LOCUS       NM_003488               3909 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens A-kinase anchoring protein 1 (AKAP1), transcript
            variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_003488
VERSION     NM_003488.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3909)
  AUTHORS   Fang,Y., Xu,J. and Huang,R.
  TITLE     AKAP1 in Renal Patients with AHF to Reduce Ferroptosis of
            Cardiomyocyte
  JOURNAL   Heart Surg Forum 27 (1), E028-E037 (2024)
   PUBMED   38286648
  REMARK    GeneRIF: AKAP1 in Renal Patients with AHF to Reduce Ferroptosis of
            Cardiomyocyte.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3909)
  AUTHORS   Bastola,T., Perkins,G.A., Kim,K.Y., Choi,S., Kwon,J.W., Shen,Z.,
            Strack,S. and Ju,W.K.
  TITLE     Role of A-Kinase Anchoring Protein 1 in Retinal Ganglion Cells:
            Neurodegeneration and Neuroprotection
  JOURNAL   Cells 12 (11), 1539 (2023)
   PUBMED   37296658
  REMARK    GeneRIF: Role of A-Kinase Anchoring Protein 1 in Retinal Ganglion
            Cells: Neurodegeneration and Neuroprotection.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3909)
  AUTHORS   Xiang,H., Xu,H., Tan,B., Yi,Q., Zhang,X., Wang,R., Chen,T., Xie,Q.,
            Tian,J. and Zhu,J.
  TITLE     AKAP1 Regulates Mitochondrial Dynamics during the
            Fatty-Acid-Promoted Maturation of Human-Induced Pluripotent Stem
            Cell-Derived Cardiomyocytes as Indicated by Proteomics Sequencing
  JOURNAL   Int J Mol Sci 24 (9), 8112 (2023)
   PUBMED   37175819
  REMARK    GeneRIF: AKAP1 Regulates Mitochondrial Dynamics during the
            Fatty-Acid-Promoted Maturation of Human-Induced Pluripotent Stem
            Cell-Derived Cardiomyocytes as Indicated by Proteomics Sequencing.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3909)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   5  (bases 1 to 3909)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 3909)
  AUTHORS   Huang,L.J., Wang,L., Ma,Y., Durick,K., Perkins,G., Deerinck,T.J.,
            Ellisman,M.H. and Taylor,S.S.
  TITLE     NH2-Terminal targeting motifs direct dual specificity
            A-kinase-anchoring protein 1 (D-AKAP1) to either mitochondria or
            endoplasmic reticulum
  JOURNAL   J Cell Biol 145 (5), 951-959 (1999)
   PUBMED   10352013
REFERENCE   7  (bases 1 to 3909)
  AUTHORS   Huang,L.J., Durick,K., Weiner,J.A., Chun,J. and Taylor,S.S.
  TITLE     Identification of a novel protein kinase A anchoring protein that
            binds both type I and type II regulatory subunits
  JOURNAL   J Biol Chem 272 (12), 8057-8064 (1997)
   PUBMED   9065479
REFERENCE   8  (bases 1 to 3909)
  AUTHORS   Lester,L.B. and Scott,J.D.
  TITLE     Anchoring and scaffold proteins for kinases and phosphatases
  JOURNAL   Recent Prog Horm Res 52, 409-29 (1997)
   PUBMED   9238861
  REMARK    Review article
REFERENCE   9  (bases 1 to 3909)
  AUTHORS   Trendelenburg,G., Hummel,M., Riecken,E.O. and Hanski,C.
  TITLE     Molecular characterization of AKAP149, a novel A kinase anchor
            protein with a KH domain
  JOURNAL   Biochem Biophys Res Commun 225 (1), 313-319 (1996)
   PUBMED   8769136
REFERENCE   10 (bases 1 to 3909)
  AUTHORS   Lin,R.Y., Moss,S.B. and Rubin,C.S.
  TITLE     Characterization of S-AKAP84, a novel developmentally regulated A
            kinase anchor protein of male germ cells
  JOURNAL   J Biol Chem 270 (46), 27804-27811 (1995)
   PUBMED   7499250
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA455114.1, BC000729.2,
            X97335.1 and AC007114.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_003488.3.
            
            Summary: The A-kinase anchor proteins (AKAPs) are a group of
            structurally diverse proteins, which have the common function of
            binding to the regulatory subunit of protein kinase A (PKA) and
            confining the holoenzyme to discrete locations within the cell.
            This gene encodes a member of the AKAP family. The encoded protein
            binds to type I and type II regulatory subunits of PKA and anchors
            them to the mitochondrion. This protein is speculated to be
            involved in the cAMP-dependent signal transduction pathway and in
            directing RNA to a specific cellular compartment. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest first
            intron.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HM005545.1, SRR1803617.167226.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000337714.8/
                                                  ENSP00000337736.3
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                DA455114.1         55-68
            15-2559             BC000729.2         1-2545
            2560-3005           X97335.1           2507-2952
            3006-3909           AC007114.8         5528-6431           c
FEATURES             Location/Qualifiers
     source          1..3909
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q22"
     gene            1..3909
                     /gene="AKAP1"
                     /gene_synonym="AKAP; AKAP121; AKAP149; AKAP84; D-AKAP1;
                     PPP1R43; PRKA1; SAKAP84; TDRD17"
                     /note="A-kinase anchoring protein 1"
                     /db_xref="GeneID:8165"
                     /db_xref="HGNC:HGNC:367"
                     /db_xref="MIM:602449"
     exon            1..153
                     /gene="AKAP1"
                     /gene_synonym="AKAP; AKAP121; AKAP149; AKAP84; D-AKAP1;
                     PPP1R43; PRKA1; SAKAP84; TDRD17"
                     /inference="alignment:Splign:2.1.0"
     exon            154..1891
                     /gene="AKAP1"
                     /gene_synonym="AKAP; AKAP121; AKAP149; AKAP84; D-AKAP1;
                     PPP1R43; PRKA1; SAKAP84; TDRD17"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..2889
                     /gene="AKAP1"
                     /gene_synonym="AKAP; AKAP121; AKAP149; AKAP84; D-AKAP1;
                     PPP1R43; PRKA1; SAKAP84; TDRD17"
                     /note="protein kinase A1; A kinase (PRKA) anchor protein
                     1; tudor domain containing 17; A-kinase anchor protein 1,
                     mitochondrial; spermatid A-kinase anchor protein 84;
                     protein kinase A anchoring protein 1; dual-specificity
                     A-kinase anchoring protein 1; AKAP 149; D-AKAP-1; A-kinase
                     anchor protein 149 kDa; protein phosphatase 1, regulatory
                     subunit 43; testicular secretory protein Li 5"
                     /codon_start=1
                     /product="A-kinase anchor protein 1, mitochondrial
                     precursor"
                     /protein_id="NP_003479.1"
                     /db_xref="CCDS:CCDS11594.1"
                     /db_xref="GeneID:8165"
                     /db_xref="HGNC:HGNC:367"
                     /db_xref="MIM:602449"
                     /translation="MAIQFRSLFPLALPGMLALLGWWWFFSRKKGHVSSHDEQQVEAG
                     AVQLRADPAIKEPLPVEDVCPKVVSTPPSVTEPPEKELSTVSKLPAEPPALLQTHPPC
                     RRSESSGILPNTTDMRLRPGTRRDDSTKLELALTGGEAKSIPLECPLSSPKGVLFSSK
                     SAEVCKQDSPFSRVPRKVQPGYPVVPAEKRSSGERARETGGAEGTGDAVLGEKVLEEA
                     LLSREHVLELENSKGPSLASLEGEEDKGKSSSSQVVGPVQEEEYVAEKLPSRFIESAH
                     TELAKDDAAPAPPVADAKAQDRGVEGELGNEESLDRNEEGLDRNEEGLDRNEESLDRN
                     EEGLDRNEEIKRAAFQIISQVISEATEQVLATTVGKVAGRVCQASQLQGQKEESCVPV
                     HQKTVLGPDTAEPATAEAAVAPPDAGLPLPGLPAEGSPPPKTYVSCLKSLLSSPTKDS
                     KPNISAHHISLASCLALTTPSEELPDRAGILVEDATCVTCMSDSSQSVPLVASPGHCS
                     DSFSTSGLEDSCTETSSSPRDKAITPPLPESTVPFSNGVLKGELSDLGAEDGWTMDAE
                     ADHSGGSDRNSMDSVDSCCSLKKTESFQNAQAGSNPKKVDLIIWEIEVPKHLVGRLIG
                     KQGRYVSFLKQTSGAKIYISTLPYTQSVQICHIEGSQHHVDKALNLIGKKFKELNLTN
                     IYAPPLPSLALPSLPMTSWLMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLD
                     QQMYLCYSQPGIPTLPTPVEITVICAAPGADGAWWRAQVVASYEETNEVEIRYVDYGG
                     YKRVKVDVLRQIRSDFVTLPFQGAEVLLDSVMPLSDDDQFSPEADAAMSEMTGNTALL
                     AQVTSYSPTGLPLIQLWSVVGDEVVLINRSLVERGLAQWVDSYYTSL"
     exon            1892..2025
                     /gene="AKAP1"
                     /gene_synonym="AKAP; AKAP121; AKAP149; AKAP84; D-AKAP1;
                     PPP1R43; PRKA1; SAKAP84; TDRD17"
                     /inference="alignment:Splign:2.1.0"
     exon            2026..2152
                     /gene="AKAP1"
                     /gene_synonym="AKAP; AKAP121; AKAP149; AKAP84; D-AKAP1;
                     PPP1R43; PRKA1; SAKAP84; TDRD17"
                     /inference="alignment:Splign:2.1.0"
     exon            2153..2280
                     /gene="AKAP1"
                     /gene_synonym="AKAP; AKAP121; AKAP149; AKAP84; D-AKAP1;
                     PPP1R43; PRKA1; SAKAP84; TDRD17"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2458
                     /gene="AKAP1"
                     /gene_synonym="AKAP; AKAP121; AKAP149; AKAP84; D-AKAP1;
                     PPP1R43; PRKA1; SAKAP84; TDRD17"
                     /inference="alignment:Splign:2.1.0"
     exon            2459..2609
                     /gene="AKAP1"
                     /gene_synonym="AKAP; AKAP121; AKAP149; AKAP84; D-AKAP1;
                     PPP1R43; PRKA1; SAKAP84; TDRD17"
                     /inference="alignment:Splign:2.1.0"
     exon            2610..2677
                     /gene="AKAP1"
                     /gene_synonym="AKAP; AKAP121; AKAP149; AKAP84; D-AKAP1;
                     PPP1R43; PRKA1; SAKAP84; TDRD17"
                     /inference="alignment:Splign:2.1.0"
     exon            2678..2751
                     /gene="AKAP1"
                     /gene_synonym="AKAP; AKAP121; AKAP149; AKAP84; D-AKAP1;
                     PPP1R43; PRKA1; SAKAP84; TDRD17"
                     /inference="alignment:Splign:2.1.0"
     exon            2752..2814
                     /gene="AKAP1"
                     /gene_synonym="AKAP; AKAP121; AKAP149; AKAP84; D-AKAP1;
                     PPP1R43; PRKA1; SAKAP84; TDRD17"
                     /inference="alignment:Splign:2.1.0"
     exon            2815..3909
                     /gene="AKAP1"
                     /gene_synonym="AKAP; AKAP121; AKAP149; AKAP84; D-AKAP1;
                     PPP1R43; PRKA1; SAKAP84; TDRD17"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3813
                     /gene="AKAP1"
                     /gene_synonym="AKAP; AKAP121; AKAP149; AKAP84; D-AKAP1;
                     PPP1R43; PRKA1; SAKAP84; TDRD17"
                     /note="major polyA site"
     regulatory      3888..3893
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AKAP1"
                     /gene_synonym="AKAP; AKAP121; AKAP149; AKAP84; D-AKAP1;
                     PPP1R43; PRKA1; SAKAP84; TDRD17"
                     /note="hexamer: CATAAA"
     polyA_site      3909
                     /gene="AKAP1"
                     /gene_synonym="AKAP; AKAP121; AKAP149; AKAP84; D-AKAP1;
                     PPP1R43; PRKA1; SAKAP84; TDRD17"
                     /note="major polyA site"
ORIGIN      
        1 agtatttaat gtctctgtgt tccacccgcc tgggctagca cgtgggggag ctgcggaagc
       61 gcggcgctgc gggccgggcc gcggggcaca gccgggggcc ggcggcggcg cgcggactcc
      121 gcatcccgca ccccgatggt agccgaggag ctggtgtaat tacttcaagc ctccaggatg
      181 gcaatccagt tccgttcgct cttccccttg gcattgcctg ggatgctggc gctcctcggc
      241 tggtggtggt ttttctctcg taaaaaaggc catgtcagca gccatgatga gcagcaggtg
      301 gaggctggtg ctgtgcagct gagggctgac cctgccatca aggaacctct ccccgtggaa
      361 gacgtctgtc ccaaagtagt gtccacaccc cccagtgtca cagagcctcc agaaaaggaa
      421 ctgtccaccg tgagcaagct gcctgcagag cccccagcat tgctccagac acacccacct
      481 tgccgaagat cagagtcctc gggcattctt cctaacacca cagacatgag attgcgacca
      541 ggaacacgca gagatgacag tacaaagctg gagctagccc tgacaggtgg tgaagccaaa
      601 tcgattcctc tagagtgccc cctttcatcc ccaaagggtg tactattctc cagcaaatca
      661 gctgaggtgt gtaagcaaga ttcccccttc agcagggtgc caaggaaggt ccagccaggc
      721 taccccgtag tccccgcaga gaagcgtagc tctggggaga gggcaagaga gacaggtggg
      781 gccgaaggga ctggtgatgc cgtgttgggg gaaaaggtgc ttgaagaagc tctgttgtct
      841 cgggagcatg tcttggaatt ggagaacagc aagggcccca gcctggcctc tttagagggg
      901 gaagaagata aggggaagag cagctcatcc caggtggtgg ggccagtgca ggaggaagag
      961 tatgtagcag agaagttgcc aagtaggttc atcgagtcgg ctcacacaga gctggcaaag
     1021 gacgatgcgg cgccagcacc cccagtcgca gacgccaaag cccaggatag aggtgtcgag
     1081 ggagaactgg gcaatgagga gagcttggat agaaatgagg agggcttgga tagaaatgag
     1141 gagggcttgg atagaaatga ggagagcttg gatagaaatg aggagggctt ggatagaaat
     1201 gaggagatta agcgggctgc cttccagata atctcccaag tgatctcaga agcaaccgaa
     1261 caggtgctgg ccaccacggt tggcaaggtt gcaggtcgtg tgtgtcaggc cagtcagctc
     1321 caagggcaga aggaagagag ctgtgtccca gttcaccaga aaactgtctt gggcccagac
     1381 actgcggagc ctgccacagc agaggcagct gttgccccgc cggatgctgg cctccccttg
     1441 ccaggcctac cagcagaggg ctcaccacca ccaaagacct acgtgagctg cctgaagagc
     1501 cttctgtcca gccccaccaa ggacagtaag ccaaatatct ctgcacacca catctccctg
     1561 gcctcctgcc tggcactgac cacccccagt gaagagttgc cggaccgggc aggcatcctg
     1621 gtggaagatg ccacctgtgt cacctgcatg tcagacagca gccaaagtgt ccctttggtg
     1681 gcttctccag gacactgctc agattctttc agcacttcag ggcttgaaga ctcttgcaca
     1741 gagaccagct cgagccccag ggacaaggcc atcaccccgc cactgccaga aagtactgtg
     1801 cccttcagca atggggtgct gaagggggag ttgtcagact tgggggctga ggatggatgg
     1861 accatggatg cggaagcaga tcattcagga ggttctgaca ggaacagcat ggattccgtg
     1921 gatagctgtt gcagtctcaa gaagactgag agcttccaaa atgcccaggc aggctccaac
     1981 cctaagaagg tcgacctcat catctgggag atcgaggtgc caaagcactt agtcggtcgg
     2041 ctaattggca agcaggggcg ctatgtgagt tttctgaagc aaacatctgg tgccaagatc
     2101 tacatttcaa ccctgcctta cacccagagc gtccagatct gccacataga aggctctcaa
     2161 catcatgtag acaaagcgct gaacttgatt gggaagaagt tcaaagagct gaacctcacc
     2221 aatatctacg ctcccccatt gccttcactg gcactgcctt ctctgccgat gacatcctgg
     2281 ctcatgctgc ctgatggcat caccgtggag gtcattgtgg tcaaccaggt caatgccggg
     2341 cacctgttcg tgcagcagca cacacaccct accttccacg cgctgcgcag cctcgaccag
     2401 cagatgtacc tctgttactc tcagcctgga atccccacct tgcccacccc agtggaaata
     2461 acggtcatct gtgccgcccc tggtgcggac ggggcctggt ggcgagccca agtggttgcc
     2521 tcctacgagg agaccaacga agtggagatt cgatacgtgg actacggcgg atataagagg
     2581 gtgaaagtag acgtgctccg gcaaatcagg tctgactttg tcaccctgcc gtttcaggga
     2641 gcagaagtcc ttctggacag tgtgatgccc ctgtcagacg atgaccagtt ttcaccggaa
     2701 gcagatgccg ccatgagcga gatgacgggg aatacagcac tgcttgctca ggtgacaagt
     2761 tacagtccaa ctggtcttcc tctgattcag ctgtggagtg tggttggaga tgaagtggtg
     2821 ttgataaacc ggtccctggt ggagcgaggc cttgcccagt gggtagacag ctactacaca
     2881 agcctttgac ccccatgctg cttcctgaga gtcttttttt gcactgttga aattgggctt
     2941 ggcactcaag tcaaagatga acatcggaat aacaaacatt gtcctctcca gaaagtcctt
     3001 tctttctcca tactgtagtc ctattgagaa gacatttcgt ctctgagaaa aaaggatgga
     3061 actatgggtt ctcttcgcaa agccaaagga tagtgtttaa caagccagct ggcttatgct
     3121 ggttctcagc tgtttaaaaa aaaaaaaaaa aaggaataga aacagtttca accagattgt
     3181 cctattcccc ctgttccatt cccctcttct tccttctatc tccttccccg gcaaaaacca
     3241 aacaaactgg cagacaggcc agggatgtat gttgcttgct tgagagggtt tcttttactt
     3301 caaaatcttt cttcagggag caagacatga actgactaat tggtatccac tacttgtaca
     3361 gcttacataa atgagttgat gatatttaac cagtttttat aaacttcatt taggtctcta
     3421 aacacagact ttttaaattg caactgtaaa tatgaaatgg tcatcacatc tgaccttggt
     3481 cagtggggag gggaactggt atcctgccaa gcctggttgt aatttgtaac cattttctat
     3541 ttgtgcaaac tctgtaaata tgtgtttaaa caaatgtaat attttgtaca agatacactg
     3601 gagaacaaag ggaactcaag attcttccag ccacatgtca cctgtaggta gaagtaaact
     3661 ctgcagtgca gcttctgctc ttggcccctc tggccagggc ccctgtggct tcctgcacac
     3721 tggacaggtg actgtatggt agagactgtg atctgggaac tttttgctgt acaaatctgt
     3781 ttaaaaaaaa aaaaaagtaa ctcattgaat taacttgcag tggtgtgttt gattcttttt
     3841 tagactggct tcagcattgt gcagtttaaa aataagtaag taacttacat aaatcttcaa
     3901 ttgtatgaa
//
