaagaagac atagcgcctg ccagggaata ggaaatgagg
     7441 gcacttacac attaatgtga attagtaatt gtggtataga aatgttttat agtgaaagat
     7501 tcaaatttgc ttttcaagaa aaatgccaaa agctatttaa ataattcgag gttacatcgt
     7561 aggttttgat ttttctcaat ttaagataca gaaatacagc aagccttaat ataaagtttc
     7621 ctaaagtttc ttcaagtatt ttttaaggtg gagaaatgca ggaattgtat aaccagaatt
     7681 gttcctgcct ttagcttttc agaacttgag atgtggcagc actggactgg gtttttttaa
     7741 atgttaggac taggaatgtt tgctcttgtt aattatgaat taattgatta ttaagtttag
     7801 aatgcatttt tacaagtatc taactatcaa attgtgttta gtaacttgag tgtatgcaca
     7861 agtttgatca acagcaaaat agagttctga atttctttta aagtgatgat atattatttt
     7921 gtgaaacttt gtgtttgaaa atgtttattt ctgtttatgg tgtaatcatt ctgaggtgag
     7981 gcttttctta tttcctttgc attttgctag agctgtgctg agttcagcat ttgcttattt
     8041 aaccactaca taatgacaga ccagttatta ggtattagca tgtgtggtaa taataatagt
     8101 ggaacttcac acttacatca attcagtgca ggggcataga ataaaatatt aaatattggc
     8161 agatgtatga aaagaagtgt gagttaaaaa tattgaatat tggcaggtgt gaaaacaagt
     8221 gtcaaaattc ctcatataga gaaaataatt ttgagtttag agtattatct tttaattaag
     8281 tgtagtctaa acttaacttt ctgtaaaggc actttgtggt ttttccaaag atgttctaga
     8341 tctatttggt tgctctatag tcaaacagct cttttgaaga caactgtctt attttattac
     8401 aaattggctt gacatattta tactgtaaca ttgtaatatt gctgtgctgt acattttggc
     8461 ccttacgaaa tacgtctttt tcagaactgt taaagttttg atgtacatcg agctgaattc
     8521 tgtttttacc agtttcaaaa ccttcaagtg atatgtggaa aaaagtgaat gagacctctg
     8581 atagggggtt ttcagaacct tgttcacacc aaaatgtgac agttctttca tgttttccta
     8641 aaccaagtta aaattacatg tatattttgg tgttaaggtt gatttttaag atacttctga
     8701 tttgtacaaa aggaatgttt cctttataaa tcacagaaga aaatgacaat atctgttgga
     8761 tatttgatat aatttaatgg tgttataaaa cctttaagag gattcatggt gaatatatgt
     8821 gataacatct ttatactttg aaaaatgttc cacttaccct tcagatattt gttgtaagtt
     8881 aattcaattc ttaatacttt aattttgctc caacaagggc tttatgttgc tggtaagaga
     8941 atttatttac taaatgcact atgtataaag tgaaagatag tttacttatc tgactttgat
     9001 attagatggc tgacattagt gcacataatg cagagtttaa ccttgattct tcaacagagt
     9061 ccagatttaa atgtctactt agttaattag ttagctgata ttcttccaca attaatatat
     9121 tcaatttccc atcagtatat cactttaaat tttatgtttt tctaaggaaa ctttccacag
     9181 aattttaaac aactgatgca tccatactca gggtgtaggg agaatacttt gcatttaaaa
     9241 accctgtcca cctgtcacca gcacaagaga attagagctt cagtgagaat ttagaaaaat
     9301 tatactaaag tgagatgcat tttttctcat tttcagcaag actcctctaa gcatttactc
     9361 atttactgta ttcctgctct gaagatgtgg atacagaatt agtcactctt gtcactttat
     9421 ttatttattg gttttttttt aaccatctgt gtacattcct ttcatagggt agagttctag
     9481 ttctagaagt tcttattttg tttttgttgt aatgtttgaa tactatttaa tatccggttt
     9541 taatattgct ggatttgcta cctttggtta cttgtgcagt gttaaaagta atccactttc
     9601 ttgtttaata taccagatac atagcaaaag cagcttggaa taattatagc tgtttatttg
     9661 gctgtgctca gttactatat taagatcttg tactgtgtaa cagtaactct tttttgcttt
     9721 tcagtaattt aatatgttca cttaacaaaa tacgaacttt gagatgcact aaagttttgt
     9781 ttcagcagtg gctcaaaaaa tttcagaaat tacttttgta attatttgca attaattgtt
     9841 cttttatctt acaattgttt aagcctgtga tctttcttct cccagctaag agttcttcaa
     9901 taaatttaag aaata
//
