LOCUS       NM_007202               4063 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens A-kinase anchoring protein 10 (AKAP10), transcript
            variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_007202
VERSION     NM_007202.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4063)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 4063)
  AUTHORS   Chung,J., Wittig,J.G., Ghamari,A., Maeda,M., Dailey,T.A.,
            Bergonia,H., Kafina,M.D., Coughlin,E.E., Minogue,C.E., Hebert,A.S.,
            Li,L., Kaplan,J., Lodish,H.F., Bauer,D.E., Orkin,S.H., Cantor,A.B.,
            Maeda,T., Phillips,J.D., Coon,J.J., Pagliarini,D.J., Dailey,H.A.
            and Paw,B.H.
  TITLE     Erythropoietin signaling regulates heme biosynthesis
  JOURNAL   Elife 6, e24767 (2017)
   PUBMED   28553927
  REMARK    GeneRIF: Here, using zebrafish, murine, and human models, the
            authors show that erythropoietin (EPO) signaling, together with the
            GATA1 transcriptional target, AKAP10, regulates heme biosynthesis
            during erythropoiesis at the outer mitochondrial membrane.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4063)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   4  (bases 1 to 4063)
  AUTHORS   Langmia,I.M., Apalasamy,Y.D., Suki,S.Z., Omar,S.Z. and Mohamed,Z.
  TITLE     Genetic association of AKAP10 gene polymorphism with reduced risk
            of preterm birth
  JOURNAL   J Perinatol 35 (9), 700-704 (2015)
   PUBMED   26110499
  REMARK    GeneRIF: Significant association between the AKAP10 polymorphisms
            and reduced risk of Preterm birth in the Malays was observed.
REFERENCE   5  (bases 1 to 4063)
  AUTHORS   Neumann,S.A., Tingley,W.G., Conklin,B.R., Shrader,C.J., Peet,E.,
            Muldoon,M.F., Jennings,J.R., Ferrell,R.E. and Manuck,S.B.
  TITLE     AKAP10 (I646V) functional polymorphism predicts heart rate and
            heart rate variability in apparently healthy, middle-aged
            European-Americans
  JOURNAL   Psychophysiology 46 (3), 466-472 (2009)
   PUBMED   19496216
  REMARK    GeneRIF: the AKAP10 Val allele predicted greater resting heart rate
            and heart rate variability
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 4063)
  AUTHORS   Michel,J.J. and Scott,J.D.
  TITLE     AKAP mediated signal transduction
  JOURNAL   Annu Rev Pharmacol Toxicol 42, 235-257 (2002)
   PUBMED   11807172
  REMARK    Review article
REFERENCE   7  (bases 1 to 4063)
  AUTHORS   Wang,L., Sunahara,R.K., Krumins,A., Perkins,G., Crochiere,M.L.,
            Mackey,M., Bell,S., Ellisman,M.H. and Taylor,S.S.
  TITLE     Cloning and mitochondrial localization of full-length D-AKAP2, a
            protein kinase A anchoring protein
  JOURNAL   Proc Natl Acad Sci U S A 98 (6), 3220-3225 (2001)
   PUBMED   11248059
REFERENCE   8  (bases 1 to 4063)
  AUTHORS   Huang,L.J., Durick,K., Weiner,J.A., Chun,J. and Taylor,S.S.
  TITLE     D-AKAP2, a novel protein kinase A anchoring protein with a putative
            RGS domain
  JOURNAL   Proc Natl Acad Sci U S A 94 (21), 11184-11189 (1997)
   PUBMED   9326583
REFERENCE   9  (bases 1 to 4063)
  AUTHORS   Lester,L.B. and Scott,J.D.
  TITLE     Anchoring and scaffold proteins for kinases and phosphatases
  JOURNAL   Recent Prog Horm Res 52, 409-29 (1997)
   PUBMED   9238861
  REMARK    Review article
REFERENCE   10 (bases 1 to 4063)
  AUTHORS   Epplen,C. and Epplen,J.T.
  TITLE     Expression of (cac)n/(gtg)n simple repetitive sequences in mRNA of
            human lymphocytes
  JOURNAL   Hum Genet 93 (1), 35-41 (1994)
   PUBMED   7505766
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP229845.1, BC017055.1,
            AC005730.1 and AC015726.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_007202.3.
            
            Summary: This gene encodes a member of the A-kinase anchor protein
            family. A-kinase anchor proteins bind to the regulatory subunits of
            protein kinase A (PKA) and confine the holoenzyme to discrete
            locations within the cell. The encoded protein is localized to
            mitochondria and interacts with both the type I and type II
            regulatory subunits of PKA. Polymorphisms in this gene may be
            associated with increased risk of arrhythmias and sudden cardiac
            death. [provided by RefSeq, May 2012].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.256198.1,
                                           SRR1803612.244754.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000225737.11/
                                                  ENSP00000225737.6
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                BP229845.1         29-44
            17-2929             BC017055.1         1-2913
            2930-3589           AC005730.1         155964-156623
            3590-4063           AC015726.8         134207-134680       c
FEATURES             Location/Qualifiers
     source          1..4063
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p11.2"
     gene            1..4063
                     /gene="AKAP10"
                     /gene_synonym="AKAP-10; D-AKAP-2; D-AKAP2; PRKA10"
                     /note="A-kinase anchoring protein 10"
                     /db_xref="GeneID:11216"
                     /db_xref="HGNC:HGNC:368"
                     /db_xref="MIM:604694"
     exon            1..237
                     /gene="AKAP10"
                     /gene_synonym="AKAP-10; D-AKAP-2; D-AKAP2; PRKA10"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..2138
                     /gene="AKAP10"
                     /gene_synonym="AKAP-10; D-AKAP-2; D-AKAP2; PRKA10"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; A-kinase anchor protein 10, mitochondrial;
                     protein kinase A anchoring protein 10; mitochondrial A
                     kinase PPKA anchor protein 10; dual specificity A
                     kinase-anchoring protein 2; A kinase (PRKA) anchor protein
                     10"
                     /codon_start=1
                     /product="A-kinase anchor protein 10, mitochondrial
                     isoform 1 precursor"
                     /protein_id="NP_009133.2"
                     /db_xref="CCDS:CCDS11214.1"
                     /db_xref="GeneID:11216"
                     /db_xref="HGNC:HGNC:368"
                     /db_xref="MIM:604694"
                     /translation="MRGAGPSPRQSPRTLRPDPGPAMSFFRRKVKGKEQEKTSDVKSI
                     KASISVHSPQKSTKNHALLEAAGPSHVAINAISANMDSFSSSRTATLKKQPSHMEAAH
                     FGDLGRSCLDYQTQETKSSLSKTLEQVLHDTIVLPYFIQFMELRRMEHLVKFWLEAES
                     FHSTTWSRIRAHSLNTVKQSSLAEPVSPSKKHETTASFLTDSLDKRLEDSGSAQLFMT
                     HSEGIDLNNRTNSTQNHLLLSQECDSAHSLRLEMARAGTHQVSMETQESSSTLTVASR
                     NSPASPLKELSGKLMKSIEQDAVNTFTKYISPDAAKPIPITEAMRNDIIARICGEDGQ
                     VDPNCFVLAQSIVFSAMEQEHFSEFLRSHHFCKYQIEVLTSGTVYLADILFCESALFY
                     FSEYMEKEDAVNILQFWLAADNFQSQLAAKKGQYDGQEAQNDAMILYDKYFSLQATHP
                     LGFDDVVRLEIESNICREGGPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLYYKYLNDL
                     IHSVRGDEFLGGNVSLTAPGSVGPPDESHPGSSDSSASQSSVKKASIKILKNFDEAII
                     VDAASLDPESLYQRTYAGKMTFGRVSDLGQFIRESEPEPDVRKSKGSMFSQAMKKWVQ
                     GNTDEAQEELAWKIAKMIVSDIMQQAQYDQPLEKSTKL"
     exon            238..285
                     /gene="AKAP10"
                     /gene_synonym="AKAP-10; D-AKAP-2; D-AKAP2; PRKA10"
                     /inference="alignment:Splign:2.1.0"
     exon            286..468
                     /gene="AKAP10"
                     /gene_synonym="AKAP-10; D-AKAP-2; D-AKAP2; PRKA10"
                     /inference="alignment:Splign:2.1.0"
     exon            469..1026
                     /gene="AKAP10"
                     /gene_synonym="AKAP-10; D-AKAP-2; D-AKAP2; PRKA10"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1125
                     /gene="AKAP10"
                     /gene_synonym="AKAP-10; D-AKAP-2; D-AKAP2; PRKA10"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1210
                     /gene="AKAP10"
                     /gene_synonym="AKAP-10; D-AKAP-2; D-AKAP2; PRKA10"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1334
                     /gene="AKAP10"
                     /gene_synonym="AKAP-10; D-AKAP-2; D-AKAP2; PRKA10"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1471
                     /gene="AKAP10"
                     /gene_synonym="AKAP-10; D-AKAP-2; D-AKAP2; PRKA10"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1616
                     /gene="AKAP10"
                     /gene_synonym="AKAP-10; D-AKAP-2; D-AKAP2; PRKA10"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1790
                     /gene="AKAP10"
                     /gene_synonym="AKAP-10; D-AKAP-2; D-AKAP2; PRKA10"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1900
                     /gene="AKAP10"
                     /gene_synonym="AKAP-10; D-AKAP-2; D-AKAP2; PRKA10"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..1983
                     /gene="AKAP10"
                     /gene_synonym="AKAP-10; D-AKAP-2; D-AKAP2; PRKA10"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2036
                     /gene="AKAP10"
                     /gene_synonym="AKAP-10; D-AKAP-2; D-AKAP2; PRKA10"
                     /inference="alignment:Splign:2.1.0"
     exon            2037..2132
                     /gene="AKAP10"
                     /gene_synonym="AKAP-10; D-AKAP-2; D-AKAP2; PRKA10"
                     /inference="alignment:Splign:2.1.0"
     exon            2133..4063
                     /gene="AKAP10"
                     /gene_synonym="AKAP-10; D-AKAP-2; D-AKAP2; PRKA10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3577..3582
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AKAP10"
                     /gene_synonym="AKAP-10; D-AKAP-2; D-AKAP2; PRKA10"
                     /note="hexamer: AATATA"
     polyA_site      3604
                     /gene="AKAP10"
                     /gene_synonym="AKAP-10; D-AKAP-2; D-AKAP2; PRKA10"
                     /note="major polyA site"
     regulatory      3869..3874
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AKAP10"
                     /gene_synonym="AKAP-10; D-AKAP-2; D-AKAP2; PRKA10"
                     /note="hexamer: AATAAA"
     polyA_site      3890
                     /gene="AKAP10"
                     /gene_synonym="AKAP-10; D-AKAP-2; D-AKAP2; PRKA10"
                     /note="major polyA site"
     regulatory      4043..4048
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AKAP10"
                     /gene_synonym="AKAP-10; D-AKAP-2; D-AKAP2; PRKA10"
                     /note="hexamer: TATAAA"
     polyA_site      4063
                     /gene="AKAP10"
                     /gene_synonym="AKAP-10; D-AKAP-2; D-AKAP2; PRKA10"
ORIGIN      
        1 aactccgggc gggcggcttg ttgataatat ggcggctgga gctgcctggg catcccgagg
       61 aggcggtggg gcccactccc ggaagaaggg tcccttttcg cgctagtgca gcggcccctc
      121 tggacccgga agtccgggcc ggttgctgaa tgaggggagc cgggccctcc ccgcgccagt
      181 ccccccgcac cctccgtccc gacccgggcc ccgccatgtc cttcttccgg cggaaagtga
      241 aaggcaaaga acaagagaag acctcagatg tgaagtccat taaagcttca atatccgtac
      301 attccccaca aaaaagcact aaaaatcatg ccttgctgga ggctgcagga ccaagtcatg
      361 ttgcaatcaa tgccatttct gccaacatgg actccttttc aagtagcagg acagccacac
      421 ttaagaagca gccaagccac atggaggccg ctcattttgg tgacctgggc agatcttgtc
      481 tggactacca gactcaagag accaaatcaa gcctttctaa gacccttgaa caagtcttgc
      541 acgacactat tgtcctccct tacttcattc aattcatgga acttcggcga atggagcatt
      601 tggtgaaatt ttggttagag gctgaaagtt ttcattcaac aacttggtcg cgaataagag
      661 cacacagtct aaacacagtg aagcagagct cactggctga gcctgtctct ccatctaaaa
      721 agcatgaaac tacagcgtct tttttaactg attctcttga taagagattg gaggattctg
      781 gctcagcaca gttgtttatg actcattcag aaggaattga cctgaataat agaactaaca
      841 gcactcagaa tcacttgctg ctttcccagg aatgtgacag tgcccattct ctccgtcttg
      901 aaatggccag agcaggaact caccaagttt ccatggaaac ccaagaatct tcctctacac
      961 ttacagtagc cagtagaaat agtcccgctt ctccactaaa agaattgtca ggaaaactaa
     1021 tgaaaagtat agaacaagat gcagtgaata cttttaccaa atatatatct ccagatgctg
     1081 ctaaaccaat accaattaca gaagcaatga gaaatgacat catagcaagg atttgtggag
     1141 aagatggaca ggtggatccc aactgtttcg ttttggcaca gtccatagtc tttagtgcaa
     1201 tggagcaaga gcactttagt gagtttctgc gaagtcacca tttctgtaaa taccagattg
     1261 aagtgctgac cagtggaact gtttacctgg ctgacattct cttctgtgag tcagccctct
     1321 tttatttctc tgagtacatg gaaaaagagg atgcagtgaa tatcttacaa ttctggttgg
     1381 cagcagataa cttccagtct cagcttgctg ccaaaaaggg ccaatatgat ggacaggagg
     1441 cacagaatga tgccatgatt ttatatgaca agtacttctc cctccaagcc acacatcctc
     1501 ttggatttga tgatgttgta cgattagaaa ttgaatccaa tatctgcagg gaaggtgggc
     1561 cactccccaa ctgtttcaca actccattac gtcaggcctg gacaaccatg gagaaggtct
     1621 ttttgcctgg ctttttgtcc agcaatcttt attataaata tttgaatgat ctcatccatt
     1681 cggttcgagg agatgaattt ctgggcggga acgtgtcgct gactgctcct ggctctgttg
     1741 gccctcctga tgagtctcac ccagggagtt ctgacagctc tgcgtctcag tccagtgtga
     1801 aaaaagccag tattaaaata ctgaaaaatt ttgatgaagc gataattgtg gatgcggcaa
     1861 gtctggatcc agaatcttta tatcaacgga catatgccgg gaagatgaca tttggaagag
     1921 tcagtgactt ggggcaattc atccgagaat ctgagcctga acctgatgta aggaaatcaa
     1981 aaggatccat gttctcacaa gctatgaaga aatgggtgca aggaaatact gatgaggccc
     2041 aggaagagct agcttggaag attgctaaaa tgatagtcag tgacattatg cagcaggctc
     2101 agtatgatca accgttagag aaatctacaa agttatgact caaaacttga gataaaggaa
     2161 atctgcttgt gaaaaataag agaacttttt tcccttggtt ggattcttca acacagccaa
     2221 tgaaaacagc actatatttc tgatctgtca ctgttgtttc caggagagaa tgggagacaa
     2281 tcctagactt ccaccataat gcagttacct gtaggcataa ttgatgcaca tgatgttcac
     2341 acagtgagag tcttaaagat acaaaatggt attgtttaca ttactagaaa attattagtt
     2401 ttccaatggc aataacccat ttatgagagt gttttagcct actggaatag acagggacca
     2461 catcctctgg gaagcagata agcatagaac tgatacttga tgcacactcg tagtggtaac
     2521 tcatccctaa tcagcattgt aaagcaggtg ccagaggtgg tttgctttgt ccttccaaag
     2581 caggtgagtc agccccaccg agagccaggc agctttgagt ggcagcgtgg tgctagcagc
     2641 ttcagcggaa cagggtgaga gttaattatg cagtcttctt gacagcggca ttaatttgga
     2701 aggaaactga caagtcatgg gtcaagtttc agtgacttcc tccttcctct gatggcagta
     2761 tatagttttc acattttaat tcctcctcct gagatgcact atacttaaaa ccattctctc
     2821 ccctgctaac agaagggtgt gaatctggtt tactttgagc attaggattt gcccctttgg
     2881 aattctgcac tccagttact taactttccc ttcagaatac atgtggaaag aaagaaagaa
     2941 atagcgatga ctccactttt gcccctgtgg caccttgaac aaagcagttc ttcccaaatt
     3001 atactttttt tttttttaaa taaggtgagc aggatgactg gggagagaga aacatttgac
     3061 tttgactgcc tcccccattc tttgctgtga gctggaaagt gtgcagttgg tcgtctttct
     3121 tctcctttct ttaggatagt aagagactca ctcactgcac ttctgctcag ttggcttctg
     3181 catcgggatc acacagccat cagcaggact gcccagttgg tgagcacact ccattgacca
     3241 cgtggcgcca gcgcttcctc aatgcacatg attgagagga aagaaagttc tcttagatgt
     3301 tactgctttt gctcagactt tgcaaaaaaa aaaatatata tatatatgta taaatatata
     3361 attattaatc acttttgtcc ttgagaaagt cttgaatgaa cagagaattt attccattgc
     3421 aatatttgat tgtatagagg cacactgttt catcgacaga agaagcaaaa aggctttgtg
     3481 taagtttttg gtactatgta ccacctctgt tattctttta aagctgaagt attcatgtac
     3541 ttaaaccata ttatatttaa ttgtgtttga ttttaaaata tatatatatg aattctattt
     3601 aaaattgtgt caactttctg ctttcagggc atttatggct cttctgttga aatatattga
     3661 tctttccaaa tattttcatt tgctttctaa aaacccagaa catgagccac tactggactt
     3721 tgccttgtgt ttgaagtgta tggcataaac ccaaggtttt tattagtcat ctatgctgtg
     3781 attaattcat tttgttcttt taacaaaata tttccatcca cttcacattg cttcaatctt
     3841 taacagaaaa gcaatataaa ggttatagaa taaaatgtgg ttttgggcaa ctcttgctgc
     3901 ctctgcatgt tttggaataa caatttctac aagactctag gctgtttaaa ctagtgcttt
     3961 cagttaagat aaattctaat catttctttg tatatacatt ttgtgcttct gagctagaga
     4021 tgccaagtag ttgtaaactg cttataaaga gaatagcagc aaa
//
