LOCUS       NM_001370424            3833 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens A-kinase anchoring protein 1 (AKAP1), transcript
            variant 5, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001370424 XM_017025191
VERSION     NM_001370424.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3833)
  AUTHORS   Fang,Y., Xu,J. and Huang,R.
  TITLE     AKAP1 in Renal Patients with AHF to Reduce Ferroptosis of
            Cardiomyocyte
  JOURNAL   Heart Surg Forum 27 (1), E028-E037 (2024)
   PUBMED   38286648
  REMARK    GeneRIF: AKAP1 in Renal Patients with AHF to Reduce Ferroptosis of
            Cardiomyocyte.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3833)
  AUTHORS   Bastola,T., Perkins,G.A., Kim,K.Y., Choi,S., Kwon,J.W., Shen,Z.,
            Strack,S. and Ju,W.K.
  TITLE     Role of A-Kinase Anchoring Protein 1 in Retinal Ganglion Cells:
            Neurodegeneration and Neuroprotection
  JOURNAL   Cells 12 (11), 1539 (2023)
   PUBMED   37296658
  REMARK    GeneRIF: Role of A-Kinase Anchoring Protein 1 in Retinal Ganglion
            Cells: Neurodegeneration and Neuroprotection.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3833)
  AUTHORS   Xiang,H., Xu,H., Tan,B., Yi,Q., Zhang,X., Wang,R., Chen,T., Xie,Q.,
            Tian,J. and Zhu,J.
  TITLE     AKAP1 Regulates Mitochondrial Dynamics during the
            Fatty-Acid-Promoted Maturation of Human-Induced Pluripotent Stem
            Cell-Derived Cardiomyocytes as Indicated by Proteomics Sequencing
  JOURNAL   Int J Mol Sci 24 (9), 8112 (2023)
   PUBMED   37175819
  REMARK    GeneRIF: AKAP1 Regulates Mitochondrial Dynamics during the
            Fatty-Acid-Promoted Maturation of Human-Induced Pluripotent Stem
            Cell-Derived Cardiomyocytes as Indicated by Proteomics Sequencing.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3833)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   5  (bases 1 to 3833)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 3833)
  AUTHORS   Huang,L.J., Wang,L., Ma,Y., Durick,K., Perkins,G., Deerinck,T.J.,
            Ellisman,M.H. and Taylor,S.S.
  TITLE     NH2-Terminal targeting motifs direct dual specificity
            A-kinase-anchoring protein 1 (D-AKAP1) to either mitochondria or
            endoplasmic reticulum
  JOURNAL   J Cell Biol 145 (5), 951-959 (1999)
   PUBMED   10352013
REFERENCE   7  (bases 1 to 3833)
  AUTHORS   Huang,L.J., Durick,K., Weiner,J.A., Chun,J. and Taylor,S.S.
  TITLE     Identification of a novel protein kinase A anchoring protein that
            binds both type I and type II regulatory subunits
  JOURNAL   J Biol Chem 272 (12), 8057-8064 (1997)
   PUBMED   9065479
REFERENCE   8  (bases 1 to 3833)
  AUTHORS   Lester,L.B. and Scott,J.D.
  TITLE     Anchoring and scaffold proteins for kinases and phosphatases
  JOURNAL   Recent Prog Horm Res 52, 409-29 (1997)
   PUBMED   9238861
  REMARK    Review article
REFERENCE   9  (bases 1 to 3833)
  AUTHORS   Trendelenburg,G., Hummel,M., Riecken,E.O. and Hanski,C.
  TITLE     Molecular characterization of AKAP149, a novel A kinase anchor
            protein with a KH domain
  JOURNAL   Biochem Biophys Res Commun 225 (1), 313-319 (1996)
   PUBMED   8769136
REFERENCE   10 (bases 1 to 3833)
  AUTHORS   Lin,R.Y., Moss,S.B. and Rubin,C.S.
  TITLE     Characterization of S-AKAP84, a novel developmentally regulated A
            kinase anchor protein of male germ cells
  JOURNAL   J Biol Chem 270 (46), 27804-27811 (1995)
   PUBMED   7499250
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007114.8.
            
            On May 7, 2019 this sequence version replaced XM_017025191.2.
            
            Summary: The A-kinase anchor proteins (AKAPs) are a group of
            structurally diverse proteins, which have the common function of
            binding to the regulatory subunit of protein kinase A (PKA) and
            confining the holoenzyme to discrete locations within the cell.
            This gene encodes a member of the AKAP family. The encoded protein
            binds to type I and type II regulatory subunits of PKA and anchors
            them to the mitochondrion. This protein is speculated to be
            involved in the cAMP-dependent signal transduction pathway and in
            directing RNA to a specific cellular compartment. [provided by
            RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.121941.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2145774
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                AC007114.8         41040-41116         c
            78-1815             AC007114.8         19694-21431         c
            1816-1949           AC007114.8         16714-16847         c
            1950-2076           AC007114.8         14948-15074         c
            2077-2204           AC007114.8         14254-14381         c
            2205-2382           AC007114.8         12236-12413         c
            2383-2533           AC007114.8         10611-10761         c
            2534-2601           AC007114.8         9945-10012          c
            2602-2675           AC007114.8         8418-8491           c
            2676-2738           AC007114.8         7828-7890           c
            2739-3833           AC007114.8         5528-6622           c
FEATURES             Location/Qualifiers
     source          1..3833
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q22"
     gene            1..3833
                     /gene="AKAP1"
                     /gene_synonym="AKAP; AKAP121; AKAP149; AKAP84; D-AKAP1;
                     PPP1R43; PRKA1; SAKAP84; TDRD17"
                     /note="A-kinase anchoring protein 1"
                     /db_xref="GeneID:8165"
                     /db_xref="HGNC:HGNC:367"
                     /db_xref="MIM:602449"
     exon            1..77
                     /gene="AKAP1"
                     /gene_synonym="AKAP; AKAP121; AKAP149; AKAP84; D-AKAP1;
                     PPP1R43; PRKA1; SAKAP84; TDRD17"
                     /inference="alignment:Splign:2.1.0"
     exon            78..1815
                     /gene="AKAP1"
                     /gene_synonym="AKAP; AKAP121; AKAP149; AKAP84; D-AKAP1;
                     PPP1R43; PRKA1; SAKAP84; TDRD17"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..2813
                     /gene="AKAP1"
                     /gene_synonym="AKAP; AKAP121; AKAP149; AKAP84; D-AKAP1;
                     PPP1R43; PRKA1; SAKAP84; TDRD17"
                     /note="protein kinase A1; A kinase (PRKA) anchor protein
                     1; tudor domain containing 17; A-kinase anchor protein 1,
                     mitochondrial; spermatid A-kinase anchor protein 84;
                     protein kinase A anchoring protein 1; dual-specificity
                     A-kinase anchoring protein 1; AKAP 149; D-AKAP-1; A-kinase
                     anchor protein 149 kDa; protein phosphatase 1, regulatory
                     subunit 43; testicular secretory protein Li 5"
                     /codon_start=1
                     /product="A-kinase anchor protein 1, mitochondrial
                     precursor"
                     /protein_id="NP_001357353.1"
                     /db_xref="CCDS:CCDS11594.1"
                     /db_xref="GeneID:8165"
                     /db_xref="HGNC:HGNC:367"
                     /db_xref="MIM:602449"
                     /translation="MAIQFRSLFPLALPGMLALLGWWWFFSRKKGHVSSHDEQQVEAG
                     AVQLRADPAIKEPLPVEDVCPKVVSTPPSVTEPPEKELSTVSKLPAEPPALLQTHPPC
                     RRSESSGILPNTTDMRLRPGTRRDDSTKLELALTGGEAKSIPLECPLSSPKGVLFSSK
                     SAEVCKQDSPFSRVPRKVQPGYPVVPAEKRSSGERARETGGAEGTGDAVLGEKVLEEA
                     LLSREHVLELENSKGPSLASLEGEEDKGKSSSSQVVGPVQEEEYVAEKLPSRFIESAH
                     TELAKDDAAPAPPVADAKAQDRGVEGELGNEESLDRNEEGLDRNEEGLDRNEESLDRN
                     EEGLDRNEEIKRAAFQIISQVISEATEQVLATTVGKVAGRVCQASQLQGQKEESCVPV
                     HQKTVLGPDTAEPATAEAAVAPPDAGLPLPGLPAEGSPPPKTYVSCLKSLLSSPTKDS
                     KPNISAHHISLASCLALTTPSEELPDRAGILVEDATCVTCMSDSSQSVPLVASPGHCS
                     DSFSTSGLEDSCTETSSSPRDKAITPPLPESTVPFSNGVLKGELSDLGAEDGWTMDAE
                     ADHSGGSDRNSMDSVDSCCSLKKTESFQNAQAGSNPKKVDLIIWEIEVPKHLVGRLIG
                     KQGRYVSFLKQTSGAKIYISTLPYTQSVQICHIEGSQHHVDKALNLIGKKFKELNLTN
                     IYAPPLPSLALPSLPMTSWLMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLD
                     QQMYLCYSQPGIPTLPTPVEITVICAAPGADGAWWRAQVVASYEETNEVEIRYVDYGG
                     YKRVKVDVLRQIRSDFVTLPFQGAEVLLDSVMPLSDDDQFSPEADAAMSEMTGNTALL
                     AQVTSYSPTGLPLIQLWSVVGDEVVLINRSLVERGLAQWVDSYYTSL"
     exon            1816..1949
                     /gene="AKAP1"
                     /gene_synonym="AKAP; AKAP121; AKAP149; AKAP84; D-AKAP1;
                     PPP1R43; PRKA1; SAKAP84; TDRD17"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2076
                     /gene="AKAP1"
                     /gene_synonym="AKAP; AKAP121; AKAP149; AKAP84; D-AKAP1;
                     PPP1R43; PRKA1; SAKAP84; TDRD17"
                     /inference="alignment:Splign:2.1.0"
     exon            2077..2204
                     /gene="AKAP1"
                     /gene_synonym="AKAP; AKAP121; AKAP149; AKAP84; D-AKAP1;
                     PPP1R43; PRKA1; SAKAP84; TDRD17"
                     /inference="alignment:Splign:2.1.0"
     exon            2205..2382
                     /gene="AKAP1"
                     /gene_synonym="AKAP; AKAP121; AKAP149; AKAP84; D-AKAP1;
                     PPP1R43; PRKA1; SAKAP84; TDRD17"
                     /inference="alignment:Splign:2.1.0"
     exon            2383..2533
                     /gene="AKAP1"
                     /gene_synonym="AKAP; AKAP121; AKAP149; AKAP84; D-AKAP1;
                     PPP1R43; PRKA1; SAKAP84; TDRD17"
                     /inference="alignment:Splign:2.1.0"
     exon            2534..2601
                     /gene="AKAP1"
                     /gene_synonym="AKAP; AKAP121; AKAP149; AKAP84; D-AKAP1;
                     PPP1R43; PRKA1; SAKAP84; TDRD17"
                     /inference="alignment:Splign:2.1.0"
     exon            2602..2675
                     /gene="AKAP1"
                     /gene_synonym="AKAP; AKAP121; AKAP149; AKAP84; D-AKAP1;
                     PPP1R43; PRKA1; SAKAP84; TDRD17"
                     /inference="alignment:Splign:2.1.0"
     exon            2676..2738
                     /gene="AKAP1"
                     /gene_synonym="AKAP; AKAP121; AKAP149; AKAP84; D-AKAP1;
                     PPP1R43; PRKA1; SAKAP84; TDRD17"
                     /inference="alignment:Splign:2.1.0"
     exon            2739..3833
                     /gene="AKAP1"
                     /gene_synonym="AKAP; AKAP121; AKAP149; AKAP84; D-AKAP1;
                     PPP1R43; PRKA1; SAKAP84; TDRD17"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3737
                     /gene="AKAP1"
                     /gene_synonym="AKAP; AKAP121; AKAP149; AKAP84; D-AKAP1;
                     PPP1R43; PRKA1; SAKAP84; TDRD17"
                     /note="major polyA site"
     regulatory      3812..3817
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AKAP1"
                     /gene_synonym="AKAP; AKAP121; AKAP149; AKAP84; D-AKAP1;
                     PPP1R43; PRKA1; SAKAP84; TDRD17"
                     /note="hexamer: CATAAA"
     polyA_site      3833
                     /gene="AKAP1"
                     /gene_synonym="AKAP; AKAP121; AKAP149; AKAP84; D-AKAP1;
                     PPP1R43; PRKA1; SAKAP84; TDRD17"
                     /note="major polyA site"
ORIGIN      
        1 gtcgcctctc tgcacctcaa cttaaccgga gcgtgcacac ccgcctgcga ggctgacccg
       61 agcgcgtccc acccaaggtg taattacttc aagcctccag gatggcaatc cagttccgtt
      121 cgctcttccc cttggcattg cctgggatgc tggcgctcct cggctggtgg tggtttttct
      181 ctcgtaaaaa aggccatgtc agcagccatg atgagcagca ggtggaggct ggtgctgtgc
      241 agctgagggc tgaccctgcc atcaaggaac ctctccccgt ggaagacgtc tgtcccaaag
      301 tagtgtccac accccccagt gtcacagagc ctccagaaaa ggaactgtcc accgtgagca
      361 agctgcctgc agagccccca gcattgctcc agacacaccc accttgccga agatcagagt
      421 cctcgggcat tcttcctaac accacagaca tgagattgcg accaggaaca cgcagagatg
      481 acagtacaaa gctggagcta gccctgacag gtggtgaagc caaatcgatt cctctagagt
      541 gccccctttc atccccaaag ggtgtactat tctccagcaa atcagctgag gtgtgtaagc
      601 aagattcccc cttcagcagg gtgccaagga aggtccagcc aggctacccc gtagtccccg
      661 cagagaagcg tagctctggg gagagggcaa gagagacagg tggggccgaa gggactggtg
      721 atgccgtgtt gggggaaaag gtgcttgaag aagctctgtt gtctcgggag catgtcttgg
      781 aattggagaa cagcaagggc cccagcctgg cctctttaga gggggaagaa gataagggga
      841 agagcagctc atcccaggtg gtggggccag tgcaggagga agagtatgta gcagagaagt
      901 tgccaagtag gttcatcgag tcggctcaca cagagctggc aaaggacgat gcggcgccag
      961 cacccccagt cgcagacgcc aaagcccagg atagaggtgt cgagggagaa ctgggcaatg
     1021 aggagagctt ggatagaaat gaggagggct tggatagaaa tgaggagggc ttggatagaa
     1081 atgaggagag cttggataga aatgaggagg gcttggatag aaatgaggag attaagcggg
     1141 ctgccttcca gataatctcc caagtgatct cagaagcaac cgaacaggtg ctggccacca
     1201 cggttggcaa ggttgcaggt cgtgtgtgtc aggccagtca gctccaaggg cagaaggaag
     1261 agagctgtgt cccagttcac cagaaaactg tcttgggccc agacactgcg gagcctgcca
     1321 cagcagaggc agctgttgcc ccgccggatg ctggcctccc cttgccaggc ctaccagcag
     1381 agggctcacc accaccaaag acctacgtga gctgcctgaa gagccttctg tccagcccca
     1441 ccaaggacag taagccaaat atctctgcac accacatctc cctggcctcc tgcctggcac
     1501 tgaccacccc cagtgaagag ttgccggacc gggcaggcat cctggtggaa gatgccacct
     1561 gtgtcacctg catgtcagac agcagccaaa gtgtcccttt ggtggcttct ccaggacact
     1621 gctcagattc tttcagcact tcagggcttg aagactcttg cacagagacc agctcgagcc
     1681 ccagggacaa ggccatcacc ccgccactgc cagaaagtac tgtgcccttc agcaatgggg
     1741 tgctgaaggg ggagttgtca gacttggggg ctgaggatgg atggaccatg gatgcggaag
     1801 cagatcattc aggaggttct gacaggaaca gcatggattc cgtggatagc tgttgcagtc
     1861 tcaagaagac tgagagcttc caaaatgccc aggcaggctc caaccctaag aaggtcgacc
     1921 tcatcatctg ggagatcgag gtgccaaagc acttagtcgg tcggctaatt ggcaagcagg
     1981 ggcgctatgt gagttttctg aagcaaacat ctggtgccaa gatctacatt tcaaccctgc
     2041 cttacaccca gagcgtccag atctgccaca tagaaggctc tcaacatcat gtagacaaag
     2101 cgctgaactt gattgggaag aagttcaaag agctgaacct caccaatatc tacgctcccc
     2161 cattgccttc actggcactg ccttctctgc cgatgacatc ctggctcatg ctgcctgatg
     2221 gcatcaccgt ggaggtcatt gtggtcaacc aggtcaatgc cgggcacctg ttcgtgcagc
     2281 agcacacaca ccctaccttc cacgcgctgc gcagcctcga ccagcagatg tacctctgtt
     2341 actctcagcc tggaatcccc accttgccca ccccagtgga aataacggtc atctgtgccg
     2401 cccctggtgc ggacggggcc tggtggcgag cccaagtggt tgcctcctac gaggagacca
     2461 acgaagtgga gattcgatac gtggactacg gcggatataa gagggtgaaa gtagacgtgc
     2521 tccggcaaat caggtctgac tttgtcaccc tgccgtttca gggagcagaa gtccttctgg
     2581 acagtgtgat gcccctgtca gacgatgacc agttttcacc ggaagcagat gccgccatga
     2641 gcgagatgac ggggaataca gcactgcttg ctcaggtgac aagttacagt ccaactggtc
     2701 ttcctctgat tcagctgtgg agtgtggttg gagatgaagt ggtgttgata aaccggtccc
     2761 tggtggagcg aggccttgcc cagtgggtag acagctacta cacaagcctt tgacccccat
     2821 gctgcttcct gagagtcttt ttttgcactg ttgaaattgg gcttggcact caagtcaaag
     2881 atgaacatcg gaataacaaa cattgtcctc tccagaaagt cctttctttc tccatactgt
     2941 agtcctattg agaagacatt tcgtctctga gaaaaaagga tggaactatg ggttctcttc
     3001 gcaaagccaa aggatagtgt ttaacaagcc agctggctta tgctggttct cagctgttta
     3061 aaaaaaaaaa aaaaaaggaa tagaaacagt ttcaaccaga ttgtcctatt ccccctgttc
     3121 cattcccctc ttcttccttc tatctccttc cccggcaaaa accaaacaaa ctggcagaca
     3181 ggccagggat gtatgttgct tgcttgagag ggtttctttt acttcaaaat ctttcttcag
     3241 ggagcaagac atgaactgac taattggtat ccactacttg tacagcttac ataaatgagt
     3301 tgatgatatt taaccagttt ttataaactt catttaggtc tctaaacaca gactttttaa
     3361 attgcaactg taaatatgaa atggtcatca catctgacct tggtcagtgg ggaggggaac
     3421 tggtatcctg ccaagcctgg ttgtaatttg taaccatttt ctatttgtgc aaactctgta
     3481 aatatgtgtt taaacaaatg taatattttg tacaagatac actggagaac aaagggaact
     3541 caagattctt ccagccacat gtcacctgta ggtagaagta aactctgcag tgcagcttct
     3601 gctcttggcc cctctggcca gggcccctgt ggcttcctgc acactggaca ggtgactgta
     3661 tggtagagac tgtgatctgg gaactttttg ctgtacaaat ctgtttaaaa aaaaaaaaaa
     3721 gtaactcatt gaattaactt gcagtggtgt gtttgattct tttttagact ggcttcagca
     3781 ttgtgcagtt taaaaataag taagtaactt acataaatct tcaattgtat gaa
//
